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Conserved domains on  [gi|514052675|ref|NP_001265487|]
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WD repeat and SOCS box-containing protein 2 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-150 3.81e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 3.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG----------- 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGVIATGTRDGHVQFW 150
Cdd:COG2319  287 -HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 154-192 1.49e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.16  E-value: 1.49e-20
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 514052675 154 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03733    1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-150 3.81e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 3.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG----------- 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGVIATGTRDGHVQFW 150
Cdd:COG2319  287 -HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-150 9.87e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 9.87e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----------- 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200  176 -HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASGSEDGTIRVW 246
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 154-192 1.49e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.16  E-value: 1.49e-20
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 514052675 154 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03733    1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 150-192 3.93e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 60.77  E-value: 3.93e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 514052675   150 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 18-57 2.10e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514052675    18 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 57
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
20-57 4.24e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 4.24e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 514052675   20 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 57
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 158-190 1.14e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 514052675  158 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 190
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
1-150 3.81e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 3.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG----------- 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGVIATGTRDGHVQFW 150
Cdd:COG2319  287 -HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
4-161 7.37e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 7.37e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   4 SAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddsDVHI 83
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL------------TGHT 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675  84 SSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW--TAPRVLSSL 159
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTL 284


                 ..
gi 514052675 160 KH 161
Cdd:COG2319  285 TG 286
WD40 COG2319
WD40 repeat [General function prediction only];
4-160 8.17e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 8.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   4 SAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsdvHI 83
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG------------HS 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675  84 SSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFWTA--PRVLSSL 159
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRTL 326


                 .
gi 514052675 160 K 160
Cdd:COG2319  327 T 327
WD40 COG2319
WD40 repeat [General function prediction only];
1-150 8.93e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 8.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------- 328

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 150
Cdd:COG2319  329 -HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
4-161 4.70e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 4.70e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   4 SAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsdvHI 83
Cdd:COG2319   95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG------------HS 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675  84 SSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW--TAPRVLSSL 159
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVrSVAFSPDGKLLASGSADGTVRLWdlATGKLLRTL 242


                 ..
gi 514052675 160 KH 161
Cdd:COG2319  243 TG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-150 9.87e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 9.87e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:cd00200  107 ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----------- 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGL-CCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200  176 -HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-150 4.57e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 4.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   2 LCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsdv 81
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG------------ 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514052675  82 HISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200  134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-150 2.05e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 2.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHhtqvdpamddsd 80
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR------------ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 VHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200  217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-150 5.73e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 5.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsd 80
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTG----------- 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514052675  81 vHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200   92 -HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
1-113 5.41e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 5.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddsD 80
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL------------T 369

                         90       100       110
                 ....*....|....*....|....*....|...
gi 514052675  81 VHISSLRSVCFSPEGLYLATVADDRLLRIWALE 113
Cdd:COG2319  370 GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-150 1.19e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675  21 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHhtqvdpamddsdVHISSLRSVCFSPEGLYLAT 100
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLAS 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514052675 101 VADDRLLRIWALELKTPIA-FAPMTNG-LCCTFFPHGGVIATGTRDGHVQFW 150
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRtLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 154-192 1.49e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.16  E-value: 1.49e-20
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 514052675 154 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03733    1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 154-192 3.20e-20

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 79.17  E-value: 3.20e-20
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 514052675 154 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03745    1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-111 2.14e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 2.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   2 LCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsdv 81
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG------------ 259

                         90       100       110
                 ....*....|....*....|....*....|
gi 514052675  82 HISSLRSVCFSPEGLYLATVADDRLLRIWA 111
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-150 8.45e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 8.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   4 SAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdpamddsdvHI 83
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG------------HT 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 514052675  84 SSLRSVCFSPEGLYLATVADDRLLRIWAL----ELKTPIAFAPMTNGLccTFFPHGGVIATGTRDGHVQFW 150
Cdd:COG2319  121 GAVRSVAFSPDGKTLASGSADGTVRLWDLatgkLLRTLTGHSGAVTSV--AFSPDGKLLASGSDDGTVRLW 189
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 150-192 3.93e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 60.77  E-value: 3.93e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 514052675   150 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 154-193 2.79e-12

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 58.67  E-value: 2.79e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 514052675 154 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRT 193
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
WD40 COG2319
WD40 repeat [General function prediction only];
1-60 1.32e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.32e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYT 60
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-57 6.77e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 6.77e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 514052675   1 MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 57
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 158-192 3.76e-09

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 50.16  E-value: 3.76e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 514052675 158 SLKHLCRKALRSFL---TTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03587    4 SLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 18-57 2.10e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 514052675    18 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 57
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
20-57 4.24e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 4.24e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 514052675   20 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 57
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 157-192 1.64e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 46.05  E-value: 1.64e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 514052675 157 SSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 192
Cdd:cd03717    4 RSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 157-192 2.01e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.48  E-value: 2.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 514052675   157 SSLKHLCRKALRSFLttYQVLALPIPKKMKEFLTYR 192
Cdd:smart00969   1 RSLQHLCRLAIRRSL--GGIDKLPLPPRLKDYLLYY 34
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 158-190 1.14e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.00  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 514052675  158 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 190
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 158-192 3.51e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 39.79  E-value: 3.51e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 514052675 158 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLTYR 192
Cdd:cd03716    5 SLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 82-110 2.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.44e-04
                           10        20
                   ....*....|....*....|....*....
gi 514052675    82 HISSLRSVCFSPEGLYLATVADDRLLRIW 110
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
SOCS_SOCS3 cd03737
SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the ...
 156-189 1.34e-03

SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the down-regulation of the JAK/STAT pathway. SOCS3 inhibits JAK activity indirectly through recruitment to the cytokine receptors. SOCS3 has been shown to play an essential role in placental development and a non-essential role in embryo development. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239706  Cd Length: 42  Bit Score: 35.32  E-value: 1.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 514052675 156 LSSLKHLCRKALRSFLTTYQ-VLALPIPkkMKEFL 189
Cdd:cd03737    3 VSTLQHLCRKTVNGHLDSYEkRTQLPLP--IKEFL 35
WD40 pfam00400
WD domain, G-beta repeat;
82-110 1.64e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*....
gi 514052675   82 HISSLRSVCFSPEGLYLATVADDRLLRIW 110
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 158-194 3.09e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.44  E-value: 3.09e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 514052675 158 SLKHLCRKALRSflTTYQVLALPIPKKMKEFLTYRTF 194
Cdd:cd03736    5 SLQHLCRITINK--CTRQIQELPLPTRLKDYLTEYTY 39
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 158-189 4.68e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 33.93  E-value: 4.68e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 514052675 158 SLKHLCRKALRSFLTTYQVLALPIPKKMKEFL 189
Cdd:cd03740    5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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