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Conserved domains on  [gi|379056369|ref|NP_001243804|]
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borealin [Homo sapiens]

Protein Classification

Nbl1_Borealin_N and Borealin domain-containing protein( domain architecture ID 10564529)

Nbl1_Borealin_N and Borealin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 163-275 2.02e-42

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


:

Pssm-ID: 463127  Cd Length: 120  Bit Score: 141.35  E-value: 2.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379056369  163 RSSRANTVTPAVGRLEV-----SMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGngSPLADS----KEIFLTVPV 233
Cdd:pfam10512   1 RSSRSKLRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSISG--SPLATGvmpeEDANVNIPV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 379056369  234 GGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSS 275
Cdd:pfam10512  79 GDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.57e-18

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


:

Pssm-ID: 463095  Cd Length: 57  Bit Score: 77.22  E-value: 1.57e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 379056369   20 KLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 163-275 2.02e-42

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


Pssm-ID: 463127  Cd Length: 120  Bit Score: 141.35  E-value: 2.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379056369  163 RSSRANTVTPAVGRLEV-----SMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGngSPLADS----KEIFLTVPV 233
Cdd:pfam10512   1 RSSRSKLRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSISG--SPLATGvmpeEDANVNIPV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 379056369  234 GGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSS 275
Cdd:pfam10512  79 GDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.57e-18

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 77.22  E-value: 1.57e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 379056369   20 KLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Name Accession Description Interval E-value
Borealin pfam10512
Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, ...
 163-275 2.02e-42

Cell division cycle-associated protein 8; The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters.


Pssm-ID: 463127  Cd Length: 120  Bit Score: 141.35  E-value: 2.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 379056369  163 RSSRANTVTPAVGRLEV-----SMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGngSPLADS----KEIFLTVPV 233
Cdd:pfam10512   1 RSSRSKLRTPMAARPKAqsadrSPLGGTPLITPKFDPRTPKTPFLRTPRAGERVYSISG--SPLATGvmpeEDANVNIPV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 379056369  234 GGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSS 275
Cdd:pfam10512  79 GDGESLSLLASDLDSVDLPQLDPETLGQIKLLQSNLAKICKK 120
Nbl1_Borealin_N pfam10444
Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger ...
 20-76 1.57e-18

Nbl1 / Borealin N terminal; Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation. In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p. In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles. Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localization, stability, integrity, and function. The N terminus of Borealin is homologous to Nbl1. This family contains both Nbl1, and the N terminal region of Borealin.


Pssm-ID: 463095  Cd Length: 57  Bit Score: 77.22  E-value: 1.57e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 379056369   20 KLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFAL 76
Cdd:pfam10444   1 KKEALLQNFDLEVEERVRRLRSKLELLLKTLRNRYELRLLRIPKAVRKMTLRELLAK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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