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Conserved domains on  [gi|375493600|ref|NP_001243645|]
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dynein axonemal assembly factor 3 isoform 4 [Homo sapiens]

Protein Classification

DUF4470 and DUF4471 domain-containing protein( domain architecture ID 10631662)

DUF4470 and DUF4471 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
100-389 9.50e-161

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


:

Pssm-ID: 464292  Cd Length: 303  Bit Score: 457.12  E-value: 9.50e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  100 LSLRALKFRERDALEAVFRFWAGGEKGPqaFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRW 179
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPESHP--FDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  180 RDTGVAFELRDSsAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHN 259
Cdd:pfam14740  79 RETGVAFEFREG-EYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  260 VTELLRDVAAWGRARATGGD--------------LEEQQHAEGSPEPGTPAAP--TPESFTVHFLPLNSAQTLHHKSCYN 323
Cdd:pfam14740 158 LLALFHELQTREPYEHDSTDsarygsvqllmtelLPEGEDSEEENTADDDKSDliTLPGVKVHFLPLDSLRKLPHKSKYR 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 375493600  324 GRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQT 389
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKPVT 303
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
23-68 9.15e-13

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


:

Pssm-ID: 464289  Cd Length: 97  Bit Score: 64.09  E-value: 9.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 375493600   23 FFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALL 68
Cdd:pfam14737  52 ITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
100-389 9.50e-161

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 457.12  E-value: 9.50e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  100 LSLRALKFRERDALEAVFRFWAGGEKGPqaFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRW 179
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPESHP--FDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  180 RDTGVAFELRDSsAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHN 259
Cdd:pfam14740  79 RETGVAFEFREG-EYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  260 VTELLRDVAAWGRARATGGD--------------LEEQQHAEGSPEPGTPAAP--TPESFTVHFLPLNSAQTLHHKSCYN 323
Cdd:pfam14740 158 LLALFHELQTREPYEHDSTDsarygsvqllmtelLPEGEDSEEENTADDDKSDliTLPGVKVHFLPLDSLRKLPHKSKYR 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 375493600  324 GRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQT 389
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKPVT 303
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
23-68 9.15e-13

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 64.09  E-value: 9.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 375493600   23 FFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALL 68
Cdd:pfam14737  52 ITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
 
Name Accession Description Interval E-value
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
100-389 9.50e-161

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 457.12  E-value: 9.50e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  100 LSLRALKFRERDALEAVFRFWAGGEKGPqaFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRW 179
Cdd:pfam14740   1 LDLSLLKFKERDQLEAIFKFWRRPESHP--FDIEKYWDQRLRQYLGTRYDSRKGVFDWDLHMKLHDRGANVIHSQEYRRW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  180 RDTGVAFELRDSsAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHN 259
Cdd:pfam14740  79 RETGVAFEFREG-EYQVPNKTLASGRVGNHKGEKVAHRGYWGDIVTGPYISFGIETEDESLLKTSNGQHVKTATDVSERN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375493600  260 VTELLRDVAAWGRARATGGD--------------LEEQQHAEGSPEPGTPAAP--TPESFTVHFLPLNSAQTLHHKSCYN 323
Cdd:pfam14740 158 LLALFHELQTREPYEHDSTDsarygsvqllmtelLPEGEDSEEENTADDDKSDliTLPGVKVHFLPLDSLRKLPHKSKYR 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 375493600  324 GRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQT 389
Cdd:pfam14740 238 NFFDIIFVSASMVHFLKPELFQILAPGAVLVVETAKYLVDLRKEQLQEFAEKVKELAKEAGFKPVT 303
DUF4470 pfam14737
Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and ...
23-68 9.15e-13

Domain of unknown function (DUF4470); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916.


Pssm-ID: 464289  Cd Length: 97  Bit Score: 64.09  E-value: 9.15e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 375493600   23 FFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALL 68
Cdd:pfam14737  52 ITLNDRDPEVVARNILLLLILLEPDDNPGLDEAAELLLHLWYSAFL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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