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Conserved domains on  [gi|394953627|ref|NP_001257388|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform k [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 156-332 8.35e-134

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23981:

Pssm-ID: 480271  Cd Length: 207  Bit Score: 379.65  E-value: 8.35e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 235
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 236 FKWLKYIVYKERV------------------------------EAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 285
Cdd:cd23981   81 FKWLKYIVYKEKVsasdgfwksvatrvprepheirilnpyfiqEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 394953627 286 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-332 8.35e-134

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 379.65  E-value: 8.35e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 235
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 236 FKWLKYIVYKERV------------------------------EAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 285
Cdd:cd23981   81 FKWLKYIVYKEKVsasdgfwksvatrvprepheirilnpyfiqEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 394953627 286 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 116-337 8.93e-77

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 236.35  E-value: 8.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  116 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 195
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  196 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVEAAFTLIGLPFNNGLM---- 264
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPvdpd 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  265 ----------------------GRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNI 322
Cdd:pfam00777 162 kvlflhpdflryvanfwlrshgLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDM 241

                         250
                  ....*....|....*
gi 394953627  323 QREKEFLRKLVKARV 337
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-332 8.35e-134

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 379.65  E-value: 8.35e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 235
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 236 FKWLKYIVYKERV------------------------------EAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 285
Cdd:cd23981   81 FKWLKYIVYKEKVsasdgfwksvatrvprepheirilnpyfiqEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 394953627 286 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 156-332 8.38e-104

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 303.44  E-value: 8.38e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 235
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 236 FKWLKYIVYKERV------------------------------EAAFTLIGLPFNNglMGRGNIPTLGSVAVTMALHGCD 285
Cdd:cd23967   81 LLWLQAVIKGKKPngkggfwkkiatsvpkppkkirilnpyilqEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCD 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 394953627 286 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23967  159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 116-337 8.93e-77

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 236.35  E-value: 8.93e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  116 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 195
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  196 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVEAAFTLIGLPFNNGLM---- 264
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPvdpd 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627  265 ----------------------GRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNI 322
Cdd:pfam00777 162 kvlflhpdflryvanfwlrshgLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDM 241

                         250
                  ....*....|....*
gi 394953627  323 QREKEFLRKLVKARV 337
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 157-332 1.75e-71

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 221.15  E-value: 1.75e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 236
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 237 KWLKYIVYKERV--------------------------------EAAFTLIGL--PFNNGLMGRGNIPTLGSVAVTMALH 282
Cdd:cd23983   82 AWLKAMVKKEPLsfwsrlffwkevadsiplkpsqfrilnpliikETALDILQYpePQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 394953627 283 GCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23983  162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 157-332 1.45e-60

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 193.04  E-value: 1.45e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 236
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 237 KWLKYIVYKERV-----------------------------EAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEV 287
Cdd:cd23984   82 RWLLDLLMGKKVsakgfwkkpalnliykpnqirilnpfilrIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNEV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 394953627 288 AVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23984  162 HIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 156-332 1.55e-59

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 190.26  E-value: 1.55e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQ 234
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 235 DFKWLKYIVYKERV-----------------------------EAAFTLIGLPfnnGLMGRGNIPTLGSVAVTMALHGCD 285
Cdd:cd23982   81 DFYWLYEILSNEKRvrkgfwkqppriwdanpkqirilnpyytyVAATKLLQVP---GQRKKKQKPTTGLLAITLALHLCD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 394953627 286 EVAVAGFGY-DMSTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKL 332
Cdd:cd23982  158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 160-332 2.43e-51

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 169.08  E-value: 2.43e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 160 CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 230
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 231 FKWQDFKWLKYivYKERVEAAFTLI-------------GLPF-NNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDM 296
Cdd:cd19952   81 AAAADFKRLKR--RKKRHDNAVLLLtdpapdllsyvrkRLEKlGLKSFFGGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 394953627 297 S-TPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 332
Cdd:cd19952  159 GhAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 107-339 7.78e-40

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 142.01  E-value: 7.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 107 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTK----EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRI 178
Cdd:cd23964   24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLNltssRYMFVLRGGRPRCIRCAVVGNGGILNGSGKGKEI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 179 DDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLK--------------- 240
Cdd:cd23964  104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDavlsgkpvpdgcdkg 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 241 ---YIVYKERVEAAFTLIGLP------FNNGL-MGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmstPNAPLHYYETVR 310
Cdd:cd23964  184 krpPPLFGPKLNATNVRLLHPdfirylFNRWLnSSTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTF 260

                        250       260
                 ....*....|....*....|....*....
gi 394953627 311 MAAIKESWTHNIQREKEFLRKLVKARVIT 339
Cdd:cd23964  261 VKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 156-339 7.50e-37

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 133.94  E-value: 7.50e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 156 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 234
Cdd:cd23966   76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 235 DFKWLK-----------YIVYKERVEA----------AFtlIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFG 293
Cdd:cd23966  151 DLQWLIsalttgeitrtYTPVKRFIKAdkdkvlvinpAF--IKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFG 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 394953627 294 YDmSTPNAPlHYYETVRmAAIKESWT--HNIQREKEFLRKLVKARVIT 339
Cdd:cd23966  229 AD-SKGNWH-HYWEKNR-SAGAFRKTgvHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 111-307 7.36e-27

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 107.27  E-value: 7.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 111 DDSFRKWARI-REFVPpfgiKGQDNLIKAILSVTK-EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLN 188
Cdd:cd23980   37 EDTYKWWLRLqREKKP----KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMN 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 189 SAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWL-----------KYIVY--KERVEAAFTLI 255
Cdd:cd23980  113 KAPTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVisatttgtishTYVPVprKIKVKKEKILI 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 394953627 256 GLP------FNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmSTPNAPlHYYE 307
Cdd:cd23980  189 YHPafikyvFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGAD-SKGNWH-HYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 153-338 2.12e-25

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 103.41  E-value: 2.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 153 DSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 232
Cdd:cd23979   76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 233 WQDFKWLKYI------------------VYKERVE----AAFTLIglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVA 290
Cdd:cd23979  152 TLDLLWITSAlstgqirftyapvkqflrVDKDKVQiynpAFFKYI---HDRWTEHHGRYPSTGMLVLFFALHVCDEVNVY 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 394953627 291 GFGYDmSTPNAPlHYYETVRMAA-IKESWTHNIQREKEFLRKLVKARVI 338
Cdd:cd23979  229 GFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLAKAGKI 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 158-332 3.31e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 99.65  E-value: 3.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 158 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFV--- 227
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVwdp 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 228 -------LAGFKWQDFKWL-KYIVYKERV-EAAFTLIGLPF----------NNGLMGRGNIPTLGSVAVTMALHGCDEVA 288
Cdd:cd23968  125 ssynvnlEKWYKKPDFDFFpNYIKYRRRHpEEPFYLIDPRFlwrlwdilqeYTPEKIKPNPPSSGFIGIVLMLHLCDWVD 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 394953627 289 VagFGYDMSTPNAPL-HYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23968  205 V--YEYVPSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 108-338 6.19e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 94.43  E-value: 6.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 108 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLRCRRCIIVGNGGVLANKSLGSRI 178
Cdd:cd23973   25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 179 DDYDIVVRLNSAPVKGFEKDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKY----- 241
Cdd:cd23973  105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEAllknk 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 242 -----IVYKERVEAAFT--------LIGLP-FNNGLMGR---GNI----------PTLGSVAVTMALHGCDEVAVAGF-- 292
Cdd:cd23973  183 tipsgAYYGRRPRSYFSgdftedkyLVLHPdFLRYVKNRflrSKTlkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFit 262

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 394953627 293 -GYDmstpNAPLHYYETvrmaaikeSWT-------HNIQREKEFLRKLVKARVI 338
Cdd:cd23973  263 eDYR----KYPDHYYDK--------KKTklvfyinHDFRLEKKLWKRLHDEKII 304
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 158-332 1.08e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 90.01  E-value: 1.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 158 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTL---------RITYPEGAMQRPEQYERD----- 223
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsilkRRYNSLKKNRDRDKFLNRlkeyn 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 224 -SLFVLAGFKWQDF-KWLKYI--VYKERVEAAFTLIGLP--------FNNgLMGRGNIPTLGSVAVTMALHGCDEVAVAG 291
Cdd:cd23963  144 gSILWYPKFSFKSStNLLLKAarALKKNGLNLTVVYSNPehflavqkFWK-RRGLEKRPSTGLYLVSLALTFCDEIHLYG 222

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 394953627 292 F---GYDMSTPNAPLHYYEtvRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23963  223 FwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEEFKLLREL 264
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 157-308 1.12e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 83.45  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPEQYERDS---LFVLa 229
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 230 gfkwqdfkWLKYIVYKERVEAAFTLIGL-----P------FNNGLMGRGN--------IPTLGS--------VAVTMALH 282
Cdd:cd23965   80 --------WGPETKMNKDGAGKYNLLRSlskkyPdvefysLTPEKMDYADelfeketgKSRIKSgtwlstgwFTMLLALD 151

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 394953627 283 GCDEVAVagfgYDMSTPN---------APLHYYET 308
Cdd:cd23965  152 VCDEIKV----YGMVPENycrehpnskVPYHYYEP 182
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 117-338 1.16e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 79.48  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 117 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDS-LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAP 191
Cdd:cd23972   37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTpGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 192 VKGFEKDVGSKTTLR-----------ITYPEGAMQRPEQYE-----------RDSLF---------VLAGFKWQD----- 235
Cdd:cd23972  117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQGQdlqyifipsdiRDYVMlrsailgvpVPEGLDKGDrphky 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 236 ---------FKWL--KYIVY-KERVEAAfTLIGLPFNNGLMgrgniPTLGSVAVTMALHGCDEVAVAGFgydmSTPNAPL 303
Cdd:cd23972  197 fgpeasakkFKLLhpDFISYlTDRFLKS-KLLNTHYGHLYM-----PSTGALMLLTALHTCDQVSAYGF----ITSNYWK 266

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 394953627 304 ---HYYETVRMAAIKESwTHNIQREKEFLRKLVKARVI 338
Cdd:cd23972  267 fsdHYYERKKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 149-332 5.06e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 77.07  E-value: 5.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 149 TPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQRPEQYER 222
Cdd:cd23969   56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 223 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVEAAFTLIGLPFNNGLMG-------RGNIPTLGSVAVTMALH 282
Cdd:cd23969  136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKTAYPPLRLNHAIRGywlttkfRIKRPSTGLLMYTLATR 215

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 394953627 283 GCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 332
Cdd:cd23969  216 FCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 157-339 1.06e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 76.71  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI-----------TYPEGAMQRPEQ------ 219
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTfstntlmnslrAYAGVGFNGPPQsketry 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 220 -----YERDSLFVLAGF--------KWQDFKWLKYIVYKERVEaAFTLIGLPFNNGLMGR-----------GNI--PTLG 273
Cdd:cd23974  164 iflpdHDRDYLLVKAALthtpidrgRDKSKRPSKYFGKDVTAE-KFKIYHPDFIRYLRNRflwspilntkqRDIyrPSTG 242

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394953627 274 SVAVTMALHGCDEVAVAGFgydmSTPNAPL---HYYETVRMAAIKESwTHNIQREKEFLRKLVKARVIT 339
Cdd:cd23974  243 AVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLWQKLHKAGLIK 306
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 146-332 9.53e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 73.43  E-value: 9.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLrITYPEGAMQRP----- 217
Cdd:cd23987   50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSVVQRAfedlv 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 218 -EQYERDSLFVLAGFKWQDFkWLKYIVYK---ERVEAAFTLIGLPFNN-----------------GLMGRGNI--PTLGS 274
Cdd:cd23987  129 nETWKEKFLQRLQSLNGSIL-WIPAFMAKggeERVEWVNDLILKHHINvrtaypslrllhavrgyWLTNKVHIkrPTTGL 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394953627 275 VAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23987  208 LMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKNL 268
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 158-207 2.99e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 71.79  E-value: 2.99e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 394953627 158 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI 207
Cdd:cd23986   50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRI 99
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 157-311 3.11e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 71.05  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 230
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 231 FKWQDFKWLKYIVYKERVEAA--------FTLI-------GLPFNN----GLMGRGNIPTLGSVAVTMALHGCDEVAVAG 291
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAkmyphlqvYTLTeekmaycDGVFQNetgkNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170       180
                 ....*....|....*....|....*
gi 394953627 292 -----FGYDMSTPNAPLHYYETVRM 311
Cdd:cd23977  161 mvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 146-205 1.75e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 69.73  E-value: 1.75e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 394953627 146 YRLTPA---LDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTL 205
Cdd:cd23970   54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL 116
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 158-226 1.81e-13

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 69.35  E-value: 1.81e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 158 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPE-QYERDSLF 226
Cdd:cd23985   46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLY 114
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 146-332 3.69e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 68.83  E-value: 3.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 146 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQR 216
Cdd:cd23988   50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 217 PEQYER---------DSLFVLAGFK----WQDFKWLKYIVYKERVEA-----AFTLIGLPFNNGLMGRGNI--PTLGSVA 276
Cdd:cd23988  130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKLKVrtaypSLRLIHAVRGYWLTNKVNIkrPSTGLLM 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 394953627 277 VTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 332
Cdd:cd23988  210 YTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKTLNVL 268
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 137-309 3.64e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 65.93  E-value: 3.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 137 KAILSVTKEYRLTPALDSLRCR---RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKG-FEKDVGSKTTL------- 205
Cdd:cd23991   41 KKILITENIFRMFPKSQPFRGYpykQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLvtanpsi 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 206 -RITYPEGAMQRPEQYER-----DSLFVLAGFKWQDFKWLKYIVYKERVEAAFTLIGLPFNNGLM--------GRG---- 267
Cdd:cd23991  121 iSIKYAKLNERRKPFLETvsvygDAFLLLPAFSYRSNTALSFKVYYTLEDFKAKQKVIFFHPIYLkhlaqfwrSKGvqvy 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 394953627 268 NIPTlGSVAVTMALHGCDEVAVAGF-GYDMSTPNAPL--HYYETV 309
Cdd:cd23991  201 RLST-GLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ 244
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 159-310 1.21e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 64.20  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 159 RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKgFEKDVGSKTTL--------RITYPEGAMQRPEQYER-----DSL 225
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNLKKRRRPFVERmkvygNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 226 FVLAGFKW--------------QDFKWLKYIV-----YKERVEAAFTLIGLPF---NNGLMgrgniptlgsvAVTMALHG 283
Cdd:cd23971  145 LLLPAFSYtsntepslralytlEDFGSPQKVLffnpeYLRNLSRYWKSKGLKArrlSTGLM-----------LVSAALEL 213

                        170       180       190
                 ....*....|....*....|....*....|
gi 394953627 284 CDEVAVAGF---GYDMSTPNAPLHYYETVR 310
Cdd:cd23971  214 CENVHLYGFwpfSTDLDGNPISHHYYDNVL 243
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 155-307 1.75e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 63.35  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 155 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITyPEGAMQR--PEQYE-----RDSLFV 227
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRilRNRNEllnvsQGTVFI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 228 L-----------AGFKWQDFKWLKYIVYKERVEAAFTLIGLPFNNgLMGR---------GNIPTLGSVAVTMALHGCDEV 287
Cdd:cd23976   92 FwgpsnymrrdgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDE-LFKRetgkdrkisNTWLSTGWFTMIIALELCDRI 170

                        170       180
                 ....*....|....*....|....*
gi 394953627 288 AVAG-----FGYDMSTPNAPLHYYE 307
Cdd:cd23976  171 NVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 157-207 2.12e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.87  E-value: 2.12e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI 207
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 157-310 1.99e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 57.25  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 157 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLAG 230
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 231 -FK--WQDFKWLKYIVYKERVEA-------AFTLIGLPFNNGLMGR---------GNIPTLGSVAVTMALHGCDEVAVAG 291
Cdd:cd23975   81 pFRnmRKDGKGIVYNMLKKAVESypqakiyVTTEKRMSYCDTVFKKetgkdrvqsGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180
                 ....*....|....*....|....
gi 394953627 292 FGYDMSTPN-----APLHYYETVR 310
Cdd:cd23975  161 MINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 155-205 4.50e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 53.68  E-value: 4.50e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 394953627 155 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTL 205
Cdd:cd23989   61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL 112
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 158-310 4.50e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 50.61  E-value: 4.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 158 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTLRITYPE---------GAMQRP-----EQYER 222
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSiiterfhklEKWRRPfyevlQVYEN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394953627 223 DSL------------------FVLAGFKWQDFKWLKYIVYKERVEAAFTLIGLpfnnglmgRGNIPTLGSVAVTMALHGC 284
Cdd:cd23990  145 ASVvlpafyntrntdvsirvkYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGV--------RAKRISSGLMLVTAALELC 216

                        170       180
                 ....*....|....*....|....*....
gi 394953627 285 DEVAVAGF-GYDMSTPNAPL--HYYETVR 310
Cdd:cd23990  217 EEVHLYGFwAFPMNPSGIFIthHYYDNVK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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