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Conserved domains on  [gi|522838250|ref|NP_001265616|]
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somatostatin receptor type 3 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
45-324 1.53e-151

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15972:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 279  Bit Score: 430.38  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRA 204
Cdd:cd15972   81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP 284
Cdd:cd15972  161 GFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRV-RATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCP 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 285 LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15972  240 LPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
 
Name Accession Description Interval E-value
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
45-324 1.53e-151

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 430.38  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRA 204
Cdd:cd15972   81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP 284
Cdd:cd15972  161 GFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRV-RATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCP 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 285 LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15972  240 LPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
61-313 9.82e-50

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 169.01  E-value: 9.82e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250   61 GNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDGINQFTSIFCLTVMS 138
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  139 VDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEPAAAWRAgFIIYTAALG 214
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTltvpEGNVTVCFIDFPEDLSKPVS-YTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  215 FFGPLLVICLCYLLIVVKVRSAGRRVwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPE-EPAFFG 293
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQ---KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDK 236
                         250       260
                  ....*....|....*....|
gi 522838250  294 LYFLVVALPYANSCANPILY 313
Cdd:pfam00001 237 ALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
47-328 2.60e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 105.25  E-value: 2.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVvLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAAAWRA 204
Cdd:PHA03087 122 FYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKdhETLICCMFYNNKTMNWKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCY--LLIVVKVRSAGRRvwapscqrrrrsERRVTRMVVAVVALFVLCWMPF------YVL 276
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYskILITLKGINKSKK------------NKKAIKLVLIIVILFVIFWLPFnvsvfvYSL 269
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 277 NIVNVV--CplpeePAFFGLYFLVVA---LPYANSCANPILYGFLSYRFKQGFRRVL 328
Cdd:PHA03087 270 HILHFKsgC-----KAVKYIQYALHVteiISLSHCCINPLIYAFVSEFFNKHKKKSL 321
 
Name Accession Description Interval E-value
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
45-324 1.53e-151

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 430.38  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15972    1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRA 204
Cdd:cd15972   81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP 284
Cdd:cd15972  161 GFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRV-RATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCP 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 285 LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15972  240 LPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 2.39e-139

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 399.14  E-value: 2.39e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15093    1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPEPAAA 201
Cdd:cd15093   81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTrenQDGSSACNMQWPEPAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15093  161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLR---AGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 282 VCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15093  238 FVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
45-324 2.65e-121

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 353.34  E-value: 2.65e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRA 204
Cdd:cd15974   81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNTCNISWPEPVSVWST 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP 284
Cdd:cd15974  161 AFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRV---GSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 285 LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15974  238 LPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
45-324 2.06e-103

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 308.07  E-value: 2.06e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPEPAAA 201
Cdd:cd14970   81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTlqeEGGTISCNLQWPDPPDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd14970  161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGA-REKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 282 VCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14970  240 LIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
45-324 1.17e-98

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 295.60  E-value: 1.17e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15971    1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV--PRGMSTCHMQWPEPAAAW 202
Cdd:cd15971   81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVqtKHGRSSCTIIWPGESSAW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15971  161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRV---GSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15971  238 VSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
45-324 2.55e-84

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 259.02  E-value: 2.55e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15973    1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV-PR--GMSTCHMQWPEPaaA 201
Cdd:cd15973   81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTaTRkgQAVACNLIWPHP--A 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV-WapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15973  159 WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAgW----QQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLN 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 281 VVCPLPEEPaffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15973  235 LFLPRLDAT----VNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
45-324 2.26e-82

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 254.07  E-value: 2.26e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15970    1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR---GMSTCHMQWPEPAAA 201
Cdd:cd15970   81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPnsdGSVACNMQMPEPSQR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV-WapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15970  161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAgW----QQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVS 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 281 VVCPLPEEPaffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15970  237 VFVGQHDAT----VSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
45-322 3.81e-66

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 212.31  E-value: 3.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVD 123
Cdd:cd15088    1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgQWYFGEVMCKIITALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPEPAA 200
Cdd:cd15088   81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLiyfPDGTTFCYVSLPSPDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRagFIIYTAALGFFGPLLVICLCYLLIVVKVrsagRRVWAP-SCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15088  161 LYW--FTIYHFILGFAVPLVVITVCYILILHRL----ARGVAPgNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVcplPEEP--AFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15088  235 NLA---MNRPtlAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
49-324 1.86e-60

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 197.70  E-value: 1.86e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15094    5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-SGVPR-GMSTCHMQWPE-PAAAWRAG 205
Cdd:cd15094   85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYaSTVPDsGRYSCTIVWPDsSAVNGQKA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWApscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNiVNVVC-- 283
Cdd:cd15094  165 FTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKS---KEKRRSHRKVTRLVLTVISVYIICWLPYWAFQ-VHLIFlp 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 284 PLPEEPAFFGLYFLVV-ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15094  241 PGTDMPKWEILMFLLLtVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
45-324 7.05e-60

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 196.11  E-value: 7.05e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSAR--WRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR---GMSTCHMQWPEPA 199
Cdd:cd15087   81 YNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSnelGRKSCVLSFPSPE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWApscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15087  161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNA---KALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15087  238 ALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
45-324 3.28e-53

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 178.99  E-value: 3.28e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP----RGMSTCHMQWPEPAA 200
Cdd:cd15091   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKvredVDSTECSLQFPDDDY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFI-IYTAALGFFGPLLVICLCYLLIVVKVRSAgrRVWAPScQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15091  161 SWWDTFMkICVFIFAFVIPVLIIIVCYTLMILRLKSV--RLLSGS-REKDRNLRRITRLVLVVVAVFVVCWTPIHIFILV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15091  238 EALGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
45-324 1.80e-51

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 174.37  E-value: 1.80e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15089    1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAA--VWVASAVVVLPVVVFSGVPR-GMSTCHMQWPEPAAA 201
Cdd:cd15089   81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICiwVLSSGVGVPIMVMAVTKTPRdGAVVCMLQFPSPSWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgRRVWApsCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15089  161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSV-RLLSG--SKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 282 VCPLPEE-PAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15089  238 LVDIDRRnPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
45-324 5.48e-50

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 170.43  E-value: 5.48e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15092    1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST--CHMQWPEPAAAW 202
Cdd:cd15092   81 YNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEieCLVEIPTPQDYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgrRVWAPScQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15092  161 DPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGV--RLLSGS-KEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15092  238 GVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
61-313 9.82e-50

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 169.01  E-value: 9.82e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250   61 GNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDGINQFTSIFCLTVMS 138
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  139 VDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEPAAAWRAgFIIYTAALG 214
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTltvpEGNVTVCFIDFPEDLSKPVS-YTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  215 FFGPLLVICLCYLLIVVKVRSAGRRVwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPE-EPAFFG 293
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQ---KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElSRLLDK 236
                         250       260
                  ....*....|....*....|
gi 522838250  294 LYFLVVALPYANSCANPILY 313
Cdd:pfam00001 237 ALSVTLWLAYVNSCLNPIIY 256
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
45-324 1.64e-49

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 169.02  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP--RGMSTCHMQWPEPAAAW 202
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKyrQGSIDCTLTFSHPSWYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgRRVWapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15090  161 ENLLKICVFIFAFIMPVLIITVCYGLMILRLKSV-RMLS--GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15090  238 VTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
49-317 1.78e-49

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 169.01  E-value: 1.78e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd00637    3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLlVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFI 207
Cdd:cd00637   83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAYT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTR----MVVAVVALFVLCWMPFYVLNIVNVVC 283
Cdd:cd00637  163 IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERkvtkTLLIVVVVFLLCWLPYFILLLLDVFG 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 522838250 284 PlPEEPAFFGLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd00637  243 P-DPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
45-324 9.91e-48

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 164.47  E-value: 9.91e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd14985    1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYdWPFGAFLCKVSSYVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWpePA 199
Cdd:cd14985   81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLqaieNLNKTACIMLY--PH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd14985  159 EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERT-----GKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYA------NSCANPILYGFLSYRFKQGF 324
Cdd:cd14985  234 DFLAQLGAIRPCFWELFLDLGLPIAtclaftNSCLNPFIYVFVDRRFRQKV 284
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
45-324 2.24e-47

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 163.61  E-value: 2.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLV---M 120
Cdd:cd15095    1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATPSWVFGDFMCKFVnymM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGinQFTSIfCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRG-----MSTCHMQW 195
Cdd:cd15095   81 QVTV--QATCL-TLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGywygpQTYCREVW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEPaaAWRAGFIIYTAALGFFGPLLVICLCYLLIVvkvrsagRRVWAPSCQRRRRSERRVT----------RMVVAVVAL 265
Cdd:cd15095  158 PSK--AFQKAYMIYTVLLTYVIPLAIIAVCYGLIL-------RRLWRRSVDGNNQSEQLSEralrqkrkvtRMVIVVVVL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 266 FVLCWMPFYVLNIVNVVCP-LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15095  229 FAICWLPNHVLNLWQRFDPnFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
45-324 2.74e-45

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 158.01  E-value: 2.74e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEPA 199
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLrnytPGNRTVCSEAWPSRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AawRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd14971  161 H--RRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRP--VLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14971  237 VALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
45-324 5.60e-45

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 157.76  E-value: 5.60e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLfCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVART---------VSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQ 194
Cdd:cd14993   81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIiivaiwviaIIIMLPLLVVYELEEIISSEPGTITIYICTED 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPEPaaAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRV-----TRMVVAVVALFVLC 269
Cdd:cd14993  161 WPSP--ELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILRskkkvARMLIVVVVLFALS 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 270 WMPFYVLNIVNVVCPLPEEPA---FFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14993  239 WLPYYVLSILLDFGPLSSEESdenFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
45-324 1.03e-43

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 153.91  E-value: 1.03e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFlAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPF-WAVYAADGWVFGSFLCKLVSALYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGM--STCHMQWPE-PAAA 201
Cdd:cd14984   80 INFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENgsSICSYDYPEdTATT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrrSERRVTRMVVAVVALFVLCWMPFYV------ 275
Cdd:cd14984  160 WKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNH-----------KKHRALRVIFAVVVVFFLCWLPYNIvllldt 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 276 ---LNIVNVVCPLPEEpafFGLYFLVV-ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14984  229 lqlLGIISRSCELSKS---LDYALQVTeSLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
45-324 2.70e-43

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 153.04  E-value: 2.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHT---ASPSVTNVYILNLALADELFMLGLPFLAAQ-NALSYWPFGSLMCRLVM 120
Cdd:cd15338    1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSkfrCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQlLGNGVWHFGETMCTLIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPE 197
Cdd:cd15338   81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLmplPDGSVGCALLLPN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAA--WragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgrrvWAPSCQRRRRS-ERRVTRMVVAVVALFVLCWMPFY 274
Cdd:cd15338  161 PETDtyW---FTLYQFFLAFALPLVVICVVYFKILQNMAST----VAPLPQRSLRVrTKKVTRMAVAICLAFFICWAPFY 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 275 VLNIVNVVCPLPEEpAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15338  234 ILQLAHLSIDRPSL-AFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-324 9.12e-43

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 151.43  E-value: 9.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15192    1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYhWPFGNFLCKIASALV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEPA 199
Cdd:cd15192   81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVffieNTNITVCAFHYPSQN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapsCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15192  161 STLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYE------IQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 280 NVV--------CPLPEepaffglyFLVVALP------YANSCANPILYGFLSYRFKQGF 324
Cdd:cd15192  235 DVLiqlkviqdCHIAD--------IVDTAMPfticiaYFNSCLNPILYGFVGKNFRKKF 285
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
45-324 4.19e-42

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 149.75  E-value: 4.19e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFvVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRT------APVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPE 197
Cdd:cd15096   81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTerntliAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAwrAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTrMVVAVVALFVLCWMPFYVLN 277
Cdd:cd15096  161 GTAA--QTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQRGKRRVTR-LVVVVVVVFAICWLPIHIIL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 278 IVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15096  238 LLKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
45-322 2.06e-41

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 147.80  E-value: 2.06e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAA-QNALSYWPFGSLMCRLVMAVD 123
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYyYLNGGWWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP---RGMSTCHMQWPEPAA 200
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIakeNNSTTCFEFLSEWLA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWrAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV- 279
Cdd:cd14982  161 SA-APIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQ------SQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILy 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 280 -----NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd14982  234 llvrlSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
46-324 3.20e-41

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 147.59  E-value: 3.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDG 124
Cdd:cd15191    2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYnWLFGSVMCKICGSLLT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARwRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWP-EPA 199
Cdd:cd15191   82 LNLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTyyieELGVNACIMAFPnEKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15191  161 AQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLK------TKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPY------ANSCANPILYGFLSYRFKQGF 324
Cdd:cd15191  235 DALARMGVINNCWVITVIDKALPFaiclgfSNSCINPFLYCFVGNHFREKL 285
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-322 6.41e-41

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 147.22  E-value: 6.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  43 SGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTAS-PSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVM 120
Cdd:cd15190    9 SYALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKrRRSADTFIANLALADLTFVVTLPLWAVYTALGYhWPFGSFLCKLSS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR----GMSTCHMQWP 196
Cdd:cd15190   89 YLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDlegtNKVICDMDYS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 -----EPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMvvavVALFVLCWM 271
Cdd:cd15190  169 gvvsnESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLLKIIITL----VVTFALCWL 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 272 PFYVLNIVNVVCPLPEEPAFFGL-YFLVVALPYA------NSCANPILYGFLSYRFKQ 322
Cdd:cd15190  245 PFHLVKTLYALMYLGILPFSCGFdLFLMNAHPYAtclayvNSCLNPFLYAFFDPRFRQ 302
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-324 1.82e-40

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 145.25  E-value: 1.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTA--SPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15098    1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPgkRRSTTNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVS----AAVWVASAVVVLPVVVFSGVPRGMST-CHMQWP 196
Cdd:cd15098   81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVlviwVLSLAMASPVAVHQDLVHHWTASNQTfCWENWP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPaaAWRAGFIIYTAALGFFGPLLVICLCYLLIV----VKVRSAGRRVWAPSCQrrrrserrVTRMVVAVVALFVLCWMP 272
Cdd:cd15098  161 EK--QQKPVYVVCTFVFGYLLPLLLITFCYAKVLnhlhKKLKNMSKKSERSKKK--------TAQTVLVVVVVFGISWLP 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 273 FYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15098  231 HHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
45-322 2.42e-40

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 144.96  E-value: 2.42e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRhTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVD 123
Cdd:cd15339    1 VILPSFIGILCSTGLVGNILVLFTIIR-SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgEWVFGSPLCTIITSLD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR---GMSTCHMQWPEPAA 200
Cdd:cd15339   80 TCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKfrdGLESCAFNLTSPDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 A-WragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSC---QRRRRSERRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15339  160 VlW---YTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRyntSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 277 NIVNVVCPLPeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15339  237 QLVNLSVSQP-TLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
49-324 1.02e-39

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 143.51  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFM--LGLPFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15203    5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSD-LLLclVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAP-----------VARTVSAAVWVASAVVVLPVVVFSGvprgmSTCHMQW 195
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHAlliialiwilsLLLSLPLAIFQELSDVPIEILPYCG-----YFCTESW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEpaAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagRRVWAPSCQRRRRSERRVTR---------MVVAVVALF 266
Cdd:cd15203  159 PS--SSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLR---KRVKKKRGKRTLSSRRRRSElrrkrrtnrLLIAMVVVF 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838250 267 VLCWMPFYVLNIVNVVCPLPEEPA----FFGLYFLVVALpyANSCANPILYGFLSYRFKQGF 324
Cdd:cd15203  234 AVCWLPLNLFNLLRDFEPLPQIDGrhfyLIFLICHLIAM--SSACVNPLLYGWLNDNFRKEF 293
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
49-324 5.61e-39

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 140.78  E-value: 5.61e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRT-APVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAaawrAGF 206
Cdd:cd14967   84 TASILNLCAISLDRYLAITRPLRYRQLMTkKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPN----KIY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 207 IIYTAALGFFGPLLVICLCYLLIVVKVRS---AGRRVwapscqrrrrserrvtrmvVAVVALFVLCWMPFYVLNIVNVVC 283
Cdd:cd14967  160 VLVSSVISFFIPLLIMIVLYARIFRVARRelkAAKTL-------------------AIIVGAFLLCWLPFFIIYLVSAFC 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 522838250 284 PLPEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14967  221 PPDCVPPI--LYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
46-322 2.12e-38

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 139.74  E-value: 2.12e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLV-YLVVCVVGLLGNSLVIYVVlRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd14974    1 IVSLVlYALIFLLGLPGNGLVIWVA-GFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHhWPFGSVLCKLNSFVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF------SGVPRGMSTCHM---- 193
Cdd:cd14974   80 SLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFrdtvthHNGRSCNLTCVEdydl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 -QWPEPAAAWRAgFIIytaalGFFGPLLVICLCYLLIVVKVRsaGRRVWAPScqrrrrserRVTRMVVAVVALFVLCWMP 272
Cdd:cd14974  160 rRSRHKALTVIR-FLC-----GFLLPLLIIAICYSVIAVKLR--RKRLAKSS---------KPLRVLLAVVVAFFLCWLP 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 273 FYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd14974  223 YHVFALLELVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRK 272
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
45-324 1.32e-37

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 138.02  E-value: 1.32e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVV--LRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMA 121
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFvWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS---GVPRGMSTCHMQWPEP 198
Cdd:cd14976   81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFStdtWSSVNHTLCLLRFPKN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAA-----WRAGFIIYTAALGFFGPLLVICLCYLLIVVKV---RSAGRRvwapscqrrrrSERRVTRMVVAVVALFVLCW 270
Cdd:cd14976  161 SSVtrwynWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLqrkRGGSKR-----------RKSRVTKSVFIVVLSFFICW 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 271 MPFYVLNIVNVVCPL---PEEPAFFGL--YFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14976  230 LPNQALSLWSALIKFddvPFSDAFFAFqtYAFPVAicLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
45-324 7.87e-37

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 135.52  E-value: 7.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15168    1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANgDHWIFGDFMCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS--GVPRGMSTCH-MQWPEPAA 200
Cdd:cd15168   81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFAttGRKNNRTTCYdTTSPEELN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAgFIIYTAALGFFGPLLVICLCYLLIVVKV-RSAGRRVWAPSCQrrrrserRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15168  161 DYVI-YSMVLTGLGFLLPLLIILACYGLIVRALiRKLGEGVTSALRR-------KSIRLVIIVLALFAVCFLPFHVTRTI 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 280 NV-------VCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15168  233 NLaarllsgTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
45-324 2.25e-35

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 131.97  E-value: 2.25e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15207    1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVfCMPFTLVDNILTGWPFGDVMCKLSPLVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPT------RSARWRTAPV-ARTVSAAVWVASAVVVLPVVVFSGVprGMSTCHMQWP 196
Cdd:cd15207   81 GVSVAASVFTLVAIAVDRYRAVVHPTepkltnRQAFVIIVAIwVLALAIMIPQALVLEVKEYQFFRGQ--TVHICVEFWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPaaAWRAgfiIYTAAL---GFFGPLLVICLCYLLIVVKV----RSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLC 269
Cdd:cd15207  159 SD--EYRK---AYTTSLfvlCYVAPLLIIAVLYVRIGYRLwfkpVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALS 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 270 WMPFYVLNIVNVVCPLPE---EPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15207  234 WLPLHTVTMLDDFGNLSPnqrEVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-322 5.03e-34

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 127.94  E-value: 5.03e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIyVVLRHTASPSVT-NVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd14999    1 AIGTVLSLMCVVGVAGNVYTL-VVMCLSMRPRASmYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP----TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS-TCHMQWPEPA 199
Cdd:cd14999   80 LTMHASIFTLTVMSTERYLAVVKPldtvKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSkRICLPTWSEE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AawragFIIYTAAL---GFFGPLLVICLCYLLIVVKVRSAGRRvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd14999  160 S-----YKVYLTLLfstSIVIPGLVIGYLYIRLARKYWLSQAA--ASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIW 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 277 NIVNVVCPLPEEPAFFGLY--FLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd14999  233 QLLYLYSPSLSLSPRTTTYvnYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
45-324 7.36e-33

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 124.87  E-value: 7.36e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAlSYWPFGSLMCRLVMAVDG 124
Cdd:cd15172    1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEA-HQWIFGNFSCKLLRGIYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST------CHMQWPEP 198
Cdd:cd15172   80 INFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDFGleeqyvCEPKYPKN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAA--WRAGFIIYTAALGFFGPLLVICLCYLLIV---VKVRSAGRRvwapscqrrrrserRVTRMVVAVVALFVLCWMPF 273
Cdd:cd15172  160 STAimWKLLVLSLQVSLGFFIPLLVMIFCYSFIIktlLQAQNSQRH--------------KAVRVVVAVVLVFLVCQVPY 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 274 YVLNIVNVV-------CPLPEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15172  226 NIVLLIEAInlgeqqsCSSEKAVAY--AKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
45-322 7.16e-32

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 122.46  E-value: 7.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFdWPFGDWLCRLTALLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVAR--TVSAAVWVASAVVVLPVVVFSGVPRGMSTChMQWPEPAAA 201
Cdd:cd15159   81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRyiCVFVWVLVFLQTLPLLFMPMTKEMGGRITC-MEYPNFEKI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAA-LGFFGPLLVICLCYLLIVVKVRSAGRRvwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15159  160 KRLPLILLGACvIGFGVPVGIILFCYSQITLKLCRTAKE---NPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQF 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 281 VVCPL------PEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15159  237 MIRKLlyqpscSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-322 9.72e-32

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 122.19  E-value: 9.72e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSY--WPFGSLMCRLVMAVD 123
Cdd:cd15189    2 IIPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWA-MNILNQfnWPFGELLCRVVNGVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEpa 199
Cdd:cd15189   81 KVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIkaipDLNITACVLLYPH-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagRRVWAPSCQrrRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15189  159 EAWHFAHIVLLNIVGFLLPLLVITFCNYNILQALR---TREESTRCE--DRNDSKATALVLAVTLLFLVCWGPYHFFTFL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVA------LPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15189  234 DFLFDVGVLDECFWEHFIDIGlqlavfLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
46-324 1.01e-31

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 121.75  E-value: 1.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVL--RHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15002    1 LVPILLGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLfSVPFRAAAYSKGSWPLGWFVCKTADWF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTvSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAA 200
Cdd:cd15002   81 GHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAV-VASIWVPACLLPLPQWLFRTVKQseGVYLCILCIPPLAH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQrrrRSERRVTRMVVAVVALFVLCWMPFYVLnIVN 280
Cdd:cd15002  160 EFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQ---IRSRKLTHMLLSVVLAFTILWLPEWVA-WLW 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 281 VVCPLPEEPAFFGLyFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15002  236 LIHIKSSGSSPPQL-FNVLAqlLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-324 5.20e-31

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 119.69  E-value: 5.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15178    5 VIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAV-SVVKGWIFGTFMCKLVSLLQEANFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSARWRTaPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMST-CHMQW-PEPAAAWR 203
Cdd:cd15178   84 SGILLLACISVDRYLAIVHATRALTQKR-HLVKFVCAGVWLLSLLLSLPALLNRDAfkpPNSGRTvCYENLgNESADKWR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVV---KVRS-----AGRRVWApscqrrrrserrvtrmvvaVVALFVLCWMPFYV 275
Cdd:cd15178  163 VVLRILRHTLGFLLPLVVMLFCYGFTIKtllQTRSfqkhrAMRVIFA-------------------VVLAFLLCWLPYNV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 276 L---------NIVNVVCPLpEEPAFFGLYFLVVaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15178  224 TvlidtlmrtKLITETCEL-RNHVDVALYVTQI-LGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
45-322 1.35e-30

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 118.84  E-value: 1.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTA-SPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAV 122
Cdd:cd15926    1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFtWLFGKAMCKIVSYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST--CHMQWPE--- 197
Cdd:cd15926   81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEelCLVKFPDnrg 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVrsAGRRVWAPSCQRRRRSERRVTRMvvavVALFVLCWMPFYVLN 277
Cdd:cd15926  161 NAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFI--TDKNITGSSTKRRSKVTKSVTIV----VLSFFLCWLPNQALT 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 278 IVNVVCPLPEEPaFFGLYFLV--------VALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15926  235 TWGILIKLNVVH-FSYEYFTTqvyifpitVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
45-324 1.74e-30

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 118.32  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFkIAYHIHGNNWIFGEALCRLVTVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAA----VWVASAVVVLPVVVFSGVPRGMSTCH--MQWPE 197
Cdd:cd15162   81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAiwllALLVTLPLYLVKQTIFLPALDITTCHdvLPEQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRAGFIIYtAALGFFGPLLVICLCYLLIVvkvrsagRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLN 277
Cdd:cd15162  161 LVGDWFYYFLSL-AIVGFLIPFILTASCYVATI-------RTLAALEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 278 IVNVVCPLPE-EPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15162  233 LAHYSLISSSgTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
45-321 2.00e-30

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 118.33  E-value: 2.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSyWPFGSLMCRLVMAVDG 124
Cdd:cd15179    1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN-WYFGNFLCKAVHVIYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAAA- 201
Cdd:cd15179   80 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSEldDRYICDRIYPEDTFEl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagrrvwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYV------ 275
Cdd:cd15179  160 WVVAFRFQHILVGLVLPGLVILTCYCIIISKLS-----------HSKGHQKRKALKTTVILILAFFACWLPYYIgisidt 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 276 ---LNIVNVVCPLpeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15179  229 fmlLEIIKQSCEM--EQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
45-326 2.89e-30

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 117.93  E-value: 2.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15193    1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGqWLFGEGLCKLSSFII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvsaavwvASAVVVLPVVVFSGVP----RGMSTCHMQWPEPA 199
Cdd:cd15193   81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCAL--------ITCCIIWAVSLVLGIPslvyRNLINESVCVEDSS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRS---------AGRRVWapscqrrrrserrvTRMVVAVVALFVLCW 270
Cdd:cd15193  153 SRFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRhfhgakrtgRRRRNS--------------LRIVFAIVTAFVLSW 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522838250 271 MPFYVLNIV-------NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSyrfkQGFRR 326
Cdd:cd15193  219 LPFNTLKAVrlllelgGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLD----RHFRR 277
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
49-324 4.26e-30

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 116.99  E-value: 4.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFMLG--LPFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15001    4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATAD-LLLLVfcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVAR--------TVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMqWPEP 198
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARkvalliwiLSAILASPVLFGQGLVRYESENGVTVYHCQKA-WPST 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 aAAWRAgFIIYTAALGFFGPLLVICLCYLLIvvkvrsagRRVWapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15001  162 -LYSRL-YVVYLAIVIFFIPLIVMTFAYARD--------TRKQ-------------VIKMLISVVVLFAVCWGPLLIDNL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 279 V---NVVCPLPEEpaffGLYFLVVA---LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15001  219 LvsfDVISTLHTQ----ALKYMRIAfhlLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-321 6.95e-30

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 116.69  E-value: 6.95e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNaLSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15182    2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH-SSGWIFGEILCKAVTSIFYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGM---STCHMQWPEpaaaW 202
Cdd:cd15182   81 GFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDedgSLCEYSSIK----W 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFiIYTAALGFFGPLLVICLCYLLIVVKV---RSAGRRvwapscqrrrrserRVTRMVVAVVALFVLCWMPFyvlNIV 279
Cdd:cd15182  157 KLGY-YYQQNLFFLIPLGIIVYCYVRILQTLmrtRTMRKH--------------RTVKLIFVIVLVFFLSWAPY---NIV 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 280 NVVCPLPEEPAFFG--------LYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15182  219 IFLRSLKDLTIPICecskqldyAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
45-324 7.37e-30

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 116.41  E-value: 7.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15173    1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAY-SAAHEWIFGTVMCKITNGLYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRS--ARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-CHMQWPEPAAa 201
Cdd:cd15173   80 INLYSSMLILTCITVDRFIVIVQATKAhnCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKiCSMVYPPDAI- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 wRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGrrvwapSCQRRRRSERRVTRMvvavvALFVLCWMPFYVLNIVNV 281
Cdd:cd15173  159 -EVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAK------GFQKHKSLKIIFVVV-----AVFILTQLPYNIMKLIRT 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 282 VCPLPEEPAFFGlYFLVV--ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15173  227 LHIENTDSTNFK-YAILIteAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
45-324 2.83e-29

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 115.31  E-value: 2.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRH-TASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15097    1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAa 200
Cdd:cd15097   81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDyaNSTVCMPGWEEAR- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 awRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15097  160 --RKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMS--ESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCY 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 281 VVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15097  236 LYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
45-324 3.70e-29

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 115.15  E-value: 3.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQN-ALSYWPFGSLMCRLVMAV 122
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMaVFCVPFSFIALlILQYWPFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRsaRWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST------CHMQWP 196
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNAscgqyiCTESWP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAAWragfiIYT---AALGFFGPLLVICLCYLLIVVKV--RSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWM 271
Cdd:cd15392  159 SDTNRY-----IYSlvlMILQYFVPLAVLVFTYTRIGIVVwaKRTPGEAENNRDQRMAESKRKLVKMMITVVAIFALCWL 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 272 PFYVLNIV-NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15392  234 PLNILNLVgDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
45-324 4.04e-29

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 115.06  E-value: 4.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15927    1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTcVPFTSTIYTLDSWPFGEFLCKLSEFLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHP----TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP---RGMSTCHmQWP 196
Cdd:cd15927   81 DTSIGVSVFTLTALSADRYFAIVNPmrkhRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLtdnQTIQICY-PYP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAAWRAGFIIYTAALGFFG-PLLVICLCYLLIVVKVRSAGRRVwaPSCQRRRRSERR-----VTRMVVAVVALFVLCW 270
Cdd:cd15927  160 QELGPNYPKIMVLLRFLVYYLiPLLIIGVFYVLMARHLIRSTRNI--GSGQNQAAQRQIearkkVAKTVLAFVVLFAVCW 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 271 MPFYVLNIVNVVCPL-PEEPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15927  238 LPRHVFMLWFHFAPNgLVDYNAFWHVLKIVGfcLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
44-324 4.87e-29

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 114.41  E-value: 4.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  44 GVLIPLvYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15206    1 ELIIPL-YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEP 198
Cdd:cd15206   80 QAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLipmsRPGGHKCREVWPNE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAawRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15206  160 IA--EQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLEAKKRV---------------IRMLFVIVVEFFICWTPLYVINT 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 279 VNVVCPLPEEPAFFGLYF-LVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15206  223 WKAFDPPSAARYVSSTTIsLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
45-324 1.34e-28

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 113.25  E-value: 1.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQnALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQ-AVHGWIFGTGLCKLAGAVFK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMST-CHMQWPEPAA 200
Cdd:cd15180   80 INFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEAtkdPRQNKTeCVHNFPQSDT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwapSCQrrRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15180  160 YWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLR--------SSQ--GFQKQRAIRVIVAVVVVFFLCWTPYNIALLVD 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 281 VVCPLPEEPAFFGLYF-------LVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15180  230 TLIDLSVLDRNCGTESrldialsVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
45-322 1.39e-28

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 113.43  E-value: 1.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTAS-PSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAV 122
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLRNCARRaPPPIDVFVFNLALADFGFALTLPFWAVESALDFhWPFGGAMCKMVLTA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEpaA 200
Cdd:cd15925   81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEvcGVELCLLKFPS--N 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMvvavvaLFVLCWMPFYVLNIVN 280
Cdd:cd15925  159 YWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVA------SFFLCWFPNHVVTFWG 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 281 VVCPLPEEPAFFGLYFL-------VVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15925  233 VLVKFRAVPWNSTFYFIhtyvfpvTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
48-322 1.40e-28

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 113.31  E-value: 1.40e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  48 PLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15174    4 PPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWAT-AASSGWVFGTFLCKVVNSMYKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVW--VASAVVVLPVVVFSGVPR--GMSTCHMQ-WPEPAAAW 202
Cdd:cd15174   83 YSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFvwLLSTILSLPEILFSQSKEeeSVTTCTMVyPSNESNRF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVrsagrrVWAPSCQRRRRSERRVTRMVV-AVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15174  163 KVAVLALKVTVGFFLPFVVMVICYTLIIHTL------LQAKRFQKHKALKVIIAVVTVfVLSQLPYNSILLIKTINAYNI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 282 VCPLPEEPAFFGLYFLVV-ALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15174  237 TITDCATSQNLDIAGQVTqSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
45-324 4.01e-28

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 112.21  E-value: 4.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAP-----VARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEP 198
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAkfiiaVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWPER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKV---RSAGrRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15202  161 ADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLwasNMPG-DATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 276 LNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15202  240 YVLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
45-322 5.45e-28

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 5.45e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVlRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFIT-GFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTC-------- 191
Cdd:cd15116   80 FLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTapsqNNNKIICfnnfslsg 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 --HMQWPEPAAAWRAGFIIYTA-ALGFFGPLLVICLCYLLIVVKVRsagRRVWAPSCQrrrrserrVTRMVVAVVALFVL 268
Cdd:cd15116  160 dnSSPEVNQLRNMRHQVMTITRfLLGFLIPFTIIICCYAAIVLKLK---RNRLAKSSK--------PFKIIAAVIVTFFL 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 269 CWMPFYVLNIVNVvcplpEEPAFFGLYF-----LVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15116  229 CWAPYHILNLLEM-----EATRSPASVFkiglpITSSLAFINSCLNPILYVFMGQDFKK 282
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
46-234 6.10e-28

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 111.43  E-value: 6.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15187    2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQA-YYLLDQWVFGNAMCKIVSGAYYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAAAWR 203
Cdd:cd15187   81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASedGRLQCIPFYPGQGNSWK 160
                        170       180       190
                 ....*....|....*....|....*....|.
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVVKVR 234
Cdd:cd15187  161 VFTNFEVNILGLLIPFSILIFCYHNILRNLR 191
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
45-324 7.63e-28

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 111.35  E-value: 7.63e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFlAAQNALSY-WPFGSLMCRLVM 120
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVAD--IIIGLfsiPF-QFQAALLQrWVLPRFMCPFCP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSarwRTAP-VARTVSAAVWVASAVVVLPVVVFSGVPRGMST--------C 191
Cdd:cd15393   78 FVQVLSVNVSVFTLTVIAVDRYRAVIHPLKA---RCSKkSAKIIILIIWILALLVALPVALALRVEELTDKtnngvkpfC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWPEPaaAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVR--SAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLC 269
Cdd:cd15393  155 LPVGPSD--DWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWgtKAPGNAQDVRDDEILKNKKKVIKMLIIVVALFALC 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 270 WMPFYVLNIVNVVCPLPEEPAFFGL-YFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15393  233 WLPLQTYNLLNEIKPEINKYKYINIiWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
50-321 2.13e-27

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 109.83  E-value: 2.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVlRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQF 128
Cdd:cd15119    6 IYIVAFVLGVPGNAIVIWVT-GFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFhWPFGVWLCKINSFVAVLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-------SGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15119   85 ASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFrdtmelsINVTICFNNFHKHDGDLIVM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagrrvwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15119  165 RHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVK-----------RRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILEL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 282 VcplpeepAFFGLYF---------LVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15119  234 S-------IHHSSYLhnvlragipLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
45-324 2.93e-27

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 109.82  E-value: 2.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASpSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15117    1 ILSLVIYSSAFVLGTLGNGLVIWVTGFRMTR-TVTTVCFLNLAVADFAFCLFLPFSVVYTALGFhWPFGWFLCKLYSTLV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF--SGVPRGMSTCHM-------- 193
Cdd:cd15117   80 VFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFrdTRKENGCTHCYLnfdpwnet 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 -----QWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRsagRRVWAPSCQrrrrserrVTRMVVAVVALFVL 268
Cdd:cd15117  160 aedpvLWLETVVQRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLW---REGWVHSSR--------PFRVLTAVVAAFFL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 269 CWMPFYVLNIVNVVCPLPEEPAFFGLYFLVV----ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15117  229 CWFPFHLVSLLELVVILNQKEDLNPLLILLLplssSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
45-321 3.14e-27

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 109.45  E-value: 3.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSyWPFGSLMCRLVMAVDG 124
Cdd:cd15181    1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGM----STC--HMQWPEP 198
Cdd:cd15181   80 LNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTnanrTSCsfHQYGIHE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAAlGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrSERRVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15181  160 SNWWLTSRFLYHVV-GFFLPLLIMGYCYATIVVTLCQSSRRL----------QKQKAIRVAILVTLVFCLCWLPYNIVIF 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 279 VNVV---------CPLPEE-PAFFGlyfLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15181  229 LDTLddlkavvknCKLNDLlDAAIT---VTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
45-321 3.82e-27

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 109.09  E-value: 3.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVV---LRHTaspsVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVM 120
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAglkMKRT----VNTIWFLNLAVADLLCCLSLPFSIAHLLLNGhWPYGRFLCKLLP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAA 200
Cdd:cd15115   77 SIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFLVA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 awragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15115  157 -----ITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA----------KSQSKTFRVIIAVVVAFFVCWAPYHIIGILS 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 522838250 281 VVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15115  222 LYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
48-322 5.49e-27

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 109.09  E-value: 5.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  48 PLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGIN 126
Cdd:cd15381    4 PIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFnWPFGEFLCKSVNAVIYMN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR----GMSTCHMQWPEPaaAW 202
Cdd:cd15381   84 LYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYfpeyNITACVLDYPSE--GW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWapscqRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15381  162 HVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKF-----KEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 283 CPLPEEPAFFGLYFLVVA------LPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15381  237 HKLGLISGCRWEDILDIGtqiatfLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
56-315 1.19e-26

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 107.95  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLT 135
Cdd:cd14975   12 AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 136 VMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGF 215
Cdd:cd14975   92 LMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHYSDGQLVFHLLLETVVGF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 216 FGPLLVICLCYLLIVVKVrsagRRVWAPSCQrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLY 295
Cdd:cd14975  172 AVPFTAVVLCYSCLLRRL----RRRRFRRRR-------RTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTL 240
                        250       260
                 ....*....|....*....|....*...
gi 522838250 296 --------FLVVALPYANSCANPILYGF 315
Cdd:cd14975  241 gkvaeagrPIAGALAFLSSSINPLLYAF 268
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
46-322 2.70e-26

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 107.19  E-value: 2.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDG 124
Cdd:cd15380    2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFnWPFGNFLCRVISGVIK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR----GMSTCHMQWPEPaa 200
Cdd:cd15380   82 ANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHvpdlNISACILLFPHE-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15380  160 AWHFARRVELNIVGFLLPLAAIVFFNFHIIASLRE---RTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLD 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 281 VVCPLPEEPAFFGLYFLVVAL------PYANSCANPILYGFLSYRFKQ 322
Cdd:cd15380  237 FLFQVEVIQGCFWEEFIDLGLqlanffAFANSCLNPVIYVFAGKLFRT 284
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
41-324 2.94e-26

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 106.28  E-value: 2.94e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  41 AVSGVLIPLVylvvcvvGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPF---LAAQNAlsYWPFGSLMC 116
Cdd:cd15053    4 ALFLLLLPLL-------TVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILvMPFavyVEVNGG--KWYLGPILC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 117 RLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTapVARTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCH 192
Cdd:cd15053   75 DIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKN--SKRVLLTIAIVWVVSAAIACPLLFGLnnvpYRDPEECR 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MQWPEpaaawragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapscqrrrrserrVTRMVVAVVALFVLCWMP 272
Cdd:cd15053  153 FYNPD--------FIIYSSISSFYIPCIVMLLLYYRIFRALRREKK----------------ATKTLAIVLGVFLFCWLP 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 273 FYVLNIVNVVCPLPEEPAF---FGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15053  209 FFTLNILNAICPKLQNQSChvgPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
45-326 7.08e-26

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 106.01  E-value: 7.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15968    1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMrDRWLFGDFMCRLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF--SGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15968   81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFarTGIIRNRTVCYDLAPPALFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKV-RSAGrrvwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV- 279
Cdd:cd15968  161 HYVPYGMALTVSGFLLPFSIILWCYCLVVRTLcRTLG-----PAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIy 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 280 -------NVVCPLPEEPAFFglYFLVVALPYANSCANPILYgFLSyrfKQGFRR 326
Cdd:cd15968  236 lavrvtpGVPCHVLEAVAAC--YKITRPLASANSVLNPLLY-FLT---KKKFGR 283
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
45-317 9.02e-26

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 105.61  E-value: 9.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVD 123
Cdd:cd16001    1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRdRWPFGDFLCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF--SGVPRGMSTCH-MQWPEPAA 200
Cdd:cd16001   81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYarTGSINNRTVCYdLTSPDNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTaALGFFGPLLVICLCYLLIvvkVRSAGRRvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd16001  161 NYFPYGMVLT-VTGFLIPFLIILLCYCLM---IKSLIRS--EEAAGVGKAARAKSIRTILLVCGLFALCFVPFHITRTIY 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 281 VV--------CP-LPEEPAFFGLYFLVVALpyaNSCANPILYgFLS 317
Cdd:cd16001  235 LFvrvylvqdCPlLQFVSLAYKIWRPLVSF---NSCINPLLY-FLS 276
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
47-328 2.60e-25

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 105.25  E-value: 2.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVvLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAAAWRA 204
Cdd:PHA03087 122 FYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKdhETLICCMFYNNKTMNWKL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCY--LLIVVKVRSAGRRvwapscqrrrrsERRVTRMVVAVVALFVLCWMPF------YVL 276
Cdd:PHA03087 202 FINFEINIIGMLIPLTILLYCYskILITLKGINKSKK------------NKKAIKLVLIIVILFVIFWLPFnvsvfvYSL 269
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 277 NIVNVV--CplpeePAFFGLYFLVVA---LPYANSCANPILYGFLSYRFKQGFRRVL 328
Cdd:PHA03087 270 HILHFKsgC-----KAVKYIQYALHVteiISLSHCCINPLIYAFVSEFFNKHKKKSL 321
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
48-324 6.66e-25

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 103.35  E-value: 6.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  48 PLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15921    4 PTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLnSHWPFGDIACRIILYVLYVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-SGVPRGMSTCHMQWPEPAAAWRAG 205
Cdd:cd15921   84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAkSKQHDEGSTRCLELAHDAVDKLLL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAgrrvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVcpL 285
Cdd:cd15921  164 INYVTLPVGFVVPFMTVIFCYIFIIKNLLKP-----SPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLI--T 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 286 PEEPAFFGLYFLVV--------ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15921  237 ERQIKESCGYILRVrkaavitlCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
45-322 7.90e-25

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 102.87  E-value: 7.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15157    1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMgSHWVFGDIACRIMSYSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTvSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWR 203
Cdd:cd15157   81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARI-LCAVIWIFVMAASSPLLSKGTSKYNSQTKCLDLHPSKIDK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTA-ALGFFGPLLVICLCYLLIV---VKVRSAGRRVWAPSCQrrrrserrVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15157  160 LLILNYIVlVVGFILPFCTLSICYILIIkalLKPRVPQSKLRVSHKK--------ALLTIIITLILFLLCFLPYHILRTV 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 280 NVVcPLPEEPAFFGLYFLVV---ALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15157  232 HLM-QWSEGQCNLRLHKAVVitlCLAAANSCLDPLLYYFAGENFKE 276
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
47-321 1.36e-24

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 102.14  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLP-FLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd14987    3 LSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPvWVVSLVQHNQWPMGEFTCKITHLIFSI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST----CHMQWPEPA-A 200
Cdd:cd14987   83 NLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNnetyCRSFYPEESfK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvTRMVVAVVALFVLCWMP-------- 272
Cdd:cd14987  163 EWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSS-----------RKIIFSYVVVFLVCWLPyhtvvlld 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 273 -FYVLNIVNVVCPLpeEPAFFGLYFLVVALPYANSCANPILYGFL--SYRFK 321
Cdd:cd14987  232 iLSFLHLIPFSCQL--ENFLYAALHVTQCFSLVHCCVNPILYSFInrNYRYE 281
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
45-324 1.47e-24

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 102.51  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFM--LGLPFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISD-LLMalFCTPFNFTYVVSLSWEYGHFLCKIVNYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRS----ARWRTAPVART---VSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQW 195
Cdd:cd14992   80 RTVSVYASSLTLTAIAFDRYFAIIHPLKPrhrqSYTTTVIIIITiwvVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQIP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIvvkvrsaGRRVWA---------PSCQRRRRSERRVTRMVVAVVALF 266
Cdd:cd14992  160 PVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARI-------SRELWFrkvpgfsikEVERKRLKCKRRVIKMLVCVVVLF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 267 VLCWMPFYVLNIVNVVCPLPE-EPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14992  233 VICWLPFHLFFLLRDFFPLIMkEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
45-230 1.96e-24

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 101.77  E-value: 1.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15175    1 WFLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAA-SAAKKWVFGEEMCKAVYCLYK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPV--ARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMqWPEPAA 200
Cdd:cd15175   80 MSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVfiSKVSSLGVWVLAFILSIPELLYSGVNNndGNGTCSI-FTNNKQ 158
                        170       180       190
                 ....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIV 230
Cdd:cd15175  159 TLSVKIQISQMVLGFLVPLVVMSFCYSVII 188
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
45-322 5.22e-24

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 100.63  E-value: 5.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPS-VTNVYILNLALADELFMLGLPFLAAQNAlSYWPFGSLMCRLVMAVD 123
Cdd:cd15188    1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVPKKKkMTEVYLLNLAVSDLLFLVTLPFWAMYVA-WHWVFGSFLCKFVSTLY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPEPAA 200
Cdd:cd15188   80 TINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQThhtNNGVWVCHADYGGHHT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLI---VVKVRSAGRRvwapscqrrrrserRVTRMVVAVVALFVLCWMPFyvlN 277
Cdd:cd15188  160 IWKLVFQFQQNLLGFLFPLLAMVFFYSRIacvLTRLRPPGQG--------------RALRFVAALVVVFFVLWFPY---N 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 278 IVNVVCPLPEEPAFFGL-------YFLVV--ALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15188  223 LTLFLHSLQDLHVIGNCersrhldYALQVteSLAFVHCCLNPLLYAFVSKRFRL 276
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
45-324 5.30e-24

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 100.89  E-value: 5.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPFLAAQNALSY-WPFGSLMCRLVMAV 122
Cdd:cd14979    1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPVELYNFWWQYpWAFGDGGCKLYYFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHP----TRSARWRTAPV------ARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCH 192
Cdd:cd14979   81 FEACTYATVLTIVALSVERYVAICHPlkakTLVTKRRVKRFilaiwlVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MqwPEPAAAWRAgFIIYTAALGFFGPLLVICLCYLLIVVKVRS--------AGRRVWAPSCQRRRRSERRVTRMVVAVVA 264
Cdd:cd14979  161 L--VVDRSTFKY-VFQVSTFIFFVLPMFVISILYFRIGVKLRSmrnikkgtRAQGTRNVELSLSQQARRQVVKMLGAVVI 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522838250 265 LFVLCWMPFYVLNIVNVVCPLPEEPAF-FGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14979  238 AFFVCWLPFHAQRLMFSYASKEDTFLFdFYQYLYPISgiLFYLSSAINPILYNLMSSRFRVAF 300
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
45-321 9.03e-24

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 99.85  E-value: 9.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQnALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15177    1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAE-TLQGWIFGNAMCKLIQGLYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS----GVPRGMSTCHMQWPEPAA 200
Cdd:cd15177   80 INFYSGFLFLTCISVDRYVVIVRATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIysrvENRSELSSCRMIFPEVVS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTA-ALGFFGPLLVICLCYLLI---VVKVRSAGRRvwapscqrrrrserRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15177  160 RTVKGATALTQvVLGFAIPLIVMAVCYAAIgrtLLAARGWERH--------------RALRVIAALVVAFVLFQLPYSVV 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 277 NIVNVVCPLPEEPAFFG------LYFLVVA-LPYANSCANPILYGFLSYRFK 321
Cdd:cd15177  226 LLLDTADLLATLELSCSqskrkdIALLVTSgLAYVRCCLNPLLYAFVGVRFR 277
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-328 9.04e-24

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 100.37  E-value: 9.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQN-ALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15377    3 LPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYfNKTDWIFGDAMCKLQRFIFHV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAG 205
Cdd:cd15377   83 NLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIY---TAALGFFGPLLVICLCYLLIvvkVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15377  163 YFIYsmcTTVAMFCVPFILILGCYGLI---VRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLR 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 283 CPL----PEEPAF----FGLYFLVVALPYANSCANPILYgFLSyrfKQGFRRVL 328
Cdd:cd15377  240 ARLdfqtPAMCAFndrvYATYQVTRGLASLNSCVDPILY-FLA---GDTFRRRL 289
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
50-324 1.01e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 99.97  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFM--LGLPFLAAQNALSYWPFGSLMCRL---VMAVDG 124
Cdd:cd14969    6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALAD-LLMsvVGYPLSFYSNLSGRWSFGDPGCVIygfAVTFLG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 InqfTSIFCLTVMSVDRYLAVVHP---TRSARWRTAPVArtvsaavwvasAVVVLPVVVFSGVP----------RGMSTC 191
Cdd:cd14969   85 L---VSISTLAALAFERYLVIVRPlkaFRLSKRRALILI-----------AFIWLYGLFWALPPlfgwssyvpeGGGTSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWPEPAAAWRAgFIIYTAALGFFGPLLVICLCYLLIVVKVRS----AGRRVWAPSCQRRRRSERRVTRMVVAVVALFV 267
Cdd:cd14969  151 SVDWYSKDPNSLS-YIVSLFVFCFFLPLAIIIFCYYKIYRTLRKmskrAARRKNSAITKRTKKAEKKVAKMVLVMIVAFL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 268 LCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVAlpYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14969  230 IAWTPYAVVSLYVSFGGESTIPPLLATIPALFA--KSSTIYNPIIYVFMNKQFRRAL 284
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
56-315 1.04e-23

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 99.89  E-value: 1.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLT 135
Cdd:cd15121   12 ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 136 VMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWPEPAAawRAGFIIYTAA 212
Cdd:cd15121   92 LMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVlkkNINMKLCIPYHPSVGH--EAFQYLFETI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 213 LGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrrSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFF 292
Cdd:cd15121  170 TGFLLPFTAIVTCYSTIGRRLRSARFR-----------RKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNA 238
                        250       260       270
                 ....*....|....*....|....*....|
gi 522838250 293 GLYF-------LVVALPYANSCANPILYGF 315
Cdd:cd15121  239 SVLKaaklarpNVTALAFLSSSVNPVLYAF 268
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
46-322 1.21e-23

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 99.77  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDG 124
Cdd:cd15160    2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS---TCHMQWpePAAA 201
Cdd:cd15160   82 TNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPnhtLCYEKY--PMEG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwAPSCQRRRRSERRVTRMvvAVVALFVLCWMPFYVL----- 276
Cdd:cd15160  160 WQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQ------SPSLEREEKRKIIGLLL--SIVVIFLLCFLPYHVVllvrs 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 277 ---NIVNVVCPLpeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15160  232 vieLVQNGLCGF--EKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
46-324 1.31e-23

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 98.97  E-value: 1.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAV--WVASAVVVLPVVVFSGVPRGMSTCHMQWpepaaaw 202
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVwvISLLITSPPLVGPSWHGRRGLGSCYYTY------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvtRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15061  154 DKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIAKERKTA----------------KTLAIVVGCFIVCWLPFFIMYLIEPF 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15061  218 CDCQFSEA---LSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
45-324 1.01e-22

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 96.80  E-value: 1.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTvsAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWR 203
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKC--LIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPCT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 A------GFIIYTAALGFFGPLLVICLCYLLIvvkVRSAGRRVWAPScqrrrrserrvtrMVVAVVALFVLCWMPFYVLN 277
Cdd:cd15063  159 CeltngrGYVIYSALGSFYIPMLVMLFFYFRI---YRAARMETKAAK-------------TVAIIVGCFIFCWLPFFTVY 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 278 IVNVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15063  223 LVRAFCEDCIPPLLFSVFFW---LGYCNSALNPCIYALFSRDFRFAF 266
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
45-321 1.22e-22

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 96.74  E-value: 1.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHtASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15372    1 RLVPSLYTLVFLVGLPANGLALWVLATQ-VKRLPSTIFLINLAVADLLLILVLPFKISYHFLgNNWPFGEGLCRVVTAFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAV----WVASAVVVLPVVVFSGVPRGMSTCHMQWPEPA 199
Cdd:cd15372   80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIwliaAALTLPLTLQRQSYPLERLNITLCHDVLPLDE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYT-AALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15372  160 QDTYLFYYFAClAVLGFLLPLVVILFCYGSVLHTLLRSGQRYGHA------------MKLTVLVLVSFVLCFTPSNLLLL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 279 VNVVCPLPEEPA-FFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15372  228 LHYSDPTLDDGGnLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
47-328 1.28e-22

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 96.70  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLV-YLVVCVVGLLGNSLVIYVVLRhTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVDG 124
Cdd:cd15114    2 VALVlYAVVFLVGVPGNALVAWVTGF-EAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDgHWPFGAAACKLLPSLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV------PRGMstCHMQWPEP 198
Cdd:cd15114   81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIhqehfpEKTV--CVVDYGGS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIyTAALGFFGPLLVICLCYLLIVVKVrsAGRRVWAPScqrrrrserRVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15114  159 TGVEWAVAII-RFLLGFLGPLVVIASCHGVLLVRT--WSRRRQKSR---------RTLKVVTAVVVGFFLCWTPYHVVGL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 279 VNVVCPlPEEPAFFGLYF---LVVALPYANSCANPILYGFlsyrFKQGFRRVL 328
Cdd:cd15114  227 IIAASA-PNSRLLANALKadpLTVSLAYINSCLNPIIYVV----AGRGFRKSL 274
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
45-322 1.39e-22

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 96.44  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15186    1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWT-HYLINEWGLHNAMCKLTTAFFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSgvPRGMSTCHMQWPEP-AAAWR 203
Cdd:cd15186   80 IGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFT--KMKENECLGDYPEVlQEIWP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQrrrrserrvtrMVVAVVALFVLCWMPFYV------LN 277
Cdd:cd15186  158 VLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIK-----------LILLVVIVFFLFWTPYNVmifletLK 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 278 IVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15186  227 LYDFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 1.52e-22

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 97.07  E-value: 1.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLvYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15208    2 VLIAL-YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIiCLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTR----SARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP---RGMSTCHMQWP 196
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMfkstAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLAnktILLTVCDERWS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPA--AAWRAGFIIYTaalgFFGPLLVICLCYLLIVVKV--------RSAGRRVWAPSCQRRRRSERR-------VTRMV 259
Cdd:cd15208  161 DSIyqKVYHICFFLVT----YLLPLCLMILAYFQIFRKLwcrqipgtSSVVQRKWNKPRKSAVAAEEKqlrsrrkTAKML 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 260 VAVVALFVLCWMPFYVLNIVNVVCPL-PEEPAFFGLYFLVVA-LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15208  237 IVVVIMFAICYLPVHLLNILRYVFGLfTVDRETIYAWFLFSHwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
46-321 1.64e-22

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 96.82  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFM--LGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15391    2 HLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSD-LIMalFCMPFTFTQIMLGHWVFPAPMCPIVLYVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRS----ARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPa 199
Cdd:cd15391   81 LVSVTASVLTNTAIGIDRFFAVIFPLRSrhtkSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGP- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIvvkvrsaGRRVW---APSCQRRRR------SERRVTRMVVAVVALFVLCW 270
Cdd:cd15391  160 DTSRSAYTVFVMLLTYIIPLLILTSTYGYV-------GFRLWnrtAPGNADKGRddmqikSKRKVIKMLVFVVLMFGICW 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 271 MPFYVLNIV----NVVCPLPEEPAfFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15391  233 LPLHLFNLVqdfsTVFRNMPQHTT-RLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
45-324 1.80e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 96.38  E-value: 1.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd14988    1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYtWLWGSFLCKFTHYFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvsaavwvasaVVVLPVVVFSGVPRGMSTCHMQ---WPEPAA 200
Cdd:cd14988   81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRR-----------ALCAGIWVLSAIIPLPEVVHMQlldGVEPMC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIY----------TAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCqrrrrserrvtRMVVAVVALFVLCW 270
Cdd:cd14988  150 LFLAPFETYdewalavsllTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHC-----------LLIYAYILVFVVCW 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838250 271 MPFYVLNIVNVV--------CPLPEEPAFFglYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14988  219 LPYHVTLLLLTLhgshislhCNLVHFLYFF--YDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
45-324 3.76e-22

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 95.44  E-value: 3.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFMLGL--PFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVAD-LLISAFntVFNFTYLLYNDWPFGLFYCKFSNFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRsaRWRTAPVARTVSAAVWVASAVVVLPVVVFSGV-------PRGMSTCHMQW 195
Cdd:cd15390   80 AITTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLLYSTTetyyyytGSERTVCFIAW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PePAAAWRAGFI--IYTAALGFFGPLLVICLCYLLIvvkvrsaGRRVWA---PSCQRRRRSERR-----VTRMVVAVVAL 265
Cdd:cd15390  158 P-DGPNSLQDFVynIVLFVVTYFLPLIIMAVAYTRV-------GVELWGsktIGENTPRQLESVrakrkVVKMMIVVVVI 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 266 FVLCWMPFYVLNI-VNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15390  230 FAICWLPYHLYFIlTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
46-322 9.88e-22

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 94.17  E-value: 9.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15183    2 LLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS--TCHMQWP-EPAAAW 202
Cdd:cd15183   82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFThhTCSAHFPrKSLIRW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIvvkVRSAGRRvwaPSCQRRRRSERRVTRMVVAVVAlfvlcWMPFYVLNIVNV- 281
Cdd:cd15183  162 KRFQALKLNLLGLILPLLVMIICYTGI---INILLRR---PNEKKAKAVRLIFVITLLFFLL-----WTPYNLAAFVSAf 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 282 ----VCPLPEEPAFFGLYFLVV-ALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15183  231 qdvlFTPSCEQSQQLDLALQVTeVIAYTHCCVNPVIYVFVGERFRK 276
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
47-335 1.27e-21

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 96.24  E-value: 1.27e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIyVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAII-MILFCKKIKTITDIYIFNLAISDLIFVIDFPFII-YNEFDQWIFGDFMCKVISASYYIG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTvSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGF 206
Cdd:PHA02638 179 FFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGII-LCIISWILSLIITSPAYFIFEASNIIFSAQDSNETISNYQCTL 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 207 IIYTAA----------------LGFFGPLLVICLCYLLIVVKVRsagrrvwapscQRRRRSERRVTRMVVAVVALFVLCW 270
Cdd:PHA02638 258 IEDNEKnnisflgrilqfeiniLGMFIPIIIFAFCYIKIILKLK-----------QLKKSKKTKSIIIVSIIIICSLICW 326
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 271 MPfyvLNIVNVVCPLPEEPAFFGL--------------YFLVVALPYANSCANPILYGFLSyrfkQGFRRVLLRPSRRV 335
Cdd:PHA02638 327 IP---LNIVILFATMYSFKGFNSIisehicgfiklgyaMMLAEAISLTHCCINPLIYTLIG----ENFRMHLLMIFRNI 398
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
45-323 1.58e-21

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 93.56  E-value: 1.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILItLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRsARWRTAPVARTVSAAVWVASAVV------VLPVVVFSGVPRGMSTCHMQWPE 197
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLK-PRITPCQGVVVIAIIWIMASCLSlphaiyQKLVEFEYSNERTRSRCLPSFPE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKV--RSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPfyv 275
Cdd:cd15389  160 PSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLwlRNAIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLP--- 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 276 LNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQG 323
Cdd:cd15389  237 LNCYHVLLSSHPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
45-326 1.61e-21

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 93.66  E-value: 1.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15373    1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADeNDWPFSEALCKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS--GVPRGMSTCHmqwPEPAAA 201
Cdd:cd15373   81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVttSDKGGNITCH---DTSSPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTA---ALGFFGPLLVICLCYLLIVvkvrsagRRVWAPSCQRRRRSERR--VTRMVVAVVALFVLCWMPFYV- 275
Cdd:cd15373  158 LFDQFVVYSSvmlVLLFCVPFVVILVCYALMV-------RKLLKPSAGTSTNSRSKkkSVKMIIIVLAVFILCFLPFHVt 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 276 ----------------LNIVNVvcplpeepaffgLYFLVVALPYANSCANPILYgFLSYrfkQGFRR 326
Cdd:cd15373  231 rtlyysfrsmdlscgtLNAINL------------AYKVTRPLASANSCLDPILY-FLAG---QSFRS 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
44-322 4.16e-21

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 92.50  E-value: 4.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  44 GVLIPLvYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY--WPFGSLMCRLVMA 121
Cdd:cd15394    1 PLIIPL-YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPrgWVFGRFMCYFVFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHP--TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPA 199
Cdd:cd15394   80 MQPVTVYVSVFTLTAIAVDRYYVTVYPlrRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFWFGQE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAwRAGFIIYTAALGFFGPLLVICLCYLLIVVKV--RSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLN 277
Cdd:cd15394  160 KQ-RLAYACSTLLITYVLPLLAISLSYLRISVKLrnRVVPGSMTQSQAEWDRARRRKTFRLLVVVVVAFAICWLPLHIFN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 278 IVNVVCPLPEEPAFFGLY-FLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15394  239 VIRDIDIDLIDKQYFNLIqLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
45-327 6.30e-21

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 92.49  E-value: 6.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPS-VTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLmCRLVMAV 122
Cdd:cd15057    1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLLVaILVMPWAAVNEVAGYWPFGSF-CDVWVSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaavWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAW 202
Cdd:cd15057   80 DIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRA-------FIMIAVAWTLSALISFIPVQLGWHRADDTSEALAL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAG-----------FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWA------------PSCQRRRRSERRVTRMV 259
Cdd:cd15057  153 YADpcqcdsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAAleraaqestnpdSSLRSSLRRETKALKTL 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 260 VAVVALFVLCWMPFYVLNIVNVVCPLPEEPAF---FGLYFLVVALPYANSCANPILYGflsyrFKQGFRRV 327
Cdd:cd15057  233 SIIMGVFVCCWLPFFILNCVLPFCDLRTAQFPcvpDTTFIVFVWLGWANSSLNPIIYA-----FNADFRKA 298
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
46-230 6.35e-21

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 91.74  E-value: 6.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15184    2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA-HYAANEWVFGNAMCKLLTGLYHI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS--TCHMQWP-EPAAAW 202
Cdd:cd15184   81 GFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGShyTCSPHFPpSQYQFW 160
                        170       180
                 ....*....|....*....|....*...
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIV 230
Cdd:cd15184  161 KNFQTLKMNILGLVLPLLVMIICYSGIL 188
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
45-317 8.87e-21

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 91.37  E-value: 8.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15369    1 RFVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFkIAYHFSGNDWLFGEAMCRVVTAAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRT---APVARTVSAAVWVASAVVVLPVVVFSGVPR-GMSTCH-MQWPEP 198
Cdd:cd15369   81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTlrrASFTCAAIWLLSIAGVVPLLLSEQTIQIPDlGITTCHdVLNEQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAALGFFGPLLVICLCYLLIVvkvrsagRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15369  161 LMGYYVYYFSIFSCLFFFVPLIITTVCYVSII-------RCLSSSSDVANSSKKTRALFMAVAVFCVFVICFGPTNVLLL 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 522838250 279 VNVV--CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd15369  234 AHYVrfAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGS 274
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
45-328 9.38e-21

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 90.86  E-value: 9.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVAD--ILVGLlimPFSLVNELMGYWYFGSVWCEIWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMstcHMQWPEPAAA 201
Cdd:cd15059   79 LDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPW---HGAEPQCELS 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15059  156 DDPGYVLFSSIGSFYIPLLIMIIVYARIYRAAKRKERRF---------------TLVLGVVMGAFVLCWLPFFFTYPLVV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 282 VCPLPEEPAffGLYFLVVALPYANSCANPILYGFlsyrFKQGFRRVL 328
Cdd:cd15059  221 VCKTCGVPE--LLFKFFFWLGYCNSALNPVIYTI----FNKDFRRAF 261
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
45-324 1.15e-20

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 91.37  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15368    1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV----FSGVPRGMSTCH--MQWPE 197
Cdd:cd15368   81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERtdltYYVKELNITTCFdvLKWTM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 -PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVK-VRSAGRrvwapscqRRRRSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15368  161 lPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKlVQTSER--------YGREQKRRAIYLALIVLLVFITCFAPNNF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 276 LNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15368  233 ILLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
46-322 1.24e-20

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 91.43  E-value: 1.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15396    2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP------TRSARWRTAPVARTVSAAVWVASAVVVLPVVVF------SGVPRGMSTCH 192
Cdd:cd15396   82 VSVSVSIFSLVLIAIERYQLIVNPrgwkpsASHAYWGIVLIWLFSLMISIPFLIFHQLTDEPFrnlsshSDFYKDKVVCI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MQWPEPAAAwragfIIYTAAL---GFFGPLLVICLCYLLIVVKVRSAGRRV-WAPSCQRRRRSERRVTRMVVAVVALFVL 268
Cdd:cd15396  162 EAWPSETER-----LIFTTSLlvfQYFVPLGFIFICYLKIFVCLKKRNSKIdRMRENESRLSENKRINTMLISIVVTFAA 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 269 CWMPfyvLNIVNVVCPLPEEPAFFGLYFLVVALPY----ANSCANPILYGFLSYRFKQ 322
Cdd:cd15396  237 CWLP---LNIFNVVFDWNHEVLMSCHHNLVFTLCHlvamVSTCINPIFYGFLNKNFQK 291
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
45-321 3.51e-20

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 89.86  E-value: 3.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15928    1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdLYRLWRYRPWRFGDLLCRLMYFFS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPE-PAAAW 202
Cdd:cd15928   81 ETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFEcTVVNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGF---IIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15928  161 SSGLlsvMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVGRVI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 -NVVCPLPEEPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFK 321
Cdd:cd15928  241 fNHSRASTKHLHYVSQYFNLVSfvLFYLSAAINPILYNLMSKRYR 285
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
46-324 3.86e-20

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 89.34  E-value: 3.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALS-YWPFGSLMCRLVMA 121
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVAD--LLVGSivmPFSILHEMTGgYWLFGRDWCDVWHS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVasavvvlpvvvfsgvprgmstCHMQWPEPAAA 201
Cdd:cd15067   79 FDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI---------------------CSALISFPAIA 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 -WRA-----------------GFIIYTAALGFFGPLLVICLCYLLIvvkVRSAGRRVWApscqrrrrserrvTRMVVAVV 263
Cdd:cd15067  138 wWRAvdpgpsppnqclftddsGYLIFSSCVSFYIPLVVMLFTYYRI---YRAAAKEQKA-------------AKTLGIVM 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 264 ALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15067  202 GVFILCWLPFFVTNILIGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
45-313 5.15e-20

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 89.48  E-value: 5.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFL----AAQNalsYWPFGSLMCRLVM 120
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLiyyyADHN---HWPFGVVACKIVR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV-PRGMST-CHMQWPEP 198
Cdd:cd15374   78 FLFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTsRKDNITlCHDTTRPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAALGFFGPLLVICLCYLLIvvkVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPF----- 273
Cdd:cd15374  158 EFDHYVHYSSAVMVLLFGIPCLVIVVCYGLM---ARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFhitrt 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 274 ------------YVLNIVNVVcplpeepaffglYFLVVALPYANSCANPILY 313
Cdd:cd15374  235 lyyvarllkadcDTLNIINVT------------YKVTRPLASANSCLDPILY 274
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-319 5.49e-20

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 89.41  E-value: 5.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELfmLGLPFLAAQNALSY---WPFGSLMCRLVMAVDGINQF 128
Cdd:cd15197    8 WVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC--VGLINVLTDIIWRItveWRAGDFACKVIRYLQVVVTY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSAR-WRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAaWRAgFI 207
Cdd:cd15197   86 ASTYVLVALSIDRYDAICHPMNFSQsGRQARVLICVAWILSALFSIPMLIIFEKTGLSNGEVQCWILWPEPWY-WKV-YM 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIVVKVRSAGRrVWAPSCQRRRRSERRVTR---------------MVVAVVALFVLCWMP 272
Cdd:cd15197  164 TIVAFLVFFIPATIISICYIIIVRTIWKKSK-IQVTINKAGLHDGSSRRSssrgiiprakiktikMTFVIVTVFIICWSP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 273 FYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYR 319
Cdd:cd15197  243 YFVFDLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
45-324 5.87e-20

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 89.70  E-value: 5.87e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFM-LGLPFLAAQNALSY-WPFGSLMCRLVMAV 122
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLiLGLPFELYTIWQQYpWVFGEVFCKLRAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHP----TRSARWRTAP-------VARTVSAAVWVASAVVVLPVVVFSGVPRGMST- 190
Cdd:cd15134   81 SEMSSYASVLTITAFSVERYLAICHPlrshTMSKLSRAIRiiiaiwiIAFVCALPFAIQTRIVYLEYPPTSGEALEESAf 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 191 CHM--QWPEPAAAWRAGFIIYtaalgFFGPLLVICLCYLLIVVKVRSAgRRVWAPSCQRRRRSERRVTR-----MVVAVV 263
Cdd:cd15134  161 CAMlnEIPPITPVFQLSTFLF-----FIIPMIAIIVLYVLIGLQLRRS-TLLRRGQRSVSGGRRSSQSRrtvlrMLVAVV 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 264 ALFVLCWMPFY---VLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15134  235 VAFFICWAPFHaqrLLTVYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
45-238 6.35e-20

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 89.00  E-value: 6.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMrLVYHLSGNHWPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvsaavwvASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWR 203
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAH--------VVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQ 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 522838250 204 ------AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGR 238
Cdd:cd15161  153 lyrekaSRGALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKR 193
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
45-324 9.04e-20

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 89.07  E-value: 9.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP--------RGMSTCHMQW 195
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEvkydflyeKRHVCCLERW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEPaaAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTR--------MVVAVVALFV 267
Cdd:cd15205  161 YSP--TQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQTIHGIEMSKISrkkkravkMMVTVVLLFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 268 LCWMPFYVLNIVNVVCPLP---EEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15205  239 VCWAPFHVVHMMIEYSNLEnkyDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
45-324 1.38e-19

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 87.64  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFM-LGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTsTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSarwrtaPVARTVSAAVWVASAVVVLPVVVFSGVPRGmstchmqWPEPAA--- 200
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRY------PSIMTERRGLLALLCVWVLSLVISIGPLFG-------WKEPAPede 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 -----AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvtrMVVAVVALFVLCWMPFYV 275
Cdd:cd15325  148 ticqiTEEPGYALFSALGSFYLPLAIILVMYCRVYVVALKFSREKKAAK-------------TLGIVVGCFVLCWLPFFL 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 276 LNIVNVVCPLPEEPAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15325  215 VMPIGSIFPAYKPSD--TVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
46-150 1.75e-19

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 87.82  E-value: 1.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDG 124
Cdd:cd15967    2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKgRKWIFGQVFCKITRFCFN 81
                         90       100
                 ....*....|....*....|....*.
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTR 150
Cdd:cd15967   82 LNLYGSIGFLTCISVYRYLAIVHPMR 107
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-238 1.81e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 88.15  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML--GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15337    9 IVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAvnGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARWRTApvARTVSAAVWVASAVVVLPVVVFSG----VPRGMST-CHMQWPEPAAAWRAg 205
Cdd:cd15337   89 ITTLAAISIDRYLVIAKPLEAMKKMTF--KRAFIMIIIIWLWSLLWSIPPFFGwgryVPEGFQTsCTFDYLSRDLNNRL- 165
                        170       180       190
                 ....*....|....*....|....*....|...
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGR 238
Cdd:cd15337  166 FILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEK 198
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
45-322 2.08e-19

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 87.87  E-value: 2.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15397    1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTrsaRWRTAP----VARTVSAAVWVASAVVVLPVVVFSGVP-RGMS--------- 189
Cdd:cd15397   81 CMSVTVSILSLVLIALERHQLIINPT---GWKPSVsqayLAVVVIWMLACFISLPFLAFHILTDEPyKNLShffapladk 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 190 -TCHMQWPEpaaawRAGFIIYTAALGFFG---PLLVICLCYLLIVVKVRSAGRRV-WAPSCQRRRRSERRVTRMVVAVVA 264
Cdd:cd15397  158 aVCTESWPS-----EHHKLAYTTWLLLFQyclPLLFILVCYLRIYLRLRRRKDMLeRRGEYNRRAGHSKRINVMLVSLVA 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838250 265 LFVLCWMPFYVLNIV----NVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15397  233 AFALCWLPLNVFNAIadwnHEAIPHCQHNLIFSLCHL---AAMASTCVNPIIYGFLNSNFKK 291
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 3.23e-19

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 87.14  E-value: 3.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVvLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVD 123
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNhWAFGTVLCKVLNSTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWP---- 196
Cdd:cd15120   80 SVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETrldEKGKTICQNNYAlstn 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 -EPAAAWRAGFIIYTAA------LGFFGPLLVICLCYLLIVVKVRSAGrrvWAPSCQrrrrserrVTRMVVAVVALFVLC 269
Cdd:cd15120  160 wESAEVQASRQWIHVAMfvfrflLGFLLPFLIITFCYVRMALKMKERG---LARSSK--------PFKVMFTAVVSFFVC 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 270 WMPFYV---LNIVNVVCPLPEEpAFFGLYFLVVALpyaNSCANPILYGFLSYRFKQGF 324
Cdd:cd15120  229 WLPYHLhsgLVLTRGRPPSLTD-ITLLLTVGTTCF---NTCFTPVLYLFVGENFKKVL 282
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
45-316 3.36e-19

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 87.22  E-value: 3.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNA-LSYWPFGSLMCRLVMAVD 123
Cdd:cd15194    1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVvLGPWRSGSFLCKGSSYII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVvlpvvvfsGVPRGMSTCHMQWPE------ 197
Cdd:cd15194   81 SVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLL--------GLPTLLSRELKKYEEkeycne 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 -PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgrrvWAPSCQrRRRSERRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15194  153 dAGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHH----YQKSGK-HQKKLRKSIKIVFIVVAAFVFSWMPFNLF 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 277 NIVNVVCPLPEEPAFFGLYFLVVA------LPYANSCANPILYGFL 316
Cdd:cd15194  228 KALAIASGLQVEVTCLPYTLAQLGmevsapLAFANSCANPFIYYFF 273
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
52-315 3.72e-19

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 86.78  E-value: 3.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVL--RHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15122    8 LLAALLGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRG----MSTCHMQWPEPAAAwrAG 205
Cdd:cd15122   88 SIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDegmnDRICEPCHASRGHA--IF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWApscqrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPL 285
Cdd:cd15122  166 HYTFETLVAFVLPFGVILFSYSVILVRLKGARFRRRA-----------RVEKLIAAIVVAFALLWVPYHVVNLLQVVANL 234
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 522838250 286 PEEPAFFGLYFL-------VVALPYANSCANPILYGF 315
Cdd:cd15122  235 APGEVLEKLGGAakaaragATALAFFSSSVNPLLYVF 271
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
45-324 4.84e-19

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 86.96  E-value: 4.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLP-FLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPvALVETWAREPWLLGEFMCKLVPFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHP-------TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQw 195
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPlqakyvcTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVCRTP- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 pePAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERR---VTRMVVAVVALFVLCWMP 272
Cdd:cd14997  160 --ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAANRHTLRSrrqVVYMLITVVVLFFVCLLP 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 273 FYVLNIVNVVCPLPEEPAF--FGLYFLVV---ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14997  238 FRVVTLWIIFAPDEDLQALglEGYLNLLVfcrVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-230 4.99e-19

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 86.42  E-value: 4.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15185    2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQWPEPAA-AW 202
Cdd:cd15185   82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQElfEEFLCSPLYPEDTEdSW 161
                        170       180
                 ....*....|....*....|....*...
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIV 230
Cdd:cd15185  162 KRFHALRMNIFGLALPLLIMVICYTGII 189
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
45-243 5.49e-19

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 86.34  E-value: 5.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15176    1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAA-DAVNGWVLGTAMCKITSALYT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTrsARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRG--MSTCHMQWP-EPAAA 201
Cdd:cd15176   80 MNFSCGMQFLACISVDRYVAITKAT--SRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENsdRYRCLPVFPpSLVTS 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKV-RSAGRRVWAP 243
Cdd:cd15176  158 AKATIQILEVLLGFVLPFLVMVFCYSRVARALsRTPNVKKSRA 200
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
46-321 9.70e-19

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 85.62  E-value: 9.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYIlNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDG 124
Cdd:cd15371    2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAIFYA-NLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP--TRSARWRTAPVA--RTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWP--EP 198
Cdd:cd15371   81 GNMYCSILLLTCISINRYLAIVHPfiYRSLPKKTYAVLicALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPecEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRS-AGRRVWapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLN 277
Cdd:cd15371  161 NSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTLNAyEHKWFW-------------YVKITALVLIIFTICFAPSNVIL 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 278 IV-NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYgFLSYRFK 321
Cdd:cd15371  228 IIhHFNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLY-FLMSKWR 271
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-324 1.06e-18

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 85.75  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelfmlglPFLAAQNAL--------SYWPFGSLMCR 117
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSD-------ASMAAFNTLinfiyalhSEWYFGEAYCR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 118 LVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPE 197
Cdd:cd16003   75 FHNFFPITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 pAAAWRAGFIIYTAALGFFGPLLVICLCYllIVVKVRSAGRRVWAPSC---QRRRRSERRVTRMVVAVVALFVLCWMPFY 274
Cdd:cd16003  155 -GPDQHFTYHIIVIVLVYCLPLLVMGITY--TIVGITLWGGEIPGDTSdkyHEQLRAKRKVVKMMIIVVLTFAICWLPYH 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 275 VLNIVNVVC-PLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd16003  232 IYFIVTGLYqQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
53-324 1.14e-18

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 85.89  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGLPFLAAQ---NALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd14986    9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIAD--LVVAFFTVLTQiiwEATGEWVAGDVLCRIVKYLQVVGLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSARWRTAPvARTVSAAVWVASAVVVLPVVVFSGVPRGMSTcHMQWPEPAAAW-RAGFII 208
Cdd:cd14986   87 STYILVSMSLDRYQAIVKPMSSLKPRKRA-RLMIVVAWVLSFLFSIPQLVIFVERELGDGV-HQCWSSFYTPWqRKVYIT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 209 YTAALGFFGPLLVICLCYLLIVVKV--RSAGRRVWAPSCQRRRRSERRVTR---------------MVVAVVALFVLCWM 271
Cdd:cd14986  165 WLATYVFVIPLIILSYCYGRILRTIwiRSRQKTDRPIAPTAMSCRSVSCVSsrvslisrakiktikMTLVIILAFILCWT 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 272 PFYVLNIVNVVCPLPEEPAFFGLYFLVVALpyANSCANPILYGFLSYRFKQGF 324
Cdd:cd14986  245 PYFIVQLLDVYAGMQQLENDAYVVSETLAS--LNSALNPLIYGFFSSHLSFEH 295
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
46-161 1.51e-18

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 85.20  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15154    2 LHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQM 81
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVAR 161
Cdd:cd15154   82 NMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVAR 117
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
45-324 1.66e-18

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 85.08  E-value: 1.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLG---LPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTD--LLLGllvLPFSAIYELRGEWPLGPVFCNIYIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARW---RTAPVARTVSAAVWVASavvvlpvvvfSGVPrgmstCHMQWPEP 198
Cdd:cd15051   79 LDVMLCTASILNLFAISLDRYLAITAPLRYPSRvtpRRVAIALAAIWVVSLAV----------SFLP-----IHLGWNTP 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AA-------------AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMV------ 259
Cdd:cd15051  144 DGrvqngdtpnqcrfELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPASTANSSKSAATARehkatv 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 260 --VAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFfglYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15051  224 tlAAVLGAFIICWFPYFTYFTYRGLCGDNINETA---LSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
45-322 1.67e-18

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 84.85  E-value: 1.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSywPFgsLMCRLVMAVD 123
Cdd:cd15920    1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFrVAYQNTAG--PL--SFCKIVGAFF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAP--VARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQwpepAAA 201
Cdd:cd15920   77 YLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPwsSAASGGVWLLLLACMIPFLFESRNEGPCDNKCFHFR----SKG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPF------YV 275
Cdd:cd15920  153 LTAGGINLTAVVIFYILSLLFLYFYAKISHKLYKVSL---GNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYhivrvpYV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 276 LNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15920  230 LAQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-324 2.31e-18

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 84.20  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  36 SPAGLAVSGVLIPLVYLVVcvvgLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSL 114
Cdd:cd15321    2 SVQATAAIAAAITFLILFT----IFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFSLANELMGYWYFRKT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 115 MCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQ 194
Cdd:cd15321   78 WCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPEPAAAWragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFY 274
Cdd:cd15321  158 CKLNEEAW---YILSSSIGSFFAPCLIMILVYLRIYLIAKNREKRF---------------TFVLAVVIGVFVLCWFPFF 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 275 VLNIVNVVCP----LPEepAFFGLYFLVvalPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15321  220 FSYSLGAICPelckVPH--SLFQFFFWI---GYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
47-324 3.40e-18

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 83.97  E-value: 3.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVDGI 125
Cdd:cd15375    3 LPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSA---RWRTAPVARTVSAAVWVASAVVVLPVVVFSGVpRGMSTC--HMQWPEPAA 200
Cdd:cd15375   83 NLYGSILFLTCFSIFRYVVIVHPLRAFqvqKRRWAIVACAVVWVISLAEVSPMTFLITTKEK-NNRTICldFTSSDNLNT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIytAALGFFGPLLVICLCYLLIVVKVRSaGRRVWAPSCQrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15375  162 IWWYNWIL--TVLGFLLPLVIVTLCYTRIIYTLAK-GPHTGSASKQ-------KARRLIILILLVFYVCFLPFHILRVVR 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 281 VVCPLPEEPA-----FFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15375  232 IETRLPPVSCclkhqVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
50-240 4.28e-18

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 84.00  E-value: 4.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15336    6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSD--FLMSLtqsPIFFVNSLHKRWIFGEKGCELYAFCGALF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTApvARTVSAAVWVASAVVVLPVVVFSG----VPRG-MSTCHMQWPEPAAA 201
Cdd:cd15336   84 GITSMITLLAISLDRYLVITKPLASIRWVSK--KRAMIIILLVWLYSLAWSLPPLFGwsayVPEGlLTSCTWDYMTFTPS 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 522838250 202 WRAgfiiYTAALG---FFGPLLVICLCYLLIVVKVRSAGRRV 240
Cdd:cd15336  162 VRA----YTMLLFcfvFFIPLGIIIYCYLFIFLAIRSTGREV 199
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
45-324 5.16e-18

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 83.31  E-value: 5.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLsFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSarwrtaPVARTVSAAVWVASAVVVLPVVVFSGVPRGmstchmqWPEPAAA-- 201
Cdd:cd15062   81 VLCCTASIMSLCVISVDRYIGVRYPLNY------PTIVTARRATVALLIVWVLSLVISIGPLLG-------WKEPAPAde 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 ------WRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvtrMVVAVVALFVLCWMPFYV 275
Cdd:cd15062  148 qacgvnEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSREKKAAK-------------TLGIVVGAFVLCWFPFFV 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 276 LNIVNVVCPLPEEPAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15062  215 VLPLGSLFSTLKPPE--PVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
46-234 8.52e-18

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 82.98  E-value: 8.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15156    2 LYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS----TCHMQWPEpaAA 201
Cdd:cd15156   82 NMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNnnseTCFENFSS--KT 159
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 522838250 202 WR---AGFIIYTAALGFFGPLLVICLCYLLIVVKVR 234
Cdd:cd15156  160 WKtylSKIVIFIEIVGFFIPLILNVTCSTMVLKTLR 195
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
49-324 9.05e-18

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 83.22  E-value: 9.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15195    5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRtAPVARTVSAAVWVASAVVVLPVVVFSGVPRgmstchmqWPEPA-------- 199
Cdd:cd15195   85 YLSSFMLVVIALDRVFAILSPLSANQAR-KRVKIMLTVAWVLSALCSIPQSFIFSVLRK--------MPEQPgfhqcvdf 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 ------AAWRAgFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRV--------TRMVVAVVAL 265
Cdd:cd15195  156 gsaptkKQERL-YYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNRRRSRTNSlerarmrtLRMTALIVLT 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838250 266 FVLCWMPFYVLNI---VNVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15195  235 FIVCWGPYYVLGLwywFDKESIKNLPPALSHIMFL---LGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
51-324 1.46e-17

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 82.63  E-value: 1.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15980    7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSAR------------WRTA-PVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWP 196
Cdd:cd15980   87 SVFTLVAIAVDRFRCIVYPFKQKLtistavviiviiWVLAiAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPVYWCREDWP 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAAwragfIIYTAALG---FFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQ----RRRRSERRVTRMVVAVVALFVLC 269
Cdd:cd15980  167 NQEMR-----KIYTTVLFaniYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQeqrhVVSRKKQKVIKMLLIVALLFILS 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 522838250 270 WMPFYVLNIVNVVCPL-PEEPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15980  242 WLPLWTLMMLSDYANLsPNQLQIINIYIYPFAhwLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
45-324 1.84e-17

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 82.17  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15399    1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAP---VARTVSAAVWVASAVVVLPVVVFSGVPRG--MSTCHMQWPEP 198
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISfliIGLTWAASALLASPLAIFREYSVIEISPDfkIQACSEKWPNG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVR-----SAGRrvwapscQRRRRSERRVTRMVVAVVALFVLCWMPF 273
Cdd:cd15399  161 TLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKnhvspGGGN-------DHYHQRRRKTTKMLVCVVVVFAVSWLPF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 274 YVL----NIVNVVCPLPEEPAFFGLyFLVVALpyANSCANPILYGFLSYRFKQGF 324
Cdd:cd15399  234 HAFqlasDIDSKVLDLKEYKLIYTI-FHVIAM--CSTFANPLLYGWMNNNYRTAF 285
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-324 1.86e-17

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 82.19  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSY-WPFGSLMCRLVMAVDG 124
Cdd:cd15133    3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLlGMPLELYELWQNYpFLLGSGGCYFKTFLFE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV------PRGMSTCHMQWPEp 198
Cdd:cd15133   83 TVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIkflgsgVPASAQCTVRKPQ- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 aaaWRAGFII-YTAALGFFGPLLVICLCYLLIVVKV--------RSAGRRVWAPSCQRRR--RSERRVTRMVVAVVALFV 267
Cdd:cd15133  162 ---AIYNMIPqHTGHLFFVLPMAVISVLYLLMALRLarergldaTGAGSKIGTRTGQLLQhpRTRAQVTKMLFILVVVFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 268 LCWMPFYVLNIV-NVVCPLPEEPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15133  239 ICWAPFHIDRLMwSFISDWTDNLHEVFQYVHIISgvFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
51-322 2.02e-17

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 81.76  E-value: 2.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15153    7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYAS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARW-RTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIY 209
Cdd:cd15153   87 ICFLTCISIQRCFFLLHPFKARDWkRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIAMM 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 210 TAA--LGFFGPLLVICLCYLLIVVKVRSAGRRvwapscQRRRRSERRVTRMVVAVVALFVLCWMP------FYVLNIVNV 281
Cdd:cd15153  167 TVAelFGFVIPLFIIAWCTWKTENSLRQRNKQ------QQSTSEKQKALRMVRMCAAVFFICFAPyhinflFYLMVSESI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 282 V--CPLPEEPAFFGLYFLVVAlpYANSCANPILYGFLSYRFKQ 322
Cdd:cd15153  241 ItnCEVSQVILQFHPISLCLA--SLNCCLDPILYYFMTSEFQD 281
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
52-323 2.03e-17

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 82.00  E-value: 2.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFM-LGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15083    8 LIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCiLNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARWRTAPvaRTVSAAVWVASAVVVLPVVVFSG----VPRGMST-CHMQWPEPAAAWRAg 205
Cdd:cd15083   88 INTLAAIAVDRYLVITRPMKASVRISHR--RALIVIAVVWLYSLLWVLPPLFGwsryVLEGLLTsCSFDYLSRDDANRS- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTR----------MVVAVVALFVLCWMPFYV 275
Cdd:cd15083  165 YVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSSPKArrqaevktakIALLLVLLFCLAWTPYAV 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 276 LNIVnvvcplpeepAFFGLYFLV--------VALPYANSCANPILYGFLSYRFKQG 323
Cdd:cd15083  245 VALI----------GQFGYLEVLtplataipAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
46-148 2.43e-17

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 81.64  E-value: 2.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQ-NALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15201    2 VLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYyLRGKHWKFGDIPCRIVLFMLA 81
                         90       100
                 ....*....|....*....|....
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15201   82 MNRAGSIFFLTAVAVDRYFRVVHP 105
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
50-324 2.76e-17

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 81.51  E-value: 2.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15155    6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS--GVPRGMSTCHMQWPEpaAAWR---A 204
Cdd:cd15155   86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSttNVSNTSTTCFEGFSK--SIWKtylS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAgrrvwAPSCQrRRRSERRVTRMVVAVVALFVLCWMPF------YVLNI 278
Cdd:cd15155  164 KITIFIEVVGFIIPLLLNLTCSSLVLRTLRKP-----ATLSQ-IGTNKEKVLKMILVHVAIFVVCFVPYnsilflYALVR 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 279 VNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15155  238 SQAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
47-324 2.97e-17

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 81.70  E-value: 2.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd14977    3 IMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTR----SARWRT----------APVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTC 191
Cdd:cd14977   83 SLGVTVFSLCALSIDRYRAAVNSMPmqtiGACLSTcvklaviwvgSVLLAVPEAVLSTVARESSLDNSSLTVCIMKPSTP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWPEPAAAWRAgFIIYtaalgFFGPLLVICLCYLLIvVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWM 271
Cdd:cd14977  163 FAETYPKARSWWL-FGCY-----FCLPLAFTAVCYLLM-ARTLIRAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 272 PFYVLNIVNVVcpLPEEPAFFGLYFLVVA------LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14977  236 PEHISNILRAT--LYNEVLIDTRSTLDILdligqfLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
46-324 3.25e-17

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 81.63  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVV-----LRHTaspsvTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLV 119
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIftdrrLRKK-----SNLFIVSLAVADLLVaLLVMTFAVVNDLLGYWLFGETFCNIW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 120 MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaavWVASAVVVLPVVVFSGVPrgmstCHMQWPEPA 199
Cdd:cd15065   76 ISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRA-------LVVIASVWILSALISFLP-----IHLGWHRLS 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAG------------------FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVA 261
Cdd:cd15065  144 QDEIKGlnhasnpkpscaldlnptYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFQVPSLSSK 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 262 VVALFV-----------------LCWMPFYVLNIVNVVCP--LPEEpaffgLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15065  224 HNNQGVsdhkaavtlgiimgvflICWLPFFIINIIAAFCKtcIPPK-----CFKILTWLGYFNSCLNPIIYSIFNSEFRR 298

                 ..
gi 522838250 323 GF 324
Cdd:cd15065  299 AF 300
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
49-324 3.43e-17

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 81.01  E-value: 3.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV--------PRGmSTCHMQWPEPA 199
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTvpvpvgdrPRG-HQCRHAWPSAQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AawRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRS---AGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15979  164 V--RQAWYVLLLLILFFIPGVVMIVAYGLISRELYRgllAKKRV---------------IRMLVVIVAMFFLCWLPIFSA 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 277 NIVNVVCPLPEEPAFFGLYF-LVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15979  227 NTWRAFDPLSAHRALSGAPIsFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
43-313 3.54e-17

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 81.73  E-value: 3.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  43 SGVLIPLVylVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFM--LGLPFLAAQNALSYWPFGSLMCRLVM 120
Cdd:cd15058    1 PGLLLLLA--LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACAD-LVMglLVVPLGATIVVTGKWQLGNFWCELWT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVvlpvvvfSGVPrgmstCHMQW--PEP 198
Cdd:cd15058   78 SVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALV-------SFVP-----IMNQWwrAND 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRA-------------GFIIYTAALGFFGPLLVICLCYLLIVV----KVRSAGRR--VWAPSCQRRRRSERRVTRMV 259
Cdd:cd15058  146 PEANDCyqdptccdfrtnmAYAIASSVVSFYIPLLIMIFVYARVFLiatrQLQLIDKRrlRFQSECPAPQTTSPEGKRSS 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 260 VAVVALFVL-------------------CWMPFYVLNIVNVVCP-LPEEPAFfglyFLVVALPYANSCANPILY 313
Cdd:cd15058  226 GRRPSRLTVvkehkalktlgiimgtftlCWLPFFIANIINVFNRnLPPGEVF----LLLNWLGYINSGLNPIIY 295
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
45-322 4.28e-17

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 81.01  E-value: 4.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15395    1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTR------------SARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTC 191
Cdd:cd15395   81 CISITVSIFSLVLIAIERHQLIINPRGwrpnnrhayvgiAVIWVLAVLTSLPFLIFQVLTDEPFKNVNVSLDAYKGKYVC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWPEPAAawRAGFIIYTAALGFFGPLLVICLCYLLIVVKV-RSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCW 270
Cdd:cd15395  161 LDQFPSDTI--RLSYTTCLLVLQYFGPLCFIFICYLKIYIRLkRRNNMMDKMRDNKYRSSETKRINIMLISIVVAFAVCW 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 271 MPfyvLNIVNVVCPLPEEPAF---FGLYFLVVAL-PYANSCANPILYGFLSYRFKQ 322
Cdd:cd15395  239 LP---LNIFNAVFDWNHEAIAtcnHNLLFLICHLtAMISTCVNPIFYGFLNKNFQR 291
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
46-323 4.46e-17

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 80.95  E-value: 4.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGLpFLAAQNALSY----WPFGSLMCRLVMA 121
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVAD--LCVGI-FCVLQNLSIYlipsWPFGEVLCRMYQF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15012   78 VHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCylLIVVKVRSAGRRVWAPSCQrrrRSERRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15012  158 DREMFNSKLYDTINFIVWYLIPLL--IMTVLYSKISIVLWKSSSI---EARRKVVRLLVAVVVSFALCNLPYHARKMWQY 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 282 -----VCPLPEEPAFFGLYFLVValpYANSCANPILYGFLSYRFKQG 323
Cdd:cd15012  233 wsepyRCDSNWNALLTPLTFLVL---YFNSAVNPLLYAFLSKRFRQS 276
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
45-324 4.93e-17

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 81.20  E-value: 4.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15048    1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVAD--FLVGLvsmPFYIPYTLTGKWPFGKVFCKAWLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQWP 196
Cdd:cd15048   79 VDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIvptgdCEVEFF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAawragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFV--------- 267
Cdd:cd15048  159 DHFY-----FTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILPASQNPSRARSQREQVKLRrdrkaaksl 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 268 --------LCWMPFYVLNIVNVVCPLPEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15048  234 ailvlvflICWAPYTILTIIRSFCSGSCVDSY--LYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 6.60e-17

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 80.29  E-value: 6.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD---ELFMLGLPFLAAQNalSYWPFGSLMCRL--- 118
Cdd:cd16002    1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEasmSAFNTVINFTYAIH--NEWYYGLEYCKFhnf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 --VMAVdginqFTSIFCLTVMSVDRYLAVVHPTRSARWRTApvARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQ 194
Cdd:cd16002   79 fpIAAV-----FASIYSMTAIALDRYMAIIHPLQPRLSATA--TKVVICVIWVLAFLLAFPQGYYSDTEEmpGRVVCYVE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPE-PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIvvkvrsaGRRVWAPSC--------QRRRRSERRVTRMVVAVVAL 265
Cdd:cd16002  152 WPEhEERKYETVYHVCVTVLIYFLPLLVIGCAYTVV-------GITLWASEIpgdssdryHEQVSAKRKVVKMMIVVVCT 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 266 FVLCWMPFYVLNIVNVVCPLPEEPAFF-GLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd16002  225 FAICWLPYHIYFLLQYFHPELYEQKFIqQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
49-324 8.13e-17

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 79.91  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15978    5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSG-VP------RGMSTCHMQWPEPAA 200
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNlVPftrinnSTGNMCRLLWPNDVT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 awRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15978  165 --QQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLMAKK---------RVIRMLIVIVILFFLCWTPIFSANAWR 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 281 VVCPLPEEPAFFGLYF-LVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15978  234 AFDTRSADRLLSGAPIsFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
49-324 1.07e-16

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 79.24  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALS-YWPFGSLMCRLVMAVDGIN 126
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVaTLVMPWVVYLEVTGgVWNFSRICCDVFVTLDVMM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHP-------TRSARWRTApVARTVSAAVWVASAVVVLPVVVFSGVPrgmSTCHMQWPEpa 199
Cdd:cd15310   85 CTASILNLCAISIDRYTAVVMPvhyqhgtGQSSCRRVS-LMITAVWVLAFAVSCPLLFGFNTTGDP---TVCSISNPD-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 aawragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15310  159 ------FVIYSSVVSFYLPFGVTLLVYVRIYVVLLREKK----------------ATQMLAIVLGAFIVCWLPFFLTHIL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVCPLPEEPAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15310  217 NTHCQACHVPP--ELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
49-322 1.08e-16

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 79.59  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML--GLPFLAaqnalsyWPF------GSLMCRLVM 120
Cdd:cd15196    5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfnVLPQLI-------WDItyrfygGDLLCRLVK 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGmSTCHMQWP--EP 198
Cdd:cd15196   78 YLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVG-SGVYDCWAtfEP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAgFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15196  157 PWGLRA-YITWFTVAVFVVPLIILAFCYGRICYVVWRAKIK---------------TVKLTLVVVACYIVCWTPFFVVQM 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 279 VNVVCP-LPEEPAFFGLYFLVVALpyaNSCANPILYGFLSYRFKQ 322
Cdd:cd15196  221 WAAWDPtAPIEGPAFVIIMLLASL---NSCTNPWIYLAFSGNLRR 262
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
45-148 1.11e-16

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 79.92  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQkDYWPFGDFTCRLVRFQF 80
                         90       100
                 ....*....|....*....|....*
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHP 105
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
53-315 1.59e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 79.46  E-value: 1.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVV---LRHTaspsVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQF 128
Cdd:cd15118    9 IVSTLGIVENLLILWVVgfrLRRT----VISIWILNLALSDLLATLSLPFFTYYLASGHtWELGTTFCRIHSSIFFLNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-SGVPR--GMSTCHMQW----PEPAA- 200
Cdd:cd15118   85 VSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFrDVIERkdGRKLCYYNFalfsPSPDNn 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 -----AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrrSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15118  165 hpickQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRR-----------RPGRFVRLVVSVVVSFALCWAPYHI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 276 LNIVNVVCplPEEPAFFGLYF----LVVALPYANSCANPILYGF 315
Cdd:cd15118  234 FSIIEVMA--HNQHSLRPLVIqglpFATTLAFLNSVLNPVLYVF 275
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
50-161 1.78e-16

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 79.40  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFlaaqNALSY-----WPFGSLMCRLVMAVDG 124
Cdd:cd15158    6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPL----RVVYYvhkgqWLFGDFLCRISSYALY 81
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVAR 161
Cdd:cd15158   82 VNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKAR 118
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
46-236 1.95e-16

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 79.16  E-value: 1.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARW-RTAPVARTVSAAVWVASAVVVLPVVVFSG-VPRG-MSTCHMQWPEPAAAW 202
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLNGNPLtRGKALLLILFIWLYALPWALLPLLFGWGRyVPEGfLTSCSFDYLTRDWNT 161
                        170       180       190
                 ....*....|....*....|....*....|....
gi 522838250 203 RAgFIIYTAALGFFGPLLVICLCYLLIVVKVRSA 236
Cdd:cd15079  162 RS-FVATIFVFAYVIPLIIIIYCYSFIVKAVFAH 194
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
46-317 2.45e-16

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 78.65  E-value: 2.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAaQNALSY--WPFGSLMCRLVMAVD 123
Cdd:cd15367    2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWL-QYVLQHdnWTYSELLCKICGILL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRT---APVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWpePAA 200
Cdd:cd15367   81 YENIYISIGFLCCISVDRYLAVVHPFRFHAFRTmkaATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCFEHY--PIK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVR-SAGRRvwapscqrrRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15367  159 AWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRkSHGTQ---------KSQKIQIKRLVLSTVVIFLVCFGPYHILLLV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 280 NVV----CPLPEepAFFGLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd15367  230 RSVferdCNFAE--GIFNYYHFSLLLTSFNCVADPVLYCFAS 269
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
45-324 2.47e-16

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 78.47  E-value: 2.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVL--RHTASPSvtNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVClvKKLRTPS--NYLIVSLAVSDLLVaLLVMPLAIIYELSGYWPFGEILCDVWIS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTapvartvsaavwvasavvvlpvvvfsgvPRGMSTC---------- 191
Cdd:cd15329   79 FDVLLCTASILNLCAISVDRYLVITRPLTYAVKRT----------------------------PKRMALMiaivwllsal 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 -----HMQWPEPAAAWRA-------GFIIYTAALGFFGPLLVICLCYLlivvkvrsagrRVWAPSCQRRRRSERRVTRMv 259
Cdd:cd15329  131 isippLFGWKNKVNDPGVcqvsqdfGYQIYATFGAFYIPLIVMLVLYY-----------KIYRAAKSERKAIKTLGIIM- 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 260 vavvALFVLCWMPFYVLNIVN-VVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15329  199 ----GAFTLCWLPFFILALLRpFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-324 2.61e-16

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 78.75  E-value: 2.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPfLAAQNALSYWP--FGSLMCRLVMAVD 123
Cdd:cd15357    3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMP-LEVYEMWSNYPflFGPVGCYFKTALF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV-----PRG-----MSTCHM 193
Cdd:cd15357   82 ETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIklqyfPNGtlipdSATCTV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 QWPepaaAWRAGFIIYTAALGFFG-PLLVICLCYLLIVVKVR-SAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWM 271
Cdd:cd15357  162 VKP----LWIYNLIIQITSLLFYVlPMGVISVLYYLMGLKLRgDKSLEADEMNVNIQRPSRKSVTKMLFVLVLVFAICWA 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 272 PFYVLNIVNVVCPLPEEP--AFFGLYFLVVA-LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15357  238 PFHVDRLFFSFVVEWTEPlaNVFNLIHVVSGvFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
45-322 2.71e-16

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 78.83  E-value: 2.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIyVVLRHTASPSVTNVYILNLALADELFML------GLPFLAAQNALSYWPFGSLMCRL 118
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLsalplfLLPYIADYSSSFLSYFYAYFLPY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 VMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVAR-----TVSAAVWVASAVVVLPVVVFSGVPRGMSTCHM 193
Cdd:cd14978   80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARrviliIIIFSLLLNLPRFFEYEVVECENCNNNSYYYV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 QWPEPAAAWRAGFIIYT---AALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVT-----RMVVAVVAL 265
Cdd:cd14978  160 IPTLLRQNETYLLKYYFwlyAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQRRerrttIMLIAVVIV 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 266 FVLCWMPFYVLNIVNVVCPLPEEPAFFgLYFLVVA--LPYANSCANPILYGFLSYRFKQ 322
Cdd:cd14978  240 FLICNLPAGILNILEAIFGESFLSPIY-QLLGDISnlLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
53-324 3.71e-16

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 78.03  E-value: 3.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSI 131
Cdd:cd15327    9 IFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLsTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 132 FCLTVMSVDRYLAVVHPTRSarwrtaPVARTVSAAVWVASAVVVLPVVVFSGVPRGmstchmqWPEP--------AAAWR 203
Cdd:cd15327   89 LSLCVISVDRYVGVKHSLKY------PTIMTERKAGVILVLLWVSSMVISIGPLLG-------WKEPpppdesicSITEE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvtrMVVAVVALFVLCWMPFY-VLNIVNVV 282
Cdd:cd15327  156 PGYALFSSLFSFYLPLMVILVMYFRVYVVALKFSREKKAAK-------------TLAIVVGVFILCWFPFFfVLPLGSFF 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15327  223 PALKPSEMVFKVIFW---LGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
47-321 4.73e-16

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 77.87  E-value: 4.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqNALS--YWPFGSLMCRLVMAVDG 124
Cdd:cd14991    3 LPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRID-YYLRgeHWIFGEAWCRVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPT-RSARWRTAPVARTVSAA-VWVASAVVVLPVVVFSGVPRGMSTCH--MQWPEPAA 200
Cdd:cd14991   82 VNRSASIAFLTAVALDRYFKVVHPHhRVNRMSVKAAAGVAGLLwALVLLLTLPLLLSTLLTVNSNKSSCHsfSSYTKPSL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTaaLGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERrvtrmvvavvalfvlcwmpfyVLNIVN 280
Cdd:cd14991  162 SIRWHNALFL--LEFFLPLGLIVFCSVRIACNLRIRQSLGKQARVQRAIRLVF---------------------LVVIVF 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 281 VVCPLPEepAFFGLYFLV--------------------VALPYANSCANPILYGFLSYRFK 321
Cdd:cd14991  219 VLCFLPS--IIAGLLALVfknlgscrclnsvaqlfhisLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
45-324 6.03e-16

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 77.09  E-value: 6.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADlAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVfsGVPRGMSTCHMQWPEPAAAWR 203
Cdd:cd15060   81 ILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI--GWNDWPENFTETTPCTLTEEK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 aGFIIYTAALGFFGPLLVICLCYLLIVV---KVRSAGRRVwapscqrrrrserrvtrmvVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15060  159 -GYVIYSSSGSFFIPLLIMTIVYVKIFIatsKERRAARTL-------------------GIIMGVFVVCWLPFFLMYVIL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 281 VVCplPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15060  219 PFC--ETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-324 6.21e-16

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 77.89  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPfLAAQNALSYWPF--GSLMCRLVMAVD 123
Cdd:cd15358    3 VCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLvLLLGMP-LELYEMWSNYPFllGAGGCYFKTLLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAA--- 200
Cdd:cd15358   82 ETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPCRGPVPDSATcml 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 ---AWRAGFIIY-TAALGFFGPLLVICLCYLLI-------------VVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVV 263
Cdd:cd15358  162 vkpRWMYNLIIQiTTLLFFFLPMGTISVLYLLIglqlkrekmllvlEAKGSKAGDSYQHRRIQQEKRRRRQVTKMLFVLV 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 264 ALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA---LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15358  242 VVFGICWAPFHTDRLMWSFISQWTGELHLAFQYVHIIsgvFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-321 6.30e-16

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 77.53  E-value: 6.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15132    1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFdLYRLWKSRPWIFGEFLCRLYHYIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV--PRGMSTCHMQW---PEP 198
Cdd:cd15132   81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVeqDNNIHPDDFSReckHTP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRA--GFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15132  161 YAVSSGllGIMIWVTTTYFFLPMLCLSFLYGFIGRKLWKSKNDLRGPNAAARERSHRQTVRILAVVVLAFIICWLPFHIG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 277 NIVnVVCPLPEEPAFFGLYFLVVALP--YANSCANPILYGFLSYRFK 321
Cdd:cd15132  241 RIL-FANTEDYRTMMFSQYFNIVAMQlfYLSASINPILYNLISRKYR 286
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
45-324 7.53e-16

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 76.85  E-value: 7.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVL--RHTASPsvTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVcnRHLRIP--TNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSarwrtaPVARTVSAAVWVASAVVVLPVVVFSGVPRGmstchmqWPEPAA- 200
Cdd:cd15326   79 VDVLCCTASILSLCAISIDRYIGVRHSLQY------PTIVTRKRAILALLGVWVLSTVISIGPLLG-------WKEPAPp 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 -------AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvtrMVVAVVALFVLCWMPF 273
Cdd:cd15326  146 ddkvceiTEEPFYALFSSLGSFYIPLIVILVMYCRVYIVALKFSREKKAAK-------------TLGIVVGMFILCWLPF 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 274 Y-VLNIVNVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15326  213 FiALPLGSLFSHLKPPETLFKIIFW---LGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
49-324 1.30e-15

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 76.27  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML--GLP----FLAAQNAlsyWPFGSLMCRLVMAV 122
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVaaGLPneieSLLGPDS---WIYGYAGCLLITYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 D--GINqfTSIFCLTVMSVDRYLAVVHPTRSARWRTapVARTVSAAVWVASAVVVLPVVVFsgvprGMSTCHMQWPEPAA 200
Cdd:cd14995   82 QylGIN--ASSLSITAFTIERYIAICHPMKAQFICT--VSRAKKIICFVWIFTSLYCSPWL-----FLLDLSIKHYGDDI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGF--------IIYTAALGFFG--PLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCW 270
Cdd:cd14995  153 VVRCGYkvsrhyylPIYLADFVLFYviPLLLAIVLYGLIGRILFSSRKQV---------------TKMLAVVVVLFALLW 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 271 MPFYVLNIVNVVCPLPeepaFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14995  218 MPYRTLVVYNSFASPP----YLDLWFLLFCrtCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-324 1.90e-15

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 75.81  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPF-LAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15052    5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVgLLVMPLsILTELFGGVWPLPLVLCLLWVTLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-----SGVPRGmSTCHMQWPEpaaa 201
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLgiidtTNVLNN-GTCVLFNPN---- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 wragFIIYTAALGFFGPLLVICLCYLLiVVKVRSAGRRvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15052  160 ----FVIYGSIVAFFIPLLIMVVTYAL-TIRLLSNEQK---------------ASKVLGIVFAVFVICWCPFFITNILTG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 282 VCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15052  220 LCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
45-324 2.59e-15

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 75.29  E-value: 2.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15324    1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLpvvvfsgvPRGMSTCHMQWpEPAAAWR 203
Cdd:cd15324   81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISF--------PPLLMTKHDEW-ECLLNDE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLI--VVKVRSAgrrvwapscqrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15324  152 TWYILSSCTVSFFAPGLIMILVYCKIyrVAKMREK-----------------RFTFVLAVVMGVFVLCWFPFFFTYSLHA 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 282 V----CPLPEepAFFGLYFLVvalPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15324  215 VcrkrCGIPD--ALFNLFFWI---GYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
52-324 2.76e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 74.99  E-value: 2.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFM-LGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15210    8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCaFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSAR-----WRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRgMSTCHMQWPEPAAAWRag 205
Cdd:cd15210   88 LLTLVLITLNRYILIAHPSLYPRiytrrGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPK-VCSCSILRDKKGRSPK-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 fiIYTAALGFFGPLLVICLCYllivvkVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIVNvvcPL 285
Cdd:cd15210  165 --TFLFVFGFVLPCLVIIICY------ARREDRRL---------------TRMMLVIFLCFLVCYLPITLVNVFD---DE 218
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 522838250 286 PEEPAffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15210  219 VAPPV---LHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
46-317 3.11e-15

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 75.59  E-value: 3.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPfLAAQNALSY--WPFGSLMCRLVMAVD 123
Cdd:cd15365    2 LFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILP-LWIDYLWNGdnWTLSGFVCIFSAFLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV---PRGMSTCHMQWpePAA 200
Cdd:cd15365   81 YTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSfheSSSHTLCYDKF--PLE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQrrrrserrVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15365  159 DWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATEDQEKKK--------IFKLLLLITVTFVICFTPYHVVLLIR 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 281 VV---CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd15365  231 SIvepCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-313 4.94e-15

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 75.01  E-value: 4.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFlaaqnALSY-------WPFGSLMC 116
Cdd:cd15204    1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVaVFCLPF-----EMDYyvvrqrsWTHGDVLC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 117 RLVMAVDGINQFTSIFCLTVMSVDRYLAVVHP--TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQ 194
Cdd:cd15204   76 AVVNYLRTVSLYVSTNALLVIAIDRYLVIVHPlkPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WP-EPAAAWRAGFIIyTAALGFFGPLLVICLCYLLIVVKVrsAGRRVwaPSCQRRRRSERR-----VTRMVVAVVALFVL 268
Cdd:cd15204  156 WPvDQQAYYKAYYLF-LFVLEFVLPVLIMTLCYLRIVRKV--WFRRV--PGQQTEQIRRRLrrrrrKVRLLVVILTAFVL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 522838250 269 CWMPFYVLNIVNVVCP--LPEEPAFFGLYFLVVALPYANSCANPILY 313
Cdd:cd15204  231 CWAPYYGYAIVRDFFPtlLSKEKLNTTIFYIVEALAMSNSMINTVVY 277
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-324 6.24e-15

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 74.99  E-value: 6.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15125    2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP----TRSARWRTAPVARTvsaaVWVASAVVVLPVVVFSGVPRGMS------TCHMQ 194
Cdd:cd15125   82 TSVGVSVFTLTALSADRYKAIVNPmdiqTSSAVLRTCLKAIA----IWVVSVLLAVPEAVFSEVAHIMPddnttfTACIP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPE-----PAAAWRAGFIIYtaalgFFGPLLVICLCYLLIVVKVRSAGRRV---WAPSCQRRRRSERRVTRMVVAVVALF 266
Cdd:cd15125  158 YPQtdemhPKIHSVLIFLVY-----FLIPLAIISIYYYHIAKTLIKSAHNIpgeYSEHSKRQMETRKRLAKIVLVFVGLF 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 267 VLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15125  233 AFCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLVArvLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
50-235 7.71e-15

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 74.29  E-value: 7.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF--LAAQNAlsyWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15165    6 VYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFkmHSSKKQ---WPLGRTLCSFLESLYFVNM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEpaAAWRAGFI 207
Cdd:cd15165   83 YGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPTNNTRCFHGFSN--KTWSKKVI 160
                        170       180
                 ....*....|....*....|....*...
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIVVKVRS 235
Cdd:cd15165  161 VVVEEFGFLIPMAVMVFCSVQIIRTLLD 188
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
49-326 7.98e-15

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 74.51  E-value: 7.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLL---GNSLVIYVVL--RHTASPsvTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVM 120
Cdd:cd15055    2 LLYIVLSSISLLtvlGNLLVIISIShfKQLHTP--TNLLLLSLAVAD--FLVGLlvmPFSMIRSIETCWYFGDTFCKLHS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAA 200
Cdd:cd15055   78 SLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNSCYGECVV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVV---------AVVALFVLCWM 271
Cdd:cd15055  158 VVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIRSHTAQVSLEGSSKKVSKKSerkaaktlgIVVGVFLLCWL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 272 PFYVLNIVNVVCPLPEEPAFFGLYFLvvalpYANSCANPILYGFlsyrFKQGFRR 326
Cdd:cd15055  238 PYYIVSLVDPYISTPSSVFDVLIWLG-----YFNSCLNPLIYAL----FYPWFRK 283
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
49-330 8.26e-15

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 74.94  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVtNVYILNLALADELFMLGLPFLAaQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVIAVLIVKRFMFVV-DVYLFNIAMSDLMLVFSFPFII-HNDLNEWIFGEFMCKLVLGVYFVGFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTR-SARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFI 207
Cdd:PHA02834 111 SNMFFVTLISIDRYILVVNATKiKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFN 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMvvavvalfvlcWMPF---------YVLNI 278
Cdd:PHA02834 191 FEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVF-----------WVPFnivlfinslQSVGL 259
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 279 VNVVCPLPEEPaffgLYFLVVA--LPYANSCANPILYGFLSYRFKQGFRRVLLR 330
Cdd:PHA02834 260 IDIGCYHFKKI----VYSIDIAelISFVHCCVNPIIYAFVGKNFKKVFKNMFCR 309
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-326 9.72e-15

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 74.04  E-value: 9.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLgLPFLAAQNALSY--WPFGSLMCRLVMAVDGINQ 127
Cdd:cd15209    6 VLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAI-YPYPLILHAIFHngWTLGQLHCQASGFIMGLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARW---RTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAaawra 204
Cdd:cd15209   85 IGSIFNITAIAINRYCYICHSLQYDRLyslRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTV----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 gFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP 284
Cdd:cd15209  160 -YTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGLAVAINP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 285 LPEEPAF-FGLYFLVVALPYANSCANPILYGFLSyrfkQGFRR 326
Cdd:cd15209  239 KEMAPKIpEWLFVASYFMAYFNSCLNAIIYGLLN----QNFRK 277
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
49-328 1.05e-14

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 74.13  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLL----GNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15318    1 LVIYLACAIGMLiivlGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLgLTVLPFSTIRSVESCWYFGDSFCRLHTCLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMStchmQWPEPAAAWR 203
Cdd:cd15318   81 TLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLA----ELLTSVPCVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALG------FFGPLLVICLCYLLIVVKVRSAGRRV--WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15318  157 SCQLLYNKLWGwlnfpvFFIPCLIMIGLYVKIFIVAKRQARAIasLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTI 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 276 LNIVNVVCPLPEEPAFFGlyfLVVALPYANSCANPILYGFlsyrFKQGFRRVL 328
Cdd:cd15318  237 DTMVDSLLNFITPPLLFD---IIIWFAYFNSACNPLIYVF----SYPWFRKAL 282
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
49-329 1.26e-14

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 73.83  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVaVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAP-VARTVSAAVWVASAVVVLPVVVFSGVPRGM---STChmQWPEPAaawr 203
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRrVTLKIVFVWLLSIAMSLPLSLMYSKDHASVlvnGTC--QIPDPV---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 agFIIYTAALGFFGPLLVICLCYLLIV----VKVRSAGRRVwapscqrrrRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15307  159 --YKLVGSIVCFYIPLGVMLLTYCLTVrllaRQRSRHGRII---------RLEQKATKVLGVVFFTFVILWSPFFVLNLL 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLL 329
Cdd:cd15307  228 PTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
50-156 1.74e-14

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 73.26  E-value: 1.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFlAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15923    6 IYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPF-KMHSYRRESAGLQKLCNFVLSLYYINMYV 84
                         90       100
                 ....*....|....*....|....*..
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSARWRT 156
Cdd:cd15923   85 SIFTITAISVDRYVAIRYPLRARELRS 111
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
50-321 2.47e-14

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 73.11  E-value: 2.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRH-TASPSVTNVYILNLALADELFMLGL-PFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15382    6 VYSVLFLIAAVGNLTVLLILLRNrRRKRSRVNILLMHLAIADLLVTFIMmPLEIGWAATVAWLAGDFLCRLMLFFRAFGL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRtapvartvsaavwVASAVVVLPVVVFSGV---PRGMSTCHMQWPE------- 197
Cdd:cd15382   86 YLSSFVLVCISLDRYFAILKPLRLSDAR-------------RRGRIMLAVAWVISFLcsiPQSFIFHVESHPCvtwfsqc 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 ------PAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRR----VWAPSCQRRRRSERRVTR---------M 258
Cdd:cd15382  153 vtfnffPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEkkedVSEKSSSVRLRRSSVGLLerarsrtlkM 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 259 VVAVVALFVLCWMPFYVLNIVNV--------VCPLPEEpaffGLYFLVValpyANSCANPILYGFLSYRFK 321
Cdd:cd15382  233 TIVIVLVFIICWTPYFIMSLWYWfdresaskVDPRIQK----GLFLFAV----SNSCMNPIVYGYFSIDLR 295
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
45-315 2.64e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 72.91  E-value: 2.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLP-----FLAAQNalsyWPFGSLMCRLV 119
Cdd:cd15366    1 LFPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPlwidyFLHRDN----WIHGPESCKLF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 120 MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR---GMSTCHMQWp 196
Cdd:cd15366   77 GFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRdryNHTFCFEKY- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 ePAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15366  156 -PMEDWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRG--------NVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 277 NIVNVV------CPLPEEPAFFGLYFLVVALPYANSCANPILYGF 315
Cdd:cd15366  227 LLSRSVvylgkpCDCGFEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
45-324 2.70e-14

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 72.36  E-value: 2.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15064    1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVaVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPR--GMSTCHMQwpepaaa 201
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDseDPSECLIS------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFIIYTAALGFFGPLLVICLCYLLIVV---KVRSAGRrvwapscqrrrrserrvtrMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15064  154 QDIGYTIFSTFGAFYIPLLLMLILYWKIYRaaaRERKAAK-------------------TLGIILGAFIVCWLPFFLVAL 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 279 VNVVCPLPEEPAFFGLYFLvvALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15064  215 IVPLCSHCWIPLALKSFFL--WLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
45-313 5.48e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 71.63  E-value: 5.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15213    1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLsLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAwR 203
Cdd:cd15213   81 WFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYTESPAD-R 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALgFFGPLLVICLCYLLIVVKVRSAGRRVWApscqrrrrserrvtrMVVAVVALFVLCWMPFYVLNIVNVVC 283
Cdd:cd15213  160 IYVVLLLVAV-FFIPFLIMLYSYFCILNTVRSFKTRAFT---------------TILILFIGFSVCWLPYTVYSLLSVFS 223
                        250       260       270
                 ....*....|....*....|....*....|
gi 522838250 284 plPEEPAFFGLYFLVVALPYANSCANPILY 313
Cdd:cd15213  224 --RYSSSFYVISTCLLWLSYLKSAFNPVIY 251
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
45-324 6.05e-14

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 71.75  E-value: 6.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVaVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVL-----------PVVVFSGVPRGMSTCH 192
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLpimqgwnhigiEDLIAFNCASGSTSCV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MQWPEPaaawragFIIYTAALGFFGPLLVICLCYLLIVVKVRS----------AGRRVWAPSCQRRRRSERRVTRMVVAV 262
Cdd:cd15056  161 FMVNKP-------FAIICSTVAFYIPALLMVLAYYRIYVAAREqahqirslqrAGSSNHEADQHRNSRMRTETKAAKTLG 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 263 VAL--FVLCWMPFYVLNIVNVVC--PLPEEPAFFGLYflvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15056  234 IIMgcFCVCWAPFFVTNIVDPFIgyRVPYLLWTAFLW-----LGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
50-324 6.24e-14

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 72.02  E-value: 6.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTAS-PSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15383    6 VTFVLFVLSACSNLAVLWSATRNRRRkLSHVRILILHLAAADLLVtFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWR-----TAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCH----MQWPEP 198
Cdd:cd15383   86 YSSAFVTVVISLDRHAAILNPLAIGSARrrnriMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQCATHgsfpAHWQET 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AaawragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVT---------RMVVAVVALFVLC 269
Cdd:cd15383  166 L------YNMFTFFCLFLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEVALRSSSDNipkarmrtlKMTIVIVSSFIVC 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 270 WMPFYVLNIVNVVCP------LPEEPA----FFGLYflvvalpyaNSCANPILYGFLSYRFKQGF 324
Cdd:cd15383  240 WTPYYLLGLWYWFSPemleqtVPESLShilfLFGLL---------NACLDPLIYGLFTISFRRGL 295
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
45-324 7.97e-14

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 71.78  E-value: 7.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15981    1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSAR------------WRTA-----PVARTVSAAVWVASAVVVLPVVVFSgvpr 186
Cdd:cd15981   81 GMSVSASVFTLVAIAVERFRCIVHPFRQKLtlrkaivtiviiWVLAliimcPSAVTLTVTREEHHFMVDDYNNSYP---- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 187 gMSTCHMQWPEPAAAwragfIIYTAALG---FFGPLLVICLCYLLIVVK-----VRSAGRRVWAPSCQRRRRSERRVTRM 258
Cdd:cd15981  157 -LYSCWEAWPDTEMR-----KIYTTVLFshiYLAPLTLIVIMYARIAFKlfkssAPIRGSQGEEEEGRRVSKRKIKVINM 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 259 VVAVVALFVLCWMPFYVLNIVNVVCPLPE-EPAFFGLYFLVVA--LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15981  231 LIIVALFFTLSWLPLWTLMLLTDYGHLSEdQLNLVTVYVFPFAhwLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
46-314 8.85e-14

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 71.27  E-value: 8.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTN-VYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVD 123
Cdd:cd15376    2 FLWPILGVEFLVAVLGNGLALWLFVTRERRPWHTGvVFSFNLAVSDLLYALSLPLLAAYYYPpKNWRFGEAACKLERFLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTrSARWRTAPV-ARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAW 202
Cdd:cd15376   82 TCNLYGSIFFITCISLNRYLGIVHPF-FTRSHVRPKhAKLVSLAVWLLVAALSAPVLSFSHLEVERHNKTECLGTAVDSR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFG---PLLVICLCYLLIVVKVRSAGRRVWAPSCQrrrrserrVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15376  161 LPTYLPYSLFLAVVGcglPFLLTLASYLAIVWAVLRSPGITTLEKRK--------VAALVAVVVALYAVSFVPYHILRNL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 280 NVV----CPLPE-EPAFFGLYFLVVALPYANSCANPILYG 314
Cdd:cd15376  233 NLYrrlqWLKAAaSLRIYFAYQVTKGLVTLNMCIHPLLYM 272
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
49-313 9.26e-14

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 71.48  E-value: 9.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGllGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15959    7 LSLAILVIVG--GNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTgHWPLGTTVCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS----GVPRGMSTCHMQWPEPAAAWR 203
Cdd:cd15959   85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQwwrdGADEEAQRCYDNPRCCDFVTN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVV------------KVR--------SAGRRV-WAPSCQRRRRSERRVTRMVVAV 262
Cdd:cd15959  165 MPYAIVSSTVSFYVPLLVMIFVYVRVFVvatrqvrlirkdKVRfppeesppAESRPAcGRRPSRLLAIKEHKALKTLGII 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 263 VALFVLCWMPFYVLNIVNVVCP-LPEEPAFFGLYFlvvaLPYANSCANPILY 313
Cdd:cd15959  245 MGTFTLCWLPFFVANIIKVFCRsLVPDPAFLFLNW----LGYANSAFNPIIY 292
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
43-321 1.05e-13

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 71.07  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  43 SGVLIPLVYLVVcvVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPfLAAQNALSY--WPFGSLMCRLVM 120
Cdd:cd15131    1 TGITVTCVLLFV--VGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMP-LDLYRLWQYrpWNFGDLLCKLFQ 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAA 200
Cdd:cd15131   78 FVSESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 ---AWRAGFI---IYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFY 274
Cdd:cd15131  158 teyAVRSGLLtimVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFH 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 275 VLNIVNVVCPLPEEP--AFFGLYFLVVA--LPYANSCANPILYGFLSYRFK 321
Cdd:cd15131  238 VGRYLFSKSFEAGSLeiALISQYCNLVSfvLFYLSAAINPILYNIMSKKYR 288
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
49-324 1.26e-13

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 70.45  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVgLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15309    6 LLTLLIFVI-VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVaTLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPepaaawraGFI 207
Cdd:cd15309   85 TASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQNECIIANP--------AFV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPE 287
Cdd:cd15309  157 VYSSIVSFYVPFIVTLLVYVQIYIVLQKEKK----------------ATQMLAIVLGVFIICWLPFFITHILNMHCDCNI 220
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 522838250 288 EPAffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15309  221 PPA---LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
46-324 1.51e-13

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 70.51  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDG 124
Cdd:cd15922    2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLgSHWPFGQFLCQLKVFLLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF------SGVPRGMSTCHMQWPEP 198
Cdd:cd15922   82 THMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVlktsviDGKTKCLSIHQSELSLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRagfiIYTAALGFFGPLLVICLCYLLI---VVKVRSAGRRVWApscqrrrrSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15922  162 YFVWN----FVLLILGFLLPFGVSLTCYALLgasIAKMNSNNARGRA--------MKAKSLQMIGISLVIFIICFVPLHV 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 276 LNIVNVV--------CPLPE--EPAffglYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15922  230 TRTVGVVvklfypesCTLLHkvEVA----YYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
45-324 1.72e-13

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 70.15  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15050    1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF----SGVPRGMSTCHMQWPEPA 199
Cdd:cd15050   81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGWhhfaRGGERVVLEDKCETDFHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWragFIIYTAALGFFGPLLVICLCYLLIVVKV---RSAGRRVwapscqrrrrserrvtrmvVAVVALFVLCWMPFYVL 276
Cdd:cd15050  161 VTW---FKVLTAILNFYIPSLLMLWFYAKIFKAVnreRKAAKQL-------------------GFIMAAFILCWIPYFIL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 277 NIVNVVCPLPEEPaffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15050  219 FMVIAFCKNCCNE---NLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
52-324 2.11e-13

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 69.98  E-value: 2.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPF-LAAQNALSYWPFGSLMCRLVMAVdginqFT 129
Cdd:cd14968    8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPLaILISLGLPTNFHGCLFMACLVLV-----LT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 130 --SIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVV--------VLPVVVFSGVPRGMSTCHMQwpepa 199
Cdd:cd14968   83 qsSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgltpmfgwNNGAPLESGCGEGGIQCLFE----- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYtaaLGFFG----PLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERR----VTRMVVAVVALFVLCWM 271
Cdd:cd14968  158 EVIPMDYMVY---FNFFAcvlvPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRSTLQkevkAAKSLAIILFLFALCWL 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 272 PFYVLNIVNVVCPLPEEPAFFgLYFLVVaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd14968  235 PLHIINCITLFCPECKVPKIL-TYIAIL-LSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
51-158 3.24e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 69.72  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLR-HTASPSVtNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15148    7 YSLIFLFGLVGNLLALWVFLFiHRKRNSV-RIFLINVAIADLLLIICLPFRILYHVNnNQWTLGPLLCKVVGNLFYMNMY 85
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSARWRTAP 158
Cdd:cd15148   86 ISIILLGFISLDRYLKINRSSRRQKFLTRK 115
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-150 3.38e-13

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 69.36  E-value: 3.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15378    3 LPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHAN 82
                         90       100
                 ....*....|....*....|....
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTR 150
Cdd:cd15378   83 LYSSILFLTFISIDRYLLIKYPFR 106
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
56-326 3.71e-13

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 69.20  E-value: 3.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCL 134
Cdd:cd15323   12 VFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 135 TVMSVDRYLAVVHPTRSARWRTA-PVARTVSAAVWVASAVVVLPVVVFSGVPRGMStchmqWPEPAAAWRAGFIIYTAAL 213
Cdd:cd15323   92 CAISLDRYWSVTQAVEYNLKRTPrRVKAIIVTVWLISAVISFPPLISMYRDPEGDV-----YPQCKLNDETWYILSSCIG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 214 GFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFY----VLNIVNVVCPLPEep 289
Cdd:cd15323  167 SFFAPCLIMILVYIRIYRVAKAREKRF---------------TFVLAVVMGVFVVCWFPFFfsysLYGICREACEVPE-- 229
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 522838250 290 AFFGLYFLVvalPYANSCANPILYGFlsyrFKQGFRR 326
Cdd:cd15323  230 PLFKFFFWI---GYCNSSLNPVIYTI----FNQDFRR 259
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
53-324 4.18e-13

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 68.82  E-value: 4.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLL------GNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15322    3 LIILVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKVWCEIYLALDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVV---LPVVVFSGVPRGMSTCHMQwpepAAAW 202
Cdd:cd15322   83 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISfppLITIEKKSGQPEGPICKIN----DEKW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 ragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15322  159 ---YIISSCIGSFFAPCLIMVLVYIRIYQIAKNREKRF---------------TFVLAVVIGVFVICWFPFFFTYTLTAV 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 283 CPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15322  221 CDCSVPETLFKFFFW---FGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
45-324 5.46e-13

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 68.50  E-value: 5.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVI--YVVLRHTASPSvtNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLV 119
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVIlsFRVNRQLRTVN--NYFLLSLACAD--LIIGLvsmNLYTVYLVMGYWPLGPLLCDLW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 120 MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQ 194
Cdd:cd15049   77 LALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYFVGERTvpdgqCYIQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPEPAAawragFIIYTAALGFFGPLLVICLCYLLI---VVKVRSAGRrvwapscqrrrrserrvtrMVVAVVALFVLCWM 271
Cdd:cd15049  157 FLDDPA-----ITFGTAIAAFYLPVLVMTILYWRIyreTARERKAAR-------------------TLSAILLAFIITWT 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 272 PFYVLNIVNVVCP--LPEEPAFFGlYFLVvalpYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15049  213 PYNILVLVSTFCAkcIPDTLWSFG-YWLC----YINSTINPFCYALCNKTFRKTF 262
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
46-148 7.72e-13

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 68.79  E-value: 7.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15123    2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQL 81
                         90       100
                 ....*....|....*....|....
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15123   82 TSVGVSVFTLTVLSADRYRAIVKP 105
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
45-160 8.33e-13

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 68.63  E-value: 8.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATAD--FLLGLcvmPFSMIRTVETCWYFGDLFCKFHTG 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVA 160
Cdd:cd15317   79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVA 117
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
50-324 8.64e-13

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 68.40  E-value: 8.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFMLGLPFLAAQNALSY--WPFGSLMCRLVMAVDGINQ 127
Cdd:cd15401    6 VLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVAD-LVVAVYPYPLILLAIFHngWTLGNIHCQISGFLMGLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTR-----SARWRTAPVARTVSAAVWVASAVVVLPVVVFSgvPRGMSTCHMQwpepaaAW 202
Cdd:cd15401   85 IGSVFNITAIAINRYCYICHSLRydklyNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYD--PRIYSCTFAQ------TV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15401  157 SSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVRQDSKQKLKANDIRNFLTMFVVFVLFAVCWGPLNFIGLAVAI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 283 CPL---PEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15401  237 NPLkvaPKIPEW--LFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
46-322 1.03e-12

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 68.07  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRlvmaVDG 124
Cdd:cd15074    2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGIsVFGYPLAIISAFAHRWLFGDIGCV----FYG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFT----SIFCLTVMSVDRYLAVVHPtRSARWRTAPvaRTVSAAVWVASAVVVLPVVVFSGV------PRGMSTCHMQ 194
Cdd:cd15074   78 FCGFLfgccSINTLTAISIYRYLKICHP-PYGPKLSRR--HVCIVIVAIWLYALFWAVAPLVGWgsygpePFGTSCSIDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPS--CQRRRRSERRVTRMVVAVVALFVLCWMP 272
Cdd:cd15074  155 TGASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDsrSKRQHKIERKVTKVAVLICAGFLIAWTP 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 273 FYVLNIVNVVCPLPEEPAFFglyFLVVALPYANSCA-NPILYGFLSYRFKQ 322
Cdd:cd15074  235 YAVVSMWSAFGSPDSVPILA---SILPALFAKSSCMyNPIIYLLFSSKFRQ 282
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-324 1.04e-12

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 67.95  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL---FMLGLPFLAAQNalSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd16004    7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSmaaFNTAFNFVYASH--NDWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSArwRTAPVARTVSAAVWVASAVVVLPVVVFSGVP--RGMSTCHMQWPEPAAA-WRA 204
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFKPR--LSAGSTKVVIAGIWLVALALAFPQCFYSTVTmdQGRTKCIVAWPGDSGGkHQL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIYTAALGFFGPLLVICLCYLLIvvkvrsaGRRVWA---PSCQRRRRSERRVTR------MVVAVVALFVLCWMPFYV 275
Cdd:cd16004  163 TYHLAVIVLIYLLPLAVMFVTYSII-------GITLWRsavPGHQAHGAYHRQLQAkkkfvkTMVVVVVTFAICWLPYHL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 276 LNIV-----NVVCPLPEEPAFFGLYFLVValpyANSCANPILYGFLSYRFKQGF 324
Cdd:cd16004  236 YFILgsfneDIYCQKYIQQVYLAIFWLAM----SSTMYNPIIYCCLNQRFRSGF 285
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
59-324 1.54e-12

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 68.11  E-value: 1.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  59 LLGNSLVIYVVL--RHTASpSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLmCRLVMAVDGINQFTSIFCLT 135
Cdd:cd15320   16 LLGNTLVCAAVIrfRHLRS-KVTNFFVISLAVSDLLVaVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 136 VMSVDRYLAVVHPTRSARWRTAPVArtvsaavWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPA---------------A 200
Cdd:cd15320   94 VISVDRYWAISSPFRYERKMTPKVA-------FIMISVAWTLSVLISFIPVQLNWHKAKPTSFLdlnaslrdltmdncdS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRR--------VWAPSCQRRRRSERRVTRMVVAVVALFVL---- 268
Cdd:cd15320  167 SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRisaleraaVHAKNCQNSTGNRGSGDCQQPESSFKMSFkret 246
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 269 ---------------CWMPFYVLNIVNVVCPLPEEPAFF---GLYFLVVALPYANSCANPILYGFlSYRFKQGF 324
Cdd:cd15320  247 kvlktlsvimgvfvcCWLPFFILNCMVPFCKPTSTEPFCissTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
57-321 1.73e-12

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 67.16  E-value: 1.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  57 VGLLGNSLVIYVVLRHTASPSVTNVYILNLALADeLFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTV 136
Cdd:cd14989   13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVAD-LILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTW 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 137 MSVDRYLAVVHPTRSARWRT-------------APVARTVSAAVWVASAVVVLPVVVFSGVPrgmstcHMQWPEpaaawr 203
Cdd:cd14989   92 MSFDRYIALAKVMKSSPLRTmqharlscgliwmASISATLLPFTAVQAQHTGEVHFCFADVR------EIQWLE------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 agfiiytAALGFFGPLLVICLCYLLIV-VKVRSAGRRVWAPSCQrrrrserRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd14989  160 -------VTLGFIIPFSIIGLCYSLIVrVLVRAQKHRRLRPRRQ-------KALRMILVVVLVFFICWLPENVFISIQLL 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 283 C----PLPEEPAFFGLYF-----LVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd14989  226 QgtqePSESYDESFRHNHpltghIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
45-322 2.99e-12

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 66.74  E-value: 2.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15370    1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLkIAYHINGNNWIYGEALCKVLIGFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHP---TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEP-A 199
Cdd:cd15370   81 YGNMYCSILFMTCLSVQRYWVIVNPmshSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQlL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15370  161 VGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKS------SINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 280 NVVCPLPE-EPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15370  235 HYFLLKNQgQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRD 278
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
46-156 5.52e-12

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 65.75  E-value: 5.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYL-VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPfgSLMCRLVMAVDG 124
Cdd:cd15164    1 LIQLIIYiPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWPD--DELCLVLQSIYF 78
                         90       100       110
                 ....*....|....*....|....*....|..
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRT 156
Cdd:cd15164   79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRS 110
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
45-324 1.04e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 64.76  E-value: 1.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVI--YVVLRHTASPSvtNVYILNLALADELF-MLGLPFLAAQNAL-SYWPFGSLMCRLVM 120
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLlsFYVDRNIRQPS--NYFIASLAVSDLLIgLESMPFYTVYVLNgDYWPLGWVLCDLWL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTApvARTVSAAVWVASAVVVLPVVV------FSGVPRGMS--TCH 192
Cdd:cd15302   79 SVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTP--RKVLLIIAITWIIPALLFFISifgwqyFTGQGRSLPegECY 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MQWPEPAAAWRAGFIIYtaalgFFGPLLVICLCYLLIvvkVRSAGRRVWApscqrrrrserrvTRMVVAVVALFVLCWMP 272
Cdd:cd15302  157 VQFMTDPYFNMGMYIGY-----YWTTLIVMLILYAGI---YRAANRARKA-------------LRTITFILGAFVICWTP 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 273 FYVLNIVNVVCPLPeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15302  216 YHILATIYGFCEAP-PCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
49-148 1.15e-11

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 64.70  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15066    4 FAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALcAMTFNASVEITGRWMFGYFMCDVWNSLDVYFS 83
                         90       100
                 ....*....|....*....|.
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQP 104
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
55-159 1.22e-11

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 64.81  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  55 CVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQnALSY--WPFGSLMCRLVMAVDGINQFTSIF 132
Cdd:cd15199   11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYF-YLNGnrWSLGGGTCKALLFMLSLSRGVSIA 89
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 133 CLTVMSVDRYLAVVHP---TRSARWRTAPV 159
Cdd:cd15199   90 FLTAVALDRYFRVVHPrgkKNSLSLQAAPY 119
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
46-152 1.42e-11

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 64.77  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNV--YILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15147    2 LFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFwIVYYHNEGNWILPKFLCNVAGCL 81
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSA 152
Cdd:cd15147   82 FFINTYCSVAFLGVISYNRYQAVTRPIKTA 111
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
42-315 1.44e-11

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 64.98  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  42 VSGVLIPLVYLVVcvvgLLGNSLVIYVVLR--HTASpSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLmCRL 118
Cdd:cd15319    2 VTGCLLSLLILWT----LLGNILVCAAVVRfrHLRS-KVTNIFIVSLAVSDLFVaLLVMPWKAVAEVAGYWPFGAF-CDV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 VMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaavWVASAVVVLPVVVFSGVP------RGMSTCH 192
Cdd:cd15319   76 WVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVA-------LVMISVAWTLSVLISFIPvqlnwhKDSGDDW 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 193 MQWPEPA----------AAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV--------WAPSCQRRRRSERR 254
Cdd:cd15319  149 VGLHNSSisrqveencdSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRIssleraaeHAQSCRSNRIDCHH 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 255 VTRMVVAVVALFVL-------------CWMPFYVLNIVNVVCPLPEEPAFFGL-------YFLVVALPYANSCANPILYG 314
Cdd:cd15319  229 HTSLRTSIKKETKVlktlsvimgvfvcCWLPFFILNCMVPFCDRPPADPDAGLpcvsettFDVFVWFGWANSSLNPIIYA 308

                 .
gi 522838250 315 F 315
Cdd:cd15319  309 F 309
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
49-324 1.67e-11

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 64.18  E-value: 1.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGIN 126
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLgFLVMPVSMLTILYGYrWPLPSKLCAVWIYLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFsgvprGMST-CHMQWPEPAAAWRAG 205
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF-----GLQDdSKVFKEGSCLLADEN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVvkvrsagrrvwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVC-P 284
Cdd:cd15304  160 FVLIGSFVAFFIPLTIMVITYFLTI------------KSLQQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICkE 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 285 LPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15304  228 SCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
41-324 1.71e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 64.49  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  41 AVSGVLIplvylVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLgLPFLAAQNALSY--WPFGSLMCRL 118
Cdd:cd15400    2 ALSSVLI-----FTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVAL-YPYPLVLVAIFHngWALGEMHCKV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 VMAVDGINQFTSIFCLTVMSVDRYLAVVHP---TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQw 195
Cdd:cd15400   76 SGFVMGLSVIGSIFNITGIAINRYCYICHSfayDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQ- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 pepaaAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15400  155 -----TASSSYTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIFAICWAPLNL 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 276 LNIVNVVCP---LPEEPAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15400  230 IGLAVAINPqemAPKVPE--WLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
46-324 2.46e-11

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 63.70  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGllGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLP-FLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15308    4 LVGGVLLILAIIA--GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPlYVYSEFQGGVWTLSPVLCDALMTMD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARwRTAPVARTVSAAVWVASAVVVLPVVVF--SGVP-RGMSTCHMQwpepaa 200
Cdd:cd15308   82 VMLCTASIFNLCAISVDRFIAVSVPLNYNR-RQGSVRQLLLISATWILSFAVASPVIFglNNVPnRDPAVCKLE------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 awRAGFIIYTAALGFFGPLLVICLCYLLIVvkvRSAGRRVWApscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15308  155 --DNNYVVYSSVCSFFIPCPVMLVLYCAMF---RGLGRERKA-------------MRVLPVVVGAFLFCWTPFFVVHITR 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 281 VVCPLPEEPAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15308  217 ALCESCSIPP--QLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
45-142 2.56e-11

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 64.05  E-value: 2.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL-SYWPFGSLMCRLVM--- 120
Cdd:cd14996    1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKgFYWKYQSTQCRIANffg 80
                         90       100
                 ....*....|....*....|...
gi 522838250 121 -AVDGINQFTSIFCLTVMSVDRY 142
Cdd:cd14996   81 tLVIHVSMCVSILILSWIAISRY 103
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
49-317 2.71e-11

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 64.02  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL--FMLGLPFLaAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15388    5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVvaFFQVLPQL-VWDITDRFRGPDVLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS--GVPRGMSTCHMQWPEPaaaW-R 203
Cdd:cd15388   84 MFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILSLPQVFIFSkvEVAPGVYECWACFIEP---WgL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLI---------------VVKVRSAGRRVWAPS-CQRRRRSERRVTRMVVAVVALFV 267
Cdd:cd15388  161 KAYVTWITLVVFVLPTLIITVCQVLIfkeihiniylksqiiVAVVKKKQLLSSRASsVAEVSKAMIKTVKMTLVIVLVYV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 268 LCWMPFYVLNIVNVVCP-LPEEPAFFGLYFLVVALpyaNSCANPILYGFLS 317
Cdd:cd15388  241 LCWAPFFLVQLWSVWDPkAPTEGATFTILMLLASL---NSCTNPWIYMAFS 288
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
44-313 2.94e-11

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 63.77  E-value: 2.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  44 GVLIPLVYLVVcvvgLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15958    4 SLLMALIVLLI----VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRGRWLYGSFFCELWTSV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAA-- 200
Cdd:cd15958   80 DVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCcd 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 201 -AWRAGFIIYTAALGFFGPLLVICLCYLLI-------VVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALF------ 266
Cdd:cd15958  160 fVTNRAYAIASSIISFYIPLLIMIFVYLRVyreakkqIKKIDKCEGRFHNTLTGLGRKCKRRPSRILALREQKAlktlgi 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 267 -----VLCWMPFYVLNIVNVVCP--LPEEpaffgLYFLVVALPYANSCANPILY 313
Cdd:cd15958  240 imgvfTLCWLPFFLVNVVNVFNRelVPDW-----LFVFFNWLGYANSAFNPIIY 288
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
45-162 3.87e-11

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 63.24  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLrHTASPSVTNVYILNLALADELFMLGLPFLAAQNA-LSYWPFGSLMCRLVMAVD 123
Cdd:cd15924    1 QLFPVLYTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAgLGPWQLRTFVCRVTSVLF 79
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVART 162
Cdd:cd15924   80 YFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKI 118
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
45-324 4.15e-11

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 63.06  E-value: 4.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF-------SGVPRGmsTCHMQWP 196
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFwqfivggRTVPEG--ECYIQFF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAAwragfIIYTAALGFFGPLLVICLCYLLIvVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15297  159 SNAAV-----TFGTAIAAFYLPVIIMTVLYWQI-SRASSREKKV---------------TRTILAILLAFIITWTPYNVM 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 277 NIVNVVCP--LPEEPAFFGLYflvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15297  218 VLINTFCAscIPNTVWTIGYW-----LCYINSTINPACYALCNATFKKTF 262
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
51-160 4.35e-11

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 63.30  E-value: 4.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15166    7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIA 86
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARWRTAPVA 160
Cdd:cd15166   87 LWLLAFISADRYMAIVQPKHAKELKNTPKA 116
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
49-326 5.82e-11

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 62.93  E-value: 5.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNAL--SYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILfeAMWPLPLVLCPIWLFLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSAR---WRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMS-TCHMQwPEPAAAw 202
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQynsRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNiTCVLT-KERFGD- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 ragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMvvavvalfvlcWMPFYVLNIVNVV 282
Cdd:cd15306  163 ---FILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLM-----------WCPFFITNITSVL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 283 CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRR 326
Cdd:cd15306  229 CDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
52-324 5.89e-11

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 62.69  E-value: 5.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCvvGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15330   10 LILC--AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVsVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMStchmqwpEPAA---AWRAGFI 207
Cdd:cd15330   88 ILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRS-------DPDActiSKDPGYT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYTAALGFFGPLLVICLCYLLIvvkVRSAGRRvwapscqrrrrseRRVTRMVVAVVALFVLCWMPFYvlnIVNVVCPLPE 287
Cdd:cd15330  161 IYSTFGAFYIPLILMLVLYGRI---FKAAARE-------------RKTVKTLGIIMGTFILCWLPFF---IVALVLPFCE 221
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 522838250 288 EPAFFG--LYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15330  222 STCHMPelLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
44-313 7.13e-11

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 62.96  E-value: 7.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  44 GVLIPLVYLVVcvvgLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGL-PFLAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15957    4 GIVMSLIVLAI----VFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVvPFGAAHILLKTWTFGNFWCEFWTSI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVvlpvvvfSGVPRGMSTCHMQWPEPAAAW 202
Cdd:cd15957   80 DVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLT-------SFLPIQMHWYRATHQEAINCY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 R----------AGFIIYTAALGFFGPLLVICLCYLLI-------VVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVA- 264
Cdd:cd15957  153 AeetccdfftnQAYAIASSIVSFYVPLVIMVFVYSRVfqeakrqLQKIDKSEGRFHNQNIDQNGSGGGGGNRRRSKFCLk 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 265 -------------LFVLCWMPFYVLNIVNVVCP--LPEEPaffglYFLVVALPYANSCANPILY 313
Cdd:cd15957  233 ehkalktlgiimgTFTLCWLPFFIVNIVHVIQDnlIRKEV-----YILLNWIGYVNSGFNPLIY 291
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
45-153 7.41e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 62.50  E-value: 7.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLrHTASPSVTNVYILNLALADELFMLGLPFLAAQNA-LSYWPFGSLMCRLVMAVD 123
Cdd:cd15969    1 IVFPVLYLIIFIGSILLNGLAVWIFF-HIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSgLGPWNFNFFLCRYTSVLF 79
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSAR 153
Cdd:cd15969   80 YASMYTSIVFLGLISLDRYLKVVKPFGDSR 109
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
45-324 1.17e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 61.52  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd17790    1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQW-PE 197
Cdd:cd17790   81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTvlagqCYIQFlSQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRagfiiyTAALGFFGPLLVICLCYLLI---VVKVRSAGRRVWApscqrrrrserrvtrmvvaVVALFVLCWMPFY 274
Cdd:cd17790  161 PIITFG------TAIAAFYLPVTIMIILYWRIyreTIKEKKAARTLSA-------------------ILLAFILTWTPYN 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 275 VLNIVNVVCP--LPEEpaffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd17790  216 IMVLVSTFCKdcVPKT-----LWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
56-326 1.24e-10

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 61.84  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCL 134
Cdd:cd15402   12 VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIyPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 135 TVMSVDRYLAVVHPTRSARWRTAPVArTVSAAVWVASAVVVLPVVVFSGV----PRGMSTCHMQWPEPAaawragfiiYT 210
Cdd:cd15402   92 TGIAINRYCYICHSLKYDKLYSDKNS-LCYVLLIWVLTVAAIVPNLFVGSlqydPRIYSCTFAQSVSSA---------YT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 211 AALGFFG---PLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP--- 284
Cdd:cd15402  162 IAVVFFHfilPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPeti 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 522838250 285 LPEEPA--FFGLYFLVvalpYANSCANPILYGFLSyrfkQGFRR 326
Cdd:cd15402  242 VPRIPEwlFVASYYMA----YFNSCLNAIIYGLLN----QNFRR 277
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
45-147 1.33e-10

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 61.72  E-value: 1.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF--LAAQNAlSYWPFGSLMCRLVMAV 122
Cdd:cd15364    1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLwtIYVSNN-HKWPWGSLACKITGYI 79
                         90       100
                 ....*....|....*....|....*
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVH 147
Cdd:cd15364   80 FFCNIYISILLLCCISIDRFVAVVY 104
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
49-321 1.72e-10

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 60.96  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPflaAQNALSYWPFGSLMCRLVMAVDG-INQ 127
Cdd:cd15163    5 VINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLP---TRIVMYYSAGNCLTCSFVHIFSYfVNM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvsaavwvasavvvlPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFI 207
Cdd:cd15163   82 YCSILFLTCICVDRYLAIVQVEASRRWRNPNYAK---------------GICVFIWLFAIVVTFSILTTAIKFASCCLSK 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 IYT-AALGFFGPLLVICLCYLLIVVKVRSAG-------RRVWApscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15163  147 LFAlTVFEFFLPLLIITFFTIRIMCALSRPGlmhqsreRRMRA-------------VQLLITVLIIFMICFTPFHVRQVA 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 522838250 280 NVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15163  214 VAFNPDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
45-324 2.11e-10

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 61.11  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPF-LAAQNALSYWPFGSLMCRLVMAV 122
Cdd:cd15068    1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFaITISTGFCAACHGCLFIACFVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 dgINQfTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV---FSGVPRGMSTCHMQWPEPA 199
Cdd:cd15068   81 --LTQ-SSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLgwnNCGQPKEGKNHSQGCGEGQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFII---YTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWA-----PSCQRRRRSERRVTRMVVAVVALF----V 267
Cdd:cd15068  158 VACLFEDVVpmnYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKqmesqPLPGERARSTLQKEVHAAKSLAIIvglfA 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 268 LCWMPFYVLNIVNVVCPLPEEPAFFGLYfLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15068  238 LCWLPLHIINCFTFFCPDCSHAPLWLMY-LAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-324 2.82e-10

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 60.73  E-value: 2.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNV---YILNLALADELFML-GLPF-LAAQNALSY-WPFGSLMCRL 118
Cdd:cd15130    1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILLlAMPVeLYNFIWVHHpWAFGDAGCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 VMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMStchmQWPEP 198
Cdd:cd15130   81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESD----DGTHP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AA---------AWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwapscqrrrrserrVTRMVVAVVALFVLC 269
Cdd:cd15130  157 GGlvctpivdtATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQALRR---------------GVLVLRAVVIAFVVC 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 522838250 270 WMPFYVLNIvnVVCPLPEE----PAF-FGLYFLVV--ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15130  222 WLPYHVRRL--MFCYISDEqwttFLFdFYHYFYMLtnALFYVSSAINPILYNLVSANFRQVF 281
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
50-322 3.66e-10

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 60.58  E-value: 3.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD---ELFMLgLPFLAAQnaLSYWPFGS-LMCRLVMAVDGI 125
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDlvvALFQV-LPQLIWE--ITYRFQGPdLLCRAVKYLQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS--GVPRGmSTCHMQWPEPAAAWR 203
Cdd:cd15386   83 SMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSlrEVDQG-SGVLDCWADFGFPWG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 A-GFIIYTAALGFFGPLLVICLCYLLIV------VKVRSAGRRV----WAP--------SCQRRRRSERRVTRMVVAVVA 264
Cdd:cd15386  162 AkAYITWTTLSIFVLPVAILIVCYSLICyeicknLKGKTQTSRSegggWRTqgmpsrvsSVRTISRAKIRTVKMTFVIVL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 265 LFVLCWMPFYVLNIVNVV-CPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15386  242 AYIACWAPFFSVQMWSVWdENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHLLQ 300
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
49-324 3.85e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 60.45  E-value: 3.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15312    5 LFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITD--FLLGFlvmPYSMVRSVESCWYFGDLFCKIHSSLDMM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArTVSAAVWVASAVVVLPVVVFSGVPR-GMSTCHMQwpepAAAWRA 204
Cdd:cd15312   83 LSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVI-KVFLVISWSVPCLFAFGVVFSEVNLeGIEDYVAL----VSCTGS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 205 GFIIY-------TAALGFFGPLLVICLCYLLIVVKVRSAGRRV-WAPSCQRRRRSERRVTRMVVAVVALFV-------LC 269
Cdd:cd15312  158 CVLIFnklwgviASLIAFFIPGTVMIGIYIKIFFVARKHAKVInNRPSVTKGDSKNKLSKKKERKAAKTLSivmgvflLC 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 270 WMPFYVLNIVNvvcPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15312  238 WLPFFVATLID---PFLNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
50-324 4.00e-10

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 60.52  E-value: 4.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLP-FLAAQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15000    5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwMFLVHDFFQNYVLGSVGCKLEGFLEGSLLL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRsARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQWPEPAAAWr 203
Cdd:cd15000   85 ASVLALCAVSYDRLTAIVLPSE-ARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKNfletyCAENTQVLPIYW- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 agFIIYTAALGFfgPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVL------- 276
Cdd:cd15000  163 --HVIITVLVWL--PLGIMLICYSAIFWKLDKYERRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALifyrykl 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 277 ----NIVNVVcplpeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15000  239 vpndNTQNSV-----SGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
48-317 5.10e-10

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 59.75  E-value: 5.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  48 PLVYLVVC-VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPF-GSLMCRLVMAVDGI 125
Cdd:cd14964    1 TTIILSLLtCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPepaaaWRAG 205
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCY-----LICT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAA--LGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVC 283
Cdd:cd14964  156 TIYLTWGflLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALV 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 522838250 284 PLPEEPAffGLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd14964  236 AAGQGLN--LLSILANLLAVLASTLNPFIYCLGN 267
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
46-155 5.46e-10

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 59.97  E-value: 5.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTAS-PSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15170    2 LVLAVYIITFLIGLPANLLAFYTFIRKVRRkPTPIDILLLNLTVSDLIFLLFLPFkMAEAASGMIWPLPYFLCPLSSFIF 81
                         90       100       110
                 ....*....|....*....|....*....|..
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWR 155
Cdd:cd15170   82 FSTIYISTLFLTAISVERYLGVAFPIKYKLRR 113
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
45-324 6.04e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 59.45  E-value: 6.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGL---PFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVAD--FAIGVismPLFTVYTALGYWPLGYEVCDTWLA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHP-TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFS------GVPRGmsTCHMQ 194
Cdd:cd15301   79 IDYLASNASVLNLLIISFDRYFSVTRPlTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPyiegkrTVPAG--TCYIQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 195 WPEPAAAWRAGfiiyTAALGFFGPLLVICLCYLlivvkvrsagrRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFY 274
Cdd:cd15301  157 FLETNPYVTFG----TALAAFYVPVTIMCILYW-----------RIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYN 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 275 VLNIVNVVCPLPEE-PAffGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15301  222 VLVLIKAFFPCSDTiPT--ELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
49-148 7.20e-10

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 59.46  E-value: 7.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVAsAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                         90       100
                 ....*....|....*....|.
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYP 104
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
52-160 8.55e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 59.78  E-value: 8.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVvGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPF-LAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15005    9 LILCV-SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFvMASVRHGSGWIYGALSCKVIAFLAVLFCFH 87
                         90       100       110
                 ....*....|....*....|....*....|.
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSARWRTAPVA 160
Cdd:cd15005   88 SAFTLFCIAVTRYMAIAHHRFYAKRMTFWTC 118
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-148 9.48e-10

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 59.14  E-value: 9.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG-LPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15124    1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                         90       100
                 ....*....|....*....|....*
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15124   81 LTSVGVSVFTLTALSADRYKAIVRP 105
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
49-324 1.42e-09

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 58.76  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGIN 126
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYaWPLPRYLCPIWISLDVLF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRSARW--RTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGM--STCHMQWPEpaaaw 202
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFnsRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKVFvnGTCVLNDEN----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 ragFIIYTAALGFFGPLLVICLCYLLIVVKVRSagrrvwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVV 282
Cdd:cd15305  160 ---FVLIGSFVAFFIPLIIMVITYCLTIQVLQR----------QQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 283 CPLP-EEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15305  227 CKEAcDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
45-329 1.67e-09

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 58.42  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15299    4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSID 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQW-PE 197
Cdd:cd15299   84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTvppdeCFIQFlSE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRagfiiyTAALGFFGPLLVICLCYLLI---VVKVRSAGRRVWApscqrrrrserrvtrmvvaVVALFVLCWMPFY 274
Cdd:cd15299  164 PIITFG------TAIAAFYLPVTIMTILYWRIykeTIKEKKAAQTLSA-------------------ILLAFIITWTPYN 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 275 VLNIVNVVCP--LPEEPAFFGLYflvvaLPYANSCANPILYGFLSYRFKQGFRRVLL 329
Cdd:cd15299  219 IMVLVNTFCDscIPKTYWNLGYW-----LCYINSTVNPVCYALCNKTFRTTFKMLLL 270
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
56-322 1.88e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 58.33  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCrlVMAVDGINQF--TSIF 132
Cdd:cd15085   12 TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALcGTTIVTVTNYEGYFYLGDAFC--IFQGFAVNYFgiVSLW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 133 CLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGV-PRGMST-CHMQWPEPAAAWRAGFIIYT 210
Cdd:cd15085   90 SLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYgPEGVQTsCSIGWEERSWSNYSYLILYF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 211 AALgFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP---LPE 287
Cdd:cd15085  170 LMC-FVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVVNPelsISP 248
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 522838250 288 EPAFFGLYFLVVALPYanscaNPILYGFLSYRFKQ 322
Cdd:cd15085  249 LAATMPTYFAKTSPVY-----NPIIYIFLNKQFRE 278
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
51-321 2.58e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 57.82  E-value: 2.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVC-VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15073    6 YLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDlGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPT---RSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGmSTCHMQWPEPAAAWrAG 205
Cdd:cd15073   86 ASIGLLTVVAVDRYLTICRPDlgrKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTG-ATCTINWRKNDSSF-VS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPL 285
Cdd:cd15073  164 YTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEP 243
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 522838250 286 PEEPAFFGLYFLVVAlpYANSCANPILYGFLSYRFK 321
Cdd:cd15073  244 KKIPPWMAIIPPLFA--KSSTFYNPCIYVIANKKFR 277
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
45-324 5.24e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 56.80  E-value: 5.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTA---SPSVTNVYILNLALADELFML-GLPF-LAAQNALSY-WPFGSLMCRL 118
Cdd:cd15356    1 VLFTAVYALIWALGAAGNALTIHLVLKKRSlrgLQGTVHYHLVSLALSDLLILLiSVPIeLYNFVWFHYpWVFGDLVCRG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 119 VMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQwPEP 198
Cdd:cd15356   81 YYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFIMGQKYELETADGE-PEP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AA---------AWRAGFIIYTAALGFFGPLLVICLCYLLIV--VKVRSAGRRVWapscqrrrrserrvtrMVVAVVALFV 267
Cdd:cd15356  160 SSrvctvlvsrATLKVFIQVNAFVSFVLPLALIAFLNGVTVshLRIQSLQHSVQ----------------VLRAIVIAYV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 268 LCWMPFYVLNIvnVVCPLPEEP------AFFGLYFLVV-ALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15356  224 ICWLPYHARRL--MFCYVPDDAwtdslyNFYHYFYMLTnTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
45-148 7.18e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 56.39  E-value: 7.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVvGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15215    1 IRSVLIVIFLCA-SLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLqTVLVMPWVIATSVPLFWPLDSHLCTALVVLM 79
                         90       100
                 ....*....|....*....|....*
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15215   80 HLFAFAGVNTIVVVSVDRYLAIIHP 104
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
46-239 9.05e-09

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 56.38  E-value: 9.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAqnalSYWPFGSL---MCRLVMAV 122
Cdd:cd15171    2 LVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAH----AAWHGGSLgnpTCKVLVAL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHP-TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRG-------MSTCHMq 194
Cdd:cd15171   78 SSVGLHSEALFNVLLTVQASRVFFHGrLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDsqkskcaFSRPHF- 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 195 WPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRR 239
Cdd:cd15171  157 LPAEETFWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRERQ 201
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
53-324 1.08e-08

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 56.09  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLR-HTASPSVTNVYILNLALADELFMLGLPFLAAQNA---------LSYWpFGSLMCRLVMAV 122
Cdd:cd14980    9 IIGILALIGNILVIIWHISsKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADQyyrgryaqySEEW-LRSPPCLLACFL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVVHPTRSARwrtAPVARTvsaavWVASAVVVLPVVVFSGVP-----------RGMSTC 191
Cdd:cd14980   88 VSLSSLMSVLMMLLITLDRYICIVYPFSNKR---LSYKSA-----KIILILGWLFSIIFAAIPilysinqpgdnRLYGYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWP----EPAaawragFIIYTAALGFFGPL--LVICLCYLLIVVKVRSAGRRVwapsCQRRRRSERRVTRMVVAVVAL 265
Cdd:cd14980  160 SICMPsnvsNPY------YRGWLIAYLLLTFIawIIICILYILIFISVRKSRKSA----RRSSSKRDKRIAIRLALILIT 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 522838250 266 FVLCWMPFYVLNIVnVVCPLPEEPAFFGLYFLVVALPYaNSCANPILYGFLSYRFKQGF 324
Cdd:cd14980  230 DLICWLPYYIVIFS-GLLTSTEIDIHVLQFIAILALPL-NSAINPYLYTLTTPTFKRDF 286
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
55-320 1.10e-08

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 55.93  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  55 CVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVDGINQFTSIFC 133
Cdd:cd15200   11 FVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNeVWRFGATACQVNLFMLSMNRTASIVF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 134 LTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWP-EPAAAWRAGFIIYtaA 212
Cdd:cd15200   91 LTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQSNSTCLSYDHGtDPSASDRWHRILF--F 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 213 LGFFGPLLVICLCYLLIVVKVRSAGrrvwapscQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFF 292
Cdd:cd15200  169 LEFFLPLGIILFCIFSIILTLKQRK--------LAKQAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFKVSQCRSL 240
                        250       260       270
                 ....*....|....*....|....*....|..
gi 522838250 293 G----LYFLVVALPYANSCANPILYGFLSYRF 320
Cdd:cd15200  241 DlctqLFHGSLAFTYLNSALDPVLYCFSSPSF 272
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
53-322 1.10e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 56.05  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLG--LPFLAAQNAL---------SYWpFGSLMCRLVMA 121
Cdd:cd15137    9 VVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIAD--FLMGvyLLIIASVDLYyrgvyikhdEEW-RSSWLCTFAGF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRsARWRTAPVARTVSAAVWVASAV-------VVLPVVVF---SGVprgmstC 191
Cdd:cd15137   86 LATLSSEVSVLILTLITLDRFICIVFPFS-GRRLGLRRAIIVLACIWLIGLLlavlpllPWDYFGNFygrSGV------C 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 ---HMQwPEPAAAWragfiIYTAALgFFG----PLLVICLCYLLIVVKVRSAGRrvwAPSCQRRRRSERRVTRMvVAVVA 264
Cdd:cd15137  159 lplHIT-DERPAGW-----EYSVFV-FLGlnflAFVFILLSYIAMFISIRRTRK---AAASRKSKRDMAVAKRF-FLIVL 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 265 LFVLCWMPFYVLNIVNVV-CPLPEEpaffgLY-FLVV-ALPyANSCANPILYGFLSYRFKQ 322
Cdd:cd15137  228 TDFLCWIPIIVIGILALSgVPIPGE-----VYaWVAVfVLP-INSALNPILYTLSTPKFRK 282
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
47-338 1.27e-08

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 55.72  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  47 IPLVYLVVCVVGLLGNSLVIYVV-LRHTASPsvTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd14973    3 IFSLTVLLSLCGLVGNGLVLWLLgFRIKRNP--FSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPT--RSAR-WRTAPVARTVSAAVWVASavvvlpvvvfsGVPRGMSTCHMQWPEPAAAW 202
Cdd:cd14973   81 SYTVGLSLLAAISTERCLSVLFPIwyRCHRpKHLSAVVCALLWALSLLL-----------SVLESYFCGFLFWKFNESAC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAgFIIYTAALGFFgPLLVICLCYLLIVVKVRSAGRRVWAPScqrrrrserrvtrmvvavvalfvlcwmpFYVL----NI 278
Cdd:cd14973  150 RT-FNFLSALLFLL-LFLVMCVSSLTLLIRVQCSSQRRPPTR----------------------------LYVVilltVL 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 279 VNVVCPLPEEPAFFGLYF-----LVVALPYA------NSCANPILYGFLSyrfkqGFRRVLLRPSRRVRSQ 338
Cdd:cd14973  200 VFLLCGLPLGIYWFLLLWfsnylFHTFHPISdllscvNSSANPIIYFFVG-----SLRGRRLREPLRVVLQ 265
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
45-233 1.65e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 55.56  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLrHTASPSVTNVYILNLALADELFMLGLPFLAAQNA-LSYWPFGSLMCRLVMAVD 123
Cdd:cd15151    1 VVFPVLYTVLFLVGLILNSVAAWIFF-HIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSgLGPWQLRAFVCRFSAVVF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSG---VPRGMSTCHMQWPEPAA 200
Cdd:cd15151   80 YITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNkpaTPISVKKCASLKSPLGL 159
                        170       180       190
                 ....*....|....*....|....*....|...
gi 522838250 201 AWRAGFiIYTAALGFFGPLLVICLCYLLIVVKV 233
Cdd:cd15151  160 KWHEVV-NYICQFIFWGVFALMVLFYTIISKKV 191
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-324 1.68e-08

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 55.62  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTAS---PSVTNVYILNLALADEL-FMLGLP-----FLAAQNAlsyWPFGSLM 115
Cdd:cd15355    1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLqhlQSTVHYHLASLALSDLLiLLLAMPvelynFIWVHHP---WAFGDAA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 116 CRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQW 195
Cdd:cd15355   78 CRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSGTHPGGL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEPAAAWRAGF---IIYTAALGFFGPLLVICLC------YLLIVVKVRSAGRRVWAPSCQRRRRSERRVT---------- 256
Cdd:cd15355  158 ICTPIVDTSTLkvvIQVNAFLSFLFPMLVISVLntlianQLTVMVNQAEQENQVCTIGGQRTVLSVSMEPgrvqslrhgv 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 257 RMVVAVVALFVLCWMPFYVLNIvnVVCPLPEEPAFFGL-------YFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15355  238 LVLRAVVIAFVVCWLPYHVRRL--MFCYVSDEQWTTFLydfyhyfYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
45-321 2.00e-08

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 55.21  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRhtaSPSVTN--VYILNLALADELFMLGLPFLAAQNA-LSYWPFGSLMCRLVMA 121
Cdd:cd15150    1 VIFPLLYTVLFIVGLTMNGLAMRVFFQ---IPSKSNfiIFLKNTVISDLLMILTFPFKILSDAkLGSWPLRGFVCQVTSV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHP---TRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEP 198
Cdd:cd15150   78 IFYFTMYISILFLGLITIDRYQKTTRPfktSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSLLKSEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 199 AAAWRAgFIIYTAALGFFGPLLVICLCYLLIVVKVrsagRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPF----- 273
Cdd:cd15150  158 GLVWHE-IVNYICQVIFWVNFLIVIVCYTLITKEL----YKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFhfari 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 274 -YVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFK 321
Cdd:cd15150  233 pYTLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFR 281
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
49-151 2.57e-08

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 54.73  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15152    5 VTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMY 84
                         90       100
                 ....*....|....*....|...
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRS 151
Cdd:cd15152   85 ASIYFLVCISVRRCLYLIYPFRY 107
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
45-325 3.08e-08

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 54.57  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVI--YVVLRHTASPSvtNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15334    1 ILISLTLSILALMTTAINSLVItaIIVTRKLHHPA--NYLICSLAVTDFLVaVLVMPFSIMYIVKETWIMGQVVCDIWLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLpvvvfsgvprgmstchmqwpePAAA 201
Cdd:cd15334   79 VDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM---------------------PPLF 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WR----------------AGFIIYTAALGFFGPLLVICLCYLLIvvkVRSAGRRVWAPScqrrrrserrvtrMVVAVVAL 265
Cdd:cd15334  138 WRhqttsredeciikhdhIVFTIYSTFGAFYIPLALILILYYKI---YRAATRERKAAT-------------TLGLILGA 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 522838250 266 FVLCWMPFYVLN-IVNVV--CPLPEEPAFFglyflVVALPYANSCANPILYGFLSYRFKQGFR 325
Cdd:cd15334  202 FVICWLPFFVKEvIVNTCdsCYISEEMSNF-----LTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
45-324 3.48e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 3.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQW-PE 197
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTvpdnqCFIQFlSN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRagfiiyTAALGFFGPLLVICLCYL---LIVVKVRSAGRRVWApscqrrrrserrvtrmvvaVVALFVLCWMPFY 274
Cdd:cd15298  161 PAVTFG------TAIAAFYLPVVIMTVLYIhisLASARERKVTRTIFA-------------------ILLAFILTWTPYN 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 275 VLNIVNVVCP--LPEEPAFFGLYflvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15298  216 VMVLVNTFCQscIPDTVWSIGYW-----LCYVNSTINPACYALCNATFKKTF 262
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
45-324 3.53e-08

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 54.42  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15333    5 ISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVsILVMPISIVYTVTGTWTLGQVVCDIWLSSD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVP--RGMSTCHMQWPEpaaa 201
Cdd:cd15333   85 ITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKaeEEVSECVVNTDH---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 wrAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVwapscqrrrrserrvTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15333  161 --ILYTVYSTVGAFYIPTLLLIALYGRIYVEARARERKA---------------TKTLGIILGAFIVCWLPFFIISLVLP 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 282 VCP--LPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15333  224 ICKdaCWFHLAIFDFFTW---LGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
45-324 3.79e-08

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 54.17  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLR----HTAspsvTNVYILNLALADelFMLG---LPFLAAQNALSYWPFGSLMCR 117
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIISIAHfkqlHTP----TNYLILSLAVAD--LLVGglvMPPSMVRSVETCWYFGDLFCK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 118 LVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaavwvasAVVVLPVVVFSGVPR-GMSTC---HM 193
Cdd:cd15314   75 IHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVV-----------LVMILISWSVSALVGfGIIFLelnIK 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 QWPEPAAAWRAG-FIIYTAALGFFGPLL------VICLC-YL--LIVVK--VRS----AGRRVWAPSCQRRRRSERRVTR 257
Cdd:cd15314  144 GIYYNHVACEGGcLVFFSKVSSVVGSVFsfyipaVIMLCiYLkiFLVAQrqARSiqsaRTKSGASSSKMERKATKTLAIV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 258 MVVAVValfvlCWMPFYVLNIVNVVCPLPEEPAffgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15314  224 MGVFLL-----CWTPFFLCNIIDPFINYSIPPV---LIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
46-150 4.12e-08

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 54.36  E-value: 4.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTN-VYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCrlvmAVDG 124
Cdd:cd14983    2 LSLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLC----PLYN 77
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 125 INQFTSIFC----LTVMSVDRYLAVVHPTR 150
Cdd:cd14983   78 LAHFSTLYAstcfLTAISAGRYLGVAFPIK 107
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
49-315 4.55e-08

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 54.04  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYL-VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLG--LPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15198    4 LIFLgVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGtaLSQIIWELLGDRWMAGDVACRLLKLLQAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHPtRSARWRTAPVAR---------TVSAAVWVASAVVVLPVVVFSGVPRgmstCHMQWP 196
Cdd:cd15198   84 ARGASANLVVLLALDRHQAIRAP-LGQPLRAWKLAAlgwllalllALPQAYVFRVDFPDDPASAWPGHTL----CRGIFA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 197 EPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKV------RSAGRRVWAPSCQRRRRSERRVTR---------MVVA 261
Cdd:cd15198  159 PLPRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWweranqAPGAKKPWKKPSKSHLRATAPSALprakvktlkMTLV 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838250 262 VVALFVLCWMPFYVLNIVNVVCPLPEEPAffGLYFLVVALPYANSCANPILYGF 315
Cdd:cd15198  239 IALLFVGCSLPYFIAELAAAFGSGDWEPE--KVAAALGVMAVANSATNPFVFLF 290
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
114-317 5.41e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 54.05  E-value: 5.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 114 LMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHM 193
Cdd:cd15387   71 FLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYDCWA 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 QWPEPAAAwrAGFIIYTAALGFFGPLLVICLCYLLIVVKV------------------RSAGRRVWA--PSCQRRRRSER 253
Cdd:cd15387  151 DFIQPWGP--KAYITWITLSVYIIPVLILSVCYGLISFKIwqnvklktrretktplssAASGGAALArvSSVKLISKAKI 228
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 254 RVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFfgLYFLVVALPYANSCANPILYGFLS 317
Cdd:cd15387  229 RTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPKEAS--PFIIAMLLASLNSCCNPWIYMFFT 290
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
45-324 5.53e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 53.49  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIgIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-----CHMQW-PE 197
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTvpereCQIQFlSE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 198 PAAAWRagfiiyTAALGFFGPLLVICLCYLLI---VVKVRSAGRRVWApscqrrrrserrvtrmvvaVVALFVLCWMPFY 274
Cdd:cd15300  161 PTITFG------TAIAAFYIPVSVMTILYCRIykeTIKERKAAQTLSA-------------------ILLAFIITWTPYN 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 275 VLNIVNVVCplpEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15300  216 IMVLVSTFC---SDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
54-324 6.59e-08

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 53.27  E-value: 6.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  54 VCVVGLL---GNSLVIYVVLRHTASPSVTNVYILNLALADelFMLGLPFL--AAQNAL-SYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15054    7 LCLIILLtvaGNSLLILLIFTQRSLRNTSNYFLVSLFMSD--LMVGLVVMppAMLNALyGRWVLARDFCPIWYAFDVMCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFI 207
Cdd:cd15054   85 SASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVEGQCRLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 208 ------IYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNIVNV 281
Cdd:cd15054  165 vslpyaLVASCLTFFLPSGAICFTYCRILLAARKALK----------------ASLTLGILLGMFFVTWLPFFVANVVQA 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 282 VCplpeEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15054  229 VC----DCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
50-157 7.73e-08

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 53.13  E-value: 7.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLvMAVDG-INQF 128
Cdd:cd15072    6 ILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQA-HGFQGfFTAL 84
                         90       100
                 ....*....|....*....|....*....
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTRSArWRTA 157
Cdd:cd15072   85 ASICSSAAIAWDRYHHYCTRSKLQ-WSTA 112
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
46-322 8.02e-08

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 53.23  E-value: 8.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPS-VTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15219    1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLtVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSA---RWRTApvartvsaavWVASAVVVLPVVVFSGVPRGMS---------TC 191
Cdd:cd15219   81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTskmRYRDA----------ALMVGYSWLHSLTFSLVALFLSwlgysslyaSC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 HMQWPEPAAAWR-AGFIIYTAALGFFGPLLVICLCYLLiVVKVRsagRRVWApscqrrrrserrvTRMVVAVVALFVLCW 270
Cdd:cd15219  151 TLHLPREEERRRfAVFTAFFHAFTFLLSLLVLCVTYLK-VLKVR---RRQRA-------------TKKISIFIGTFVLCF 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 271 MPFYVLNIVNVVCPLPeEPAFFGLyfLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15219  214 APYVITRLVELLPFVT-INRYWGI--VSKCLTYSKAASDPFVYSLLRQQYRK 262
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
45-324 8.85e-08

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 53.00  E-value: 8.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15335    1 MLIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaavwVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAW- 202
Cdd:cd15335   81 MTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRA--------GLMILTVWTISIFISIPPLFWRNHHDANIPSQCIi 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 ---RAGFIIYTAALGFFGPLLVICLCYLLI---VVKVRSAGRrvwapscqrrrrserrvtrMVVAVVALFVLCWMPFYVL 276
Cdd:cd15335  153 qhdHVIYTIYSTFGAFYIPLTLILILYYRIyhaASRERKAAR-------------------ILGLILGAFILSWLPFFIK 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 277 NIV---NVVCPLPEEPAFfglyflVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15335  214 ELIvglSVMTVSPEVADF------LTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
45-322 1.01e-07

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 53.31  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15403    1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAawR 203
Cdd:cd15403   81 WFFVLEGVAILLIISVDRFLIIVQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARAPQCVLGYTESPA--D 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALF----------------- 266
Cdd:cd15403  159 RVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHADSLCLSQVSKLGLMGLQRPHQMnvdmsfktrafttilil 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838250 267 ----VLCWMPFYVLNIVNVVC-PLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15403  239 fvgfSLCWLPHTVFSLLSVFSrRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
51-153 1.47e-07

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 52.46  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  51 YLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd15167    7 YYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVkIAVDLGIAPWKLKIFHCQVTACLIYINMYL 86
                         90       100
                 ....*....|....*....|....
gi 522838250 130 SIFCLTVMSVDRYLAVVHPTRSAR 153
Cdd:cd15167   87 SIIFLGFVSIDRYLQLTHSSKLYR 110
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
53-323 1.92e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 52.44  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSI 131
Cdd:cd15384    9 VMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 132 FCLTVMSVDRYLAVVHPTRSARwrtAPVARTVSAAVWVASAVVVLPVVVF-----SGVPRGMSTCHMQWPEPAAAWRAG- 205
Cdd:cd15384   89 YITVLISLDRCVAILYPMKRNQ---APERVRRMVTVAWILSPIFSIPQAVifhveRGPFVEDFHQCVTYGFYTAEWQEQl 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 206 FIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSC----------QRRRRSERRVTRMVVAVVALFVLCWMPFYV 275
Cdd:cd15384  166 YNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIytrnrgpnrqRLFHKAKVKSLRMSAVIVTAFILCWTPYYV 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 522838250 276 LNIVNVV---CPLPEEpAFFGLYFLVValpyANSCANPILYG-FLSYRFKQG 323
Cdd:cd15384  246 IMIWFLFfnpYPLNDI-LFDVIFFFGM----SNSCVNPLIYGaFHITKKKGG 292
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-145 2.53e-07

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 51.78  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15976    5 VVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASV 84
                         90
                 ....*....|....*...
gi 522838250 128 FTSIFCLTVMSVDRYLAV 145
Cdd:cd15976   85 GITVLSLCALSIDRYRAV 102
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
45-324 2.55e-07

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 51.59  E-value: 2.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPfLAAQNALS-YWPFGSLMCRLVMAV 122
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVaVLVMP-LSAVYEVSqHWFLGPEVCDMWISM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAVvhpTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGvprgmstchmqWPEPAAAW 202
Cdd:cd15331   80 DVLCCTASILHLVAIALDRYWAV---TNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFG-----------WKDEDDLD 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 R------------AGFIIYTAALGFFGPLLVICLCYLLIVvkvRSAGR-RVWAPScqrrrrserrvtrmVVAVVALFVLC 269
Cdd:cd15331  146 RvlktgvclisqdYGYTIFSTVGAFYVPLLLMIIIYWKIY---QAAKReRKAART--------------LAIITGAFVVC 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838250 270 WMPFYVLNIVNVVCPLPEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15331  209 WLPFFLVALVMPFCGAWQISRF--LESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
49-150 3.25e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 51.69  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPF-LAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15212    5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFaFLTLFSRPGWLFGDRLCLANGFFNACF 84
                         90       100
                 ....*....|....*....|....
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTR 150
Cdd:cd15212   85 GIVSTLTMTLISFDRYYAIVRQPQ 108
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-150 5.91e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 50.67  E-value: 5.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPFLAAQNALSYWPFGSLMCRLVMAVDGINQ 127
Cdd:cd15977    5 ILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILiAIPINVIKLIAEDWPFGVHVCKLYPFIQKASV 84
                         90       100
                 ....*....|....*....|...
gi 522838250 128 FTSIFCLTVMSVDRYLAVVHPTR 150
Cdd:cd15977   85 GITVLSLCALSIDRYRAVASWSR 107
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
50-315 7.49e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 50.37  E-value: 7.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL---------FMLGLPFLAAQNALSYWPFGSLMCRLVm 120
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafvftfLSVLLVSLTPSPATWLLRKGSLVLSLL- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 121 avdginqfTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvsaavwVASAVVVLPVVVFSGVPrgmstcHMQW----- 195
Cdd:cd14972   83 --------ASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVK-------VLIALVWVWSVLLALLP------VLGWncvlc 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 196 PEPAAAWRAG-----FIIYTAALgFFGPLLVICLCYLLIVVKVRS----AGRRVWAPSCQRRRRSERRVTRMVVAVVALF 266
Cdd:cd14972  142 DQESCSPLGPglpksYLVLILVF-FFIALVIIVFLYVRIFWCLWRhanaIAARQEAAVPAQPSTSRKLAKTVVIVLGVFL 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 522838250 267 VlCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALpyANSCANPILYGF 315
Cdd:cd14972  221 V-CWLPLLILLVLDVLCPSVCDIQAVFYYFLVLAL--LNSAINPIIYAF 266
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
53-322 8.50e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 50.29  E-value: 8.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLG--LPFLAAQNALSY---------WPFGSLmCRLV-- 119
Cdd:cd15136    9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFAD--FCMGiyLGLLAIVDAKTLgeyynyaidWQTGAG-CKTAgf 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 120 MAVdginqFT---SIFCLTVMSVDRYLAVVHP---TRSARWRTAPVARTVSAAVWVASAVVVLPvvvfsGVPRGMSTC-- 191
Cdd:cd15136   86 LAV-----FSselSVFTLTVITLERWYAITHAmhlNKRLSLRQAAIIMLGGWIFALIMALLPLV-----GVSSYSKTSic 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 192 -HMQWPEPAAAWRAGFIIYTAALGFFgpllVICLCYLLIVVKVRSAGRrvwAPSCQRRRRSERRVTRMvvavvALFVLCW 270
Cdd:cd15136  156 lPFETETPVSKAYVIFLLLFNGLAFL----IICGCYIKIYLSVRGSGR---AANSNDTRIAKRMALLV-----FTDFLCW 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 522838250 271 MPFyvlnivnvvcplpeepAFFGL---------------YFLVVALPYaNSCANPILYGFLSYRFKQ 322
Cdd:cd15136  224 API----------------AFFGLtaafglplisvsnakILLVFFYPL-NSCANPFLYAIFTKQFRR 273
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
45-328 8.92e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 50.21  E-value: 8.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVgLLGNSLVI--YVV---LRHTaspsvTNVYILNLALADelFMLG---LPFLAAQNALSYWPFGSLMC 116
Cdd:cd15295    2 VLLFLMSLLALVI-VLGNALVIiaFVVdknLRHR-----SNYFFLNLAISD--FFVGaisIPLYIPYTLTNRWDFGRGLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 117 RLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTrSARWRTAPVARTVSAAVWVASAVVVL---PVVVFSGVPRGMSTCHm 193
Cdd:cd15295   74 VFWLVIDYLLCTASVYNIVLISYDRYQSVSNAV-SYRNQQTATLRIVTQMVAVWVLAFLVhgpAILVSDSWKTEDGECE- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 194 qwPEPAAAWRagFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGR-RVWAPScqrrrrserrvtrmVVAVVALFVLCWMP 272
Cdd:cd15295  152 --PEFFSNWY--ILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRdRKLAKS--------------LAIILGTFAICWAP 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522838250 273 FYVLNIVNVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGFRRVL 328
Cdd:cd15295  214 YSLFTIIRAACEKHRGSPWYNFAFW---LQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
52-324 1.14e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 49.93  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSlmCRLVMAVDGINQFTS 130
Cdd:cd15069    8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADvAVGLFAIPFAITISLGFCTDFHS--CLFLACFVLVLTQSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 131 IFCLTVMSVDRYLAVVHPTRSARWRTAPVARtvSAAVWVASAVVVLPVVVFSGVPRGMSTCH-MQWPEPAAAWRAGFII- 208
Cdd:cd15069   86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRAR--GVIAVLWVLAFGIGLTPFLGWNKAMSATNnSTNPADHGTNHSCCLIs 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 209 ----------YTAALGFFG----PLLVICLCYLLI-VVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPF 273
Cdd:cd15069  164 clfenvvpmsYMVYFNFFGcvlpPLLIMLVIYIKIfLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPV 243
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 522838250 274 YVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15069  244 HILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
50-144 1.95e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 49.02  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVvLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFT 129
Cdd:cd14994    7 LYSVVLIGGVIGVILMSFL-LVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHL 85
                         90
                 ....*....|....*
gi 522838250 130 SIFCLTVMSVDRYLA 144
Cdd:cd14994   86 TFLFYVIILVIRYLI 100
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
50-148 2.03e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 49.00  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGL-PFLAAQNALSYWPFGSLMCRLVMAVDGINQF 128
Cdd:cd15398    6 LYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCsPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVM 85
                         90       100
                 ....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15398   86 VSTLMLMSIAIVRYHMIKHP 105
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
53-324 3.66e-06

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 48.30  E-value: 3.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALAD-ELFMLGLPFLAAQNALSYWPFGSlmCRLVMAVDGINQFTSI 131
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 132 FCLTVMSVDRYLAVVHPTRSARW---RTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFII 208
Cdd:cd15071   87 LALLAIAVDRYLRVKIPTRYKSVvtpRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAWAANSSMGELVIKCQFETVI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 209 ---YTAALGFFG----PLLVICLCYLLIVVKVRSAGRRV---WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNI 278
Cdd:cd15071  167 smeYMVYFNFFVwvlpPLLLMLLIYLEVFYLIRKQLNKKvssSSSDPQKYYGKELKIAKSLALILFLFALSWLPLHILNC 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 522838250 279 VNVVCPLPEEPAFfgLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15071  247 ITLFCPSCKKPMI--LTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
46-148 3.68e-06

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 48.31  E-value: 3.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLrHTASPSVTNVYILNLALADELFMLGLPF-LAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15149    2 VIPVFYSLVFIVGILLNGVNFWIFF-YVPSNKSFIVYLKNIVFADLLMSLTFPFkILSDVELGPWQLNVIVCRYSAVIFY 80
                         90       100
                 ....*....|....*....|....
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15149   81 LNMYVGIIFFGLIGFDRYYKIVKP 104
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
56-321 1.50e-05

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 46.36  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  56 VVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS-YWPFGSLMCRLVMAVDGINQFTSIFCL 134
Cdd:cd15080   12 LLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHgYFVFGPTGCNLEGFFATLGGEIALWSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 135 TVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSG-VPRGM-STCHMQW----PEpaaAWRAGFII 208
Cdd:cd15080   92 VVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRyIPEGMqCSCGIDYytlkPE---VNNESFVI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 209 YTAALGFFGPLLVICLCYLLIVVKVRSAGRRvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMP-----FYVLNivnvvc 283
Cdd:cd15080  169 YMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQ--QQESATTQKAEKEVTRMVIIMVIAFLICWVPyasvaFYIFT------ 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 522838250 284 plpEEPAFFGLYFLVVALPYANSCA--NPILYGFLSYRFK 321
Cdd:cd15080  241 ---HQGSDFGPIFMTIPAFFAKSSAvyNPVIYILMNKQFR 277
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
45-313 1.52e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 46.37  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVD 123
Cdd:cd15404    1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLaVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 124 GINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEpAAAWR 203
Cdd:cd15404   81 WLFVMEGVAILLIISIDRFLIIVQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSRAPQCVFGYTT-NPGYQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 204 AgFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWApscqrrrrserrvtrMVVAVVALFVLCWMPFYVLNIVNVVC 283
Cdd:cd15404  160 A-YVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRAFT---------------TILILFIVFTVCWAPFTTYSLVATFN 223
                        250       260       270
                 ....*....|....*....|....*....|.
gi 522838250 284 P-LPEEPAFFGLYFLVVALPYANSCANPILY 313
Cdd:cd15404  224 ShFYHKHNFFEISTWLLWLCYLKSALNPLIY 254
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
215-324 1.71e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 46.31  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 215 FFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALfvlCWMPFYVLNIVNVVCPLPEEPAFFGL 294
Cdd:cd15102  165 FAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIA---CWGPLFILLLLDVACPVKTCPILYKA 241
                         90       100       110
                 ....*....|....*....|....*....|.
gi 522838250 295 -YFLVVALpyANSCANPILYGFLSYRFKQGF 324
Cdd:cd15102  242 dWFLALAV--LNSALNPIIYTLRSRELRRAV 270
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
52-148 2.11e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15214    7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSAS 86
                         90
                 ....*....|....*...
gi 522838250 131 IFCLTVMSVDRYLAVVHP 148
Cdd:cd15214   87 MLTLGAIAIDRYYAVLYP 104
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
45-151 2.83e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 45.56  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYV--VLRHTA--SPSVTNvYILNLALADEL-FMLGLP---FLAAQNALSyWPFGSLMC 116
Cdd:cd15135    1 ITLTLLYSLILVAGILGNSATIKVtqVLQKKGylQKSVTD-HMVSLACSDLLvLLLGMPvelYSAIWDPFA-TPSGNIAC 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 522838250 117 RLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRS 151
Cdd:cd15135   79 KIYNFLFEACSYATILNVATLSFERYIAICHPFKY 113
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
59-315 3.23e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 45.44  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  59 LLGNSLVIYVVLRHT-ASPSVTNVYILNLALADELFMLGLPFLAAQNALSY-WPFGSLMCRLVMAVDGINQFTSIFCLTV 136
Cdd:cd15104   14 ITGNLLVIVALLKLIrKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDgENTQKVLCLLRMCFVITSCAASVLSLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 137 MSVDRYLAVVHPTRSARWRTAPVArtvsaavwVASAVVVLPVVVFSGVPRGMSTCHMQWPEPA-----AAWRAGFIIYTA 211
Cdd:cd15104   94 IAFDRYLALKQPLRYKQIMTGKSA--------GALIAGLWLYSGLIGFLPLISPQFQQTSYKGkcsffAAFHPRVLLVLS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 212 ALGFFGPLLVICLCYLLI----------VVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFvlcWMPFYVLNIVNV 281
Cdd:cd15104  166 CMVFFPALLLFVFCYCDIlkiarvhsraIYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLS---WLPFQITGLVQA 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 522838250 282 VC--PLPEEPAFFGLYFLVValpyANSCANPILYGF 315
Cdd:cd15104  243 LCdeCKLYDVLEDYLWLLGL----CNSLLNPWIYAF 274
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
49-147 5.77e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 44.94  E-value: 5.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVvGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL-FMLGLPF-LAAQNALSYWPFGSLMCRLVMAVDGIN 126
Cdd:cd15217    6 LLGLIICV-SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIrSAVCFPFvLVSIRNGSAWTYSVLSCKIVAFMAVLF 84
                         90       100
                 ....*....|....*....|.
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVH 147
Cdd:cd15217   85 CFHAAFMLFCISVTRYMAIAH 105
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
45-155 7.09e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 44.40  E-value: 7.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLG---LPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15296    1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISD--FLVGgfcIPLYIPYVLTGRWKFGRGLCKLWLV 78
                         90       100       110
                 ....*....|....*....|....*....|....
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVvhpTRSARWR 155
Cdd:cd15296   79 VDYLLCTASVFNIVLISYDRFLSV---TRAVSYR 109
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
53-324 8.40e-05

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 43.96  E-value: 8.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSI 131
Cdd:cd15086    9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 132 FCLTVMSVDRYLAVVHPT--RSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAwRAGFIIY 209
Cdd:cd15086   89 ISLAVLSYERYCTLLRPTeaDVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRSAN-SISYIIC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 210 TAALGFFGPLLVICLCYLLIVVKVRSAGRrvwaPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVnvvcplpeep 289
Cdd:cd15086  168 LFIFCLLLPFLVMVYCYGRLLYAIKQVGK----INKSTARKREQHVLLMVVTMVICYLLCWLPYGVMALL---------- 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 522838250 290 AFFGLYFLVVA--------LPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15086  234 ATFGKPGLVTPvasivpsiLAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
50-151 1.20e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 43.66  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADEL--FMLGLPFLAAQnaLSYWPFG-SLMCRLVMAVDGIN 126
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVvaFFQVLPQLCWD--ITYRFYGpDFLCRIVKHLQVLG 83
                         90       100
                 ....*....|....*....|....*
gi 522838250 127 QFTSIFCLTVMSVDRYLAVVHPTRS 151
Cdd:cd15385   84 MFASTYMLVMMTADRYIAICHPLKT 108
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
49-148 1.79e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 43.16  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRHTASPSVTnVYILNLALADELFMLGLPFLAAQNALsywPFGSLMCRLVMAVDGINQF 128
Cdd:cd15110    5 WVSLIICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCIFILSIMYIG---PFNFSHSRDYVAMLIFIIL 80
                         90       100
                 ....*....|....*....|....*.
gi 522838250 129 ------TSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15110   81 flfgynTGLYLLTAISVERCLSVLYP 106
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-321 2.46e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 42.54  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSI 131
Cdd:cd15084   19 MVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVtLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 132 FCLTVMSVDRYLAVVHPTRSARW-RTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMST-CHMQWpEPAAAWRAGFIIY 209
Cdd:cd15084   99 WSLAILAFERYLVICKPMGDFRFqQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTsCGPNW-YTGGTNNNSYILA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 210 TAALGFFGPLLVICLCYLLIVVKVRSAGRRvwAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCP-LPEE 288
Cdd:cd15084  178 LFVTCFALPLSTIIFSYSNLLLTLRAVAAQ--QKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKdVVIQ 255
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 522838250 289 PAFFGL--YFLVVALPYanscaNPILYGFLSYRFK 321
Cdd:cd15084  256 PTLASLpsYFSKTATVY-----NPIIYVFMNKQFR 285
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
52-149 2.67e-04

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 42.43  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  52 LVVCVVGLLGNSLVIYVV-LRHTASPsvTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTS 130
Cdd:cd15108    8 MFTCVCGMAGNGLVVWLLsCRGRRTP--FCVYVLHLAVADLLFLLCMASTLSLETSPLVITHDLAYEVVRRVKYFAYTAS 85
                         90
                 ....*....|....*....
gi 522838250 131 IFCLTVMSVDRYLAVVHPT 149
Cdd:cd15108   86 LSLLTAISTQRCLSVLFPI 104
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
45-328 2.84e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 42.54  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADelFMLG---LPFLAAQNALSYWPFGSLMCRLVMA 121
Cdd:cd15316    1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACAD--FLVGvtvMPFSTVRSVESCWYFGESFCTFHTC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 VDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVArtvsaAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15316   79 CDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVS-----GICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFII-------YTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVV----------AVVA 264
Cdd:cd15316  154 CVGGCQIilnqnwvLVDFLLFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSSESYKDRVARrerkaaktlgITVI 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838250 265 LFVLCWMPFYVLNIVNVVCPLPEEPAffgLYFLVVALPYANSCANPILYGFlsyrFKQGFRRVL 328
Cdd:cd15316  234 AFLVSWLPYLIDVLIDAFMNFITPPY---IYEICCWCAYYNSAMNPLIYAL----FYPWFRKAI 290
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
50-148 3.15e-04

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 42.17  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFML-GLPF---LAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15006    5 VQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLvCVPFdivLSASPHCCWWIYTLLFCKVIKFLHKV 84
                         90       100
                 ....*....|....*....|...
gi 522838250 126 NQFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd15006   85 FCSVTVLSFAAIALDRYYSVLYP 107
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
49-322 3.55e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 42.07  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVV-CVVGL---LGNSLVIYVVLRHTASPSVTNVYILNLALAD---ELFMLGLPFLAAQNALSYWPFGSLMCRLVMa 121
Cdd:cd15070    1 VTYISIeILIGLcavVGNVLVIWVVKLNPSLRTTTFYFIVSLALADiavGVLVIPLAIVVSLGVTIHFYSCLFMSCLLV- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 122 vdgINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTApvARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15070   80 ---VFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQ--RRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 WRAGFII-YTAALGFFG----PLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALF--VLCWMPFY 274
Cdd:cd15070  155 FTSVMRMdYMVYFSFFTwiliPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFlfAVCWLPLS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 522838250 275 VLNIVNVVCPLPEEPAFfglyFLVVALPYANSCANPILYGFLSYRFKQ 322
Cdd:cd15070  235 IINCVVYFNPKVPKIAL----YLGILLSHANSMMNPIVYACKIKKFKE 278
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
46-322 4.45e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 41.71  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  46 LIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15082   15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVsLTGGTISFLTNARGYFFLGVWACVLEGFAVT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGM--STCHMQWPEPAAAW 202
Cdd:cd15082   95 FFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKigTTCEPNWYSGNMHD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAgFIIYTAALGFFGPLLVICLCYLLIVVKVRSAG------RRVWAPSCQrrrrserrVTRMVVAVVALFVLCWMPFYVL 276
Cdd:cd15082  175 HT-YIITFFTTCFILPLGVIFVSYGKLLQKLRKVSntqgrlGNARKPERQ--------VTRMVVVMIVAFMVCWTPYAAF 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 522838250 277 NIVNVVCP-------LPEEPAFFGlyflvvalpYANSCANPILYGFLSYRFKQ 322
Cdd:cd15082  246 SILVTAHPtihldprLAAIPAFFS---------KTAAVYNPIIYVFMNKQFRK 289
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
50-324 1.58e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 40.15  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELF----MLGLPFLAAQNALSYWPFGSLMCRLVMAVDGI 125
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGslykTLENILIILADMGYLNRRGPFETKLDDIMDSL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 126 ---NQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSgvprgmstchmqwpepaaaw 202
Cdd:cd15350   86 fclSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMILFF-------------------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 203 RAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWA--PSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVN 280
Cdd:cd15350  146 HFVATVICFTVLFFLMLVLILCLYVHMFLLARSHARKIASlpNHHAQHQRSNMRGAITLTILLGVFVCCWAPFVLHLLLM 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 281 VVCPL-PEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15350  226 MFCPMnPYCACYRSLFQVNGTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
50-158 1.84e-03

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 39.89  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  50 VYLVVCVVGLLGNSLVIYVvLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQF- 128
Cdd:cd15109    6 IFLLLCLCGLVGNGLVLWF-FGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGLCTFl 84
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 129 TSIFCLTVMSVDRYLAVVHPTrsARWRTAP 158
Cdd:cd15109   85 TGVSLLPAISIERCVSVIFPT--WYWRRRP 112
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
215-317 2.20e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 39.77  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 215 FFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALfvlCWMPFYVLNIVNVVCPLPEEPAFFGL 294
Cdd:cd15349  166 FFIILLTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMV---CWGPLFILLLVDFFCSSRSCKPLFGM 242
                         90       100
                 ....*....|....*....|...
gi 522838250 295 YFlVVALPYANSCANPILYGFLS 317
Cdd:cd15349  243 EW-VLALAVLNSAINPLIYSFRS 264
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
45-324 3.97e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 38.78  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  45 VLIPLVYLVVCVvgLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALS--YWPFGSLMCRLVMAV 122
Cdd:cd15328    3 VLTLLAMLVVAT--FLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgrRWQLGRSLCQVWISF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 123 DGINQFTSIFCLTVMSVDRYLAV---VHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQwPEPA 199
Cdd:cd15328   81 DVLCCTASIWNVTAIALDRYWSItrhLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVS-QEPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 aawragFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRrvwapscqrrrrserrVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15328  160 ------YTVFSTFGAFYLPLCVVLFVYWKIYKAAQKEKR----------------AALMVGILIGVFVLCWIPFFLTELI 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 522838250 280 NVVCPLPEEPAFFGLYFLvvaLPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15328  218 SPLCSCDIPPIWKSIFLW---LGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-316 4.08e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.59  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLGNSLVIYVVLRhtaSPSVTN-VYILNLALADEL---FMLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15220    4 FCMVLLDLTALVGNTAVMVVIAK---TPHLRKfAFVCHLCVVDLLaalLLMPLGILSSSPFFLGVVFGEAECRVYIFLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAA-----VWVASAVVVLPVVVFSGVPRGMSTCHMQWPEpa 199
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGvwvkaLLLGLLPVLGWPSYGGPAPIAARHCSLHWSH-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 200 AAWRAGFIIYTAALGFFGPLLVICLCYlLIVVKVRSAGRRVWAPscqrrrrserrvtrmvVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15220  159 SGHRGVFVVLFALVCFLLPLLLILVVY-CGVFKVFGGGKAALTL----------------AAIVGQFLCCWLPYFAFHLY 221
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 522838250 280 NVVCPLPEEPAffGLYFLVVALPYANSCANPILYGFL 316
Cdd:cd15220  222 SALAASPVSGG--EAEEVVTWLAYSCFAVNPFFYGLL 256
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
55-158 4.65e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 38.34  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250   55 CVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNaLSYWPFGSLMCRLVMAVDGINQFTSIFCL 134
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLL-FTGTQLTRNECFWMISFYIFGQTAQGPLM 79
                          90       100
                  ....*....|....*....|....
gi 522838250  135 TVMSVDRYLAVVHPTRSARWRTAP 158
Cdd:pfam10320  80 LMIGIDRLIAVKFPIFYRLLSSSK 103
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
53-148 5.06e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 38.38  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  53 VVCVVGLLGNSLVIYVVLRHTAS--PSVTNVYILNLALADEL--FMLGLPFLAAQNALSYWPFGSLMCR---LVMAVDGi 125
Cdd:cd14981    9 LMFVFGVLGNLLALIVLARSSKShkWSVFYRLVAGLAITDLLgiLLTSPVVLAVYASNFEWDGGQPLCDyfgFMMSFFG- 87
                         90       100
                 ....*....|....*....|...
gi 522838250 126 nqFTSIFCLTVMSVDRYLAVVHP 148
Cdd:cd14981   88 --LSSLLIVCAMAVERFLAITHP 108
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
49-322 5.13e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 38.66  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250  49 LVYLVVCVVGLLG---NSLVIYVVLRHTASPSVTNVYILNLALADELF-MLGLPFLAAQNALSYWPFGSLMCRLVMAVDG 124
Cdd:cd15078    2 LLALLIATIGFLGvcnNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 125 INQFTSIFCLTVMSVDRYLAVVHP---TRSARWRtapvARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAA 201
Cdd:cd15078   82 LFGIVSIMTLTVLAYERYIRVVHAkvvNFSWSWR----AITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 202 wRAGFIIYTAALGFFGPLLVICLCY--LLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIV 279
Cdd:cd15078  158 -DTSFVLLFFLGCLVVPLGIMAYCYghILYEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLL 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 522838250 280 ------NVVCP-LPEEPAFFGLyflvvalpyANSCANPILYGFLSYRFKQ 322
Cdd:cd15078  237 vtsgysKLVTPtIAIIPSLFAK---------SSTAYNPVIYIFMIRKFRQ 277
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
215-324 6.60e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 38.26  E-value: 6.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838250 215 FFGPLLVICLCYLLIVVKVRSAGRRVwapSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGL 294
Cdd:cd15345  165 FIAILVAIVILYARIYILVKSSSRRV---TNHRNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQCPILYKA 241
                         90       100       110
                 ....*....|....*....|....*....|
gi 522838250 295 YFLvVALPYANSCANPILYGFLSYRFKQGF 324
Cdd:cd15345  242 DWF-IALAVLNSAMNPIIYTLASKEMRRAF 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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