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Conserved domains on  [gi|386642905|ref|NP_001245390|]
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fas-activated serine/threonine kinase isoform 5 [Homo sapiens]

Protein Classification

FAST kinase domain-containing protein( domain architecture ID 10535844)

FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 328-417 2.82e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.53  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386642905  328 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 406
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 386642905  407 LCASSSGAVLP 417
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 250-316 2.45e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 2.45e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386642905  250 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 316
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 457-509 3.46e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 3.46e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 386642905   457 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 509
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 328-417 2.82e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.53  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386642905  328 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 406
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 386642905  407 LCASSSGAVLP 417
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 250-316 2.45e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 2.45e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386642905  250 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 316
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 457-509 3.46e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 3.46e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 386642905   457 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 509
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 456-509 2.44e-10

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 56.05  E-value: 2.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 386642905  456 ERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 509
Cdd:pfam08373   5 GPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Name Accession Description Interval E-value
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 328-417 2.82e-18

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 79.53  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386642905  328 RRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRArcKYSHKDIVAEGLRQLLGEEKY-RQDLTVPPGYCTDFL 406
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKK--KSPLQKEVLEALKELLGGENYfRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 386642905  407 LCASSSGAVLP 417
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 250-316 2.45e-12

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 62.12  E-value: 2.45e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386642905  250 VQKLVLPFGRLNYLP-LEQQFMPCLERILARE-AGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFIN 316
Cdd:pfam06743   1 LLSLLLPFARLNYLPpNAEEFFEKLESVLESYlSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQ 69
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 457-509 3.46e-12

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 61.48  E-value: 3.46e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 386642905   457 RWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 509
Cdd:smart00952   6 PSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 456-509 2.44e-10

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 56.05  E-value: 2.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 386642905  456 ERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQK 509
Cdd:pfam08373   5 GPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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