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Conserved domains on  [gi|428980688|ref|NP_001258818|]
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calcium and integrin-binding family member 2 isoform 3 [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
58-124 7.03e-08

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 46.48  E-value: 7.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428980688   58 KANYAFKIYDFNTDNFICKEDLELTLARL-TKSELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 124
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeEGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
58-124 7.03e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 46.48  E-value: 7.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428980688   58 KANYAFKIYDFNTDNFICKEDLELTLARL-TKSELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 124
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeEGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 32-124 1.45e-07

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 47.45  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  32 DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKsELDEEEVvlvcDKVIEEADLDG 111
Cdd:PTZ00184  59 DGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE-KLTDEEV----DEMIREADVDG 133

                         90
                 ....*....|...
gi 428980688 112 DGKLGFADFEDMI 124
Cdd:PTZ00184 134 DGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 58-125 1.05e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 43.31  E-value: 1.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428980688  58 KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEevvlvCDKVIEEADLDGDGKLGFADFEDMIA 125
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
23-120 7.54e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  23 ERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEltlARLTKSELDEEEVvlvcDK 102
Cdd:COG5126   36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                         90
                 ....*....|....*...
gi 428980688 103 VIEEADLDGDGKLGFADF 120
Cdd:COG5126  108 LFARLDTDGDGKISFEEF 125
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
58-124 7.03e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 46.48  E-value: 7.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428980688   58 KANYAFKIYDFNTDNFICKEDLELTLARL-TKSELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 124
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeEGEPLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 32-124 1.45e-07

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 47.45  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  32 DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKsELDEEEVvlvcDKVIEEADLDG 111
Cdd:PTZ00184  59 DGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE-KLTDEEV----DEMIREADVDG 133

                         90
                 ....*....|...
gi 428980688 112 DGKLGFADFEDMI 124
Cdd:PTZ00184 134 DGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 58-125 1.05e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 43.31  E-value: 1.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 428980688  58 KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEevvlvCDKVIEEADLDGDGKLGFADFEDMIA 125
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
23-120 7.54e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.08  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  23 ERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEltlARLTKSELDEEEVvlvcDK 102
Cdd:COG5126   36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                         90
                 ....*....|....*...
gi 428980688 103 VIEEADLDGDGKLGFADF 120
Cdd:COG5126  108 LFARLDTDGDGKISFEEF 125
PTZ00183 PTZ00183
centrin; Provisional
 19-128 8.31e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 37.36  E-value: 8.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  19 NPFKERIVAAFSEDGEGNLTFNDFVDMFSV-LCESAPRElKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEevv 97
Cdd:PTZ00183  52 KEEIKQMIADVDKDGSGKIDFEEFLDIMTKkLGERDPRE-EILKAFRLFDDDKTGKISLKNLKRVAKELGETITDEE--- 127

                         90       100       110
                 ....*....|....*....|....*....|.
gi 428980688  98 lvCDKVIEEADLDGDGKLGFADFEDMIAKAP 128
Cdd:PTZ00183 128 --LQEMIDEADRNGDGEISEEEFYRIMKKTN 156
EFh_calglandulin_like cd16252
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ...
 35-126 1.14e-03

EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix).


Pssm-ID: 319995 [Multi-domain]  Cd Length: 106  Bit Score: 36.35  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 428980688  35 GNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKS----ELDEEEVvlvcDKVIEEADLD 110
Cdd:cd16252   15 GSFNYSKFFEYMQKFQTSEQQEEAIRKAFQMLDKDKSGFIEWNEIKYILSTVPSSmpvaPLSDEEA----EAMIQAADTD 90

                         90
                 ....*....|....*.
gi 428980688 111 GDGKLGFADFEDMIAK 126
Cdd:cd16252   91 GDGRIDFQEFSDMVKK 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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