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Conserved domains on  [gi|522838254|ref|NP_001265618|]
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EGF domain-specific O-linked N-acetylglucosamine transferase isoform a precursor [Homo sapiens]

Protein Classification

glycosyltransferase family 61 protein( domain architecture ID 10518999)

glycosyltransferase family 61 protein may function as a glycosyltransferase; similar to plant beta-(1,2)-xylosyltransferase, which catalyzes beta-1,2 glycosidic linkages, and to metazoan EGF domain-specific O-linked N-acetylglucosamine transferase, which catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins

CAZY:  GT61
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 309-442 1.48e-13

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


:

Pssm-ID: 428020  Cd Length: 124  Bit Score: 67.33  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838254  309 VCFKEAVFSLLPRMRYGLFyntplisgcqnTGLFRAFAQHVLHRLNITQEGPKdgkiRVTILARS-TEYRKILNQNELVN 387
Cdd:pfam04577   8 VFAERLYVPSSPRPHHGLF-----------GFGLAFLRKRLLAKFNLSNIKPT----RYVYISRGdARRRRILNEDELEA 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 522838254  388 ALKTVSTFEvqIVDYKyrELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAV 442
Cdd:pfam04577  73 ALKKEYGFE--IVDPE--KLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVV 123
 
Name Accession Description Interval E-value
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 309-442 1.48e-13

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 67.33  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838254  309 VCFKEAVFSLLPRMRYGLFyntplisgcqnTGLFRAFAQHVLHRLNITQEGPKdgkiRVTILARS-TEYRKILNQNELVN 387
Cdd:pfam04577   8 VFAERLYVPSSPRPHHGLF-----------GFGLAFLRKRLLAKFNLSNIKPT----RYVYISRGdARRRRILNEDELEA 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 522838254  388 ALKTVSTFEvqIVDYKyrELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAV 442
Cdd:pfam04577  73 ALKKEYGFE--IVDPE--KLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVV 123
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
326-465 1.81e-11

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 64.60  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838254 326 LFYNTPLISGCQNTGLFRAFAQHVLHRLNITQEGPKDGKIRVTILARSTEYRKILNQNELVNALKTvstFEVQIVDYKyr 405
Cdd:COG4421   86 LIVPSPLGGESGVHRVPPWLLRFLRERLLPAATPPPAPPRRIYISRRDASRRRILNEEELEALLEK---YGFEIVDPE-- 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838254 406 ELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNcED--ERCYLDLARLRGVHY 465
Cdd:COG4421  161 ELSFAEQIALFAEAEVIVGPHGAGLTNLVFCRPGTKVIELFP-PGyvNPYFWLLAALLGLRY 221
 
Name Accession Description Interval E-value
Glyco_transf_61 pfam04577
Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in ...
 309-442 1.48e-13

Glycosyltransferase 61; This family represents the Glycosyltransferase Family 61. Members in this family are further processed into a mature form. It includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as AGO61 or EOGLT) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This family also includes plant beta-1,2-xylosyltransferases.


Pssm-ID: 428020  Cd Length: 124  Bit Score: 67.33  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838254  309 VCFKEAVFSLLPRMRYGLFyntplisgcqnTGLFRAFAQHVLHRLNITQEGPKdgkiRVTILARS-TEYRKILNQNELVN 387
Cdd:pfam04577   8 VFAERLYVPSSPRPHHGLF-----------GFGLAFLRKRLLAKFNLSNIKPT----RYVYISRGdARRRRILNEDELEA 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 522838254  388 ALKTVSTFEvqIVDYKyrELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAV 442
Cdd:pfam04577  73 ALKKEYGFE--IVDPE--KLSLEEQVKLFSSAKVIVGPHGSGLTNSIFMPPGTVV 123
COG4421 COG4421
Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];
326-465 1.81e-11

Capsular polysaccharide biosynthesis protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443536  Cd Length: 258  Bit Score: 64.60  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838254 326 LFYNTPLISGCQNTGLFRAFAQHVLHRLNITQEGPKDGKIRVTILARSTEYRKILNQNELVNALKTvstFEVQIVDYKyr 405
Cdd:COG4421   86 LIVPSPLGGESGVHRVPPWLLRFLRERLLPAATPPPAPPRRIYISRRDASRRRILNEEELEALLEK---YGFEIVDPE-- 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838254 406 ELGFLDQLRITHNTDIFIGMHGAGLTHLLFLPDWAAVFELYNcED--ERCYLDLARLRGVHY 465
Cdd:COG4421  161 ELSFAEQIALFAEAEVIVGPHGAGLTNLVFCRPGTKVIELFP-PGyvNPYFWLLAALLGLRY 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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