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Conserved domains on  [gi|525507373|ref|NP_001267486|]
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zinc transporter ZIP4 isoform 3 [Homo sapiens]

Protein Classification

ZIP family transporter( domain architecture ID 579)

ZIP family transporter may function as a zinc transporter, mediating the uptake of zinc in bacteria or the transport of zinc from one cellular compartment to another in eukaryotes

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653|10748254
TCDB:  2.A.5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zip super family cl00437
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-140 5.59e-25

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


The actual alignment was detected with superfamily member pfam02535:

Pssm-ID: 444905 [Multi-domain]  Cd Length: 325  Bit Score: 97.06  E-value: 5.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373    1 MITLGDAVHNFADGLAVGaaFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALA 80
Cdd:pfam02535 182 LLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPLGILIGIG 259

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 525507373   81 VGVSEES------EAWILAVATGLFLYVALCDMLPAMLKVRDPRPWlLFLLHNVGLLGGWTVLLLL 140
Cdd:pfam02535 260 VSSIGNSpgaditSGILLAFSAGTFLYVALVELLPHELLRNKSSEK-LSLLQLLALLLGFALMALL 324
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-140 5.59e-25

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 97.06  E-value: 5.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373    1 MITLGDAVHNFADGLAVGaaFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALA 80
Cdd:pfam02535 182 LLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPLGILIGIG 259

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 525507373   81 VGVSEES------EAWILAVATGLFLYVALCDMLPAMLKVRDPRPWlLFLLHNVGLLGGWTVLLLL 140
Cdd:pfam02535 260 VSSIGNSpgaditSGILLAFSAGTFLYVALVELLPHELLRNKSSEK-LSLLQLLALLLGFALMALL 324
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
1-139 9.20e-18

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 76.76  E-value: 9.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373   1 MITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYV-AL 79
Cdd:COG0428  106 LIALGITLHNFPEGLAIGVAFAADPALGLALALAIALHNIPEGLAVAAPLRAAGYSRRKALLLGLLSGLVEPLGALLgYL 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373  80 AVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLhnVGLLGGWTVLLL 139
Cdd:COG0428  186 LLSLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSRLATLGLL--LGFLLMMLLDVL 243
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
 1-140 5.59e-25

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 97.06  E-value: 5.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373    1 MITLGDAVHNFADGLAVGaaFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALA 80
Cdd:pfam02535 182 LLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQAGFSRKKAVLLALLFALTTPLGILIGIG 259

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 525507373   81 VGVSEES------EAWILAVATGLFLYVALCDMLPAMLKVRDPRPWlLFLLHNVGLLGGWTVLLLL 140
Cdd:pfam02535 260 VSSIGNSpgaditSGILLAFSAGTFLYVALVELLPHELLRNKSSEK-LSLLQLLALLLGFALMALL 324
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
1-139 9.20e-18

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 76.76  E-value: 9.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373   1 MITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYV-AL 79
Cdd:COG0428  106 LIALGITLHNFPEGLAIGVAFAADPALGLALALAIALHNIPEGLAVAAPLRAAGYSRRKALLLGLLSGLVEPLGALLgYL 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507373  80 AVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLhnVGLLGGWTVLLL 139
Cdd:COG0428  186 LLSLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSRLATLGLL--LGFLLMMLLDVL 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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