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Conserved domains on  [gi|503774352|ref|NP_001265138|]
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nuclear pore complex protein Nup153 isoform 1 [Homo sapiens]

Protein Classification

zinc finger Ran-binding domain-containing protein( domain architecture ID 13755483)

zinc finger Ran-binding domain-containing protein similar to Arabidopsis thaliana chloroplastic zinc finger protein VAR3, which is involved in C-to-U editing of chloroplastic RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-652 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


:

Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 731.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEErqgltvlpklissscaqaiipswplkvlrlQEMEVPVLPKISLPITS 512
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEED------------------------------EVVEVPVLPKISLPIST 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   513 SSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELS 591
Cdd:pfam08604  369 ASLPTFNFSSPTSSTSSSSPPSVTKSAENKAQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELS 448

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503774352   592 GSSSTLEPIISSSAHhvTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPK 652
Cdd:pfam08604  449 GSSGTSVVSVVSTET--TTVNSTSNKKEEEEEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1417-1506 1.56e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


:

Pssm-ID: 371156  Cd Length: 86  Bit Score: 81.65  E-value: 1.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1417 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1496
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 503774352  1497 KIKTAVRRRK 1506
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
754-782 2.32e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.32e-09
                           10        20
                   ....*....|....*....|....*....
gi 503774352   754 IGTWDCDTCLVQNKPEAIKCVACETPKPG 782
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
882-911 9.22e-09

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.22e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   882 PEGSWDCELCLVQNKADSTKCLACESAKPG 911
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
824-853 1.02e-08

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   824 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 853
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
692-718 3.84e-07

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.84e-07
                           10        20
                   ....*....|....*....|....*..
gi 503774352   692 SWQCDTCLLQNKVTDNKCIACQAAKLS 718
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
Chi1 super family cl43877
Chitinase [Carbohydrate transport and metabolism];
1292-1468 3.74e-05

Chitinase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3469:

Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1292 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1371
Cdd:COG3469    37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1372 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1451
Cdd:COG3469   117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                         170
                  ....*....|....*..
gi 503774352 1452 SSTPAASAQPSGSGGFP 1468
Cdd:COG3469   197 SATTTATTTGPPTPGLP 213
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-652 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 731.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEErqgltvlpklissscaqaiipswplkvlrlQEMEVPVLPKISLPITS 512
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEED------------------------------EVVEVPVLPKISLPIST 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   513 SSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELS 591
Cdd:pfam08604  369 ASLPTFNFSSPTSSTSSSSPPSVTKSAENKAQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELS 448

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503774352   592 GSSSTLEPIISSSAHhvTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPK 652
Cdd:pfam08604  449 GSSGTSVVSVVSTET--TTVNSTSNKKEEEEEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1417-1506 1.56e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 81.65  E-value: 1.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1417 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1496
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 503774352  1497 KIKTAVRRRK 1506
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
754-782 2.32e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.32e-09
                           10        20
                   ....*....|....*....|....*....
gi 503774352   754 IGTWDCDTCLVQNKPEAIKCVACETPKPG 782
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
882-911 9.22e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.22e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   882 PEGSWDCELCLVQNKADSTKCLACESAKPG 911
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
824-853 1.02e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   824 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 853
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
692-718 3.84e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.84e-07
                           10        20
                   ....*....|....*....|....*..
gi 503774352   692 SWQCDTCLLQNKVTDNKCIACQAAKLS 718
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 755-779 8.02e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 8.02e-06
                            10        20
                    ....*....|....*....|....*
gi 503774352    755 GTWDCDTCLVQNKPEAIKCVACETP 779
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1292-1468 3.74e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1292 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1371
Cdd:COG3469    37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1372 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1451
Cdd:COG3469   117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                         170
                  ....*....|....*..
gi 503774352 1452 SSTPAASAQPSGSGGFP 1468
Cdd:COG3469   197 SATTTATTTGPPTPGLP 213
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
 1296-1472 1.61e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 46.20  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1296 STGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSS--------------------FVFGTgPSAPSASPAFGANQT 1355
Cdd:pfam15967   12 STATAGGGFSFGAAAASNPGSTGGFSFGTLGAAPAATATtttatlglggglfgqkpatgFTFGT-PASSTAATGPTGLTL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1356 PTFGQSQGASQPNPPGFGSISSST---ALFPTGSQPAPPTFGTVSSSSQPPvfgQQPSQSAFGSGTTPNSSSAFQFG--- 1429
Cdd:pfam15967   91 GTPAATTAASTGFSLGFNKPAASAtpfSLPASSTSGGGLSLGSVLTSTAAQ---QGATGFTLNLGGTPATTTAVSTGlsl 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 503774352  1430 ----SSTTNFNFTNNSPSGV------FTFGANSSTPAASAQPS-GSGGFPFNQS 1472
Cdd:pfam15967  168 gstlTSLGGSLFQNTNSTGLgqttlgLTLLATSTAPVSAPAASeGLGGLDFSTS 221
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 691-714 2.68e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.61  E-value: 2.68e-04
                            10        20
                    ....*....|....*....|....
gi 503774352    691 SSWQCDTCLLQNKVTDNKCIACQA 714
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 884-906 3.33e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 3.33e-04
                            10        20
                    ....*....|....*....|...
gi 503774352    884 GSWDCELCLVQNKADSTKCLACE 906
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 826-847 1.52e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.30  E-value: 1.52e-03
                            10        20
                    ....*....|....*....|..
gi 503774352    826 GSWECSVCCVSNNAEDNKCVSC 847
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
 
Name Accession Description Interval E-value
Nup153 pfam08604
Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and ...
 113-652 0e+00

Nucleoporin Nup153-like; This family contains both the nucleoporin Nup153 from human and Nup154 from fission yeast. These have been demonstrated to be functionally equivalent.


Pssm-ID: 462533 [Multi-domain]  Cd Length: 507  Bit Score: 731.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   113 PSTTSTASNYPDVLTRPSLHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 192
Cdd:pfam08604    1 PSTSRSALNFQDVLTRPSLHRSHLNFTVLDSPALFCQPSTSTAFPIGSSGFSLVKEIKDSTSQHDDDNISTTSGFSSRAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   193 DKDITVSKNTSLPPLWSPEAERSHSLSQHTATSSKKPAFNLSAFGTLSPSLGNSSILKTSQLGDSPFYPGKTTYGGaAAA 272
Cdd:pfam08604   81 DKDIPVSKTVSLPLLWSPEAERSHSLSQHSASSSKKPAFNLSAFGTLSPSLGNSSVLNTSQLGDSPFYPGKTTYGG-AAA 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   273 VRQSKLRNTPYQAPVRRQMKAKQLSAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSIVSSPLNSPLDRSGIDITDFQA 352
Cdd:pfam08604  160 VRSSRVRGTPYQAPVRRQIKAKPANAQSYGVTSSTARRILQSLEKMSSPLADAKRIPSTVSSPLSSPLDRSDLDITNFQS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   353 KREKVDSQYPPVQRLMTPKPVSIATNRSVYFKPSLTPSGEFRKTNQRIDNKCSTgYEKNMTPGQNREQRESGFSYPNFSL 432
Cdd:pfam08604  240 KRKKVDSQYPPVQKLVTPKAISVSGNRSVYFKPSLTPSGQSNKTSRRVDKDHRE-TEVRQSPEQAVEPSESSLSYPKFST 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   433 PAANGLSSGVGGGGGKMRRERTRFVASKPLEEErqgltvlpklissscaqaiipswplkvlrlQEMEVPVLPKISLPITS 512
Cdd:pfam08604  319 PASNSLSSGGNGGGGKMRRERGRRPSSKPAEED------------------------------EVVEVPVLPKISLPIST 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352   513 SSLPTFNFSSPEITTSSPSPINSSQALTNKVQMTSPSSTGSPMFKFSSPIVKSTEANVLPP-SSIGFTFSVPVAKTAELS 591
Cdd:pfam08604  369 ASLPTFNFSSPTSSTSSSSPPSVTKSAENKAQKQPPSTSGSPAFTFSSPIVKSTEASVPPPsPSIGFTFSVPVAKTAELS 448

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 503774352   592 GSSSTLEPIISSSAHhvTTVNSTNCKKTPPEDCEGPFRPAEILKEGSVLDILKSPGFASPK 652
Cdd:pfam08604  449 GSSGTSVVSVVSTET--TTVNSTSNKKEEEEEFEGPFKPAKVLKQGSVLDILKSPGFASPK 507
Nup_retrotrp_bd pfam10599
Retro-transposon transporting motif; This is the highly conserved C-terminal motif ...
 1417-1506 1.56e-18

Retro-transposon transporting motif; This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organizms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localization signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity.


Pssm-ID: 371156  Cd Length: 86  Bit Score: 81.65  E-value: 1.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1417 GTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPAASAQPSGSGGFPFNQSPAAFTVGSNGKNvfsssGTSFSGR 1496
Cdd:pfam10599    2 EGTPDPASVFGFGSSNTNFNFTNNNPSTPFGFGASPSTPQAANPPSAFTPPAFSQSPASFNVGSNGSN-----MFSVSGR 76

                           90
                   ....*....|
gi 503774352  1497 KIKTAVRRRK 1506
Cdd:pfam10599   77 KIAQMRRRRR 86
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
754-782 2.32e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 53.90  E-value: 2.32e-09
                           10        20
                   ....*....|....*....|....*....
gi 503774352   754 IGTWDCDTCLVQNKPEAIKCVACETPKPG 782
Cdd:pfam00641    2 EGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
882-911 9.22e-09

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 9.22e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   882 PEGSWDCELCLVQNKADSTKCLACESAKPG 911
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
824-853 1.02e-08

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 51.97  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 503774352   824 PIGSWECSVCCVSNNAEDNKCVSCMSEKPG 853
Cdd:pfam00641    1 REGDWDCSKCLVQNFATSTKCVACQAPKPD 30
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
692-718 3.84e-07

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 47.73  E-value: 3.84e-07
                           10        20
                   ....*....|....*....|....*..
gi 503774352   692 SWQCDTCLLQNKVTDNKCIACQAAKLS 718
Cdd:pfam00641    4 DWDCSKCLVQNFATSTKCVACQAPKPD 30
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 755-779 8.02e-06

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 43.85  E-value: 8.02e-06
                            10        20
                    ....*....|....*....|....*
gi 503774352    755 GTWDCDTCLVQNKPEAIKCVACETP 779
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGAP 25
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1292-1468 3.74e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1292 ATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG 1371
Cdd:COG3469    37 ATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1372 FGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGAN 1451
Cdd:COG3469   117 TGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTP 196

                         170
                  ....*....|....*..
gi 503774352 1452 SSTPAASAQPSGSGGFP 1468
Cdd:COG3469   197 SATTTATTTGPPTPGLP 213
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
 1296-1472 1.61e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 46.20  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1296 STGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSS--------------------FVFGTgPSAPSASPAFGANQT 1355
Cdd:pfam15967   12 STATAGGGFSFGAAAASNPGSTGGFSFGTLGAAPAATATtttatlglggglfgqkpatgFTFGT-PASSTAATGPTGLTL 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352  1356 PTFGQSQGASQPNPPGFGSISSST---ALFPTGSQPAPPTFGTVSSSSQPPvfgQQPSQSAFGSGTTPNSSSAFQFG--- 1429
Cdd:pfam15967   91 GTPAATTAASTGFSLGFNKPAASAtpfSLPASSTSGGGLSLGSVLTSTAAQ---QGATGFTLNLGGTPATTTAVSTGlsl 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 503774352  1430 ----SSTTNFNFTNNSPSGV------FTFGANSSTPAASAQPS-GSGGFPFNQS 1472
Cdd:pfam15967  168 gstlTSLGGSLFQNTNSTGLgqttlgLTLLATSTAPVSAPAASeGLGGLDFSTS 221
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 691-714 2.68e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.61  E-value: 2.68e-04
                            10        20
                    ....*....|....*....|....
gi 503774352    691 SSWQCDTCLLQNKVTDNKCIACQA 714
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACGA 24
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 884-906 3.33e-04

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 39.22  E-value: 3.33e-04
                            10        20
                    ....*....|....*....|...
gi 503774352    884 GSWDCELCLVQNKADSTKCLACE 906
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFACG 23
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 826-847 1.52e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 37.30  E-value: 1.52e-03
                            10        20
                    ....*....|....*....|..
gi 503774352    826 GSWECSVCCVSNNAEDNKCVSC 847
Cdd:smart00547    1 GDWECPACTFLNFASRSKCFAC 22
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1239-1425 3.51e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.66  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1239 GGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLL----FSQDSKLATTSSTGTAVTPFVFGPGASSNN 1314
Cdd:COG3469    24 GAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTaatsSTTSTTATATAAAAAATSTSATLVATSTAS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1315 TTTSGFGFGATTTSSSAGssfvfGTGPSAPSASPAFGANQTPTFGQSQGASQPNPPG--FGSISSSTALFPTGSQPAPPT 1392
Cdd:COG3469   104 GANTGTSTVTTTSTGAGS-----VTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGteTATGGTTTTSTTTTTTSASTT 178

                         170       180       190
                  ....*....|....*....|....*....|...
gi 503774352 1393 FGTVSSSSQPPVFGQQPSQSAFGSGTTPNSSSA 1425
Cdd:COG3469   179 PSATTTATATTASGATTPSATTTATTTGPPTPG 211
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1205-1403 7.00e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1205 GAQTSTTADQGAAKPVFSFLNNSSSSSSTPATSAGG-GIFGSSTSSSNPPVATFVFGQSSNPVSSSAFG-NTAESSTSQS 1282
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGsVVVAASGSAGSGTGTTAASSTAATSSTTSTTAtATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503774352 1283 LLFSQDSKLATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASPAF--GANQTPTFGq 1360
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETAtgGTTTTSTTT- 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 503774352 1361 sQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVSSSSQPP 1403
Cdd:COG3469   171 -TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGL 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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