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Conserved domains on  [gi|394581969|ref|NP_001257373|]
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retbindin isoform 1 precursor [Homo sapiens]

Protein Classification

folate receptor family protein( domain architecture ID 10503420)

folate receptor family protein similar to folate receptors that bind to folate and reduced folic acid derivatives and mediate delivery of 5-methyltetrahydrofolate to the interior of cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 29-183 2.20e-34

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


:

Pssm-ID: 397250  Cd Length: 172  Bit Score: 121.03  E-value: 2.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   29 GGSRPLQARSQQHHGLAADLGKGklhlagPCCPSEMDTTETSGPGN----HPERCGVPSPECESFLEHLQRA------LR 98
Cdd:pfam03024   6 KHHKPKPSPEPNLHELCAPWKEN------SCCTANTSEEAHRDPSIlynfNWNHCGTLSPECEKFFIQLQCFyecspnLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   99 SRFRLRLLGVRQAQPLCEELCQAWFANCEDDITC----GPTWLPLSEKRGC--EPSCLTYGQTFADGTDLCRSALGHALP 172
Cdd:pfam03024  80 PWIQPWRRERILNVPLCKEFCDAWFEACKDDYTCksnwGKGWLWSSGKNGCpdEPSCRPFKQMFPNGTDLCESIWGHSFK 159

                         170
                  ....*....|...
gi 394581969  173 VA--APGARHCFN 183
Cdd:pfam03024 160 VSpsSRGSGRCLQ 172
 
Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 29-183 2.20e-34

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 121.03  E-value: 2.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   29 GGSRPLQARSQQHHGLAADLGKGklhlagPCCPSEMDTTETSGPGN----HPERCGVPSPECESFLEHLQRA------LR 98
Cdd:pfam03024   6 KHHKPKPSPEPNLHELCAPWKEN------SCCTANTSEEAHRDPSIlynfNWNHCGTLSPECEKFFIQLQCFyecspnLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   99 SRFRLRLLGVRQAQPLCEELCQAWFANCEDDITC----GPTWLPLSEKRGC--EPSCLTYGQTFADGTDLCRSALGHALP 172
Cdd:pfam03024  80 PWIQPWRRERILNVPLCKEFCDAWFEACKDDYTCksnwGKGWLWSSGKNGCpdEPSCRPFKQMFPNGTDLCESIWGHSFK 159

                         170
                  ....*....|...
gi 394581969  173 VA--APGARHCFN 183
Cdd:pfam03024 160 VSpsSRGSGRCLQ 172
 
Name Accession Description Interval E-value
Folate_rec pfam03024
Folate receptor family; This family includes the folate receptor which binds to folate and ...
 29-183 2.20e-34

Folate receptor family; This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.


Pssm-ID: 397250  Cd Length: 172  Bit Score: 121.03  E-value: 2.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   29 GGSRPLQARSQQHHGLAADLGKGklhlagPCCPSEMDTTETSGPGN----HPERCGVPSPECESFLEHLQRA------LR 98
Cdd:pfam03024   6 KHHKPKPSPEPNLHELCAPWKEN------SCCTANTSEEAHRDPSIlynfNWNHCGTLSPECEKFFIQLQCFyecspnLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394581969   99 SRFRLRLLGVRQAQPLCEELCQAWFANCEDDITC----GPTWLPLSEKRGC--EPSCLTYGQTFADGTDLCRSALGHALP 172
Cdd:pfam03024  80 PWIQPWRRERILNVPLCKEFCDAWFEACKDDYTCksnwGKGWLWSSGKNGCpdEPSCRPFKQMFPNGTDLCESIWGHSFK 159

                         170
                  ....*....|...
gi 394581969  173 VA--APGARHCFN 183
Cdd:pfam03024 160 VSpsSRGSGRCLQ 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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