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Conserved domains on  [gi|387598055|ref|NP_001248371|]
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exostosin-like 2 isoform 4 [Homo sapiens]

Protein Classification

glycosyltransferase family 64 protein( domain architecture ID 141570)

glycosyltransferase family 64 protein catalyzes the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans

CAZY:  GT64
Gene Ontology:  GO:0016757

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_64 super family cl20374
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 66-146 6.41e-29

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


The actual alignment was detected with superfamily member pfam09258:

Pssm-ID: 430488  Cd Length: 241  Bit Score: 105.84  E-value: 6.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598055   66 FTLIMQT-YNRTDLLLKLLNHYQAVPNLHKVIVVWNNigEKAPDELWNSLGPHpIPVIFKQQTANRMRNRLQVFPELETN 144
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN--PKPPPELSRWPGTG-VPVTVIRQKRNSLNNRFLPYPEIETD 77


                  ..
gi 387598055  145 AI 146
Cdd:pfam09258  78 AV 79
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 66-146 6.41e-29

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 105.84  E-value: 6.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598055   66 FTLIMQT-YNRTDLLLKLLNHYQAVPNLHKVIVVWNNigEKAPDELWNSLGPHpIPVIFKQQTANRMRNRLQVFPELETN 144
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN--PKPPPELSRWPGTG-VPVTVIRQKRNSLNNRFLPYPEIETD 77


                  ..
gi 387598055  145 AI 146
Cdd:pfam09258  78 AV 79
 
Name Accession Description Interval E-value
Glyco_transf_64 pfam09258
Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction ...
 66-146 6.41e-29

Glycosyl transferase family 64 domain; Members of this family catalyze the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.


Pssm-ID: 430488  Cd Length: 241  Bit Score: 105.84  E-value: 6.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598055   66 FTLIMQT-YNRTDLLLKLLNHYQAVPNLHKVIVVWNNigEKAPDELWNSLGPHpIPVIFKQQTANRMRNRLQVFPELETN 144
Cdd:pfam09258   1 FTAVINTyYSRIDLLLKLLQRYAGSPHLAKIIVLWNN--PKPPPELSRWPGTG-VPVTVIRQKRNSLNNRFLPYPEIETD 77


                  ..
gi 387598055  145 AI 146
Cdd:pfam09258  78 AV 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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