|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
711-1036 |
3.59e-80 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
:
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 264.22 E-value: 3.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 711 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 788
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 789 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 863
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 864 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 941
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 942 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1021
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154123 1022 PQVETLAMWTPTIPF 1036
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
339-510 |
1.01e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 339 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 417
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 418 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 495
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154123 496 TKQAQIYMRHYFENS 510
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
635-740 |
1.18e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.75 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 635 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 703
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154123 704 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 740
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
711-1036 |
3.59e-80 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 264.22 E-value: 3.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 711 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 788
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 789 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 863
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 864 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 941
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 942 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1021
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154123 1022 PQVETLAMWTPTIPF 1036
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
339-510 |
1.01e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 339 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 417
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 418 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 495
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154123 496 TKQAQIYMRHYFENS 510
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
898-1049 |
1.28e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.77 E-value: 1.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 898 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALaKSLLRLSLYNNC 977
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399154123 978 ICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1049
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
635-740 |
1.18e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.75 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 635 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 703
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154123 704 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 740
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
966-992 |
1.97e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 1.97e-04
10 20
....*....|....*....|....*..
gi 399154123 966 KSLLRLSLYNNCICDEGAKSLARVLPD 992
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
711-1036 |
3.59e-80 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 264.22 E-value: 3.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 711 LTRYLKRLKLGTLRAGRLLELLHCaheTQEPGIWKHVSHQlpGHLSFLGTRLTAP--DVYVLGRALETASqdfslDLRQT 788
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 789 GIEPSRLGDLVGLSCVTSFRASLS-DTMALWESLQH---QGETQLLQAAEEKfTIEPFKAKSPKDV-EDLDSLVQTQRLR 863
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 864 N--PSADAAKDLPAIRDLKKLEFALGPvLGPQAFPTLAKILPAFSSLQHLDLDSlseNKIGDKGVSKLSATFPQLKALET 941
Cdd:cd00116 150 EgaSCEALAKALRANRDLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDLNN---NGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 942 LNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLqKC 1021
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESL-LE 304
|
330
....*....|....*
gi 399154123 1022 PQVETLAMWTPTIPF 1036
Cdd:cd00116 305 PGNELESLWVKDDSF 319
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
339-510 |
1.01e-50 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 175.96 E-value: 1.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 339 QVVAVLGKAGQGKSHWARTVSHIWAQGQLPQY-DFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPD 417
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 418 RVLLILDAFEELEAQDSLLHGpcgplspePCSLRGLLAGLFQRKLLRGCTLLLTARPRGR--LAQSLSKADaIFEVPSFS 495
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151
|
170
....*....|....*
gi 399154123 496 TKQAQIYMRHYFENS 510
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
898-1049 |
1.28e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.77 E-value: 1.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 898 LAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALaKSLLRLSLYNNC 977
Cdd:COG5238 284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQ 359
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399154123 978 ICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKcPQVETLAMWTPTIPFGVQEHLQQLDARI 1049
Cdd:COG5238 360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
890-1027 |
1.05e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.52 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 890 LGPQAFPTLAKILPAFSSLQHLDLdslSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALpALAKSLL 969
Cdd:COG5238 248 IGDEGVIALAEALKNNTTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLH 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 399154123 970 RLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETL 1027
Cdd:COG5238 324 TLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
909-1044 |
1.83e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 73.67 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 909 QHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALpALAKSLLRLSLYNNCICDEGAKSLAR 988
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 989 VLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPF----GVQEHLQQ 1044
Cdd:COG5238 259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
897-1027 |
2.81e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 63.80 E-value: 2.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 897 TLAKILPAFSSLQHLDldsLSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgackLAEALPALaKSLLRLSLYNN 976
Cdd:COG4886 127 DLPEELANLTNLKELD---LSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNL-TNLKELDLSNN 192
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 399154123 977 CIcdegaKSLARVLPDMVSLRVMDVQFNKFTAvgaqqLTSSLQKCPQVETL 1027
Cdd:COG4886 193 QI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETL 233
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
902-1027 |
5.43e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 59.56 E-value: 5.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 902 LPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgackLAEALPALaKSLLRLSLYNNCIcde 981
Cdd:COG4886 109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTD-----LPEPLGNL-TNLKSLDLSNNQL--- 171
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 399154123 982 gaKSLARVLPDMVSLRVMDVQFNKFTavgaqQLTSSLQKCPQVETL 1027
Cdd:COG4886 172 --TDLPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEEL 210
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
337-917 |
1.90e-07 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 55.58 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 337 ETQVVAVLGKAGQGKSHWAR-TVSHIWAQGQLPQYDFVFYVPCQCLDRPGDtyhLRDLLCPPNLQPLAMDDEVIDHIVRQ 415
Cdd:COG5635 179 KKKRLLILGEPGSGKTTLLRyLALELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKRGGEPEDALERLLRN 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 416 pDRVLLILDAFEELEAQDSLLHgpcgplspepcsLRGLLAGLFQRklLRGCTLLLTARPRGRLAQSLSKADaIFEVPSFS 495
Cdd:COG5635 256 -GRLLLLLDGLDEVPDEADRDE------------VLNQLRRFLER--YPKARVIITSRPEGYDSSELEGFE-VLELAPLS 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 496 TKQAQIYMRHYFENSGTAGshDKALGLLEGQPFLLTHSHSPVLCSAVCQLSKalldqgAEAQLPCTLTGLY--------- 566
Cdd:COG5635 320 DEQIEEFLKKWFEATERKA--ERLLEALEENPELRELARNPLLLTLLALLLR------ERGELPDTRAELYeqfvellle 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 567 ----VGLLGPAAQNSPPGALVELAKLAWELgrrHQStlQETQFPSVEVKTWAVAQGLMQQTTEA---QLAFSSFLLQC-- 637
Cdd:COG5635 392 rwdeQRGLTIYRELSREELRELLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEAlldELLLRTGLLVErg 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 638 -------------FLGAVWLAqcnemkdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHC-----LGALVEPA 699
Cdd:COG5635 467 egrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKelidaLLARDDAA 538
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 700 MAAVADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQEPGIWKHVSHQLPGHLSFLGTRLTAPDVYVLGRALETASQ 779
Cdd:COG5635 539 ALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLAL 618
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 780 DFSLDLRQTGIEPSRLGDLVGLSCVTSFRASLSDTMALWESLQHQGETQLLQAAEEKFTIEPFKAKSPKDVEDLDSLVQT 859
Cdd:COG5635 619 ALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLA 698
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 399154123 860 QRLRNPSADAAKDLPAIRDLKKLEFALGPVLGPQAFPTLAKILPAFSSLQHLDLDSLS 917
Cdd:COG5635 699 LALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
897-1019 |
3.50e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.78 E-value: 3.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 897 TLAKILPAFSSLQHLDLdslSENKIGDkgvskLSATFPQLKALETLNLSQNSITDvgacklaeaLPALA--KSLLRLSLY 974
Cdd:COG4886 196 DLPEPLGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTD---------LPELGnlTNLEELDLS 258
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 399154123 975 NNCICDegakslarvLPD---MVSLRVMDVQFNKFTAVGAQQLTSSLQ 1019
Cdd:COG4886 259 NNQLTD---------LPPlanLTNLKTLDLSNNQLTDLKLKELELLLG 297
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
635-740 |
1.18e-05 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 45.75 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154123 635 LQCFLGAVWLAQCnEMKDKELPQYLALTPRKKRPYDNWLEGVP-----------RFLAGLVFQPRAHCLGALVEPAmaaV 703
Cdd:pfam17776 4 FQEFFAALFYVLS-FKEEKSNPLKEFFGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCK---L 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 399154123 704 ADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQE 740
Cdd:pfam17776 80 SSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
966-992 |
1.97e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 1.97e-04
10 20
....*....|....*....|....*..
gi 399154123 966 KSLLRLSLYNNCICDEGAKSLARVLPD 992
Cdd:smart00368 2 PSLRELDLSNNKLGDEGARALAEALKD 28
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
907-979 |
1.55e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.31 E-value: 1.55e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 399154123 907 SLQHLDLdslSENKIGDkgVSKLSAtfpqLKALETLNLSQNSITDVGAckLAEALPALaKSLLRLSLYNNCIC 979
Cdd:cd21340 121 SLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDLEE--LLDLLSSW-PSLRELDLTGNPVC 181
|
|
| |
