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Conserved domains on  [gi|392996931|ref|NP_001255213|]
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volume-regulated anion channel subunit LRRC8E isoform 1 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-331 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 576.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHELQENLSEAPCQQLLPRGIPEQ 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931   81 --------IGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsspsASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  153 LGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKEKVLAEPEKVVTE-PPVVTLLDKK 226
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  227 EGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 392996931  307 HLFSKLAFCYISFVCIYGLTCIYTL 331
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
521-772 1.84e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 521 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 600
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 601 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996931 761 PeELGNCGGLKK 772
Cdd:COG4886  244 P-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-331 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 576.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHELQENLSEAPCQQLLPRGIPEQ 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931   81 --------IGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsspsASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  153 LGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKEKVLAEPEKVVTE-PPVVTLLDKK 226
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  227 EGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 392996931  307 HLFSKLAFCYISFVCIYGLTCIYTL 331
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
521-772 1.84e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 521 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 600
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 601 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996931 761 PeELGNCGGLKK 772
Cdd:COG4886  244 P-ELGNLTNLEE 254
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-755 3.66e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 3.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 607 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSYNKLETLpSQLGLCSGLRLLDVSHN 686
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 687 glhSLPPEV----------GLLQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLS---QLSPHVGALRALSRLELK 753
Cdd:cd21340  101 ---RLPPGEkltfdprslaALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 392996931 754 GN 755
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
586-764 1.80e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 586 ELELVACGLERIPHAV--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 646
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 647 EHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEELffCRKLRT 726
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 392996931 727 LLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEEL 764
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
LRR_8 pfam13855
Leucine rich repeat;
676-734 3.04e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.04e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996931  676 SGLRLLDVSHNGLHSLPPEVGL-LQNLQHLALSYNALEALPEELFFC-RKLRTLLLGDNQL 734
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-331 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 576.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931    1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHELQENLSEAPCQQLLPRGIPEQ 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931   81 --------IGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISI 152
Cdd:pfam12534  81 aptvsspsASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  153 LGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKEKVLAEPEKVVTE-PPVVTLLDKK 226
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  227 EGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 392996931  307 HLFSKLAFCYISFVCIYGLTCIYTL 331
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
521-772 1.84e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 1.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 521 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 600
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 601 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996931 761 PeELGNCGGLKK 772
Cdd:COG4886  244 P-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
351-721 7.93e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 7.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 351 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLP 430
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 431 DTVFELSEVESLrleaicDITFPPGLSQLVHLQELSLLHSparlpfslqvflrdhlkvmrvkceELREVPLWVFGLRGLE 510
Cdd:COG4886   90 TDLGDLTNLTEL------DLSGNEELSNLTNLESLDLSGN------------------------QLTDLPEELANLTNLK 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 511 ELHLEGLFPQELAraatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDgaRLVAL-NSLKKLAALRELE 588
Cdd:COG4886  140 ELDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNQlTDLPEELGNLT-NLKELDLSNN--QITDLpEPLGNLTNLEELD 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQhcrKLVTLRLWHNQIAYVPEhVRKLRSLEQLYLSYNKLETL 668
Cdd:COG4886  212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 392996931 669 P-SQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 721
Cdd:COG4886  288 KlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-755 3.66e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 3.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 607 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSYNKLETLpSQLGLCSGLRLLDVSHN 686
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 687 glhSLPPEV----------GLLQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLS---QLSPHVGALRALSRLELK 753
Cdd:cd21340  101 ---RLPPGEkltfdprslaALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 392996931 754 GN 755
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
586-764 1.80e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 586 ELELVACGLERIPHAV--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 646
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 647 EHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEELffCRKLRT 726
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 392996931 727 LLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEEL 764
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 534-757 2.12e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 2.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 534 LKQLKVLSLRSNA--GKVPASVTDVAGHLQRLSLHNDG-ARLVALNSLKKLAALRELELVACGleRIPHAVFSLGALQEL 610
Cdd:PLN00113  92 LPYIQTINLSNNQlsGPIPDDIFTTSSSLRYLNLSNNNfTGSIPRGSIPNLETLDLSNNMLSG--EIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 611 DLKDNHLrsIEEI-LSFQHCRKLVTLRLWHNQ-IAYVPEHVRKLRSLEQLYLSYNKLE-TLPSQLGLCSGLRLLDVSHNG 687
Cdd:PLN00113 170 DLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNN 247

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392996931 688 LH-SLPPEVGLLQNLQHLALSYNALEA-LPEELFFCRKLRTLLLGDNQLSQLSPH-VGALRALSRLELKGNRL 757
Cdd:PLN00113 248 LTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGEIPElVIQLQNLEILHLFSNNF 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 499-766 5.85e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 5.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 499 VPLWVFGLRGLEEL-----HLEGLFPQELAraatleslrELKQLKVLSLRSN--AGKVPASVTDVAgHLQRLSLHNDGAR 571
Cdd:PLN00113 276 IPPSIFSLQKLISLdlsdnSLSGEIPELVI---------QLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFS 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 572 LVALNSLKKLAALRELELVACGLE-RIPHAVFSLGALQELDLKDNHLRSiEEILSFQHCRKLVTLRLWHNQIA-YVPEHV 649
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPSEF 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 650 RKLR------------------------SLEQLYLSYNK-LETLPSQLGlCSGLRLLDVSHNGLH-SLPPEVGLLQNLQH 703
Cdd:PLN00113 425 TKLPlvyfldisnnnlqgrinsrkwdmpSLQMLSLARNKfFGGLPDSFG-SKRLENLDLSRNQFSgAVPRKLGSLSELMQ 503

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392996931 704 LALSYNALEA-LPEELFFCRKLRTLLLGDNQLS-QLSPHVGALRALSRLELKGNRLEA-LPEELGN 766
Cdd:PLN00113 504 LKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGN 569
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
631-789 3.03e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 3.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 631 KLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNA 710
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPER--LPSALQSLDLFHNK 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392996931 711 LEALPEELffCRKLRTLLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEELGNcgGLKKagLLVEDTLYQGLPAEV 789
Cdd:PRK15370 274 ISCLPENL--PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLPP--GLKT--LEAGENALTSLPASL 344
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 473-735 8.70e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.65  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 473 RLPFSLQVFLRDHlKVMRVKCEELREVPLWVFGLRGLEEL---------HLEGLFPQELARAATLESLRELKQLKVLSLR 543
Cdd:COG5238   62 YLRFEGQGDPGLN-PVALEKAAEAFPTQLLVVDWEGAEEVspvalaetaTAVATPPPDLRRIMAKTLEDSLILYLALPRR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 544 SNagkVPASVTDVAG-HLQRLSLHNDGARLVALNSLKKLAALRELELVAC--------GLERIPHAVFSLGALQELDLKD 614
Cdd:COG5238  141 IN---LIQVLKDPLGgNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnqigdeGIEELAEALTQNTTVTTLWLKR 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 615 NHL--RSIEEILS-FQHCRKLVTLRLWHNQI-----AYVPEHVRKLRSLEQLYLSYNKL-----ETLPSQLGLCSGLRLL 681
Cdd:COG5238  218 NPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSL 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392996931 682 DVSHNGLhSLPPEVGLLQNLQH------LALSYNAL-----EALPEELFFCRKLRTLLLGDNQLS 735
Cdd:COG5238  298 DLSVNRI-GDEGAIALAEGLQGnktlhtLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIG 361
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 597-693 2.51e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 597 IPHAVFSLGALQELDLKDNHLRS-IEEILSfqHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSYNKLE-TLPSQLG 673
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGeIPDELS--SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                         90       100
                 ....*....|....*....|.
gi 392996931 674 LCSGLRLLDVSHNGLH-SLPP 693
Cdd:PLN00113 569 NVESLVQVNISHNHLHgSLPS 589
LRR_8 pfam13855
Leucine rich repeat;
676-734 3.04e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.04e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996931  676 SGLRLLDVSHNGLHSLPPEVGL-LQNLQHLALSYNALEALPEELFFC-RKLRTLLLGDNQL 734
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
528-718 3.08e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 528 LESLRELKQ--LKVLSLRSNA-GKVPASVTDVaghLQRLSLhnDGARLVALNSlKKLAALRELELVACGLERIPHAVFSl 604
Cdd:PRK15370 211 LKSLPENLQgnIKTLYANSNQlTSIPATLPDT---IQEMEL--SINRITELPE-RLPSALQSLDLFHNKISCLPENLPE- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 605 gALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSYNKLETLPSQL------------ 672
Cdd:PRK15370 284 -ELRYLSVYDNSIRTLPAHLP----SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLppelqvldvskn 356

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 392996931 673 -------GLCSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEEL 718
Cdd:PRK15370 357 qitvlpeTLPPTITTLDVSRNALTNLPEN--LPAALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
699-757 8.93e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 8.93e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996931  699 QNLQHLALSYNALEALPEELFF-CRKLRTLLLGDNQLSQLSPHVGA-LRALSRLELKGNRL 757
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
606-757 1.78e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.70  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 606 ALQELDLKDNHLRSIEEILSfqhcrKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL------------- 672
Cdd:PRK15387 303 GLQELSVSDNQLASLPALPS-----ELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELyklwaynnrltsl 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 673 -GLCSGLRLLDVSHNGLHSLPPevgLLQNLQHLALSYNALEALPeelFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLE 751
Cdd:PRK15387 378 pALPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVN 451


                 ....*.
gi 392996931 752 LKGNRL 757
Cdd:PRK15387 452 LEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 505-668 3.08e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 505 GLRGLEELHLEGlfpQELARAATLESLRELKQLKVLSLRSNAGKV----PASVTDVAGHLQRLSLHNDGarlvaLNSLKK 580
Cdd:cd21340   66 NLVNLKKLYLGG---NRISVVEGLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNSLRVLNISGNN-----IDSLEP 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 581 LAALRELElvacgleriphavfslgalqELDLKDNHLRSIEEIL-SFQHCRKLVTLRLWHNQIAyvpeHVRKLRslEQLY 659
Cdd:cd21340  138 LAPLRNLE--------------------QLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC----KKPKYR--DKII 191


                 ....*....
gi 392996931 660 LSYNKLETL 668
Cdd:cd21340  192 LASKSLEVL 200
PLN03150 PLN03150
hypothetical protein; Provisional
 644-711 5.92e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 5.92e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 644 YVPEHVRKLRSLEQLYLSYNKLE-TLPSQLGLCSGLRLLDVSHNGLH-SLPPEVGLLQNLQHLALSYNAL 711
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
630-688 7.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 7.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996931  630 RKLVTLRLWHNQIAYVPEHV-RKLRSLEQLYLSYNKLETL-PSQLGLCSGLRLLDVSHNGL 688
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
584-642 7.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 7.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  584 LRELELVACGLERIPHAVFS-LGALQELDLKDNHLRSIEEIlSFQHCRKLVTLRLWHNQI 642
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 520-760 1.86e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 520 QELARAATLESLRELKQLKVLSLRSNagkvpasvtdvaghlqrlSLHNDGARLVAlNSLKKLAALRELELVACGLERIPH 599
Cdd:cd00116    8 ELLKTERATELLPKLLCLQVLRLEGN------------------TLGEEAAKALA-SALRPQPSLKELCLSLNETGRIPR 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 600 AVFSLG-------ALQELDLKDNHLrSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKL--------RSLEQLYLSYN 663
Cdd:cd00116   69 GLQSLLqgltkgcGLQELDLSDNAL-GPDGCGVLESLLRSSSLQELKlNNNGLGDRGLRLLakglkdlpPALEKLVLGRN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931 664 KL-----ETLPSQLGLCSGLRLLDVSHN-----GLHSLPPEVGLLQNLQHLALSYNALE-----ALPEELFFCRKLRTLL 728
Cdd:cd00116  148 RLegascEALAKALRANRDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLN 227

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 392996931 729 LGDNQLSQ------LSPHVGALRALSRLELKGNRLEAL 760
Cdd:cd00116  228 LGDNNLTDagaaalASALLSPNISLLTLSLSCNDITDD 265
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 584-761 8.41e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.94  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  584 LRELELVACGLERIPHAVFSLGALQELDLKDNhlRSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKLRSLEQLYLSY 662
Cdd:PLN03210  613 LVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGS--KNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996931  663 -NKLETLPSQLGL----------CSGLRL----------LDVSHNGLHSLPPEVGlLQNLQHLALSYNALEALPEELFFC 721
Cdd:PLN03210  691 cENLEILPTGINLkslyrlnlsgCSRLKSfpdistniswLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVQPL 769

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 392996931  722 RKLRTLL--------LGDNQ-LSQLSPHVGALRALSRLELKGNR-LEALP 761
Cdd:PLN03210  770 TPLMTMLspsltrlfLSDIPsLVELPSSIQNLHKLEHLEIENCInLETLP 819
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 698-772 1.46e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392996931 698 LQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLSQLsPHVGALRALSRLELKGNRLEALpEELGNCGGLKK 772
Cdd:cd21340    1 LKRITHLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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