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Conserved domains on  [gi|424036683|ref|NP_001258738|]
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protocadherin-11 X-linked isoform a precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 13228258)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-977 2.27e-86

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


:

Pssm-ID: 462451  Cd Length: 217  Bit Score: 280.09  E-value: 2.27e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   775 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   851 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 928
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 424036683   929 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 977
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  253 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 424036683  333 GSTP--ARATVLVNVTDINDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 3.56e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  574 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 424036683  652 SRSSTARVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-566 5.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  471 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 549
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 424036683  550 LMSNATVFVTVLDQNDN 566
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 7.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  143 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 222
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 424036683  223 DGGFPQRSSTAILQVSVADTNDN 245
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 680-772 2.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 2.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  680 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 759
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 424036683  760 dSLFNVVNVNFFI 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 5.69e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 5.69e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    384 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 424036683    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-99 1.50e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 44.44  E-value: 1.50e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 424036683    28 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 99
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
FAM47 super family cl25915
FAM47 family; The function of this Chordate family of proteins is not known.
 1148-1223 2.04e-04

FAM47 family; The function of this Chordate family of proteins is not known.


The actual alignment was detected with superfamily member pfam14642:

Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 44.87  E-value: 2.04e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 424036683  1148 PATLTNPSPSQIKTSAICHSPPRPRLSVRRYSPPVTQTVTICHSPPVTQAIALCHSPPPVQVTVPRHSPPPAQASA 1223
Cdd:pfam14642  182 PCGEFSPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-977 2.27e-86

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 280.09  E-value: 2.27e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   775 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   851 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 928
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 424036683   929 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 977
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  253 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 424036683  333 GSTP--ARATVLVNVTDINDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 3.56e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  574 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 424036683  652 SRSSTARVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-566 5.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  471 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 549
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 424036683  550 LMSNATVFVTVLDQNDN 566
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-568 9.74e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 9.74e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    489 SATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNS 567
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 424036683    568 P 568
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
254-346 1.73e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   254 IEVSIPENAPIGSSVTQLHATDADIGENARIHFyfsNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGG 333
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 424036683   334 STPARATVLVNVT 346
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-671 6.26e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 6.26e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    593 TVTDPDYGENSAVTLSILD--VNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNK 670
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 424036683    671 P 671
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 272-353 2.03e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 2.03e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    272 HATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTP--ARATVLVNVTDIN 349
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 424036683    350 DNVP 353
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
575-663 7.92e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 7.92e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   575 YNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSIL--DVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVS 652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 424036683   653 RSSTARVTINV 663
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
471-561 1.29e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.29e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   471 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 549
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 424036683   550 LMSNATVFVTVL 561
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 7.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  143 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 222
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 424036683  223 DGGFPQRSSTAILQVSVADTNDN 245
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 680-772 2.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 2.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  680 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 759
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 424036683  760 dSLFNVVNVNFFI 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 163-247 4.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 4.48e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    163 AIDPDIGINGVQNYQlIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADT 242
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 424036683    243 NDNHP 247
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 5.69e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 5.69e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    384 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 424036683    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
144-239 5.88e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 5.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   144 INISIPENSAINSRYSLPAAIDPDIGINGVQNYqLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 424036683   224 GGFPQRSSTAILQVSV 239
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
370-456 1.15e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   370 LSENAPLNTKIALITVMDKDSEHNGRVTcftdhevpFR-LRPVFSNQF-------LLETAAFLDFESTREYAIKLLAADA 441
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 424036683   442 GKPPLNQSSMLLIKV 456
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
691-772 1.41e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   691 PGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNF 770
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 424036683   771 FI 772
Cdd:pfam00028   90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 699-772 1.41e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.41e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 424036683    699 VAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLK-----EKcmvsdLGLHRVIVKANDLGQPdSLFNVVNVNFFI 772
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTkpldrEE-----QPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-99 1.50e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 44.44  E-value: 1.50e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 424036683    28 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 99
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1148-1223 2.04e-04

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 44.87  E-value: 2.04e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 424036683  1148 PATLTNPSPSQIKTSAICHSPPRPRLSVRRYSPPVTQTVTICHSPPVTQAIALCHSPPPVQVTVPRHSPPPAQASA 1223
Cdd:pfam14642  182 PCGEFSPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1141-1268 7.99e-04

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 42.61  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683 1141 HSDSCWMPATLTNPSPSQIkTSAICHSPPrprlsvrrYSPPVTQTVTICHSPPVTQAIALCHSPPPVQVTVPRHSPPP-- 1218
Cdd:cd21974    34 SSDSSDEDDAPESPKDFHS-LSSLCMTPP--------YSPPFFEASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqr 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 424036683 1219 AQASAV----SYSPTLVQAVVIHHSPPLPQAATHHRTQAQPPMGLQQGWVQGAG 1268
Cdd:cd21974   105 AQATSVirhtADPVPVSPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQKPAL 158
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-135 4.45e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   27 NYTVREEMPENVLIGDLL-KDlnlsliPDKSLTTPMQFKLVYKTGDvPLIRIEEGTGEIFTTGaRIDREKlcagivldaR 105
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSaTD------PDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAK-PLDREE---------Q 65

                          90       100       110
                  ....*....|....*....|....*....|...
gi 424036683  106 CFYEVEVAVLPDEIFRL---VKIRFLIEDINDN 135
Cdd:cd11304    66 SSYTLTVTATDGGGPPLsstATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Protocadherin pfam08374
Protocadherin; The structure of protocadherins is similar to that of classic cadherins ...
 775-977 2.27e-86

Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.


Pssm-ID: 462451  Cd Length: 217  Bit Score: 280.09  E-value: 2.27e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   775 SVPNATLIYELVRRSIDAPANQNT-ETTSASSPTTDYVKIMVAIVAGTITVVLVIFITAVVR-CRQP--PHLKASQKnkQ 850
Cdd:pfam08374    1 SLANATLVEELVRRSLETPLDRDIaGDPDYSSLGKDYLKILIAILAGAMTVILVIFIVVLVRyCRQKekPGYKAGKK--Q 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   851 NSEWVTPNPENRQMIMMKKKKKKKKKHP--PKNLLLNFVTIEEAKPDDGENERNSVTLDLPIeleeqtmgkynwgTTPTT 928
Cdd:pfam08374   79 NSDWVTPNPENKQMKGKKKKKKKRPKPAklPKSLLLNLVTIEESKPDDVENEGDSPRIDLPI-------------TLPTT 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 424036683   929 FKPDSPDLARHYKSASPQPAFQIQPETPLN-SKHHIIQELPLDNTFVG-CD 977
Cdd:pfam08374  146 FKPDSPDLARHYKSNSPLPAFQLQPESPSAsKKHQAVQELPLDNTFVGtGD 196
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-351 1.15e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  253 EIEVSIPENAPIGSSVTQLHATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDG 332
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 424036683  333 GSTP--ARATVLVNVTDINDN 351
Cdd:cd11304    78 GGPPlsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-669 3.56e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 3.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  574 EYNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSILDVNDQ--FTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRV 651
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 424036683  652 SRSSTARVTINVVDVNDN 669
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-566 5.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 5.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  471 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 549
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 424036683  550 LMSNATVFVTVLDQNDN 566
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 489-568 9.74e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 9.74e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    489 SATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPPLMSNATVFVTVLDQNDNS 567
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 424036683    568 P 568
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
254-346 1.73e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 1.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   254 IEVSIPENAPIGSSVTQLHATDADIGENARIHFyfsNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGG 333
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY---SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|...
gi 424036683   334 STPARATVLVNVT 346
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 593-671 6.26e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 6.26e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    593 TVTDPDYGENSAVTLSILD--VNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVSRSSTARVTINVVDVNDNK 670
Cdd:smart00112    1 SATDADSGENGKVTYSILSgnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 424036683    671 P 671
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 272-353 2.03e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 2.03e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    272 HATDADIGENARIHFYfsnLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTP--ARATVLVNVTDIN 349
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVN 77


                    ....
gi 424036683    350 DNVP 353
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
575-663 7.92e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 7.92e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   575 YNFYVPESLPKHGTVGLITVTDPDYGENSAVTLSIL--DVNDQFTIDPQSGVIRPNISFDRERQESYTFYVKAEDGGRVS 652
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 424036683   653 RSSTARVTINV 663
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
471-561 1.29e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.29e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   471 ISLSVPENNSPGAQLTKISATDADSGQNAEISY-MLGFDAPPEFNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIPP 549
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 424036683   550 LMSNATVFVTVL 561
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 143-245 7.57e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 7.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  143 VINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIkSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVE 222
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGE----ITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 424036683  223 DGGFPQRSSTAILQVSVADTNDN 245
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 680-772 2.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 2.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  680 YSFEwVLPSTNPGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQP 759
Cdd:cd11304     2 YEVS-VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|...
gi 424036683  760 dSLFNVVNVNFFI 772
Cdd:cd11304    81 -PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 163-247 4.48e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 4.48e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    163 AIDPDIGINGVQNYQlIKSQNIFGLDVIETPEGdkmpQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADT 242
Cdd:smart00112    2 ATDADSGENGKVTYS-ILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 424036683    243 NDNHP 247
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-464 5.69e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 5.69e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683    384 TVMDKDSEHNGRVTCF---TDHEVPFRLRPvfsNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKVKDEN 460
Cdd:smart00112    1 SATDADSGENGKVTYSilsGNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 424036683    461 DNAP 464
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
144-239 5.88e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 5.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   144 INISIPENSAINSRYSLPAAIDPDIGINGVQNYqLIKSQNIFGLDVIETPEGDkmpqLIVQKELDREEKDTYVMKVKVED 223
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY-SILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 424036683   224 GGFPQRSSTAILQVSV 239
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
370-456 1.15e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   370 LSENAPLNTKIALITVMDKDSEHNGRVTcftdhevpFR-LRPVFSNQF-------LLETAAFLDFESTREYAIKLLAADA 441
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIF--------YSiLGGGPGGNFridpdtgDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 424036683   442 GKPPLNQSSMLLIKV 456
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
691-772 1.41e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   691 PGTVVFKVVAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLKEKCMVSDLGLHRVIVKANDLGQPdSLFNVVNVNF 770
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATVTI 89


                   ..
gi 424036683   771 FI 772
Cdd:pfam00028   90 TV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 471-566 4.15e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 52.35  E-value: 4.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  471 ISLSVPENNSPGAQLTKI-SATDADSGQNAEISYMlGFDAPPE-FNLDQRTGILTAVKKLDREKQEKYYFTVLAQDNGIP 548
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIpTDLIASSGEIIKISAA-GKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                          90
                  ....*....|....*...
gi 424036683  549 PLMSNATVFVTVLDQNDN 566
Cdd:cd00031    81 VPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 699-772 1.41e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.41e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 424036683    699 VAIDDDIGMNAEVLYSIVGGNTKGLFMIEQTSGNITLK-----EKcmvsdLGLHRVIVKANDLGQPdSLFNVVNVNFFI 772
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTkpldrEE-----QPEYTLTVEATDGGGP-PLSSTATVTITV 73
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 254-319 1.79e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 47.14  E-value: 1.79e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 424036683   254 IEVSIPENAPIGSSVTQLhATD--ADIGE----NARIhfyfsnlVSNIAKRLFHLNTTTGLITVKEPLDREE 319
Cdd:pfam08266    2 IRYSVPEETERGSFVGNL-AKDlgLEVGElaarGARV-------VSKGNKQYFQLNPETGDLLLNEKLDREE 65
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 28-99 1.50e-05

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 44.44  E-value: 1.50e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 424036683    28 YTVREEMPENVLIGDLLKDLNLSLipdKSLTTpMQFKLVYKtGDVPLIRIEEGTGEIFTTGaRIDREKLCAG 99
Cdd:pfam08266    4 YSVPEETERGSFVGNLAKDLGLEV---GELAA-RGARVVSK-GNKQYFQLNPETGDLLLNE-KLDREELCGS 69
FAM47 pfam14642
FAM47 family; The function of this Chordate family of proteins is not known.
 1148-1223 2.04e-04

FAM47 family; The function of this Chordate family of proteins is not known.


Pssm-ID: 405345 [Multi-domain]  Cd Length: 257  Bit Score: 44.87  E-value: 2.04e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 424036683  1148 PATLTNPSPSQIKTSAICHSPPRPRLSVRRYSPPVTQTVTICHSPPVTQAIALCHSPPPVQVTVPRHSPPPAQASA 1223
Cdd:pfam14642  182 PCGEFSPRPPETRVSCLPPEPPKTPVSSLRPEPPETGVSHLRPQPPKTQVSSLHLEPPETGVSHLRPEPPKTQVSS 257
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1141-1268 7.99e-04

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 42.61  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683 1141 HSDSCWMPATLTNPSPSQIkTSAICHSPPrprlsvrrYSPPVTQTVTICHSPPVTQAIALCHSPPPVQVTVPRHSPPP-- 1218
Cdd:cd21974    34 SSDSSDEDDAPESPKDFHS-LSSLCMTPP--------YSPPFFEASHSPSVASLHPPSAASSQPPPEPESSEPPAASPqr 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 424036683 1219 AQASAV----SYSPTLVQAVVIHHSPPLPQAATHHRTQAQPPMGLQQGWVQGAG 1268
Cdd:cd21974   105 AQATSVirhtADPVPVSPPPVLCQMLPVSSSSGVIVAFLKAPQQPSPQPQKPAL 158
KLF3_N cd21577
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ...
 1154-1257 8.98e-04

N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3.


Pssm-ID: 410554 [Multi-domain]  Cd Length: 214  Bit Score: 42.33  E-value: 8.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683 1154 PSPSQIKTSAICHSPPRPRLSVRRYSPPVTQTVTICHS-PPVTqaIALCHSPPPVQVTVPRHSPPPAQASAVSYSPTLVQ 1232
Cdd:cd21577    41 SSSSSSSSPSSRASPPSPYSKSSPPSPPQQRPLSPPLSlPPPV--APPPLSPGSVPGGLPVISPVMVQPVPVLYPPHLHQ 118

                          90       100
                  ....*....|....*....|....*
gi 424036683 1233 AVVIHHSPPLPQAATHHRTQAQPPM 1257
Cdd:cd21577   119 PIMVSSSPPPDDDHHHHKASSMKPS 143
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 254-351 2.77e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.48  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683  254 IEVSIPENAPIGSSVTQLHAT-DADIGENARIhfyfSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLA-TD 331
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIPTDlIASSGEIIKI----SAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAaSL 77

                          90       100
                  ....*....|....*....|.
gi 424036683  332 GGSTPARATVLV-NVTDINDN 351
Cdd:cd00031    78 GANVPQTSSVFSiEVYDENDN 98
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 1128-1246 3.87e-03

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 40.30  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683 1128 ASDTCTQECLILG-----HSDSCWMpatlTNP-SPSQIKTSAICHSPPRPRLSVRRYSPPVTQTVT-------------- 1187
Cdd:cd21974    34 SSDSSDEDDAPESpkdfhSLSSLCM----TPPySPPFFEASHSPSVASLHPPSAASSQPPPEPESSeppaaspqraqats 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 424036683 1188 -ICH---SPPVTQAIALCHSPP--PVQVTVPRHSPPPAQASAVSYSPTLVQAVVIHHSPPLPQAA 1246
Cdd:cd21974   110 vIRHtadPVPVSPPPVLCQMLPvsSSSGVIVAFLKAPQQPSPQPQKPALPQPQVVLVGGQVPQGP 174
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 27-135 4.45e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 424036683   27 NYTVREEMPENVLIGDLL-KDlnlsliPDKSLTTPMQFKLVYKTGDvPLIRIEEGTGEIFTTGaRIDREKlcagivldaR 105
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSaTD------PDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAK-PLDREE---------Q 65

                          90       100       110
                  ....*....|....*....|....*....|...
gi 424036683  106 CFYEVEVAVLPDEIFRL---VKIRFLIEDINDN 135
Cdd:cd11304    66 SSYTLTVTATDGGGPPLsstATVTITVLDVNDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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