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Conserved domains on  [gi|436408724|ref|NP_001258941|]
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inositol 1,4,5-trisphosphate receptor-interacting protein precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mab-21_C super family cl48430
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 408-479 6.30e-05

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


The actual alignment was detected with superfamily member pfam20266:

Pssm-ID: 466416  Cd Length: 102  Bit Score: 42.23  E-value: 6.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 436408724  408 CLQIASFLLSKQSR--LTGPSGLSSYHLKTALLHLLLLR-QAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFI 479
Cdd:pfam20266   5 CLRILKKLKEPGKRdvKTELSKICSYHLKTLFLWECEKHpDDSDWDKENLSDRFLGLLEELHKCLRNGKLPHFFI 79
Radial_spoke_3 super family cl25553
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 34-83 8.33e-04

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


The actual alignment was detected with superfamily member pfam06098:

Pssm-ID: 461827  Cd Length: 286  Bit Score: 41.47  E-value: 8.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 436408724   34 EEEIIRKMQAHQEKLQ-------LEQLRLEEEVARLAAEKEA-LEQVAEEGRQQNETR 83
Cdd:pfam06098 151 EEEELANLREQQRAFEelrnaelAEVQRLEEQERRLREEKERrIAQQREALKKEKETA 208
 
Name Accession Description Interval E-value
Mab-21_C pfam20266
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 408-479 6.30e-05

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 466416  Cd Length: 102  Bit Score: 42.23  E-value: 6.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 436408724  408 CLQIASFLLSKQSR--LTGPSGLSSYHLKTALLHLLLLR-QAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFI 479
Cdd:pfam20266   5 CLRILKKLKEPGKRdvKTELSKICSYHLKTLFLWECEKHpDDSDWDKENLSDRFLGLLEELHKCLRNGKLPHFFI 79
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 34-83 8.33e-04

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 41.47  E-value: 8.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 436408724   34 EEEIIRKMQAHQEKLQ-------LEQLRLEEEVARLAAEKEA-LEQVAEEGRQQNETR 83
Cdd:pfam06098 151 EEEELANLREQQRAFEelrnaelAEVQRLEEQERRLREEKERrIAQQREALKKEKETA 208
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
5-73 2.15e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.55  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408724   5 LFRVCLVVVTAIINHPLLFPREN-ATVPENEEEIiRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVA 73
Cdd:COG2919    5 LRTLVLLLLLAYLQYHLWFGDGGlLAYRELRQEI-AELEAENAKLKARNAELEAEVADLKDGPDYIEERA 73
 
Name Accession Description Interval E-value
Mab-21_C pfam20266
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 408-479 6.30e-05

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 466416  Cd Length: 102  Bit Score: 42.23  E-value: 6.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 436408724  408 CLQIASFLLSKQSR--LTGPSGLSSYHLKTALLHLLLLR-QAADWKAGQLDARLHELLCFLEKSLLQKKLHHFFI 479
Cdd:pfam20266   5 CLRILKKLKEPGKRdvKTELSKICSYHLKTLFLWECEKHpDDSDWDKENLSDRFLGLLEELHKCLRNGKLPHFFI 79
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 34-83 8.33e-04

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 41.47  E-value: 8.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 436408724   34 EEEIIRKMQAHQEKLQ-------LEQLRLEEEVARLAAEKEA-LEQVAEEGRQQNETR 83
Cdd:pfam06098 151 EEEELANLREQQRAFEelrnaelAEVQRLEEQERRLREEKERrIAQQREALKKEKETA 208
DivIC pfam04977
Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and ...
 32-73 1.37e-03

Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.


Pssm-ID: 428231 [Multi-domain]  Cd Length: 69  Bit Score: 37.20  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 436408724   32 ENEEEIIRKmQAHQEKLQLEQLRLEEEVARLAAEKEALEQVA 73
Cdd:pfam04977  10 QLKQEIAQL-QAEIAKLKQENEELEAEIKDLKSDPDYIEERA 50
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
5-73 2.15e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.55  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408724   5 LFRVCLVVVTAIINHPLLFPREN-ATVPENEEEIiRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVA 73
Cdd:COG2919    5 LRTLVLLLLLAYLQYHLWFGDGGlLAYRELRQEI-AELEAENAKLKARNAELEAEVADLKDGPDYIEERA 73
Transcrip_act pfam04949
Transcriptional activator; This family of proteins may act as a transcriptional activator. It ...
 28-79 2.65e-03

Transcriptional activator; This family of proteins may act as a transcriptional activator. It plays a role in stress response in plants.


Pssm-ID: 398553 [Multi-domain]  Cd Length: 154  Bit Score: 38.58  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 436408724   28 ATVPENEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQ 79
Cdd:pfam04949  29 STFRAKEEEIERKKMEVREKVQAQLGRVEEETKRLAEIREELEALADPMRKE 80
UPF0242 pfam06785
Uncharacterized protein family (UPF0242) N-terminus; This region includes an N-terminal ...
 33-81 8.73e-03

Uncharacterized protein family (UPF0242) N-terminus; This region includes an N-terminal transmembrane region and a C-terminal coiled-coil.


Pssm-ID: 429117 [Multi-domain]  Cd Length: 194  Bit Score: 37.49  E-value: 8.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 436408724   33 NEEEIIRKMQAHQEKLQLEQLRLEEEVARLAAEKEALEQVAEEGRQQNE 81
Cdd:pfam06785  87 ILEETLEELQSEEERLEEELSQKEEELRRLTEENQQLQIQLQQISQDFA 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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