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Conserved domains on  [gi|386781846|ref|NP_001247437|]
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G protein-activated inward rectifier potassium channel 1 isoform 2 [Homo sapiens]

Protein Classification

inward rectifier potassium channel family protein( domain architecture ID 10470165)

inward rectifier potassium (IRK) channel family protein possess a pore domain and transports potassium (K+), with a greater tendency for K+ uptake than K+ export

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
47-187 6.65e-77

Inward rectifier potassium channel transmembrane domain;


:

Pssm-ID: 460023  Cd Length: 141  Bit Score: 228.22  E-value: 6.65e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781846   47 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVAN 126
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386781846  127 VYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQP 187
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_C super family cl39196
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
 194-234 2.00e-20

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


The actual alignment was detected with superfamily member pfam17655:

Pssm-ID: 465439  Cd Length: 174  Bit Score: 84.56  E-value: 2.00e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 386781846  194 LMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLK 234
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLK 41
 
Name Accession Description Interval E-value
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
47-187 6.65e-77

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 228.22  E-value: 6.65e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781846   47 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVAN 126
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386781846  127 VYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQP 187
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
 194-234 2.00e-20

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 84.56  E-value: 2.00e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 386781846  194 LMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLK 234
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLK 41
 
Name Accession Description Interval E-value
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
47-187 6.65e-77

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 228.22  E-value: 6.65e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781846   47 VDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVAN 126
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDQRPDDGHTPCVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386781846  127 VYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQP 187
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMARP 141
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
 194-234 2.00e-20

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 84.56  E-value: 2.00e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 386781846  194 LMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLK 234
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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