NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|401461771|ref|NP_001257869|]
View 

exportin-6 isoform 1 [Homo sapiens]

Protein Classification

exportin/importin beta family protein( domain architecture ID 10658450)

exportin/importin beta family protein such as human exportin-T, which mediates the nuclear export of aminoacylated tRNAs or transportin-3 (importin), which transports target proteins into the nucleus

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 89-239 2.38e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 97.29  E-value: 2.38e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    89 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 166
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401461771   167 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 239
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 17-82 2.36e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.36e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401461771     17 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 82
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 89-239 2.38e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 97.29  E-value: 2.38e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    89 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 166
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401461771   167 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 239
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 17-82 2.36e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.36e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401461771     17 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 82
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 8-178 6.56e-09

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 60.34  E-value: 6.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    8 CTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAH--- 84
Cdd:COG5101    25 QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGIRNYVVQLVIEKsqd 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771   85 ---HKTLPYFIrNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTT-PLGLIMLKTTSEELACPRED-LSVARKEELR 159
Cdd:COG5101   105 dkvRDKQKYVL-NKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVcENNMIVLKLLSEEVFDFSAEqMTQVKKRLLK 183

                         170
                  ....*....|....*....
gi 401461771  160 KLLLDQVQTVLGLLTGILE 178
Cdd:COG5101   184 NQMKIEFPQIFGLCKQILE 202
IBN_N pfam03810
Importin-beta N-terminal domain;
18-82 9.78e-05

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.46  E-value: 9.78e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    18 EELLNNFAQQIGAWRFCLYFLSSTRND-YVMMYSLTVFENLINKMW----LGVPSQDKMEIRSCLPKLLL 82
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLG 71
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
 7-136 2.85e-03

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 41.76  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    7 DCT--TNERKREIEEL-LNNFAQQIGAWRFCLYFLSSTRNDY-VMMYSLTVFENLINKMW-----LGVPSQDKMEIRSCL 77
Cdd:COG5656    10 LQTldADAGKRTIAEAmLKDLEKQPGFVMALLHICSKDEGDLnVKLSAAIYFKNKIIRSWsskrdDGIKADEKSEAKKYL 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 401461771   78 PKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPL--GLIML 136
Cdd:COG5656    90 IENILDVFLYSPEVTRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANHVytGLLCL 150
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 89-239 2.38e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 97.29  E-value: 2.38e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    89 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 166
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401461771   167 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 239
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 17-82 2.36e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.36e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401461771     17 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 82
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 8-178 6.56e-09

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 60.34  E-value: 6.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    8 CTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAH--- 84
Cdd:COG5101    25 QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGIRNYVVQLVIEKsqd 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771   85 ---HKTLPYFIrNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTT-PLGLIMLKTTSEELACPRED-LSVARKEELR 159
Cdd:COG5101   105 dkvRDKQKYVL-NKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVcENNMIVLKLLSEEVFDFSAEqMTQVKKRLLK 183

                         170
                  ....*....|....*....
gi 401461771  160 KLLLDQVQTVLGLLTGILE 178
Cdd:COG5101   184 NQMKIEFPQIFGLCKQILE 202
IBN_N pfam03810
Importin-beta N-terminal domain;
18-82 9.78e-05

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.46  E-value: 9.78e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    18 EELLNNFAQQIGAWRFCLYFLSSTRND-YVMMYSLTVFENLINKMW----LGVPSQDKMEIRSCLPKLLL 82
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLG 71
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
 7-136 2.85e-03

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 41.76  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401461771    7 DCT--TNERKREIEEL-LNNFAQQIGAWRFCLYFLSSTRNDY-VMMYSLTVFENLINKMW-----LGVPSQDKMEIRSCL 77
Cdd:COG5656    10 LQTldADAGKRTIAEAmLKDLEKQPGFVMALLHICSKDEGDLnVKLSAAIYFKNKIIRSWsskrdDGIKADEKSEAKKYL 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 401461771   78 PKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPL--GLIML 136
Cdd:COG5656    90 IENILDVFLYSPEVTRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANHVytGLLCL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH