NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446711828|ref|NP_001263312|]
View 

sphingosine-1-phosphate transporter SPNS2 isoform 2 [Mus musculus]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-369 2.19e-160

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 456.70  E-value: 2.19e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17328   48 MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIR 160
Cdd:cd17328  126 GVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17328  206 NPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLG 320
Cdd:cd17328  278 TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLG 357

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLIRQStKDSPLWEFLSLGYALMLCPFVVVLGGMFFL 369
Cdd:cd17328  358 DAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-369 2.19e-160

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 456.70  E-value: 2.19e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17328   48 MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIR 160
Cdd:cd17328  126 GVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17328  206 NPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLG 320
Cdd:cd17328  278 TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLG 357

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLIRQStKDSPLWEFLSLGYALMLCPFVVVLGGMFFL 369
Cdd:cd17328  358 DAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-369 5.24e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.31  E-value: 5.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG2271   59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRAL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalir 160
Cdd:COG2271  137 GIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGLPGLLLALLRFWLL------------------------------ 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 nrsyvfsSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLR 240
Cdd:COG2271  186 -------ALAYFLVYFALYGFLTWLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQRADPLVCAVGMLGSAIFICLIFVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLG 320
Cdd:COG2271  243 LGRRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLG 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLirqstkdsplwefLSLGYALMLCPFVVVLGGMFFL 369
Cdd:COG2271  320 GALGPLLVGYLLDA-------------TGYQAAFLLLAALALLAALLAL 355
MFS_1 pfam07690
Major Facilitator Superfamily;
2-318 7.70e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.84  E-value: 7.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:pfam07690  47 LAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALG 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   82 VFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRN 161
Cdd:pfam07690 125 LVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  162 RSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRT 241
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446711828  242 QRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 318
Cdd:pfam07690 268 LL---LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 8-363 2.14e-09

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 58.89  E-value: 2.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    8 GYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAI 87
Cdd:TIGR00893  50 GWLLDRFGARKTLAVFIVIWGVFTGLQAFA--GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQ 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   88 PLGSGLGY-ITGSSVkqAAGDWHWALRVSPVLGMITGTLILILVP----------------ATKRGHADQLGGQlkARTS 150
Cdd:TIGR00893 128 GLGGIIGGpLVGWIL--IHFSWQWAFIIEGVLGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTP 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  151 WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTG 230
Cdd:TIGR00893 204 KKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILG 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  231 AGATRWCRLRTQR---ADPLVCAVGMLGS-AIFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRA 306
Cdd:TIGR00893 272 GRLSDLLLRRGKSlvfARKTAIIAGLVLSlLMFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNI 344

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  307 TAVALQSFtsHLLGDAGS---PYLIGFIsdlirQSTKDSPLWEFLSLGYALMLCPFVVVL 363
Cdd:TIGR00893 345 AGLTGGLI--NSLGNLGGivgPIVIGAI-----AATTGSFAGALMVVAALALIGALSYLL 397
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-369 2.19e-160

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 456.70  E-value: 2.19e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17328   48 MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIR 160
Cdd:cd17328  126 GVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17328  206 NPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLG 320
Cdd:cd17328  278 TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLG 357

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLIRQStKDSPLWEFLSLGYALMLCPFVVVLGGMFFL 369
Cdd:cd17328  358 DAGSPYLIGLISDLLRQN-KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-364 7.38e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 93.02  E-value: 7.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17325   45 LLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAM 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSwlrdMKALIR 160
Cdd:cd17325  123 GIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSG----LRLLLR 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETCnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17325  198 DRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQI---------GLLFGAQGLASALSQPPAGKLSDRIGRKP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 tqradplVCAVGMLGSAI-FICLIFVAAKTSIVGAYICIFVGETLLFSnwAITAdILMYVVIPTRRATAVALQSfTSHLL 319
Cdd:cd17325  267 -------LILIGLLLSAVaLLLLPLATSFWLLLLLLALLGLGLGLVFP--ATLA-LLADIVPPEGRGTAMGLFN-TAFSL 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446711828 320 GDAGSPYLIGFISDLIrqstkdSPLWEFLSLGYALMLCPFVVVLG 364
Cdd:cd17325  336 GMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAVLFLLL 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-369 5.24e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.31  E-value: 5.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG2271   59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRAL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalir 160
Cdd:COG2271  137 GIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGLPGLLLALLRFWLL------------------------------ 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 nrsyvfsSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLR 240
Cdd:COG2271  186 -------ALAYFLVYFALYGFLTWLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQRADPLVCAVGMLGSAIFICLIFVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLG 320
Cdd:COG2271  243 LGRRRKLVLAIGLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLG 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLirqstkdsplwefLSLGYALMLCPFVVVLGGMFFL 369
Cdd:COG2271  320 GALGPLLVGYLLDA-------------TGYQAAFLLLAALALLAALLAL 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-369 5.90e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 84.79  E-value: 5.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd06174   45 ALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAG-DWHWALRVSPVLGMITGTLILILVPATKrgHADQLGGQLKARTSWLRDMKALI 159
Cdd:cd06174  123 GLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLLKRVL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 160 RNRSYVFSSLATSAVSFATGALGMWIPLYLHRaqvvqktaetcnsppCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRL 239
Cdd:cd06174  201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD---------------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 240 RTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADIlmyvVIPTRRATAVALQSFTSHlL 319
Cdd:cd06174  266 LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL----FPPEIRGTAFGLLNTFGF-L 340

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 446711828 320 GDAGSPYLIGFISDlirqstkdsplwEFLSLGYALMLCPFVVVLGGMFFL 369
Cdd:cd06174  341 GGAIGPLLAGFLLA------------ATFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-322 3.76e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.94  E-value: 3.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG2814   59 ALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRghadqlggqlKARTSWLRDMKALIR 160
Cdd:COG2814  137 GLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLR 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAEtcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA-----------GLLLALFGLGGVLGALLAGRLADRFGRRR 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 tqradplVCAVGMLGSAIFICLIFVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLG 320
Cdd:COG2814  275 -------LLLIGLLLLALGLLLLALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                 ..
gi 446711828 321 DA 322
Cdd:COG2814  346 PL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
2-318 7.70e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.84  E-value: 7.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:pfam07690  47 LAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALG 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   82 VFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRN 161
Cdd:pfam07690 125 LVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  162 RSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRT 241
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446711828  242 QRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 318
Cdd:pfam07690 268 LL---LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 8-363 7.02e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.14  E-value: 7.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   8 GYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAI 87
Cdd:cd17319   59 GWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  88 PLGSGLGYITGSSVkQAAGDWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFS 167
Cdd:cd17319  137 PLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAVLWWFYL-------------------------------RQVWGL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 168 SLATSAVSFATGALGMWIPLYLHRAqvvqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPL 247
Cdd:cd17319  185 ALGYFGINYALYGLLTWLPTYLKQA---------------RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 248 VCAVGMLGSAIFICLIFVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGdAGSPYL 327
Cdd:cd17319  250 VIIIGLLLAAVGLLLAYLT--TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLL 326

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 446711828 328 IGFISDlirqsTKDSPLWEFLSLGyALMLCPFVVVL 363
Cdd:cd17319  327 IGYLVD-----ATGSYTAAFLFLA-AVALLAALLVL 356
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-191 2.23e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 64.88  E-value: 2.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17324   48 ALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHADQLGgqlkartsWLRDMKALIR 160
Cdd:cd17324  126 GLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG--------LLSSLLLLLR 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHR 191
Cdd:cd17324  197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-332 8.46e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.92  E-value: 8.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17316   50 PIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGDWhWALRVSPVLGMITGTLILILVPATkrghadqlggqlkartswlrdmkalir 160
Cdd:cd17316  128 GLLQSGWALGALLAALVASLLIPLLSGD-WGWRILFLIGALPALLALLLRRRT--------------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 nrsyVFSSLATSAVSFATGALGMWIPLYLhraqvvqktAETCNSPPcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17316  180 ----LLLILLWFFISFGYYGLTTFLPTYL---------QTVLGLSP--ATSSLYLLLISLGALVGALIAGLLSDRIGRKK 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TQradplvcAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAItADILMYVVIPTR-RATAVALQSFTSHLL 319
Cdd:cd17316  245 TL-------VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGA-LYAYLAELFPTEvRATGVGLSYNLGRLG 316

                        330
                 ....*....|...
gi 446711828 320 GdAGSPYLIGFIS 332
Cdd:cd17316  317 G-GGAPPLIALLL 328
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-363 1.15e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 59.51  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:cd17474   49 VLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  82 VFYFAIPLGSGLGYITGSSVkqAAGDWHWALRVSPVLGMITGTLILILVPATKRghadqlgGQLKARTSWLRDMKALIRN 161
Cdd:cd17474  127 LYEAALGLGIAVGPLLGGLL--AAISWRYPFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRG 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 162 RSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnsppcgakDSLIFGAITCFTGFLGVVTGAGATRWCRLRT 241
Cdd:cd17474  198 RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGI---------------SPIIIGLLFAGWSVLLALGSLFVGRLLKKRF 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 242 QRADPLVcaVGMLGSAIFICLIFVAakTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTsHLLGD 321
Cdd:cd17474  263 GARRILV--IGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV-RFLGQ 337

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446711828 322 AGSPYLIGFISDLIrqstkdSPLWEFLSLGyALMLCPFVVVL 363
Cdd:cd17474  338 AVGPLLFGLLLEIF------GLSAPFLVGA-AIALAAAVLLA 372
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-233 1.29e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 58.67  E-value: 1.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG0477   63 AIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRAL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIR 160
Cdd:COG0477  141 GLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGA 233
Cdd:COG0477  219 LLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 8-363 2.14e-09

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 58.89  E-value: 2.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    8 GYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAI 87
Cdd:TIGR00893  50 GWLLDRFGARKTLAVFIVIWGVFTGLQAFA--GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQ 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   88 PLGSGLGY-ITGSSVkqAAGDWHWALRVSPVLGMITGTLILILVP----------------ATKRGHADQLGGQlkARTS 150
Cdd:TIGR00893 128 GLGGIIGGpLVGWIL--IHFSWQWAFIIEGVLGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTP 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  151 WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTG 230
Cdd:TIGR00893 204 KKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILG 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  231 AGATRWCRLRTQR---ADPLVCAVGMLGS-AIFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRA 306
Cdd:TIGR00893 272 GRLSDLLLRRGKSlvfARKTAIIAGLVLSlLMFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNI 344

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  307 TAVALQSFtsHLLGDAGS---PYLIGFIsdlirQSTKDSPLWEFLSLGYALMLCPFVVVL 363
Cdd:TIGR00893 345 AGLTGGLI--NSLGNLGGivgPIVIGAI-----AATTGSFAGALMVVAALALIGALSYLL 397
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-153 3.54e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.97  E-value: 3.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVkqAAGDWHWalrvsPVLGMITGTLILILV------PATKRGHADQLGGQLKARTSWLR 153
Cdd:cd17473  127 GLQSAAMSLGGVVFLLLGGAL--AEIGWRA-----PFLVYLLALPVLILVllflpePARKSKSAASPGAATAAALPWKR 198
Sugar_tr pfam00083
Sugar (and other) transporter;
1-131 1.50e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 56.13  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQY-FWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLM 79
Cdd:pfam00083  60 FIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGAL 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446711828   80 LSVFYFAIPLGSGLGYITGSSVKQAAGDWHWalRVSPVLGMITGTLILILVP 131
Cdd:pfam00083 140 GSLYQLAITFGILLAYIFGLGLNKTSNSDGW--RIPLGLQLVPALLLIIGLL 189
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 8-281 1.80e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 55.64  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   8 GYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA-SYSTIApTIIGDLFTKNTRTLMLSVFYFA 86
Cdd:cd17380   55 GYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAG 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  87 IPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATkrghadqlggqlkartsWlrdmkALIrnrsyvf 166
Cdd:cd17380  134 SYLGTLLGGLIGPLLLEYYG-WPSVFYFFGLLGLLWALVWLIYLPPV-----------------W-----AII------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 167 ssLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgaKDSLIFGAITCFTGFL-GVVTGAGATRWC--RLRTQR 243
Cdd:cd17380  184 --VAHFCMNWGFYILLSWLPTYFHEVLVPL-------------AKGWVFNVVPWLVMFPsSNVAGWLADHLIsrGWTVTS 248

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446711828 244 ADPLVCAVGMLGSAifICLIFVAAKTSIVGAYICIFVG 281
Cdd:cd17380  249 VRKLMQSIGFLGPA--LFLLLLSHTDSFSLALLCMSVA 284
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-334 2.48e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG2223   54 ALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLAL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHAdqlggqlKARTSWLRDMKALIR 160
Cdd:COG2223  132 GLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------AAAKASLRDQLEALR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLH-RAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRL 239
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAATA------------GLLAALFALLGALGRPLGGWLSDRIGGR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 240 RTqradplvcAVGMLGSAIFICLIFVAAKTSIVGAYICIFVgetlLFSNWAITADILMYVV---IPTRRATAVALQSFTS 316
Cdd:COG2223  272 RV--------LLIVFALMALGLLLLALALGSLWLFLVLFLL----LGLALGGGNGAVFALVpdiFPTKNAGAVYGLVGAA 339

                        330
                 ....*....|....*...
gi 446711828 317 HLLGDAGSPYLIGFISDL 334
Cdd:COG2223  340 GGLGGFLGPLLFGALLDA 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-369 5.23e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.47  E-value: 5.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMl 80
Cdd:COG0738   57 LLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVspvlgMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIR 160
Cdd:COG0738  134 NLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPY-----LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:COG0738  209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL------------SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 241 TqradplVCAVGMLGSAIFIcLIFVAAKTSIVGAYICIFVGetLLFSNWAITADILMYVVIPTRRATAVALQSFTShLLG 320
Cdd:COG0738  277 R------LLRLSALLAAVGL-LLALLAPGPWLALIGLALVG--LGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVG 346

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 446711828 321 DAGSPYLIGFISDLIRqstkdsplwefLSLGYALMLCPFVVVLGGMFFL 369
Cdd:COG0738  347 GAIGPPLIGFLADAFG-----------LRAAFLVPLVCYLLILLLALAL 384
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 2-288 3.03e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.84  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  82 VFYFAIPLGSGLGYITGSSVKQAAGDW-HWALRVSPVLGMItgtLILILVPATKRGHADQlggqlkARTSWLRDMKALIR 160
Cdd:cd17329  128 LLYWAINLGVAIGPLLGGLLLLYSFRLlFLAAAVLFLLAAL---VLLFLLPETRPKRRAA------EKTEILRGYKIVLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 240
Cdd:cd17329  199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---------------ESLLGLLLALNALLIVLLQFPVARLVERF 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 446711828 241 TQRADPLVCAVGMlgSAIFICLIFVAAKTSIVGAYICIFVGETLLFSN 288
Cdd:cd17329  264 RLRKILMIGILLF--AIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 6-131 3.28e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 51.81  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   6 IFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYF 85
Cdd:cd17323   53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN--IAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSL 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446711828  86 AIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVP 131
Cdd:cd17323  131 GPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLP 175
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-188 1.08e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17489   45 LLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdwHWALRVSPVLGMITGTLILILVPATKRGHadqlggqlKARTSWLRDMKALIR 160
Cdd:cd17489  123 GYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVA--------AEEAEAGTRAFRRLV 192

                        170       180
                 ....*....|....*....|....*...
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLY 188
Cdd:cd17489  193 EKKVLPPALILFLASIAYGAISTFLPLY 220
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 6-189 1.33e-06

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 50.07  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    6 IFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYF 85
Cdd:TIGR00881  49 VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS--LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNC 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   86 AIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV---PATK----------RGHADQLGGQLKARTSWL 152
Cdd:TIGR00881 127 SHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLrdsPQSCglppaeempnEEPDGDAEKKEEELTKKQ 206

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 446711828  153 RDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYL 189
Cdd:TIGR00881 207 IFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYL 243
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 2-171 2.19e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.09  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLS 81
Cdd:cd17478   46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMS 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  82 VFYFAIPLGSGLGYITGSSVKQaagdwHWALRVSPVLGMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKAL 158
Cdd:cd17478  123 IFSVGGNLGFALGPLIAAALVA-----LFGGLGLLILLIIPGLAVALLllrLRPLKKPEAKKAAAKSSARSTLKGVWRAL 197

                        170
                 ....*....|....*....
gi 446711828 159 IR------NRSYVFSSLAT 171
Cdd:cd17478  198 LLlliivfLRSWVLSSLTT 216
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-148 3.95e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL-------FTK 73
Cdd:COG2211  278 LLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGR 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  74 NTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG---------DWHWALRVS----PVLGMITGTLILILVPATKRGHAdQ 140
Cdd:COG2211  358 RREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspSALTGIRLLffllPAVLLLLAALLLLFYPLTRERHA-E 436


                 ....*...
gi 446711828 141 LGGQLKAR 148
Cdd:COG2211  437 IRAELAAR 444
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-133 4.28e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.35  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17365   48 AIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAV 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALrvspVLGMITGTLILILVPAT 133
Cdd:cd17365  126 TLMFCGYPLGAALGGFLAAALIPAFG-WRSVF----LLGGVPPLILLPLLRGT 173
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-334 4.76e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 48.33  E-value: 4.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLML 80
Cdd:COG2807   67 GLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITgtlILILVPATKRGHADQlggqlkARTSWLRDMKALIR 160
Cdd:COG2807  144 GLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLA---LLLWLPLLRRRPAAA------AAAPAAASLRSLWR 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 161 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdslifGAITCFTGFLGVVTGAGATRWC-RL 239
Cdd:COG2807  214 SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA----------------GLLLSLFQLAGIPGSLLVPLLAdRL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 240 RTQRadPLVCAVGMLGSAIFICLIFVAAKTSIVGAyICIFVGETLLFSnwAITADILMYVVIPTRRATAVALQSFTSHLL 319
Cdd:COG2807  278 GDRR--PLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFP--LALTLIGLRARTPAEAAALSGMAQSVGYLL 352

                        330
                 ....*....|....*
gi 446711828 320 GdAGSPYLIGFISDL 334
Cdd:COG2807  353 A-ALGPLLVGALHDA 366
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-99 7.28e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.58  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17317   39 LIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVG 116

                         90       100
                 ....*....|....*....|...
gi 446711828  81 SVFYFAIPLG----SGLGYITGS 99
Cdd:cd17317  117 ILFGLFWALGymllALLAYLIRD 139
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 6-371 7.49e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.68  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   6 IFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYF 85
Cdd:cd17371   53 LGGILADRFGRVRVLVITILLFAVFTLLCGFA--QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQS 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  86 AIPLGSGLGYITGSSVKQAAGDwHWALRVSPVLGMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIRNR 162
Cdd:cd17371  131 GWAVGWLLATLLAALLFPLLPP-EIAWRVLFLLGALPALLVLFIrrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLR 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 163 SYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLG-VVTGAGATRWCRLRT 241
Cdd:cd17371  210 TTLLASLLATGALGGYYGITTWLPSYLTGERGLS------------FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNN 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 242 qradplvCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETL--LFSNWAitadILMYVVIPTR-RATAVALQSFTSHL 318
Cdd:cd17371  278 -------FALFALGSAISILLYFFLPLSPTLILILGFPLGFFAsgPFSGMG----AYLTELFPTAvRATAQGFCYNVGRI 346

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446711828 319 LGdAGSPYLIGFISDLIrqstkdsplweflSLGYALML---CPFVVVLGGMFFLAT 371
Cdd:cd17371  347 IG-ALFPFLVGFLATSG-------------SLGTAIAVfaaVYYIAGLVLALLLPE 388
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-389 8.49e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 8.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRK-----------VILS--CGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTII 67
Cdd:COG2211   60 AITDPLIGALSDRTRTRwgrrrpwiligAIPLalSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  68 GDlftKNTRTLMLSVFYFAIPLGSGLGYITGSS-VKQAAGDWHWALRVSPVLGMITGTL-ILILVPATKRGHADQlggql 145
Cdd:COG2211  140 PD---YEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPVPE----- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 146 KARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnsppcgakdSLIFGAITCFTGFL 225
Cdd:COG2211  212 EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF--KYVLGLSAAL----------VGLLLALYFLAALL 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 226 GV-VTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGE----TLLFSNWAITADILMYVV 300
Cdd:COG2211  280 GApLWPRLAKRFGKKKA-------FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGiglgAILVLPWAMLADVVDYDE 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 301 IPT---RRATAVALQSFTSHlLGDAGSPYLIGFISDLIR-QSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLataLFFL 376
Cdd:COG2211  353 WKTgrrREGLYFGIFTFAIK-LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL---LFYP 428

                        410
                 ....*....|...
gi 446711828 377 SDRAKAEQQVNQL 389
Cdd:COG2211  429 LTRERHAEIRAEL 441
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 1-131 9.84e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.57  E-value: 9.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRK-VILSCGIFF---WSAVTFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 76
Cdd:cd17358   55 LIGALLSGKLADRIGRKrTLLISAIPCilgWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446711828  77 TLMLSVFYFAIPLGSGLGYITGSSVkqaagdwHWalRVSPVLGMITGTLILILVP 131
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFL-------PW--RTLALIGAIPPVVFLILLF 174
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-126 1.16e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYsTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17504   45 AVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQ 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLI 126
Cdd:cd17504  122 GILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV 166
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 1-135 3.23e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 45.72  E-value: 3.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSSSfipqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTL 78
Cdd:cd17360   49 AVGAAIGGWLNDRFGRRpcILLADALFTIGAIVMAAA----PNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGR 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446711828  79 MLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILvPATKR 135
Cdd:cd17360  125 LVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFL-PESPR 180
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 3-129 5.31e-05

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 44.87  E-value: 5.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   3 AAPIF-GYLGDRF--NRKVILSCGIFFwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKN--TRT 77
Cdd:cd17346   55 LTPIIgGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENdpRRD 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446711828  78 LMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVlGMITGTLILIL 129
Cdd:cd17346  133 SGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYGFGLAAV-GMLLGLLIFLL 182
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 1-129 1.18e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 44.24  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828    1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIAPTIIGDLFTKNTRTL-- 78
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVF-RLLVGMGIGGIWVQAVVLNTEFLPKKQRAIvg 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446711828   79 MLSVFYFAIplgsglGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILIL 129
Cdd:TIGR00898 219 TLIQVFFSL------GLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-94 1.24e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.72  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIpQQYFWLLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17330   48 FLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGL-SRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAF 124

                         90
                 ....*....|....
gi 446711828  81 SVFYFAIPLGSGLG 94
Cdd:cd17330  125 GIISAAFGLGFILG 138
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 1-135 5.72e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.78  E-value: 5.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRK--VILSCGIFFWSAV--TFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 76
Cdd:cd17359   50 AIGALFAGRLADRFGRRktLLISAVLFFISALgsAFSPNF------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEIR 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446711828  77 TLMLSVFYFAIPLGSGLGYITGSSVKQAAGD-------WHWALRVSPVLGMITGtLILILVPATKR 135
Cdd:cd17359  124 GRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPAILFL-LGMLFIPESPR 188
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 5-318 8.90e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   5 PIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFY 84
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  85 FAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtlililvpatkrghadqlggqlkartswlrdmkALIRNRSY 164
Cdd:cd17321  127 AVVGIGAALGPLLGGLLLELFG-WRWIFLINVPIGLV-----------------------------------ALLLARTF 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 165 VFSSLATSAVSFATGALGMWIPLYLHRAQvvqktaetcNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRA 244
Cdd:cd17321  171 SGAVLAAFLLGAALGGLLFLLPLYLQGVL---------GYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446711828 245 DPLVCAVGMLGSAIficLIFVAAKTSIVGAYICIFVGETLLfsnWAITADILMYVVIPTRRATAVALQSFTSHL 318
Cdd:cd17321  240 GLLLTAVGLLLLAL---LGADSSVWLLLPGLVLLGLGLGLF---ATPLTNAALSSVPKEKAGAASGILNTARQL 307
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-135 9.41e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 9.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:COG2271  230 IVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS 309

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKR 135
Cdd:COG2271  310 GLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 1-110 9.51e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 40.74  E-value: 9.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLM- 79
Cdd:cd17374   49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAi 126

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446711828  80 -LSVFYFAIplgsglGYITGSSVKQAAGDWHW 110
Cdd:cd17374  127 tLTSCFFSI------GQMLLAGLAYAIRDWRL 152
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 2-94 1.22e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFssSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:cd17370  249 LAAYPAGRLSDRIGRKKLLILGYLSLALAYL--GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326

                         90
                 ....*....|...
gi 446711828  82 VFYFAIPLGSGLG 94
Cdd:cd17370  327 LFNTVVGIGWLLA 339
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 1-64 1.28e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 1.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446711828   1 MVAAPIFGYLGDRFN-RKVILSCGIFFWSAVTFSSSFIPQQYFWLLVlsrgLVGIGEASYSTIAP 64
Cdd:cd17335   46 FLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLL----LVILGAFFSAPVVP 106
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 1-333 1.29e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 40.68  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGeasYSTIAPT---IIGDLFTKNTRT 77
Cdd:cd17475   45 AVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--VGSYPVLLVLLFLVGAG---YGSVQPGggrAIMRWFPPRERG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  78 LMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILilvpatkRGHADQLGGQLKARTS--WLRDM 155
Cdd:cd17475  120 LAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFW-------LFYREPPAASAATESAstLLRSL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 156 KALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAkdslIFGAITCFTGFLGVVTGAGATR 235
Cdd:cd17475  192 KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL--------SVVAAG----ALLAVAQLGGALGRIGLGRVSD 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 236 wcRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY-ICIFVGetLLFSNWAITADILMYVVIPTRRATAVALQSF 314
Cdd:cd17475  260 --RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG--LFAIGWNGLYLTLVAESAGPEQAGTALGLAN 335

                        330
                 ....*....|....*....
gi 446711828 315 TSHLLGDAGSPYLIGFISD 333
Cdd:cd17475  336 TINFIGIAIGPPLFGLLVD 354
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 1-99 1.49e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 40.30  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIPQqyfwLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17336   52 LLAVLLVSYFGGRGHRPRWIGIGSIL-MGLGCFLLALPH----FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYI 126

                         90
                 ....*....|....*....
gi 446711828  81 SVFYFAIPLGSGLGYITGS 99
Cdd:cd17336  127 GILYAMRVLGPALGFLLGS 145
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 6-130 1.59e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 40.33  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   6 IFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYF 85
Cdd:cd17312   57 ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWST 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446711828  86 AIPLGSGLGYITGSSVKQaAGDWHWALRVSPVLGMITGTLILILV 130
Cdd:cd17312  135 SHNFGGILAPILAASLAS-YYGWRAAFLVPGIVGLVVAIILFFFL 178
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 2-146 1.75e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 40.30  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTL 78
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446711828  79 MLSVFYFAIPLGSGLG-YITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV--PATKRGHADQLGGQLK 146
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYhpPPRPQLHGSSTRQKLK 191
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 1-135 3.14e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 39.55  E-value: 3.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRT 77
Cdd:cd17357   63 AIGSFISAFLANRFGRKNGLlisNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRG 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446711828  78 LMLSVFYFAIPLGSGLGYITG-SSVKQAAGDWHWALrVSPVLGMITGTLILILVPATKR 135
Cdd:cd17357  141 ALGSLTQIGVTLGILLGQVFGlPSVLGTETLWPYLL-FFPGIPALLQLAALPFFPESPK 198
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 1-121 3.16e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.44  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIApTIIGDLFTKNTRTLML 80
Cdd:cd17372   48 MIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP-NYMWLIIL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWM 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMI 121
Cdd:cd17372  125 VLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAFSSVPSSL 164
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 1-121 3.68e-03

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 39.02  E-value: 3.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILScGIFFWSA-VTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTiAPTIIGDLFTKNTRTLM 79
Cdd:cd17442   50 MVFSILLGLLADRYGRWKILL-LSFVWGAyFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGYM 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446711828  80 L---SVFYFAiplGSGLGYITGSSVKQAAGdWHWALRVSPVLGMI 121
Cdd:cd17442  126 LplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPGII 166
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 8-361 3.70e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   8 GYLGDRFNRKVILSCGIFFWSAVTFSssFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFtKNTRTLMLSVFYFAI 87
Cdd:cd17333   52 GFLMKRLGRRRTLILGLLLISLALAL--IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  88 PLGSGLGYITGSSVKQAAGDWHWALrvspvlgMITGTLILILVPATKRGHADQLGG---QLKARTSWLRDMKALIRNRSY 164
Cdd:cd17333  129 GLGALIGPLIATSLLTSELSWSWAY-------LIIGLIYLLLAILILLTLFPELPSarnPQQSVGAFSASASRLLRNPSI 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 165 VFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRwcrlrtqRA 244
Cdd:cd17333  202 ILGALALFLYVGAETAFSSWVPSYLVEKKHV------------SDGLAGYLLSGFWVGITIGRLLGGPISR-------RI 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828 245 DPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGetLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGS 324
Cdd:cd17333  263 KPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLG--LFMAALFPTILSLGISNLPYAKGKGTSVLL-AAGSIGGAII 339

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 446711828 325 PYLIGFIsdlIRQSTKDSPLWEFLSLgYALMLCPFVV 361
Cdd:cd17333  340 PFIMGFI---AEAVGIQTAMLLITIL-YAIIFVLALL 372
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 2-110 3.81e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.08  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   2 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTL 78
Cdd:cd17502   45 AFQPIYGKLSDLFGRKWVLLIAIVIFelgSLLCGLAPNMTM-----LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGK 119

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446711828  79 MLSVFYFAIPLGSGLGYITGSSVKQAAGdWHW 110
Cdd:cd17502  120 YQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 8-129 5.40e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 38.71  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   8 GYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAI 87
Cdd:cd17315   55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMI 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446711828  88 PLGSGLGYITGSSVKQ-AAGDWHWALRVSPVLGMITGTLILIL 129
Cdd:cd17315  133 TFGILLAYLLGLALSLsPPGWWRLMFALAAVPALLQLLLMFFL 175
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-106 5.79e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   1 MVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLML 80
Cdd:cd17489  241 LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA--GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318

                         90       100
                 ....*....|....*....|....*.
gi 446711828  81 SVFYFAIPLGSGLGYITGSSVKQAAG 106
Cdd:cd17489  319 GTFFIFFDLGIGLGGLLLGLVAELFG 344
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 5-189 7.38e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 38.33  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   5 PIFGYLGDRFNRKvilscGIFFWSAVTF-SSSFIP--QQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 81
Cdd:cd17503   49 PLSGWLADRFGTR-----RLFLTALALFtLGSLLCglAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  82 VFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtlILILVPatkrghadqlggqlkartswLRDMKALiRN 161
Cdd:cd17503  124 LVGLVILLAPAIGPTLGGWLTDNLS-WRWIFYINLPIGIL----ALLLAP--------------------LLDLRLF-KD 177

                        170       180
                 ....*....|....*....|....*...
gi 446711828 162 RSYVFSSLATSAVSFATGALGMWIPLYL 189
Cdd:cd17503  178 RNFTLGLLLSFLLGLGLFGAMFLLPLYL 205
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 6-177 8.48e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 37.94  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828   6 IFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYF 85
Cdd:cd17320   53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALASS--IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMM 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446711828  86 AIPLGSGLGYITGSSVkQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHAdqlGGQLKARTswLRDMKALIRNRSYV 165
Cdd:cd17320  131 ILAIAPALAPLLGGLL-LLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEK---RKPLLSSL--LRAYKRVLKNRRFL 204

                        170
                 ....*....|..
gi 446711828 166 FSSLATSAVSFA 177
Cdd:cd17320  205 GYALALGLSFAG 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH