BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346217   2 LADKHAKEIEEESEttveaDLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYD 81
Cdd:cd04709   56 LADQHRRELEEKSD-----DLTPKQRHQLRHRELFLSRQVETLPATHIRGKCSVTLLNDTESARSYLAREDTFFYSLVYD 130

                         90       100       110
                 ....*....|....*....|....*....|...
gi 544346217  82 PSLKTLLADKGEIRVGPRYQADIPEMLLEGESD 114
Cdd:cd04709  131 PEQKTLLADQGEIRVGPSYQAKLPDLQPFPSPD 163

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 544346217 214 EWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKT 259
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46

zinc finger binding to DNA consensus sequence [AT]GATA[AG];

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 544346217   319 GRACESCYATQSHQWYSWGPPNmqCRLCAICWLYWKKYGGLKMPTQSEEE 368
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKD 50

BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346217   2 LADKHAKEIEEESEttveaDLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYD 81
Cdd:cd04709   56 LADQHRRELEEKSD-----DLTPKQRHQLRHRELFLSRQVETLPATHIRGKCSVTLLNDTESARSYLAREDTFFYSLVYD 130

                         90       100       110
                 ....*....|....*....|....*....|...
gi 544346217  82 PSLKTLLADKGEIRVGPRYQADIPEMLLEGESD 114
Cdd:cd04709  131 PEQKTLLADQGEIRVGPSYQAKLPDLQPFPSPD 163

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 544346217 214 EWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKT 259
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46

zinc finger binding to DNA consensus sequence [AT]GATA[AG];

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 544346217   319 GRACESCYATQSHQWYSWGPPNmqCRLCAICWLYWKKYGGLKMPTQSEEE 368
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKD 50

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 544346217  322 CESCYATQSHQWYSWgpPNMQCRLCAICWLYWKKYGGL 359
Cdd:pfam00320   1 CSNCGTTKTPLWRRG--PNGNRTLCNACGLYYKKKGLK 36

Bromo adjacent homology domain;

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544346217    28 HQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDK--EDTFFYSLVYDPSLKTLLADK 91
Cdd:smart00439  56 ALFDKNEVFLSDEYDTVPLSDIIGKCNVLYKSDYPGLRPEGSIgePDVFFCESAYDPEKGSFKKLP 121

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 544346217   213 EEWSASEASLFEEALEKYG-KDFNDIRQdFLPWKSLTSIIEYYYMWKTT 260
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAK-ELPGRTAEQCRERWRNLLKP 49

BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346217   2 LADKHAKEIEEESEttveaDLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYD 81
Cdd:cd04709   56 LADQHRRELEEKSD-----DLTPKQRHQLRHRELFLSRQVETLPATHIRGKCSVTLLNDTESARSYLAREDTFFYSLVYD 130

                         90       100       110
                 ....*....|....*....|....*....|...
gi 544346217  82 PSLKTLLADKGEIRVGPRYQADIPEMLLEGESD 114
Cdd:cd04709  131 PEQKTLLADQGEIRVGPSYQAKLPDLQPFPSPD 163

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 544346217 214 EWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKT 259
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46

zinc finger binding to DNA consensus sequence [AT]GATA[AG];

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 544346217   319 GRACESCYATQSHQWYSWGPPNmqCRLCAICWLYWKKYGGLKMPTQSEEE 368
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGN--KTLCNACGLYYKKHGGLKRPLSLKKD 50

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 544346217  322 CESCYATQSHQWYSWgpPNMQCRLCAICWLYWKKYGGL 359
Cdd:pfam00320   1 CSNCGTTKTPLWRRG--PNGNRTLCNACGLYYKKKGLK 36

BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346217   8 KEIEEESETTVEA---------DLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDK--EDTFFY 76
Cdd:cd04370   29 EELWEDTNGSKQVkvrwfyrpeETPKGLSPFALRRELFLSDHLDEIPVESIIGKCKVLFVSEFEGLKQRPNKidTDDFFC 108

                         90
                 ....*....|.
gi 544346217  77 SLVYDPSLKTL 87
Cdd:cd04370  109 RLAYDPTTKEF 119

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 544346217  214 EWSASEASLFEEALEKYGKDFNDIrQDFLPWKSLTSIIEYYYMWK 258
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 544346217 214 EWSASEASLFEEALEKYG-KDFNDIRQdFLPWKSLTSIIEYYYMWK 258
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAK-ELPGRTPKQCRERWRNLL 45