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Conserved domains on  [gi|384081581|ref|NP_001244895|]
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protein crumbs homolog 1 isoform 4 precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10810785)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 9.84e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 9.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581  514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210   1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 384081581  592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210  81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.14e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 1.67e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 384081581   397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.37e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 2.40e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.40e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581  72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 761-797 5.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 5.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581 761 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 797
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.72e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 384081581 262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 4.45e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.45e-04
                         10        20
                 ....*....|....*....|....*....
gi 384081581 309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 677-707 2.81e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.81e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 384081581 677 ESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 9.84e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 9.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581  514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210   1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 384081581  592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210  81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-649 8.05e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 8.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581 485 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 562
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581 563 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 639
Cdd:cd00110   77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                        170
                 ....*....|
gi 384081581 640 VGCLQDIKID 649
Cdd:cd00110  142 VGCIRDLKVN 151
LamG smart00282
Laminin G domain;
509-649 2.22e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581   509 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 586
Cdd:smart00282   1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384081581   587 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 649
Cdd:smart00282  80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.14e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 1.67e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 384081581   397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.37e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-424 8.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.41e-06
                         10        20
                 ....*....|....*....|....*....
gi 384081581 397 DVNECSS-NPCQNGGTCENLPGNYTCHCP 424
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 1.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.10e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 2.40e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.40e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581  72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 761-797 5.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 5.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581 761 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 797
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-222 9.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 9.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYS-GVNCE 222
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.72e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 384081581 262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 4.45e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.45e-04
                         10        20
                 ....*....|....*....|....*....
gi 384081581 309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
224-260 6.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   224 EIDECWS-QPCLNGATCQDALGAYFCDCAPGF-LGDHCE 260
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 401-424 7.04e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....
gi 384081581  401 CSSNPCQNGGTCENLPGNYTCHCP 424
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 8.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.57e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581  152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-220 8.82e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.82e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581  190 CASDPCKNEATCLNEIGRYTCICPHNYSGVN 220
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
761-797 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   761 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 797
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 1.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 384081581    77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179   9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 677-707 2.81e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.81e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 384081581 677 ESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
309-337 4.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.06e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 384081581   309 PCHNNATCEDSVDNYTCHCWPGYT-GAQCE 337
Cdd:smart00179  10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 8.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 8.99e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581   74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-299 9.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 384081581   262 NTDECAS-QPCLHGGLCVDGENRYSCNCtGSGFT-GTHCE 299
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 514-649 9.84e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 9.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581  514 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 591
Cdd:pfam02210   1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 384081581  592 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 649
Cdd:pfam02210  81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 485-649 8.05e-18

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 8.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581 485 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 562
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581 563 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 639
Cdd:cd00110   77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                        170
                 ....*....|
gi 384081581 640 VGCLQDIKID 649
Cdd:cd00110  142 VGCIRDLKVN 151
LamG smart00282
Laminin G domain;
509-649 2.22e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581   509 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 586
Cdd:smart00282   1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384081581   587 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 649
Cdd:smart00282  80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
Laminin_G_1 pfam00054
Laminin G domain;
514-649 2.67e-08

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 2.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581  514 FQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQsKVLLFISHNTSDGEWHFVEVifaEAVT--LTLIDDSCKE 589
Cdd:pfam00054   1 FRTTEPSGLLLYngTQTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVEL---ERNGrsGTLSVDGEAR 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 384081581  590 KCIAkapTPLESDQSICAFQNSFLGGLPvgmtSNGVALLNFynmPSTPSFVGCLQDIKID 649
Cdd:pfam00054  77 PTGE---SPLGATTDLDVDGPLYVGGLP----SLGVKKRRL---AISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.14e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 4.14e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-438 1.67e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 384081581   397 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 438
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-222 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.37e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 187 VDECAS-DPCKNEATCLNEIGRYTCICPHNYSGVNCE 222
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-424 8.41e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.41e-06
                         10        20
                 ....*....|....*....|....*....
gi 384081581 397 DVNECSS-NPCQNGGTCENLPGNYTCHCP 424
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 1.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.10e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 225-260 2.40e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.40e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 384081581 225 IDEC-WSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Cdd:cd00054    2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581  72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 761-797 5.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 5.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 384081581 761 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 797
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-222 9.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 9.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYS-GVNCE 222
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 262-299 1.72e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.72e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 384081581 262 NTDECASQ-PCLHGGLCVDGENRYSCNCTgSGFTGTHCE 299
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 309-337 4.45e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.45e-04
                         10        20
                 ....*....|....*....|....*....
gi 384081581 309 PCHNNATCEDSVDNYTCHCWPGYTGAQCE 337
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
224-260 6.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   224 EIDECWS-QPCLNGATCQDALGAYFCDCAPGF-LGDHCE 260
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 401-424 7.04e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....
gi 384081581  401 CSSNPCQNGGTCENLPGNYTCHCP 424
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 8.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.57e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581  152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-220 8.82e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.82e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581  190 CASDPCKNEATCLNEIGRYTCICPHNYSGVN 220
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
761-797 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 384081581   761 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 797
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 1.63e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 384081581    77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179   9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 677-707 2.81e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.81e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 384081581 677 ESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 151-182 3.09e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.09e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 384081581 151 ECA-SSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
309-337 4.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 4.06e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 384081581   309 PCHNNATCEDSVDNYTCHCWPGYT-GAQCE 337
Cdd:smart00179  10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 8.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 8.99e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 384081581   74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
262-299 9.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 384081581   262 NTDECAS-QPCLHGGLCVDGENRYSCNCtGSGFT-GTHCE 299
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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