NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|375364517|ref|NP_001243625|]
View 

PR domain-containing protein 11 isoform 2 [Homo sapiens]

Protein Classification

PR domain-containing protein 11( domain architecture ID 17511780)

PR domain-containing protein 11 (PRDM11) may be involved in transcription regulation

EC:  2.1.1.-
Gene Symbol:  PRDM11
Gene Ontology:  GO:0005515|GO:1904047
PubMed:  12372294|17013555

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 2.58e-91

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


:

Pssm-ID: 380972  Cd Length: 127  Bit Score: 273.27  E-value: 2.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195    1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375364517 189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195   81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
zf_PR_Knuckle super family cl39781
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 6.30e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


The actual alignment was detected with superfamily member pfam18445:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 6.30e-04
                          10        20
                  ....*....|....*....|....*..
gi 375364517   75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 2.58e-91

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 273.27  E-value: 2.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195    1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375364517 189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195   81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 129-230 2.91e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.95  E-value: 2.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517   129 VRCvNEVIPKGHIFGPYEGQISTQD---KSAGFFSWLIVDKNNRYKS-----IDGSDetKANWMRYVVISREEREQNLLA 200
Cdd:smart00317  15 VRA-TEDIPKGEFIGEYVGEIITSEeaeERPKAYDTDGAKAFYLFDIdsdlcIDARR--KGNLARFINHSCEPNCELLFV 91

                           90       100       110
                   ....*....|....*....|....*....|.
gi 375364517   201 FQ-HSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:smart00317  92 EVnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 130-225 1.62e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.05  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517  130 RCV--NEVIPKGHIFGPYEGQ--ISTQDKSAGFFSWLIVDKNNRYK------------SIDGSDETKANWMRYVvisREE 193
Cdd:pfam00856   2 RGLfaTEDIPKGEFIGEYVEVllITKEEADKRELLYYDKLELRLWGpylftldedseyCIDARALYYGNWARFI---NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 375364517  194 REQNLLAF----QHSERIYFRACRDIRPGEWLRVWY 225
Cdd:pfam00856  79 CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 6.30e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 6.30e-04
                          10        20
                  ....*....|....*....|....*..
gi 375364517   75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 2.58e-91

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 273.27  E-value: 2.58e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 188
Cdd:cd19195    1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375364517 189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRLHS 235
Cdd:cd19195   81 ISREEREQNLLAFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRLHS 127
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 111-233 5.43e-41

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 142.76  E-value: 5.43e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 111 LTIPQGMEVvkdtsGESDVR------CVNEVIPKGHIFGPYEGQISTQDKSAGF-FSWLIVDKNNRYKSIDGSDETKANW 183
Cdd:cd19193    2 LTLPPGLSI-----KRSSIPgaglgvWAEAPIPKGMVFGPYEGEIVEDEEAADSgYSWQIYKGGKLSHYIDAKDESKSNW 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 375364517 184 MRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19193   77 MRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 113-226 9.29e-28

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 105.74  E-value: 9.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 113 IPQGMEVVKDTSGESDVR-CVNEVIPKGHIFGPYEGQIstqdksagffswlivdknnryksidgsdetkaNWMRYVVISR 191
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGvFARRTIPAGTRFGPLEGVV--------------------------------NWMRFVRPAR 48

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 375364517 192 EEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYS 226
Cdd:cd10534   49 NEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-233 5.15e-27

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 105.10  E-value: 5.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 112 TIPQGMeVVKDTSGESDVRCV--NEVIPKGHIFGPYEGQISTQDK-----SAGFFsWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19187    2 SLPRNL-TLKYSSVGREVLGVwsSDYIPRGTRFGPLVGEIYTNDPvpkgaNRKYF-WRIYSNGEFYHYIDGFDPSKSNWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 375364517 185 RYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19187   80 RYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 108-233 7.25e-26

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 102.11  E-value: 7.25e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 108 RAALTIPQGMEVVKDTSGESDVRCVNEvIPKGHIFGPYEGQI-STQDKSAgFFSWLIVDKNNRYKSIDGSDETKANWMRY 186
Cdd:cd19199    2 RARSSLPDNLEIRQLEDGSEGVFALVP-LVKRTQFGPFEAKRvARLDGFA-VFPLKVFEKDGSVVYLDTSNEDDCNWMMF 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 375364517 187 VVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19199   80 VRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 131-229 1.62e-25

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 101.01  E-value: 1.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 131 CVNEVIPKGHIFGPYEGQISTQDKSAGFFS-----WLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHS 204
Cdd:cd19191   20 CAAQRIPQGTWIGPFEGVLVSPEKQIGAVRntqhlWEIYDQEGTLQHfIDGGDPSKSSWMRYIRCARHCGEQNLTVVQYR 99

                         90       100
                 ....*....|....*....|....*
gi 375364517 205 ERIYFRACRDIRPGEWLRVWYSEDY 229
Cdd:cd19191  100 GCIFYRACRDIPRGTELLVWYDDSY 124
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 111-233 1.81e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.54  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 111 LTIPQGMEVVKDTSGE---SDVRCvNEVIPKGHIFGPYEG------QISTQDKSAgfFSWLIVDKNNRYKSIDGSDETkA 181
Cdd:cd19198    1 LDLPEGLRVLQTSFGGtphYGVFC-KKTIPKGTRFGPFRGrvvntsEIKTYDDNS--FMWEIFEDGKLSHFIDGRGST-G 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 375364517 182 NWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19198   77 NWMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFM 128
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 136-225 3.24e-22

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 91.73  E-value: 3.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 136 IPKGHIFGPYEGQIST-QDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRD 214
Cdd:cd19188   28 IPKGRKFGPFVGEKKKrSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKP 107

                         90
                 ....*....|.
gi 375364517 215 IRPGEWLRVWY 225
Cdd:cd19188  108 IAPGEELLCWY 118
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 108-233 1.62e-20

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 87.02  E-value: 1.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 108 RAALTIPQGMEVVKdtSGESDVRCVNE-VIPKGHIFGPYEGQISTQDKSAG--FFSWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19194    1 RARASLPLILQIFR--FGETLGGVFAKrRIPKRTQFGPLEGPLVKKSELKDnkIHPLELEEDDGEDLYFDLSDENKCNWM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 375364517 185 RYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19194   79 MFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 108-233 1.71e-19

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 84.44  E-value: 1.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 108 RAALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQIS------TQDKSAGFFSWLIVDKNNRYKSIDGSDETKA 181
Cdd:cd19189    1 RARLSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQShsaevaDWTDKAAPHIWKIYHNDVLEFCIITTDENEC 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 375364517 182 NWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYMKRL 233
Cdd:cd19189   81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 136-230 4.06e-19

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 83.18  E-value: 4.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 136 IPKGHIFGPYEGQISTQD----KSAGFFSWLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFR 210
Cdd:cd19196   25 IKEGTEMGPYTGRIVSPEdvdpCKNNNLMWEVFNEDGTVSHfIDASQENHRSWMTFVNCARNEQEQNLEVVQIGESIYYR 104

                         90       100
                 ....*....|....*....|
gi 375364517 211 ACRDIRPGEWLRVWYSEDYM 230
Cdd:cd19196  105 AIKDIPPDQELLVWYGNSYN 124
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 136-231 2.17e-16

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 75.48  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 136 IPKGHIFGPYEGQISTQDKSAGFfSWLIVDKNNRYKS-IDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRD 214
Cdd:cd19200   34 IEVGEKFGPFVGVQRSSVKDPTY-AWEIVDEFGKVKFwIDASEPGTGNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRD 112

                         90
                 ....*....|....*..
gi 375364517 215 IRPGEWLRVwysedYMK 231
Cdd:cd19200  113 IQPGEELLL-----YMK 124
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 123-228 2.98e-13

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 66.69  E-value: 2.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 123 TSGESDVRCVNEvIPKGHIFGPYEGQ-----------ISTQDKSAGFFSWLIVdknnryKSIDGSDETKANWMRYVVISR 191
Cdd:cd19192   16 TDIFTSVVTTTD-IPAGTIFGPCVLSftlgydiadiaLKTTDKRVVPYIFRVD------TGACNGSSEPSDWLRLVQPAR 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 375364517 192 EEREQNLLAFQHSE-RIYFRACRDIRPGEWLRVWYSED 228
Cdd:cd19192   89 DRHEQNLEAFRKNEgQVYFRTLRRIRKGEELLVWYSDE 126
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 88-229 1.30e-11

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 62.65  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517  88 PNHGPPVfvsdtPVPVGIPDRaaLTIPQGMEVVKDTSGESDVRCVNEV-IPKGHIFGPYEGQISTQDKSAgFFSWLIVDK 166
Cdd:cd19214   12 PKEGSPY-----KAPIYIPDD--IPIPSEFELRESNIPGTGLGIWTKRkIEVGEKFGPYVGEQRSNLKDP-SYGWEVLDE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375364517 167 NNRYK-SIDGSDETKANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWY-SEDY 229
Cdd:cd19214   84 FGNVKfCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMkSEDY 148
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 136-226 1.44e-11

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 60.99  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 136 IPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSI---DGSDETKANWMRYVVISREEREQNLLAFQHSE--RIYFR 210
Cdd:cd19197    1 IPAGLRLGPVPGIFKLGKYLSDRKEPGNKKKVRRVRGDylvDESGSPATEWIGLVRAARNNQEQNLEAIADLPggQIFYR 80

                         90
                 ....*....|....*.
gi 375364517 211 ACRDIRPGEWLRVWYS 226
Cdd:cd19197   81 ALRDIQPGEELTVWYS 96
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 129-227 2.12e-11

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 60.90  E-value: 2.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 129 VRCVNEVIPKGHIFGPYEGQISTQDKSAGffswLIVDKNNRYKSIDGSD-ETKANWMRYVVISREEREQNLLAFQHSERI 207
Cdd:cd10520   23 VWCVGDALQKGTFLGPLEEELESHDLTEG----GSPRQEESGQSGDVLAcEQSSKWMRFACRARSEEESNVAVVRLSGRL 98

                         90       100
                 ....*....|....*....|
gi 375364517 208 YFRACRDIRPGEWLRVWYSE 227
Cdd:cd10520   99 HLRVCKDIEPGSELLLWPEE 118
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 113-228 1.16e-09

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 56.20  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 113 IPQGMEVVKDTSGESDVRCV--NEVIPKGHIFGPYEGQISTQDKSAGffSWLIVDKNNRYKSIDGSDET--KANWMRYVV 188
Cdd:cd19201    3 LPGELELRKPSQDAGRSGGVwaKQPLPEGTRFGPYPGKLVKEPLDPS--YEWKVEAQGSKGGEGLLLLTedSGTWLKLVR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 375364517 189 ISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSED 228
Cdd:cd19201   81 SADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREP 120
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 139-227 1.99e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 56.42  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 139 GHIFGPYEG-QISTQDKSAgfFSWLIVDKNNRYKS------------------IDGSDETKANWMRYVVISREEREQNLL 199
Cdd:cd19213   47 GERFGPYTGvQRSTLKDTN--FGWEQILNDVEVSSqegcitkivddlgnekfcVDAGQAGAGSWLKYIRVACSCDEQNLT 124

                         90       100
                 ....*....|....*....|....*...
gi 375364517 200 AFQHSERIYFRACRDIRPGEWLRVWYSE 227
Cdd:cd19213  125 ACQINEQIYYKVIKDIEPGEELLVYVKD 152
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 129-230 2.91e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.95  E-value: 2.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517   129 VRCvNEVIPKGHIFGPYEGQISTQD---KSAGFFSWLIVDKNNRYKS-----IDGSDetKANWMRYVVISREEREQNLLA 200
Cdd:smart00317  15 VRA-TEDIPKGEFIGEYVGEIITSEeaeERPKAYDTDGAKAFYLFDIdsdlcIDARR--KGNLARFINHSCEPNCELLFV 91

                           90       100       110
                   ....*....|....*....|....*....|.
gi 375364517   201 FQ-HSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:smart00317  92 EVnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 134-231 5.25e-08

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 51.19  E-value: 5.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 134 EVIPKGHIFGPYEGQISTQDKSA-----GFFSWLIVDKNNRYKSIDGSdeTKANWMRYVVISRE---EREQNLLAFQHse 205
Cdd:cd10522   21 ETIAKGEFVGEYTGEVLDRWEEDrdsvyHYDPLYPFDLNGDILVIDAG--KKGNLTRFINHSDQpnlELIVRTLKGEQ-- 96

                         90       100
                 ....*....|....*....|....*.
gi 375364517 206 RIYFRACRDIRPGEWLRVWYSEDYMK 231
Cdd:cd10522   97 HIGFVAIRDIKPGEELFISYGPKYWK 122
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 105-230 9.97e-06

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 44.98  E-value: 9.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517 105 IPDRAALTIPQgmevVKDTSGESDVRCVNevipKGHIFGPYEGQ---ISTQDKSAGF-FSWLIV-DKNNRYKSIDGSDET 179
Cdd:cd19190    5 VPDRFSLKSSK----VQDGMGLYTARRVK----KGEKFGPFAGEkrmPNELDESMDPrLMWEVRgSKGEVLYILDASNPR 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 375364517 180 KANWMRYVVISREEREQNLLAFQHSERIYFRACRDIRPGEWLRVWYSEDYM 230
Cdd:cd19190   77 HSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 130-225 1.62e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 44.05  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375364517  130 RCV--NEVIPKGHIFGPYEGQ--ISTQDKSAGFFSWLIVDKNNRYK------------SIDGSDETKANWMRYVvisREE 193
Cdd:pfam00856   2 RGLfaTEDIPKGEFIGEYVEVllITKEEADKRELLYYDKLELRLWGpylftldedseyCIDARALYYGNWARFI---NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 375364517  194 REQNLLAF----QHSERIYFRACRDIRPGEWLRVWY 225
Cdd:pfam00856  79 CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 6.30e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 37.27  E-value: 6.30e-04
                          10        20
                  ....*....|....*....|....*..
gi 375364517   75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH