|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
172-593 |
1.51e-150 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 447.44 E-value: 1.51e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 172 HNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQakvntdk 251
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRKGV------LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 252 drsllldwdrvrvfdreiaqmflnmtklekEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ 331
Cdd:cd00186 68 ------------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 332 GYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWR 407
Cdd:cd00186 118 GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFK 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 408 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQ 487
Cdd:cd00186 197 LYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 488 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQ 567
Cdd:cd00186 277 TQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEK 355
|
410 420
....*....|....*....|....*.
gi 530788288 568 LNLIAQGKADYRQVLGHTLDVFKRKF 593
Cdd:cd00186 356 LDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
3-752 |
4.73e-146 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 451.38 E-value: 4.73e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 3 TVLMVAEKPSLAQSIAKILSRGSLS--SHKGLNgacsVHEytgtFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAE 80
Cdd:PRK07219 1 TELIIAEKNNAARRIADILSGGKAKkkRVNGVP----YYE----FERKGEKWIVIGLSGHIVTVDFPEEYGDWRDVDPAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 81 LFSqAPTEKKEANPklNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVmnkahgGEKTVFRARFSSITDTDI 160
Cdd:PRK07219 73 LID-ADPVKKITKQ--NYINALKKLAKDADEIIIATDYDREGELIGKEAYHILREV------CQVPVKRARFSSLTKKEI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 161 CNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFqGKYGDLDssLISFGPCQTPTLGFCVERHDKIQSFKPETY 240
Cdd:PRK07219 144 RKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSV-RQLGRWD--FLSVGRVQTPTLAFIVDREREIRAFDPEDY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 241 WVLQAKVNTD---KDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMG 317
Cdd:PRK07219 221 WKIEALLDKEaqyFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 318 PQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKG-HDAGDHPPITPMKSA 396
Cdd:PRK07219 301 PKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGkKETTDHPPIHPVDVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 397 TEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSvPLEESLPTCQRGDAF 476
Cdd:PRK07219 381 KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEK-FDEKELPDLEEGEKL 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 477 PVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTveSGRRLKPTNLGIVLVHGYYKIDAELV 556
Cdd:PRK07219 460 KVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYVI--EGDPPRPTDLGIAVIEALEKYAPEIV 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 557 LPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELMEvSFSPLAATGKPLSRCGKCHRFMKYIQ 635
Cdd:PRK07219 538 SEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIgDHLAG-SLKAENRSLKTIGKCPECGGDLIIIR 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 636 AKPSR--LHCS---HCDETYTLPQNGTIKL--------------------YKELRCPLDDFELvlwSSGSRGKSYPLCPY 690
Cdd:PRK07219 617 TDKGSrfVGCSgypDCRNTFPLPSTGRIKVldevcekcglpvikilrgkqTFVVGCPDCEAEK---EEEDPDEVIGPCPK 693
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530788288 691 CYNHPPFRDMKKG--MGCNEctHPSCQHSLSM-------LGIGQCVECESGVLVLDPTSGPKWKVACN-KCN 752
Cdd:PRK07219 694 CGGELAIKQLKYGsfLGCTN--YPKCKYTLPLprrgkitVTDEKCPECGLPLLRVKGGFGDELGCCNNpKCN 763
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
169-582 |
5.96e-140 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 421.27 E-value: 5.96e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 169 EPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKygdldsSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVN 248
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKGN------KLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 249 TDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEK-EAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAER 327
Cdd:pfam01131 75 DGGGVFANAKWKRGRIFDKEEAEAILE--KLKKgTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 328 LYTQ-GYISYPRTETTHYPENFDLKGSLR-QQANHPYWADTVKRLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGG 403
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEyLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 404 DAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKM 483
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 484 LEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSA 563
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAE 390
|
410
....*....|....*....
gi 530788288 564 VEKQLNLIAQGKADYRQVL 582
Cdd:pfam01131 391 LEEKLDEIAEGKLDWKDVL 409
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
290-544 |
3.73e-105 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 324.97 E-value: 3.73e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 290 RKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADTVK 368
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 369 RLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCS 443
Cdd:smart00437 82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 444 GKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 523
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|.
gi 530788288 524 RNYVTVEsGRRLKPTNLGIVL 544
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
5-594 |
3.45e-94 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 306.25 E-value: 3.45e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 5 LMVAEKPSLAQSIAKILSRGslsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLdflgkYNKWDKVDPAELFsq 84
Cdd:COG0550 3 LVIVESPAKAKTIAKYLGKD---------------------------YVVTASVGHLRDL-----PKPELDVDVENDF-- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 85 APT----EKKEanPKLNMVKFLqveGRGCDYIVLWLDCDKEGENICFEVLDAVlpvmnkahGGEKTVFRARFSSITDTDI 160
Cdd:COG0550 49 EPKyeviPGKK--KQVKELKKL---AKKADEVILATDPDREGEAIAWHLLELL--------GDKKPVKRVVFNEITKKAI 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 161 CNAMACLGEPDHNeaLsVDA---RQELDLRIGCAFTRFQTKYFQGKygdldsslISFGPCQTPTLGFCVERHDKIQSFKP 237
Cdd:COG0550 116 KEAFKNPRDIDMN--L-VDAqqaRRILDRLVGYNLSPLLWKKVKRG--------LSAGRVQSPALRLIVEREREIEAFVP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 238 ETYWVLQAKVNTDKD--RSLLLDWDRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLG 315
Cdd:COG0550 185 EEYWTIEATFKTGGGefTAKLVKIDGKKILDEEEAEAILAALK-GKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 316 MGPQHAMQTAERLYTQGYISYPRTETTHYPEnfDLKGSLRQQANhpywADTVKRLLAEGINRPRKGHDA-GDHPPITP-M 393
Cdd:COG0550 264 FSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAAREYIE----ALYGKEYLPEKPRVYKTSKNAqEAHEAIRPtG 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 394 KSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEE----SLPT 469
Cdd:COG0550 338 VTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEeeekRLPP 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 470 CQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIV--- 543
Cdd:COG0550 418 LKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGrpsTYASI---IETLQDRGYVERE-GKRLVPTELGFIvid 493
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 530788288 544 LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYRQVLGHtldvFKRKFH 594
Cdd:COG0550 494 LLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLEE----FYKPFK 537
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-167 |
2.83e-54 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 184.74 E-value: 2.83e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 3 TVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGacsvheytgTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAE-L 81
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKGRYY---------EFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLEdP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 82 FSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNkahggeKTVFRARFSSITDTDIC 161
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKR------KPVKRAWFSSLTPKAIR 145
|
....*.
gi 530788288 162 NAMACL 167
Cdd:cd03362 146 RAFKNL 151
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-155 |
1.42e-10 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 58.52 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 4 VLMVAEKPSLAQSIAKILSRGSlsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLDFlgkynkwdkvdpaelfs 83
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGF--------------------------QAVVAVLGHLLSLEK----------------- 37
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530788288 84 qaptekkeaNPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVmnkahggEKTVFRARFSSI 155
Cdd:pfam01751 38 ---------GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELL-------ENAGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
4-137 |
1.04e-05 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 44.17 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 4 VLMVAEKPSLAQSIAKILSRgslsshkglngacsvheytgtfagqpvRFKMTSVCGHVMTLDflgkynkwdkvdpaelfs 83
Cdd:smart00493 2 VLIIVEGPADAIALEKAGGK---------------------------RGNVVALGGHLLSKE------------------ 36
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 530788288 84 qaptekkeanpklnMVKFLQVEGRGCdYIVLWLDCDKEGENICFEVLDAVLPVM 137
Cdd:smart00493 37 --------------QIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPAG 75
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
172-593 |
1.51e-150 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 447.44 E-value: 1.51e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 172 HNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQakvntdk 251
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRKGV------LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 252 drsllldwdrvrvfdreiaqmflnmtklekEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ 331
Cdd:cd00186 68 ------------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 332 GYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWR 407
Cdd:cd00186 118 GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFK 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 408 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQ 487
Cdd:cd00186 197 LYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 488 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQ 567
Cdd:cd00186 277 TQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEK 355
|
410 420
....*....|....*....|....*.
gi 530788288 568 LNLIAQGKADYRQVLGHTLDVFKRKF 593
Cdd:cd00186 356 LDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
3-752 |
4.73e-146 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 451.38 E-value: 4.73e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 3 TVLMVAEKPSLAQSIAKILSRGSLS--SHKGLNgacsVHEytgtFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAE 80
Cdd:PRK07219 1 TELIIAEKNNAARRIADILSGGKAKkkRVNGVP----YYE----FERKGEKWIVIGLSGHIVTVDFPEEYGDWRDVDPAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 81 LFSqAPTEKKEANPklNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVmnkahgGEKTVFRARFSSITDTDI 160
Cdd:PRK07219 73 LID-ADPVKKITKQ--NYINALKKLAKDADEIIIATDYDREGELIGKEAYHILREV------CQVPVKRARFSSLTKKEI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 161 CNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFqGKYGDLDssLISFGPCQTPTLGFCVERHDKIQSFKPETY 240
Cdd:PRK07219 144 RKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSV-RQLGRWD--FLSVGRVQTPTLAFIVDREREIRAFDPEDY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 241 WVLQAKVNTD---KDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMG 317
Cdd:PRK07219 221 WKIEALLDKEaqyFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 318 PQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKG-HDAGDHPPITPMKSA 396
Cdd:PRK07219 301 PKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGkKETTDHPPIHPVDVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 397 TEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSvPLEESLPTCQRGDAF 476
Cdd:PRK07219 381 KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEK-FDEKELPDLEEGEKL 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 477 PVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTveSGRRLKPTNLGIVLVHGYYKIDAELV 556
Cdd:PRK07219 460 KVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYVI--EGDPPRPTDLGIAVIEALEKYAPEIV 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 557 LPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELMEvSFSPLAATGKPLSRCGKCHRFMKYIQ 635
Cdd:PRK07219 538 SEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIgDHLAG-SLKAENRSLKTIGKCPECGGDLIIIR 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 636 AKPSR--LHCS---HCDETYTLPQNGTIKL--------------------YKELRCPLDDFELvlwSSGSRGKSYPLCPY 690
Cdd:PRK07219 617 TDKGSrfVGCSgypDCRNTFPLPSTGRIKVldevcekcglpvikilrgkqTFVVGCPDCEAEK---EEEDPDEVIGPCPK 693
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530788288 691 CYNHPPFRDMKKG--MGCNEctHPSCQHSLSM-------LGIGQCVECESGVLVLDPTSGPKWKVACN-KCN 752
Cdd:PRK07219 694 CGGELAIKQLKYGsfLGCTN--YPKCKYTLPLprrgkitVTDEKCPECGLPLLRVKGGFGDELGCCNNpKCN 763
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
169-582 |
5.96e-140 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 421.27 E-value: 5.96e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 169 EPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKygdldsSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVN 248
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKGN------KLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 249 TDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEK-EAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAER 327
Cdd:pfam01131 75 DGGGVFANAKWKRGRIFDKEEAEAILE--KLKKgTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 328 LYTQ-GYISYPRTETTHYPENFDLKGSLR-QQANHPYWADTVKRLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGG 403
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEyLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 404 DAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKM 483
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 484 LEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSA 563
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAE 390
|
410
....*....|....*....
gi 530788288 564 VEKQLNLIAQGKADYRQVL 582
Cdd:pfam01131 391 LEEKLDEIAEGKLDWKDVL 409
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
290-544 |
3.73e-105 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 324.97 E-value: 3.73e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 290 RKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADTVK 368
Cdd:smart00437 2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 369 RLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCS 443
Cdd:smart00437 82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 444 GKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 523
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|.
gi 530788288 524 RNYVTVEsGRRLKPTNLGIVL 544
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
5-658 |
2.02e-101 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 331.34 E-value: 2.02e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 5 LMVAEKPSLAQSIAKILSRGSLSSHKglngACSVHEYTGTFAGQpvRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFsQ 84
Cdd:PRK07220 3 LIITEKNIAARRIAQILAPKKPKKTR----VSGVDVYRYEDNGD--DTVVVGLSGHIVNIDFPKEYNNWQKVDARDLI-D 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 85 APTEKKEANPKLnmVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHggektVFRARFSSITDTDICNAM 164
Cdd:PRK07220 76 AEIITTPTQKKI--VTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKVNPDIK-----FDRVRYSAITKKEIERAF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 165 ACLGEPDHNEALSVDARQELDLRIGCAFTRfqtkYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQ 244
Cdd:PRK07220 149 SNPVEVDFNLADAGHSRQVIDLVWGAALTR----YISLAAGRLGKMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 245 AKVnTDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEKEAQVEATSRKEKAKQRPLALNTVEMLRvASSSLGMGPQHAMQT 324
Cdd:PRK07220 225 ATL-ENNGETFVAQHSTRRFWEKEEADRVFE--KLGKTAEVTEVEKGTKTDKPPTPFNTTEFIS-AANSIGFSAANAMRI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 325 AERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYwADTVKRLLAEGINRPRKG-HDAGDHPPITPMKSATEAELGG 403
Cdd:PRK07220 301 AESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGPF-GEYAQKLLEKGELVPTRGkKETTDHPPIYPASLAKKSELKE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 404 DAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWqSVPLEESLPTCQRGDAFPVGEVKM 483
Cdd:PRK07220 380 DEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPY-NAPEDRLLPELSEGEELKVKKKEM 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 484 LEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtveSGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSA 563
Cdd:PRK07220 459 LDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYI---HGNPIQPTNTAFAVVDALEKYAPTITKPDMTSR 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 564 VEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSiagMDELMEVSFSPLAATgKPLSRCGKC-HRFMKYIQAKPSR-L 641
Cdd:PRK07220 536 LEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKN---REKIRESLREGLRED-KIIGKCPLCgSDLMVRRSKRGSRfI 611
|
650 660
....*....|....*....|
gi 530788288 642 HCS---HCDETYTLPQNGTI 658
Cdd:PRK07220 612 GCEgypECTFSLPLPKSGQI 631
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
5-594 |
3.45e-94 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 306.25 E-value: 3.45e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 5 LMVAEKPSLAQSIAKILSRGslsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLdflgkYNKWDKVDPAELFsq 84
Cdd:COG0550 3 LVIVESPAKAKTIAKYLGKD---------------------------YVVTASVGHLRDL-----PKPELDVDVENDF-- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 85 APT----EKKEanPKLNMVKFLqveGRGCDYIVLWLDCDKEGENICFEVLDAVlpvmnkahGGEKTVFRARFSSITDTDI 160
Cdd:COG0550 49 EPKyeviPGKK--KQVKELKKL---AKKADEVILATDPDREGEAIAWHLLELL--------GDKKPVKRVVFNEITKKAI 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 161 CNAMACLGEPDHNeaLsVDA---RQELDLRIGCAFTRFQTKYFQGKygdldsslISFGPCQTPTLGFCVERHDKIQSFKP 237
Cdd:COG0550 116 KEAFKNPRDIDMN--L-VDAqqaRRILDRLVGYNLSPLLWKKVKRG--------LSAGRVQSPALRLIVEREREIEAFVP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 238 ETYWVLQAKVNTDKD--RSLLLDWDRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLG 315
Cdd:COG0550 185 EEYWTIEATFKTGGGefTAKLVKIDGKKILDEEEAEAILAALK-GKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 316 MGPQHAMQTAERLYTQGYISYPRTETTHYPEnfDLKGSLRQQANhpywADTVKRLLAEGINRPRKGHDA-GDHPPITP-M 393
Cdd:COG0550 264 FSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAAREYIE----ALYGKEYLPEKPRVYKTSKNAqEAHEAIRPtG 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 394 KSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEE----SLPT 469
Cdd:COG0550 338 VTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKDDEEEeeekRLPP 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 470 CQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIV--- 543
Cdd:COG0550 418 LKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGrpsTYASI---IETLQDRGYVERE-GKRLVPTELGFIvid 493
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 530788288 544 LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYRQVLGHtldvFKRKFH 594
Cdd:COG0550 494 LLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLEE----FYKPFK 537
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
5-621 |
6.90e-80 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 277.50 E-value: 6.90e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 5 LMVAEKPSLAQSIAKILSRGSLSSHKGlNGACSVHEYTGTFAgqpvrfkmTSVCGHVMTLDFLGKYNKWDKVD--PAELF 82
Cdd:PRK14973 3 LIIAEKNIAANRIAQILAGKTKVQVKK-DGGVSTYSFDDTVV--------VGLRGHVVEVDFEPGYTNWRSEEhtPRSLI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 83 S----QAPTEKKeanpklnMVKFLQVEGRGCDYIVLWLDCDKEGENI---CFEVLDAVLPvmnkahggEKTVFRARFSSI 155
Cdd:PRK14973 74 DadtiKKPTEKK-------IVGLIQKLAKKADRVTIATDFDTEGELIgkeAYELVRAVNP--------KVPIDRARFSAI 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 156 TDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTkyFQGKYGDldSSLISFGPCQTPTLGFCVERHDKIQSF 235
Cdd:PRK14973 139 TKEEIVTAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFIS--LAAHRGG--DNILSVGRVQSPTLAMIVDREKEIEAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 236 KPETYWVLQakVNTDKD-RSLLLDWDRVRVFDREIAQMFLNMTKlekeAQVEATSRKEKAKQ--RPLALNTVEMLrVASS 312
Cdd:PRK14973 215 VPEKYWMLS--LATEKDgEGIEARHTHGRFTDSAAAEAAYDATK----EPLVVTEVKEGHKVdrAPTPFDTTTFI-VAAS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 313 SLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADtVKRLLAEGINRPRKGH-DAGDHPPIT 391
Cdd:PRK14973 288 RLGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLATLAKGAFSKD-VAWVKDNRRPVPTRGKkSSTDHPPIH 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 392 PMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWqSVPLEESLPTCQ 471
Cdd:PRK14973 367 PTGVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPY-SEAKENILPAFA 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 472 RGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtveSGRRLKPTNLGIVLVHGYYKI 551
Cdd:PRK14973 446 LGEKLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYI---EGNPLRPTLVGRAVTESLEEH 522
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530788288 552 DAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELM-----EVSFSPLAATGKPL 621
Cdd:PRK14973 523 AGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDELEANEAVIgRDIMertaeELTIGPCPVCGKDL 598
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
4-629 |
3.55e-61 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 219.86 E-value: 3.55e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 4 VLMVAEKPSLAQSIAKILSRGSLSSHKGlngacSVHEYTGTFAGQpvRFKMTSVCGHVMTLDFLGK-YNKWDkVDPAELF 82
Cdd:PRK05776 3 ILVIAEKPKAARKIAEALSEKPIRCRIY-----GVPYWIVKRDGK--KIVVAPAAGHLFGLHTKSKgFPVFD-YEWKPLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 83 sQAPTEKKEANPKLNMVKFLqveGRGCDYIVLWLDCDKEGENICFEVLdavlpvmnKAHGGEKTVFRARFSSITDTDICN 162
Cdd:PRK05776 75 -EIDKGSKYTKKYYELLSSL---SKYADEFINACDYDIEGSVIGYLII--------KYLGDPKKAKRMKFSALTKSDIRR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 163 AMACLGEPDHNEALSVDARQELDLRIGCAFTRFQT---KYFQGKygdldSSLISFGPCQTPTLGFCVERHDKIQSFKPET 239
Cdd:PRK05776 143 AFRNLETLDYEMINAGIARHELDWLWGINVSRALMssvRDASGK-----RVILSAGRVQSPTLKYVVEREIERNLFVPLP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 240 YWVLQAKVNTdKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQ 319
Cdd:PRK05776 218 YFSVSIIIEK-NGYEFTLKYENKKFETKEEAKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPY 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 320 HAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAE--GINRPRKG-HDAGDHPPITPMKSA 396
Cdd:PRK05776 297 KTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQYRPLVNLLLKEtkGVLKPVQGpKDDPAHPAIYPTGEP 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 397 TEaELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG--PELFTCSGKTVLSPGFTEVMPWqSVPLEESLPTCQRGD 474
Cdd:PRK05776 377 PK-NLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPgfPLVFSASGQRIEERGWLKYYPF-HKFDEEELPLLKKGE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 475 AFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTvESGRRLKPTNLGIVLVHGYYKIDAE 554
Cdd:PRK05776 455 RVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLT-SNGKYIEVTPLGFGVAEVLEKYFPD 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 555 LVLPTIRSAVEKQLNLIAQGKADYRQVLGHT-------LDVFKRKFHYFVDSIAGMDELMevsfsplaatgKPLSRCGKC 627
Cdd:PRK05776 534 IVSVELTRDFEEKLEMIRTGKATREEVIEEAketlnklLEEFKKNKDEIGEELAKALGLI-----------KPVGKCKIC 602
|
..
gi 530788288 628 HR 629
Cdd:PRK05776 603 GR 604
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-167 |
2.83e-54 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 184.74 E-value: 2.83e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 3 TVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGacsvheytgTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAE-L 81
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKGRYY---------EFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLEdP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 82 FSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNkahggeKTVFRARFSSITDTDIC 161
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKR------KPVKRAWFSSLTPKAIR 145
|
....*.
gi 530788288 162 NAMACL 167
Cdd:cd03362 146 RAFKNL 151
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-646 |
3.36e-51 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 190.76 E-value: 3.36e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTVLmvAEKPSLAQSIAKILSrgslsSHKGLNGACSVHEYTGTFAgqpvrfkmtsvCGHVMTL----DFLGKYNKWDKV 76
Cdd:PRK07726 1 MRLFI--AEKPSVGRDIADVLK-----PHKKGDGYIEGNGYIVTWA-----------IGHLLELaepeAYDERYKRWRLE 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 77 D----PAELFSQApteKKEANPKLNMVKFL--QVegrgcDYIVLWLDCDKEGENICFEVLDAVlpvmnkahGGEKTVFRA 150
Cdd:PRK07726 63 DlpiiPEKWKLVV---KKKTAKQFNVVKKLlkQA-----TEIVIATDADREGELIAREILDYC--------GVRKPIKRL 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 151 RFSSITDTDICNAMACL--G---EPDHNEALsvdARQELDLRIGCAFTR-FQTKYFQGKYGDLdsslISFGPCQTPTLGF 224
Cdd:PRK07726 127 WISSLTDKAIKRAFANLkpGketIPLYYSAL---ARSRADWLVGINMTRaYTLLGRKAGYNGV----LSVGRVQTPTLAL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 225 CVERHDKIQSFKPETYWVLQAKVNTDKDRSLLldW--------DRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEKAKQ 296
Cdd:PRK07726 200 VVRRDEEIENFVPKPYWEVEAHLTPGERFTAK--WqpsepyqdEEGRLLDRPLAEQVVARIQ-GQPAKVTEVETKRKKEY 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 297 RPLALNTVEMLRVASSSLGMGPQHAMQTAERLY-TQGYISYPRTETTHYPEnfDLKGSLRQ-----QANHPYwadtvKRL 370
Cdd:PRK07726 277 APLLYDLSELQIDANKRFGLSAKETLDIAQSLYeTHKLITYPRTDSRYLPE--DMVATLPEvlnaiSKVDPY-----LLL 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 371 LAEGINRPRKGH---DA--GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSG 444
Cdd:PRK07726 350 APPVLDPSIRSRawnDKkvTAHHAIIPtEQPPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKG 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 445 KTVLSPGFTEVMPWQSVPLEES--LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLM-----------------EK 505
Cdd:PRK07726 430 KQVVEAGWKALLGKKEEDEEKEqpLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeniarfvqdkelkktlkET 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 506 HGIGTDA---SIpvhINNICQRNYVTVEsGRRLKPTNLGIVLvhgyykIDA---ELVLPTIRSAVEKQLNLIAQGKADYR 579
Cdd:PRK07726 510 DGLGTEAtraGI---IEKLFKRGYLEKK-GKYIHATDKGKQL------IDAlpeELTSPDMTAKWEQALDQISEGQLSYQ 579
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530788288 580 QvlghtldvfkrkfhyFVDSIAG-MDELME---VSFSPLAATGKPLSRCGKCHRFMKyiQAKPSRLHCSHC 646
Cdd:PRK07726 580 D---------------FMQPLKQwLKQLVEqakQSSEKYKFDNLTGPKCPDCGKPML--KVKGKNGKMLVC 633
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-167 |
2.94e-44 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 156.23 E-value: 2.94e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 3 TVLMVAEKPSLAQSIAKILSRGSLSSHkglngacsvheytgtFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELF 82
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSKKKG---------------FYGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPLELF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 83 sQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPvmnkahgGEKTVFRARFSSITDTDICN 162
Cdd:cd01028 66 -PFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKC-------DNKPVKRAWFSEITPKAIRE 137
|
....*
gi 530788288 163 AMACL 167
Cdd:cd01028 138 AFKNL 142
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-688 |
2.40e-37 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 149.62 E-value: 2.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTVLMVAEKPSLAQSIAKILSRGslsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLDflgkyNKWDKVDPAE 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKD---------------------------YKVLASFGHVRDLP-----KKKGGVDPDN 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 81 LFsqAPT----EKKEanpklNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDavlpVMNKAHGGEKTVFRARFSSIT 156
Cdd:PRK06599 49 DF--APKyeiiEGKE-----KVVDALKKAAKKADAVYLATDPDREGEAIAWHIAE----VLKEAKLKDKNVKRVVFNEIT 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 157 DTDICNAMAclgEP-DHNEALsVD---ARQELDLRIGcaftrFQ------TKYFQGKygdldssliSFGPCQTPTLGFCV 226
Cdd:PRK06599 118 KKAVQEAIE---NPrDIDMDL-VDaqqARRALDYLVG-----FKlspllwKKVRRGL---------SAGRVQSVALRLIC 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 227 ERHDKIQSFKPETYWVLQAKVNTDKDRSL---LLDWD-----RVRVFDREIAQmflnmtKLEKEAQ-----VEATSRKEK 293
Cdd:PRK06599 180 EREDEIEAFIPQEYWTIEADLATSNGEPFtakLVEVNgkkleKFSITNEEQAK------ALVKALEgqaytVDKIEKKER 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 294 AKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY--------TQGYISYPRTETThypenfdlkgslrqqanhpywad 365
Cdd:PRK06599 254 KRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYegidlgegTVGLITYMRTDSV----------------------- 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 366 tvkRLLAEGINRPRK------GHD-AGDHPPI--TPMKSATEAE------------------LGGDAWRLYEYITRHFIA 418
Cdd:PRK06599 311 ---RLSNEALDEARKyitkkyGKEyLPAKPRVykKKSKNAQEAHeairptsinrtpeslkpyLTPDQFKLYELIWKRTVA 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 419 TVSHDCKYLQSTISF--RIGPELFTCSGKTVLSPGFTEVMPwQSVPLEES-----LPTCQRGDAFPVGEVkmLEKQ--TN 489
Cdd:PRK06599 388 SQMAPAILDQTSVDIasENGKYVFRATGSVILFPGFLKVYG-ESKDDEEEddeklLPPLKEGEKLKLDEL--LPEQhfTE 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 490 PPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLG-IV---LVHGY-----YKIDAELvl 557
Cdd:PRK06599 465 PPPRYSEASLVKKLEEYGIGrpsTYASI---ISTLQDREYVELE-KKRFIPTDLGrIVndfLVEHFpkyvdYDFTAGL-- 538
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 558 ptirsavEKQLNLIAQGKADYRQVlghtLDVFKRKFHYFVDSIAGMDELMEVSFSPLAAT-----GKPLS-RCGKCHRFm 631
Cdd:PRK06599 539 -------EDELDEIAEGKKDWKPV----LREFWEPFISNLEKVEEDVRTEKVTQEETDETcpkcgGGPLVlKLGKNGKF- 606
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 632 kyiqakpsrLHCSH---CDETYTLPQNG-----TIKLYKELRCPLDDFELVLwSSGSRGK-----SYPLC 688
Cdd:PRK06599 607 ---------LGCSGypeCKYTKNITRDEdepieEEEIVEEEKCPKCGGPLVL-KKGRYGKflacsGYPEC 666
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
108-631 |
1.26e-36 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 148.79 E-value: 1.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 108 GCDYIVLWLDCDKEGENICFEVLDaVLpvmnkaHGGEKTVFRARFSSITDTDICNAMAclgEP-DHNEALsVDA---RQE 183
Cdd:PRK07561 86 DADELYLATDPDREGEAIAWHLLE-VL------GGDDVPVKRVVFNEITKNAIQEAFE---NPrELDINL-VNAqqaRRF 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 184 LDlRIgcaftrfqtkyfqgkYGDLDSSLI--------SFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSL 255
Cdd:PRK07561 155 LD-RL---------------VGYMVSPLLwkkiarglSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDAF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 256 LLD--------WDRVRVFDREIAQMFLnmTKLEKeAQVEATSRKEKAKQR-PLALNTVEMLRVASSS-LGMGPQHAMQTA 325
Cdd:PRK07561 219 EARlthldgkkFAPVDLLNEAQAEAAV--AALEG-ARYSVASVEDKPTTRkPSAPFTTSTLQQEASRkLGFSVKKTMRIA 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 326 ERLYTQGYISYPRTETTHY-PENFDlkgSLRQQANHPYWADtvkrLLAEGinrPR------KG----HDAgdhppITP-- 392
Cdd:PRK07561 296 QRLYEAGYITYMRTDSTNLsQEAIN---AARGYIGDNYGKK----YLPEK---PRqysskaKNaqeaHEA-----IRPsd 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 393 -MKSATE-AELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQS--VPLEES-- 466
Cdd:PRK07561 361 vFRTPDQlKGLEGDAQRLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRddALDDEDrr 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 467 LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLG-I 542
Cdd:PRK07561 441 LPALKVGDALTLEKLDPTQHFTKPPARYSEASLVKELEKLGIGrpsTYASI---ISTIQDRGYVRLE-NRRFYPEKMGrI 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 543 V--LVHGYYkidAELVLPTIRSAVEKQLNLIAQGKADYRQVlghtLDVFKRKFHYFVDSIA------GMDELMEVsfspl 614
Cdd:PRK07561 517 VtdRLEEFF---PRLVDYDFTARMEEELDDIANGEADWKPV----LDDFYKDFSQQLEKAEelreegGMRPNQMV----- 584
|
570
....*....|....*...
gi 530788288 615 aatgkPLSR-CGKCHRFM 631
Cdd:PRK07561 585 -----ITDRdCPTCGRGM 597
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-647 |
6.97e-34 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 140.19 E-value: 6.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTVLMVAEKPSLAQSIAKILsrGSLSSHKglngacsvhEYtgtFAGQpvRFKMTSVCGHVMTL----DFLGKYNKWD-- 74
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARAL--GGFTKHD---------EY---FESD--EYVLSSAVGHLLEIaapeEYEVKRGKWSfa 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 75 --KVDPaELFSQAPTEKKEANPKLnMVKflQVEGRGCDYIVLWLDCDKEGENICFEVLDAVlpvmnkahGGEKTVFRARF 152
Cdd:PRK08173 65 hlPVIP-PHFDLNPIAKTESRLKV-LTK--LIKRKDVTRLINACDAGREGELIFRLIAQHA--------KAKKPVKRLWL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 153 SSITDTDICNAMACLGEPDHNEALSvDA---RQELDLRIGCAFTRFQTKyFQGKYGDLdsSLISFGPCQTPTLGFCVERH 229
Cdd:PRK08173 133 QSMTPQAIRDGFANLRSDEDMQPLA-DAarcRSEADWLVGINGTRAMTA-FNSKGGGF--FLTTVGRVQTPTLSIVVERE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 230 DKIQSFKPETYWVLQA-------------------KVNTDKDRsllldwdRV-RVFDREIAQMFLNMTKlEKEAQVEATS 289
Cdd:PRK08173 209 EKIRRFVPRDYWEVRAefvaaagfyegrwfdpkfkKDEFDPEK-------RAsRLWSEAAAEAIVAACR-GKPGTVTEES 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 290 rKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ-GYISYPRTETTHYPENF--DLKGSLRQQANHPYWADT 366
Cdd:PRK08173 281 -KPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYlgTVKQTLEMLKESNNYLPH 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 367 VKRLLAEGINRPRK----GHDAGDHPPITPM----KSATEAELggdawRLYEYITRHFIATVSHDCKYLQSTISFRIGPE 438
Cdd:PRK08173 360 AKQILDKGWVKPNKrifdNSKISDHFAIIPTlqapKSLSEPEQ-----KLYDLVVKRFLAVFFPAAEFLVTTRITEVAGH 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 439 LFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLME-------------- 504
Cdd:PRK08173 435 HFKTEGKVLVNPGWLAVYGKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelrea 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 505 --KHGIGTDASIPVHINNICQRNYVtVESGRRLKPT----NLgIVLVHGyYKIDaELVLPTIRSAVEKQLNLIAQGK--- 575
Cdd:PRK08173 515 maEKGLGTPATRAAIIEGLLGEKYL-VREGRELIPTakafQL-MTLLRG-LGVE-ELTSPELTGEWEYKLSQIERGKlsr 590
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530788288 576 -ADYRQVLGHTLDVFKRKFHYFVDSIAGmdelmevSFSPLAAtgkPLSRCGkchrfmKYIQAKPSRLHCSHCD 647
Cdd:PRK08173 591 dAFMQEIAQMTQQIVKRAKEYDSDTIPG-------DYATLQT---PCPNCG------GVVKENYRRFACTKCD 647
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
147-242 |
1.10e-32 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 121.54 E-value: 1.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 147 VFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYgdldsslISFGPCQTPTLGFCV 226
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNGV-------LSAGRVQTPTLGLIV 73
|
90
....*....|....*.
gi 530788288 227 ERHDKIQSFKPETYWV 242
Cdd:smart00436 74 EREREIKNFVPKPYWE 89
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-635 |
3.80e-31 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 131.04 E-value: 3.80e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTVLMVAEKPSLAQSIAKILSRGslsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLdflgkYNKWDKVDPAE 80
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKD---------------------------FTVLASYGHVRDL-----VPKEGAVDPEN 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 81 LFSQ--APTEKKEANpklnmVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVlpvmnKAHG--GEKTVFRARFSSIT 156
Cdd:PRK08780 49 GFAMryDLIDKNEKH-----VEAIAKAAKSADDLYLATDPDREGEAISWHLAEIL-----KERGllKDKPMQRVVFTEIT 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 157 DTDICNAMAclgepdHNEALSVD------ARQELDLRIGCAFTRFQTKYFQgkygdldsSLISFGPCQTPTLGFCVERHD 230
Cdd:PRK08780 119 PRAIKEAMA------KPRDIASDlvdaqqARRALDYLVGFNLSPLLWRKIQ--------RGLSAGRVQSPALRMIVEREE 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 231 KIQSFKPETYWVLQAKVNTDKD----RSLLLDWDRVRVF---DREIAQMFLNmtKLEKEAQ----VEATSRKEKaKQRPL 299
Cdd:PRK08780 185 EIEAFIAREYWSIEADCAHPSQpfnaKLIKLDGQKFEQFtitDGDTAEAARL--RIQQAAQgtlhVTDVESKER-KRNPA 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 300 ALNTVEMLRV-ASSSLGMGPQHAMQTAERLY---------TQGYISYPRTETTHYPEnfDLKGSLRQQANHPYWADTVKR 369
Cdd:PRK08780 262 PPFTTSTLQQeASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDSVNLSQ--DALAEIRDVIARDYGTASLPD 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 370 LLAEGINRPRKGHDAgdHPPITP---MKSATE--AELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPE-LFTCS 443
Cdd:PRK08780 340 QPNTYKTKSKNAQEA--HEAVRPtsaLRTPAQvaRFLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSEhVFRAT 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 444 GKTVLSPGFTEVM-------PWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDAS 513
Cdd:PRK08780 418 GSTVVVPGFLAVYeegkddkSAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGrpsTYAS 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 514 IpvhINNICQRNYVTVEsGRRLKPTNLGIVlVHGY----------YKIDAELvlptirsavEKQLNLIAQGKADYRQVLG 583
Cdd:PRK08780 498 I---ISTLQFRKYVEME-GRRFRPTDVGRA-VNKFltghftryvdYDFTARL---------EDDLDAVSRGEKEWIPLME 563
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 530788288 584 HTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLS-RCGkchRFMKYIQ 635
Cdd:PRK08780 564 KFWGPFKELVEEKKDSVDRTEAGQVRELGTDPKSGKPVSvRIG---RFGPMVQ 613
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
1-602 |
4.24e-23 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 105.81 E-value: 4.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTvLMVAEKPSLAQSIAKILS--RGSLSSHKglngacsvhEYtgtFAGQpvRFKMTSVCGHVMTL----DFLGKYNKWD 74
Cdd:PRK14724 1 TKT-LVIAEKPSVAQDIVRALTpvAGKFEKHD---------EH---FESD--SYVVTSAVGHLVEIqapeEFDVKRGKWS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 75 ----KVDPAElFSQAPTEKKEAnpKLNMVkFLQVEGRGCDYIVLWLDCDKEGENIcFEVLDAVlpVMNKAHGGEKTVFRA 150
Cdd:PRK14724 66 fanlPVIPPY-FDLKPVDKTKT--RLNAV-VKLAKRKDVTELVNACDAGREGELI-FRLIEQY--AGGAKGGLGKPVKRL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 151 RFSSITDTDICNAMACLGEPDHNEALSVDAR--QELDLRIGCAFTRFQTKyFQGKYGDLdsSLISFGPCQTPTLGFCVER 228
Cdd:PRK14724 139 WLQSMTPQAIRDGFDNLRSDAQMQGLASAARsrSEADWLVGINGTRAMTA-FNSRDGGF--FLTTVGRVQTPTLSLVVER 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 229 HDKIQSFKPETYWVLQAKVNTDKDRSL--LLD--WDRV---------RVFDREIAQMFLNMTKlEKEAQVEATSrKEKAK 295
Cdd:PRK14724 216 EEKIRKFVSRDYWEIHAGFHAEAGEYLgkWFDpqWKKAsddpearadRVWSEREARAIADAVR-GKAATVTEES-KPTTQ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 296 QRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ-GYISYPRTETTHYPEN--------FDL--KGSLRQQANHPYWA 364
Cdd:PRK14724 294 ASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDylpvakqtFEMlaTSGMRHLAPFAQQA 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 365 dtvkrlLAEGINRPRK----GHDAGDHPPITPMKSA----TEAElggdaWRLYEYITRHFIATVSHDCKYLQST-ISFRI 435
Cdd:PRK14724 374 ------LDGNYVRPSKrifdNSKVSDHFAIIPTTQApsglSEAE-----QKLYDLVVRRFMAVFFPSAEYQVTTrISQVV 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 436 GPElFTCSGKTVLSPGF---------TEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLME-- 504
Cdd:PRK14724 443 GHS-FKTEGKVLVKPGWlaiygkeaaNEVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsa 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 505 --------------KHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDA-ELVLPTIRSAVEKQLN 569
Cdd:PRK14724 522 gkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLRE-GRELIPTAKAFQLMTLLRGLGVeELSRAELTGEWEYKLA 600
|
650 660 670
....*....|....*....|....*....|....*..
gi 530788288 570 LIAQGK----ADYRQVLGHTLDVFKRKFHYFVDSIAG 602
Cdd:PRK14724 601 QMEKGQlsreAFMQQIAAMTEKLVKKAKEYDRDTIPG 637
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-589 |
4.02e-21 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 99.13 E-value: 4.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 1 MKTVLMVAEKPSLAQSIAKILSRGslsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTL-----------DFLGK 69
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEG---------------------------FIFASSLGHIVDLpakefgidienDFEPD 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 70 YnkwdkvdpaelfsQAPTEKKEanpklnMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDaVLPVMNKahggektVFR 149
Cdd:PRK06319 54 Y-------------QILPDKEE------VINKICKLAKKCDVVYLSPDPDREGEAIAWHIAN-QLPKNTK-------IQR 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 150 ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERH 229
Cdd:PRK06319 107 ISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQRRSG------VSAGRVQSVALKLVVDRE 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 230 DKIQSFKPETYWVLQAKVNTDKDRSLLL---------DWDR-----------VRVFDREIAQMFLNMtkLEKEA-QVEAT 288
Cdd:PRK06319 181 KAIEAFVPVEYWNIRVHLKDPKTQKTFWahlysvdgkKWEKeipegktedevLLINSKEKADHIVEL--LESATyTVTRV 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 289 SRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY---------TQGYISYPRTETTHY-PENFD-LKGSLRQQ 357
Cdd:PRK06319 259 ESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYegvdldsegATGLITYMRTDSVRTdPEALKqVRKYIEGT 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 358 ANHPYWADTVKRLLAEginrpRKGHDAgdHPPITPMKSATEAE-----LGGDAWRLYEYITRHFIATVSHDCKY--LQST 430
Cdd:PRK06319 339 FGKEFLPSSPNVYTTK-----KMAQDA--HEAIRPTDITLTPEklrskLTEDQYKLYSLIWKRFVASQMIPAIYdtLAIR 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 431 ISFRIGPELfTCSGKTVLSPGFTEV---MPWQSVPLEE--SLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEK 505
Cdd:PRK06319 412 ITTNKGIDL-RATGSLLKFKGFLAVyeeKRDDEGDEEEniHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEK 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 506 HGIGTDASIPVHINNICQRNYvTVESGRRLKPTNLGIVLVHGYykidaELVLPTI-----RSAVEKQLNLIAQGKADYRQ 580
Cdd:PRK06319 491 SGIGRPSTYATIMNKIQSREY-TLKENQRLRPTELGKIISQFL-----ETNFPRImdigfTALMEDELELIADNKKPWKL 564
|
....*....
gi 530788288 581 VLGHTLDVF 589
Cdd:PRK06319 565 LLQEFWELF 573
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
112-573 |
8.78e-12 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 69.20 E-value: 8.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 112 IVLWLDCDKEGENICFEVLDAVLPVMNKAhggeKTVF-RARFSSITDTDICNAMA--CLGEPDHNEALSVDARQELDlRI 188
Cdd:PTZ00407 128 IILATDPDREGELIAVHALQTIKRLYPKL----KVPFsRAYMHSITEDGIRKAMRerHVEACDYDLANAAETRHAMD-RI 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 189 gcaftrfqtkyfqgkYGDLDSSLI--------SFGPCQTPTLGFCVERHDKIQSF--KPETYWVLQA------------- 245
Cdd:PTZ00407 203 ---------------FGFLGSSVVraansqmrSIGRVQTPALILINEREDKIKAFleSNKSTFEVQAmcqfpsphgttfs 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 246 ---KVNTDKdRSLLLDWDRVRVFDREIAQMFLNMT---KLEKEAQVEATsrkEKAKQRPLALNTveMLRVASSSLGMGPQ 319
Cdd:PTZ00407 268 qvvTITPDR-KGGASHWATEAEARRCLEQWKLNNCtgfSVPLEPKPQPS---VVPPPQPFTMAT--AIAKANRQLKYSSE 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 320 HAMQTAERLYTQGYISYPRTETTHYPENF--DLKGSLRQQANhpywadtvKRLLAEGINRPRKGHDaGDHPPITPMKSAT 397
Cdd:PTZ00407 342 MVSGCLQDLFQLGHITYPRTDSTRIDESAlpDIYAAVKKEFG--------KEFLYRLEDRTVSAQE-GKGSKKTGKKRST 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 398 EAELGGDAWR------------------------------LYEYITRHFIAT--VSHDCKYLQSTISFRI--GPEL-FTC 442
Cdd:PTZ00407 413 KQKKGADTPVgnvedaheairptnidttgeslslspptraVYDLVRRNTLAVfmIPMKTEKIVATVKFTSgsGEKLeFEL 492
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 443 SGKTVLSPGFTE----------------------------VMPWQS-------VPLEESLPTCQRGDAFPVGEVKMLEKQ 487
Cdd:PTZ00407 493 QGKRVVEPGWTRafhkgdkgttgpaeetdeditaveegapVVPSLSqeefkaiMNLRSQLGSGVQKGFFELRSPQVRENR 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 488 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHgyykiDAELVLPTI-----RS 562
Cdd:PTZ00407 573 PVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKGRCETTPVGRMLVE-----TAKSTFPSIvdigfTA 647
|
570
....*....|.
gi 530788288 563 AVEKQLNLIAQ 573
Cdd:PTZ00407 648 AFEKKLDRIAK 658
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-155 |
1.42e-10 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 58.52 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 4 VLMVAEKPSLAQSIAKILSRGSlsshkglngacsvheytgtfagqpvrFKMTSVCGHVMTLDFlgkynkwdkvdpaelfs 83
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGGGF--------------------------QAVVAVLGHLLSLEK----------------- 37
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530788288 84 qaptekkeaNPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVmnkahggEKTVFRARFSSI 155
Cdd:pfam01751 38 ---------GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELL-------ENAGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
4-137 |
1.04e-05 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 44.17 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530788288 4 VLMVAEKPSLAQSIAKILSRgslsshkglngacsvheytgtfagqpvRFKMTSVCGHVMTLDflgkynkwdkvdpaelfs 83
Cdd:smart00493 2 VLIIVEGPADAIALEKAGGK---------------------------RGNVVALGGHLLSKE------------------ 36
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 530788288 84 qaptekkeanpklnMVKFLQVEGRGCdYIVLWLDCDKEGENICFEVLDAVLPVM 137
Cdd:smart00493 37 --------------QIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPAG 75
|
|
|