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Conserved domains on  [gi|539845980|ref|NP_001269342|]
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protein phosphatase 1 regulatory subunit 7 isoform 6 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-295 5.10e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 136.45  E-value: 5.10e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 104 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 183
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 184 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 255
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 539845980 256 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 295
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 24-139 1.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  24 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 94
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 539845980  95 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 139
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-295 5.10e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 136.45  E-value: 5.10e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 104 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 183
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 184 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 255
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 539845980 256 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 295
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-253 3.06e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  36 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 114
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 115 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 190
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 539845980 191 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 253
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 24-139 1.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  24 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 94
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 539845980  95 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 139
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
64-185 1.36e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980   64 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 141
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 539845980  142 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 185
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-277 5.85e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 5.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  43 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 116
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 117 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 168
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 169 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 235
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 539845980 236 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 277
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 61-103 6.86e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 6.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 539845980   61 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 103
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 277-295 3.81e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.81e-03
                           10
                   ....*....|....*....
gi 539845980   277 DPQYRRKVMLALPSVRQID 295
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-295 5.10e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 136.45  E-value: 5.10e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 104 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 183
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 184 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 255
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 539845980 256 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 295
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-253 3.06e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  36 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 114
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 115 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 190
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 539845980 191 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 253
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-272 1.35e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  46 LRQNLIKCIENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKI-EN 122
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 123 LSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYL 200
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDL 257

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 539845980 201 SHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 272
Cdd:COG4886  258 SNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-278 2.17e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.68  E-value: 2.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  13 INLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISF 92
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  93 NLLRNIEGVDKLTRLKKLFLVNnkISKIENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDAL 170
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELD--LSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 171 TNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDN 247
Cdd:COG4886  159 TNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 539845980 248 LLeswSDLDELKGARSLETVYLERNPLQKDP 278
Cdd:COG4886  239 QL---TDLPELGNLTNLEELDLSNNQLTDLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-280 2.19e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 2.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  23 DLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI- 98
Cdd:COG4886  142 DLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLp 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  99 EGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSM 178
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 179 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDEL 258
Cdd:COG4886  302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                        250       260
                 ....*....|....*....|..
gi 539845980 259 KGARSLETVYLERNPLQKDPQY 280
Cdd:COG4886  382 LALLLLTLLLLLLTTTAGVLLL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 28-186 6.92e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 6.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  28 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 107
Cdd:cd21340   35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 108 kklflvnnkiskIENLSNlhQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALTNLTVLSMQSNRL 183
Cdd:cd21340  115 ------------LAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180


                 ...
gi 539845980 184 TKI 186
Cdd:cd21340  181 CKK 183
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-267 1.48e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  20 EDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLR 96
Cdd:COG4886  162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  97 NIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR--AIENIDTLTNLESLFLGKNKITKLQNLDALTNLT 174
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 175 VLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSD 254
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|...
gi 539845980 255 LDELKGARSLETV 267
Cdd:COG4886  402 LLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 24-139 1.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  24 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 94
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 539845980  95 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 139
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
64-185 1.36e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 1.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980   64 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 141
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 539845980  142 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 185
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
LRR_9 pfam14580
Leucine-rich repeat;
132-295 2.24e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.84  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  132 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNgievi 208
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNN----- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  209 eglennnkltmldiasnrikkienisHLTELqefwmndnlleswSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 288
Cdd:pfam14580  99 --------------------------NLQEL-------------GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139


                  ....*..
gi 539845980  289 PSVRQID 295
Cdd:pfam14580 140 PQLRLLD 146
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 10-281 2.31e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.80  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  10 METINLDRDAEDVDLNHYRIGKiEGFEVLKKVktlcLRQNlikcienleelQSLRELDLYDNQIKKiENLEALteleild 89
Cdd:COG5238  173 MAKALQNNSVETVYLGCNQIGD-EGIEELAEA----LTQN-----------TTVTTLWLKRNPIGD-EGAEIL------- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  90 isfnllrnIEGVDKLTRLKKLFLVNNKISK------IENLSNLHQLQMLELGSNRIRA------IENIDTLTNLESLFLG 157
Cdd:COG5238  229 --------AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLS 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 158 KNKITKlQNLDALtnltvlsmqsnrltkIEGLQNLVNLRELYLSHNGIEV------IEGLENNNKLTMLDIASNRI---- 227
Cdd:COG5238  301 VNRIGD-EGAIAL---------------AEGLQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgdeg 364

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 539845980 228 -----KKIENISHLTELQEFWMNDNLLESWSDLDELKGARsLETVYLERNPLQKDPQYR 281
Cdd:COG5238  365 aialaKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQR 422
LRR_8 pfam13855
Leucine rich repeat;
171-227 3.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 539845980  171 TNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRI 227
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-277 5.85e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 5.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  43 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 116
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 117 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 168
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980 169 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 235
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 539845980 236 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 277
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_8 pfam13855
Leucine rich repeat;
149-205 7.43e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 7.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 539845980  149 TNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 205
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 171-203 3.91e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 3.91e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 539845980  171 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 203
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
83-139 4.00e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 539845980   83 TELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRI 139
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 61-103 6.86e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 6.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 539845980   61 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 103
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 149-191 7.20e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 7.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 539845980  149 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSN-RLTKIEGLQN 191
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
105-161 1.29e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 539845980  105 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 161
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
22-97 1.50e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 1.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 539845980   22 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-LQSLRELDLYDNQIKKIENLEALTELEILDiSFNLLRN 97
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 105-150 2.19e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 2.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 539845980  105 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIraIENIDTLTN 150
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
194-249 2.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980  194 NLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLL 249
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 194-235 3.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 539845980  194 NLRELYLSHNGIEVIEGLENNNKLTMLDIASN-RIKKIENISH 235
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 277-295 3.81e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.81e-03
                           10
                   ....*....|....*....
gi 539845980   277 DPQYRRKVMLALPSVRQID 295
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 83-125 4.16e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 4.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 539845980   83 TELEILDISFNLLRNIEGVDKLTRLKKLFLV-NNKISKIENLSN 125
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
62-117 7.60e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 7.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 539845980   62 SLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKI 117
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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