NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|501354967|ref|NP_001265147|]
View 

protein dispatched homolog 1 [Mus musculus]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033   289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033   363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033   416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033   462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033   526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033   592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033   672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                         650
                  ....*....|
gi 501354967 1125 FQCLCRCLGP 1134
Cdd:COG1033   752 LPALLLLLDP 761
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033   289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033   363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033   416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033   462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033   526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033   592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033   672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                         650
                  ....*....|
gi 501354967 1125 FQCLCRCLGP 1134
Cdd:COG1033   752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 434-1114 3.51e-23

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 107.06  E-value: 3.51e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   434 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 510
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   511 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 577
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   578 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   656 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 731
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   732 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 808
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   809 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 884
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   885 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 959
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   960 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 1039
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501354967  1040 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 1114
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 977-1154 1.25e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   977 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 1048
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  1049 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 1125
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 501354967  1126 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 1154
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
495-1134 1.91e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 171.20  E-value: 1.91e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  495 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 572
Cdd:COG1033   212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  573 A-FVLcdvwnyTKFDKPRAETS---EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMV 648
Cdd:COG1033   289 GiHLL------NRYREERRKGLdkrEALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSL 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  649 TWLPAVIVLheryllniftcFRKPQPQaydkscwavlcqkcRRVLFAVSEASRIFfeKVLPCIVIKFRYLWLIWFLALTV 728
Cdd:COG1033   363 TLLPALLSL-----------LPRPKPK--------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAV 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  729 GGAYIVcvnPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeL 808
Cdd:COG1033   416 VSLYGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------V 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  809 TLDSTFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcI 888
Cdd:COG1033   462 DTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----L 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  889 KKAIMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLSrgWFVS- 967
Cdd:COG1033   526 AQLLLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTg 591

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  968 -NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGL 1046
Cdd:COG1033   592 sAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGI 671

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967 1047 SVDFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:COG1033   672 GVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLL 751

                         650
                  ....*....|
gi 501354967 1125 FQCLCRCLGP 1134
Cdd:COG1033   752 LPALLLLLDP 761
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 434-1114 3.51e-23

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 107.06  E-value: 3.51e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   434 DFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 510
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   511 AIVLLIM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 577
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   578 DVWNYTkfdkpRAETS--EAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:pfam02460  301 AAWQRT-----TATLSvkKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIM 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   656 VLHERYLLNIFTCFRKPqPQAYDKSCWAVLCQKCRRVLfAVSEASRIFFEKVLPCI----VIKFRYLWLIWFLALTVGGa 731
Cdd:pfam02460  376 AICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEPDKSHN-IEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   732 yivCVNPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL--- 808
Cdd:pfam02460  453 ---CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnem 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   809 --TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevf 884
Cdd:pfam02460  513 vdEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA-------- 572

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   885 elcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapeg 959
Cdd:pfam02460  573 ---------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE---- 618

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   960 LSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVT 1039
Cdd:pfam02460  619 FNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMIT 698

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 501354967  1040 ISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 1114
Cdd:pfam02460  699 IIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
972-1125 1.59e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 85.30  E-value: 1.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  972 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1051
Cdd:COG1033   210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501354967 1052 VHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLVMCVSWAFATFFF 1125
Cdd:COG1033   290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
507-661 8.63e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 82.99  E-value: 8.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 585
Cdd:COG1033   612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501354967  586 DKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 661
Cdd:COG1033   687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 506-670 1.84e-14

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 72.23  E-value: 1.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   506 PAIAIAIVLLIMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfnfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 585
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   586 DKPraeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHER----Y 661
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143


                   ....*....
gi 501354967   662 LLNIFTCFR 670
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 977-1154 1.25e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 66.56  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   977 SLSDGTLIAMGLSVAVAFSVMLL---TTWNIIISLyaIVSIAGTIFVTVGSLVLLGwELNVlesvtISVA-----VGLSV 1048
Cdd:TIGR03480  266 TVSEGATVAGLLSFVLVLVLLWLalrSPRLVFAVL--VTLIVGLILTAAFATLAVG-HLNL-----ISVAfavlfIGLGV 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  1049 DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 1125
Cdd:TIGR03480  338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416

                          170       180
                   ....*....|....*....|....*....
gi 501354967  1126 QCLCRCLGPQGTCGQIPFPTKLQCSPFSH 1154
Cdd:TIGR03480  417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 451-657 8.48e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 63.70  E-value: 8.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   451 SMLFSPTEKgESMMNIYLDNFENWNSSDGIT-TVTG--IEFGIKHSLFQDYLLMDTVYPAIAIAIVLLImcVY---TKSM 524
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   525 FiTLMTMFAIISSLIVSYFLYRVVFnfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPRAETS--EAVSVTLQ 601
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 501354967   602 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 657
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 454-1081 1.04e-09

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.39  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   454 FSPTEKGESMM---NIYLDNFENWNSSDGITTVTgieFGIKHSLfQDYLLMDTVYPAIAIAIVLLIMCVYT--------- 521
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   522 -KSMFITLMTMFAIISSLIVsyfLYRVVFNFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 585
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   586 DKPRAETSE-AVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HER 660
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   661 YLLNIFTCFRKPQPqayDKSCWAVLCQKCRRVLFavseasrIFFEKVLPCIVIK--FRYLWLIWFLALTVGG-AYIVCVN 737
Cdd:TIGR00917  755 KRVDCFPCIKTSKS---SISAEKGSGQRKAGLLT-------RYFKEVYAPVLLHwiVKIVVIAFFVGLLMAGiALSTRVE 824

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   738 P----KMKLPSleLSEFQVFRSShpferydaefkklfMFERVHHGEELHMPI------TVIWGVSPEDSGDPLNPKSKGE 807
Cdd:TIGR00917  825 IgldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIkgdynyTDFESQNKLCTMGGCDKDSIVN 888

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   808 LTLDSTFnIASPASqAWILHF-----------CQKLRNQTFFHQTEQQDFtSCFIET-----------FKQWMENQDCDE 865
Cdd:TIGR00917  889 VFNNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNAL 965

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   866 PAlyPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTpgpRFDINDTIRAvVLEFQSTFLFTLAYE--KMQQFYK 943
Cdd:TIGR00917  966 PS--ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNT---QVDFINAMRA-AQEFAAKVSRSSKMEvyPYSVFYV 1039

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   944 evdswishelssapeglsrgwfvsnleFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIVSIAGTIFVTV 1022
Cdd:TIGR00917 1040 ---------------------------FFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCV 1092

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 501354967  1023 GSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAI 1081
Cdd:TIGR00917 1093 GIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 970-1108 6.78e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 60.55  E-value: 6.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  970 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLV--------LLGWELNVLESVT-- 1039
Cdd:COG2409   507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967 1040 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRMGSAIAMAAL---TTFVAgamMMPSTVLAYTQL 1106
Cdd:COG2409   587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRVITSAALimaAVFAA---FATSPLVFLKQI 657


                  ..
gi 501354967 1107 GT 1108
Cdd:COG2409   658 GF 659
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 973-1109 1.37e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   973 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 1048
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 501354967  1049 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 1109
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
528-680 3.56e-07

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 55.27  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   528 LMTMFAIISSLIVSYFLyRVVFN---FEFFPFMNLtaliilvGIGADDAFVLCDVWNYTKfdkPRAETSEAVSVTLQHAA 604
Cdd:TIGR00918  435 LLVALSVAAGLGLCALL-GISFNaatTQVLPFLAL-------GVGVDDVFLLAHAFSETG---QNIPFEERTGECLKRTG 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   605 LSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFRKP-------- 672
Cdd:TIGR00918  504 ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSPcsarviqi 583


                   ....*...
gi 501354967   673 QPQAYDKS 680
Cdd:TIGR00918  584 EPQAYADG 591
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 507-657 2.40e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 52.31  E-value: 2.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSyflyrvvfnFEFFPFM----NL--TALIIL-VGIGADDAFVLCdv 579
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILT---------AAFATLAvghlNLisVAFAVLfIGLGVDFAIQFS-- 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   580 wnyTKFDKPR---AETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIV 656
Cdd:TIGR03480  345 ---LRYREERfrgGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLR 421


                   .
gi 501354967   657 L 657
Cdd:TIGR03480  422 L 422
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 507-702 3.15e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 3.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSlivsyflyrVVFNFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 578
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   579 vwnyTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 501354967   656 VL--HERYLLNIFTCFRKPQPQAYDKSCWAVLCQKCRRVLFAVSEASRI 702
Cdd:TIGR00921  345 QSidIGREKVKKEIIAIGGKSSEIEEELSKVLSITVRHPVPALVAALII 393
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 507-674 7.40e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 50.74  E-value: 7.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 581
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   582 YTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 661
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335

                          170
                   ....*....|...
gi 501354967   662 LLniftcFRKPQP 674
Cdd:TIGR00833  336 GL-----MKPGRK 343
COG4258 COG4258
Predicted exporter [General function prediction only];
1041-1125 1.68e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967 1041 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRMGSAIAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLVMCVSW 1118
Cdd:COG4258   310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383


                  ....*..
gi 501354967 1119 AFATFFF 1125
Cdd:COG4258   384 LTTLLWL 390
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 507-657 1.78e-05

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 48.83  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   507 AIAIAIVLLIMCVYTKSMFITLMTMFAIISSL-----IVSYFLYRVVFNFEFFPFMNLTalIILVGIGADDAFVLcdvwn 581
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgLVAILAHILGIGLSTFALNLLV--VLLIAVGTDYALFL----- 221

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 501354967   582 YTKFDKPRAE---TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 657
Cdd:pfam03176  222 VSRYREELRAgedREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 971-1123 4.18e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 48.29  E-value: 4.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   971 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 1050
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501354967  1051 AVHygVAYRLAPDPDREGKV---IFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLVMCVSWAFATF 1123
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 972-1124 1.09e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 46.75  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   972 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1051
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 501354967  1052 VHYGVAYRlapDPDREGK-----VIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 1124
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 971-1109 2.80e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 45.53  E-value: 2.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  971 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 1046
Cdd:COG2409   160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 501354967 1047 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRMGSAIAMAALTtfVAGAMMmpstVLAYTQLGTF 1109
Cdd:COG2409   239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
COG4258 COG4258
Predicted exporter [General function prediction only];
986-1088 7.02e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  986 MGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 1065
Cdd:COG4258   645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718

                          90       100
                  ....*....|....*....|...
gi 501354967 1066 REGkvifSLSRMGSAIAMAALTT 1088
Cdd:COG4258   719 DKG----ELARTLLSILLAALTT 737
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
983-1098 1.46e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 43.33  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967   983 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIVSIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 1059
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 501354967  1060 LAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPS 1098
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 507-657 2.19e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.45  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  507 AIAIAIVLLIMcVYtKS---MFITLMT-MFAIISSLIVSYFLYRVvfnFEFFPFMNLTALIILVGIGADDA-FVLcdvwn 581
Cdd:COG2409   178 TLPVALVVLLL-VF-RSlvaALLPLLTaGLAVGVALGLLALLAAF---TDVSSFAPNLLTMLGLGVGIDYAlFLV----- 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  582 yTKFdkpRAE------TSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVI 655
Cdd:COG2409   248 -SRY---REElragedREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALL 323


                  ..
gi 501354967  656 VL 657
Cdd:COG2409   324 AL 325
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 490-657 7.64e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 40.90  E-value: 7.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  490 IKHSLFQDYLLMdtVypAIAIAIVLLIMCVYTKSMFI----TLMTMFAIISSLIVSYFLY---RVVFNFE------FFPF 556
Cdd:COG2409   511 ISDALADDLPLV--I--PVVLGLIFLLLLLLFRSVVAplkaVLTNLLSLGAALGVLVLVFqhgWLLLGFTpgpldsFVPL 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 501354967  557 MnltALIILVGIGAD-DAFVLCDVW-NYTKfdkpRAETSEAVSVTLQH-------AALSMFVTsFttaAAFyanYVSNIT 627
Cdd:COG2409   587 L---LFVILFGLGMDyEVFLVSRIReEYDR----GGGTREAVIRGLARtgrvitsAALIMAAV-F---AAF---ATSPLV 652

                         170       180       190
                  ....*....|....*....|....*....|.
gi 501354967  628 AIRCFGVYAGTAILVNYVLMVTWL-PAVIVL 657
Cdd:COG2409   653 FLKQIGFGLAVGVLLDAFVVRMLLvPALMAL 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH