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Conserved domains on  [gi|527317358|ref|NP_001268388|]
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solute carrier family 35 member C2 isoform e [Homo sapiens]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 1750314)

triose-phosphate transporter (TPT) family protein belongs to the drug/metabolite transporter (DMT) superfamily; similar to the well-characterized triose phosphate and sugar phosphate permeases of chloroplasts and its functionally uncharacterized homologs found in yeast and animals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT_S35C2 super family cl40580
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 1-192 3.28e-102

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


The actual alignment was detected with superfamily member cd21092:

Pssm-ID: 411044  Cd Length: 248  Bit Score: 296.10  E-value: 3.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358   1 MTKSSAVLFILIFSLIFKLEEL---------------------STQFNVEGFALVLGASFIGGIRWTLTQMLLQKAELGL 59
Cdd:cd21092   36 MTKSSAIIFILFFSLVFKLEKPrwslvlvvlliagglfmftykSTQFNLEGFILVLSASFLGGLRWTLAQLLMQKAELGL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358  60 QNPIDTMFHLQPLMFLGLFPLFAVFEGLHLSTSEKIFRFQDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSI 139
Cdd:cd21092  116 QNPIDMMYHLQPWMILGLLPLAIGFEGLHLATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSI 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 527317358 140 AGIFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGP 192
Cdd:cd21092  196 AGIFKEICTLLLAVHINGDHLSLLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 1-192 3.28e-102

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 296.10  E-value: 3.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358   1 MTKSSAVLFILIFSLIFKLEEL---------------------STQFNVEGFALVLGASFIGGIRWTLTQMLLQKAELGL 59
Cdd:cd21092   36 MTKSSAIIFILFFSLVFKLEKPrwslvlvvlliagglfmftykSTQFNLEGFILVLSASFLGGLRWTLAQLLMQKAELGL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358  60 QNPIDTMFHLQPLMFLGLFPLFAVFEGLHLSTSEKIFRFQDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSI 139
Cdd:cd21092  116 QNPIDMMYHLQPWMILGLLPLAIGFEGLHLATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSI 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 527317358 140 AGIFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGP 192
Cdd:cd21092  196 AGIFKEICTLLLAVHINGDHLSLLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 1-192 3.28e-102

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 296.10  E-value: 3.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358   1 MTKSSAVLFILIFSLIFKLEEL---------------------STQFNVEGFALVLGASFIGGIRWTLTQMLLQKAELGL 59
Cdd:cd21092   36 MTKSSAIIFILFFSLVFKLEKPrwslvlvvlliagglfmftykSTQFNLEGFILVLSASFLGGLRWTLAQLLMQKAELGL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527317358  60 QNPIDTMFHLQPLMFLGLFPLFAVFEGLHLSTSEKIFRFQDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSI 139
Cdd:cd21092  116 QNPIDMMYHLQPWMILGLLPLAIGFEGLHLATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLEFSEFLLVSKTSSLTLSI 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 527317358 140 AGIFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGP 192
Cdd:cd21092  196 AGIFKEICTLLLAVHINGDHLSLLNWLGLVICLCGISLHVVLKALHSKEDSVP 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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