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Conserved domains on  [gi|538260582|ref|NP_001269309|]
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arpin isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UPF0552 super family cl11201
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
 1-128 1.27e-80

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


The actual alignment was detected with superfamily member pfam10574:

Pssm-ID: 463152  Cd Length: 224  Bit Score: 236.15  E-value: 1.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260582    1 MSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLE 80
Cdd:pfam10574  97 MSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRLKTRGDGPFIFSLAKLD 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 538260582   81 AGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEW 128
Cdd:pfam10574 177 AGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Name Accession Description Interval E-value
UPF0552 pfam10574
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
 1-128 1.27e-80

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


Pssm-ID: 463152  Cd Length: 224  Bit Score: 236.15  E-value: 1.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260582    1 MSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLE 80
Cdd:pfam10574  97 MSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRLKTRGDGPFIFSLAKLD 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 538260582   81 AGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEW 128
Cdd:pfam10574 177 AGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Name Accession Description Interval E-value
UPF0552 pfam10574
Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting ...
 1-128 1.27e-80

Arp2/3-interacting proteins Arpin; This family includes proteins such as Arp2/3-interacting proteins (Arpin). Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.


Pssm-ID: 463152  Cd Length: 224  Bit Score: 236.15  E-value: 1.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 538260582    1 MSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLE 80
Cdd:pfam10574  97 MSSYKVEAKGQSDRLSEDQLKALVNKTELLKVTEKHTPSGTLAFWLPEAEMEKTELELGDEVRLKTRGDGPFIFSLAKLD 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 538260582   81 AGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEW 128
Cdd:pfam10574 177 AGTVTKCNFAGDDKVGASWTDKIMANKSDQESASEPRGQGDGAEDDEW 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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