|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
30-478 |
1.69e-168 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 485.54 E-value: 1.69e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 30 EMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVG 109
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 110 VILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVV 189
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 190 GNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVE 269
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 270 WWAYEIGSFLMGLL-SVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAVS 348
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYM--------------IPLGISIAASVRVGNELGAGNPKRAKLAAIV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 349 GVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYI 428
Cdd:cd13132 307 ALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYL 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 375331925 429 IGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEE 478
Cdd:cd13132 387 IGLPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
34-473 |
4.91e-64 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 216.21 E-value: 4.91e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQ 113
Cdd:cd13131 5 LLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 114 RGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCV 193
Cdd:cd13131 84 QGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 194 NGVANYALVS----VLNLGVRGSAYANIISQFAQTVFLLLYIVLKKL--HLETWAGWSSQCLQDWGPFFSLAVPSMLMIC 267
Cdd:cd13131 164 NIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGLPIGLTIF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 268 VEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAV 347
Cdd:cd13131 244 FEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFM--------------VPLGISMAATVRVGFALGAGDPADARRAGL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 348 SGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYY 427
Cdd:cd13131 310 VGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYW 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 375331925 428 IIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWK 473
Cdd:cd13131 390 GIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
33-466 |
1.09e-62 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 212.31 E-value: 1.09e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGVIL 112
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 113 QRGALVLLLC-CLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGN 191
Cdd:COG0534 88 GQALLLALLLgLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 192 CVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWW 271
Cdd:COG0534 168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 272 AYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVL 351
Cdd:COG0534 248 GFLVLNALVARLGTAAVAAYGIALRIESLAFM--------------PALGLGQAAQPLVGQNLGAGDYDRARRAARLALL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 352 SIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGL 431
Cdd:COG0534 314 LALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRL 393
|
410 420 430
....*....|....*....|....*....|....*
gi 375331925 432 PLGILLTFvVRMRIMGLWLGMLACVFLATAAFVAY 466
Cdd:COG0534 394 PLAYLLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
40-390 |
4.76e-50 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 176.28 E-value: 4.76e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 40 PLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAvAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVL 119
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 120 LLCCLPCWALFLNTQHILLLFRQ-DPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVAN 198
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 199 YALVSVL--NLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIG 276
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 277 SFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGI 356
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFM--------------PAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLL 305
|
330 340 350
....*....|....*....|....*....|....
gi 375331925 357 SLVLGTLISILKNQLGHIFTNDEDVIALVSQVLP 390
Cdd:TIGR00797 306 GLVLAIILILFREFIARLFTNDPEVLELAAIYLI 339
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
38-466 |
4.03e-46 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 167.50 E-value: 4.03e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 38 SGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRG-A 116
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSiV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 117 LVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGV 196
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 197 ANYALV---SVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAY 273
Cdd:cd12082 160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 274 EIGSFLMG-LLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLS 352
Cdd:cd12082 240 LIIVAIVAaFGGAAALAAYTVAFRIASLAFM--------------PALGLAQAALPVVGQNLGAGNFDRARRITWVALLI 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 353 IVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLP 432
Cdd:cd12082 306 GLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLP 385
|
410 420 430
....*....|....*....|....*....|....
gi 375331925 433 LGILLTfVVRMRIMGLWLGMLACVFLATAAFVAY 466
Cdd:cd12082 386 LAYVLA-YLGLGLYGIWLALVISLILAALVLLLF 418
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-473 |
1.11e-40 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 153.05 E-value: 1.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVcGVSVGVGLSSACDTLMSQSFGSPNKKHVG-VI 111
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWL-LLVLNMALGTGTVALVSQSYGAGDYERARrAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 112 LQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGN 191
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 192 CVNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMIC 267
Cdd:cd13137 161 VLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 268 VEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAV 347
Cdd:cd13137 241 LRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFM--------------PGFGFSMAASTLVGQNLGAGDPDEARRYGK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 348 SGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYY 427
Cdd:cd13137 307 RALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMW 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 375331925 428 IIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWK 473
Cdd:cd13137 387 LVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-472 |
9.55e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 150.37 E-value: 9.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAvAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQ 113
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 114 RG-ALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNC 192
Cdd:cd13133 86 QGlYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 193 VNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLH--LETWAGWSSqCLQDWGPFFSLAVPSMLMI 266
Cdd:cd13133 166 VNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrFGLRRAWRF-DRELLRRILRLGLPSGLQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 267 CVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtriPL-GLSIGVCVRVGMALGAADTVQAKRS 345
Cdd:cd13133 245 FLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFL---------------PMiGLGIAVSSLVGQALGAGRPDLAMRV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 346 AVSGVLSIVGISLVLGTLISILKNQLGHIFTNDED---VIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVN 422
Cdd:cd13133 310 TRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAE 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 375331925 423 AITYYIIGLPLGILLtFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDW 472
Cdd:cd13133 390 LIVAWLYLLPPAYLL-VVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-454 |
1.61e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 144.18 E-value: 1.61e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVgLSSACDTLMSQSFGSPNKKHVGVIL 112
Cdd:cd13134 4 SLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSF-ISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 113 QRGALVLLLC-CLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGN 191
Cdd:cd13134 83 GVALLFNLLLgLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 192 CVNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMIC 267
Cdd:cd13134 163 ILNIVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 268 VEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAV 347
Cdd:cd13134 243 SYNLSQTVITAFIARLGTAALAARTYASNISMFVFL--------------FSLAIGQATQIIVGHLVGAGDFDEAYKRVL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 348 SGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYY 427
Cdd:cd13134 309 KSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMW 388
|
410 420
....*....|....*....|....*..
gi 375331925 428 IIGLPLGILLTFVVRMRIMGLWLGMLA 454
Cdd:cd13134 389 GISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
27-493 |
8.08e-34 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 134.17 E-value: 8.08e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 27 FGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVA-FVNVcgVSVGVGLSSACDTLMSQSFGSPNK 105
Cdd:PRK01766 7 YKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiWLPV--ILFGHGLLLALTPIVAQLNGAGRR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 106 KHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQ-DPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQV 184
Cdd:PRK01766 85 ERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 185 LSGVVGNCVNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKL--HLETWAGWSSQCLQDWGPFFSL 258
Cdd:PRK01766 165 VIGFLGLLINIPLNYIFIygkfGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 259 AVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAAD 338
Cdd:PRK01766 245 GLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFM--------------LPLSLAMALTIRVGFELGAGR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 339 TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFG 418
Cdd:PRK01766 311 TLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVI 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375331925 419 AAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLacVFLATAAfVAYTARLDWklaaeeAKKHSGRQQQQRAES 493
Cdd:PRK01766 391 FFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLI--IGLTAAA-ILLLLRLRK------LQRQPSAIILQRAAR 456
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-473 |
4.25e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 131.43 E-value: 4.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGH-LGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVG-V 110
Cdd:cd13138 4 TLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAKkA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 111 ILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQ----KITWPQVLS 186
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLgdskTPLYFVIIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 187 GVVgncvNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLE-TWAGWSSQcLQDWGPFFSLAVPSMLM 265
Cdd:cd13138 163 CVL----NIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKlSLKDFRFD-KEILKEILKIGLPSALQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 266 ICVEwwayEIGSFLM----GLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQ 341
Cdd:cd13138 238 QSLV----SISFLIInsivNSYGVVASAAYGIANKINSFAFL--------------PPSAIGQAVSTFVAQNIGAGKIER 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 342 AKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAV 421
Cdd:cd13138 300 AKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMII 379
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 375331925 422 NAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWK 473
Cdd:cd13138 380 SILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
53-464 |
3.20e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 120.31 E-value: 3.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 53 IVSTVFCGHL-GKVELASVTLAVAFVNVC-GVSVGVGLSSAcdTLMSQSFGSPNKKHVGVILQRG-ALVLLLCCLPCWAL 129
Cdd:cd13143 25 IVDGIFVGHGvGALALAAVNLVFPIIMLLmALGLMIGVGGA--SLISRRLGAGDREKANRIFSTAlLLSLILGLLLTILG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 130 FLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSVLNLGV 209
Cdd:cd13143 103 LLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVLGLGI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 210 RGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMicvewwayEIGS---------FLM 280
Cdd:cd13143 183 AGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLM--------QLSSsvvtivlnlTLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 281 GLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVL 360
Cdd:cd13143 255 GYGGDIGVAAFGIVTRILTFLFL--------------PLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 361 GTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFV 440
Cdd:cd13143 321 FLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRL 400
|
410 420
....*....|....*....|....*
gi 375331925 441 vrMRIMGLWLGM-LACVFLATAAFV 464
Cdd:cd13143 401 --FGLDGIWLAFpLAEILTLLLALI 423
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
31-473 |
2.37e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 111.90 E-value: 2.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 31 MWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVcGVSVGVGLSSACDTLMSQSFGSPNKKHVGV 110
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFL-FISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 111 ILQR--GALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQ---NQKITWPQVL 185
Cdd:cd13142 89 VAGQtfSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRgigDTKTPMKIMF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 186 SGVVGNCV-NGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLlYIVLK-----KLHLET-WAGWssqclqDWGP-FFS 257
Cdd:cd13142 169 GSVLLNVIlDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGL-YLLFKgrvglKISLRDlKPDW------EWLKkIFR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 258 LAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAViyevatvtymrhSHRLAyaAHVTRIPLGLSIGVCVRVGMALGAA 337
Cdd:cd13142 242 IGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGI------------GNRII--SLVFLPAFGLARATSTMVGQNLGAG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 338 DTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAF 417
Cdd:cd13142 308 QIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLT 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 375331925 418 GAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWK 473
Cdd:cd13142 388 AMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWK 443
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
31-454 |
3.39e-21 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 96.09 E-value: 3.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 31 MWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGK-VELASVTLAVAFVNVCGVSVGVgLSSACDTLMSQSFGSPNKKHVG 109
Cdd:cd13136 2 HREILALALPAILSNITVPLLGLVDTAVVGHLGSaAYLGAVALGTTIFNTLFWLFGF-LRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 110 VILQRG---ALVLLLCCLPCWALFLNtqHILLLFRQDPDVSRLTQDYVMIFIPGLP-VIFLYNLLAKYLQNQKITWPQVL 185
Cdd:cd13136 81 ALLVRAlllALAIGLLLILLQSPLLA--LALLLLGASAAVAALARQYLRIRILGAPaVLLNYVATGWFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 186 SgVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAqTVFLLLYIVLKKLHLETWAGWSSQC-LQDWGPFFSLAVPSML 264
Cdd:cd13136 159 Q-IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYL-GALLGLWLLRRRVRLLGKSLSRRLPsKAALKRLFKLNRDIFI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 265 MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTymrhshrlAYAAHvtriplGLSIGVCVRVGMALGAADTVQAKR 344
Cdd:cd13136 237 RTLALLAAFLFFTALAARLGDVILAANQILLQFWLLS--------SYFLD------GFAYAAEALVGRALGAGDRKAARR 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 345 sAVSGVLSI-VGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNA 423
Cdd:cd13136 303 -VARRLLQWgLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSML 381
|
410 420 430
....*....|....*....|....*....|.
gi 375331925 424 ITyYIIGLPLGILLTFVVRMRimGLWLGMLA 454
Cdd:cd13136 382 VS-LAVFLPLLFLLVPLWGNH--GLWLALIL 409
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
261-436 |
5.22e-20 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 87.24 E-value: 5.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 261 PSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTV 340
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFM--------------FLLGLGTALTTLVGQALGAGNFK 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 341 QAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAA 420
Cdd:pfam01554 67 RAGVALRQGLILGLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMY 146
|
170
....*....|....*.
gi 375331925 421 VNAITyYIIGLPLGIL 436
Cdd:pfam01554 147 INIIS-LLLNIPLNYL 161
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
40-199 |
6.09e-19 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 84.15 E-value: 6.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 40 PLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVcGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVL 119
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASL-IFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 120 LLC-CLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVAN 198
Cdd:pfam01554 80 LLLsLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
.
gi 375331925 199 Y 199
Cdd:pfam01554 160 Y 160
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
28-486 |
8.14e-17 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 83.26 E-value: 8.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 28 GTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVgVGLSSACDTLMSQSFGSPNKKH 107
Cdd:PRK00187 6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFC-VGVIAAVGTLVAIRHGAGDIEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 108 VGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSG 187
Cdd:PRK00187 85 ATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVIS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 188 VVGNCVNGVANYALVSVL----NLGVRGSAYANIISQFAQTVFLLLYIVLKKLH--LETWAGWSSQCLQDWGPFFSLAVP 261
Cdd:PRK00187 165 LAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYaaYPLRKGLSRPSRAALRELWRLGLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 262 SMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMrhshrlayaahvtrIPLGLSIGVCVRVGMALGAADTVQ 341
Cdd:PRK00187 245 IGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFM--------------VPVGLSYAVTMRVGQHYGAGRLLE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 342 AKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDED-----VIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQA 416
Cdd:PRK00187 311 ARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDAR 390
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331925 417 FGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGM---LACVFLA-TAAFVAYTARLDWKLAAEEAKKHSGRQ 486
Cdd:PRK00187 391 TTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLalgLACAAVAlTLAFEWKTARLLRKARASEAVALSAAQ 464
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-437 |
6.78e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 76.89 E-value: 6.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVgvilQ 113
Cdd:cd13144 10 LLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEA----N 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 114 RGALVLLLCCLPCWALFLntqhILLLF---------RQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQV 184
Cdd:cd13144 85 KAANNGLLLALLSYLLFL----LLGLFgvkpffrlfTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 185 LSGVVGNCVNGVAN----YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAV 260
Cdd:cd13144 161 IAQLIGAIINIILDpiliFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 261 PSMLMICvewwayeIGSFLMGLLSVVDL-------SAQAVIYEVATVTYMrhshrlayaahvtriPL-GLSIGVCVRVGM 332
Cdd:cd13144 241 PSIIMQA-------ISSVMVFGLNKILAgfgptavAVFGIYFKLQSFVFM---------------PVfGLNNGLIPIVAY 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 333 ALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGT 412
Cdd:cd13144 299 NYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQAL 378
|
410 420
....*....|....*....|....*
gi 375331925 413 GKQAFGAAVNAITYYIIGLPLGILL 437
Cdd:cd13144 379 GRGVYSLIISVARQLVVLLPLAWLL 403
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-470 |
6.48e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 73.97 E-value: 6.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTlAVAFVNVCG---VSVGVGLSSACDTLMSQSFGSPNKKHVGV 110
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVG-GIGLVFPLGmifLALGNGIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 111 ILQRG-ALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVV 189
Cdd:cd13146 89 AADSGlALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 190 GNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKK----LHLETWAGWSSQCLQdwgpFFSLAVPSMLM 265
Cdd:cd13146 169 GTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKsnvtIHIKLSNISSSVIVE----ILRVGLPQMLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 266 ICVEWWAYEIGSFLMGLLSVVDLSAQAVIyevatvtymrhsHRLAYAAhvtRIP-LGLSIGVCVRVGMALGAADTVQAKR 344
Cdd:cd13146 245 QLISSISFLIYNRIIIDIDPVAMTAFTLV------------GRLDQFI---LIPiFAISSALLTIAGQNWGRGNYDRMLQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 345 SAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAI 424
Cdd:cd13146 310 ILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLI 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 375331925 425 TYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLatAAFVAYTARL 470
Cdd:cd13146 390 RHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFF--TALLAMFWGL 433
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-469 |
2.07e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 66.08 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 42 FLFQVltfMIYIVSTVFCGHLGKVELASVTLA--VAFVNVcgvSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVL 119
Cdd:cd13145 22 FFFNT---MFNVVDTFFAGKISTEALAALSLSfpIFFIII---AIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 120 LLCCLPCWALFLNTQHILLLFRQDPDVSR-LTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVAN 198
Cdd:cd13145 96 IILAILLTVIGLFAAPPLFRLLGAEGDYLdLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 199 YALV----SVLNLGVRGSAYANIISQFAQTVFlLLYIVLKKLHLETwAGWsSQCLQDWGPFFSLA---VPSML-MICVew 270
Cdd:cd13145 176 PLFIfgggGIPAMGVSGIALATIISQFIGMFY-LLYKVRKSGIISG-CRL-RDFIPRLDVYKEILkqgFPASLnMMTI-- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 271 wayEIGSFLMgLLSVVDLSAQAVI-YEVATvtymrhshRLayaAHVTRIP-LGLSIGVCVRVGMALGAADTVQAKRSAVS 348
Cdd:cd13145 251 ---GLGIFVI-TYFVGQFGDEAVAaYGIAL--------RI---EQILLLPtIGLNTAVLSIAGQNFGAKKYDRVRETYKK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 349 GVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYI 428
Cdd:cd13145 316 ALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLV 395
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 375331925 429 IGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTAR 469
Cdd:cd13145 396 GPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-452 |
2.66e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 62.54 E-value: 2.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASV---------TLAVAFVNVCGVSVGVglssacdtlmSQSFGSP 103
Cdd:cd13140 6 TLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVKV----------SQSIGAK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 104 NKKHVGVILQRGALV--LLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITW 181
Cdd:cd13140 76 DEKEARKYARNALQLnlLLGILYGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 182 PQVLSGVVGNCVNGVANYALVSVLN----LGVRGSAYANIISQFaqTVFLLLYIVLKKLHLETWagwssqclqDWGPFFS 257
Cdd:cd13140 156 TPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQA--IVFLLFLYALKKKKGLFL---------KIRILKR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 258 LAVPSMLMICVEWWAYEIGSFLMGLLSVV-----------DLSAQAVIYEVATVTYMrhshrlayAAHvtriplGLSIGV 326
Cdd:cd13140 225 PDRKYIKEILKLGLPVALQSILFALISMIlariiasfgpvAIAAQKVGSQIESISWM--------TAE------GFSTAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 327 CVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYG 406
Cdd:cd13140 291 AAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTT 370
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 375331925 407 GVLRGTGKQAFgAAVNAITYYIIGLPLGILLTFVVrMRIMGLWLGM 452
Cdd:cd13140 371 GAFNGLGRTKP-PAIISIVFNGLRIPLALLLSPTG-LGLNGIWWAI 414
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
37-467 |
2.45e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 59.48 E-value: 2.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 37 LSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGA 116
Cdd:cd13147 14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 117 LVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGV 196
Cdd:cd13147 93 LLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNII 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 197 ANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKK-LHLETWAG---WSSQCLQDwgpFFSLAVPSMLmicvewwA 272
Cdd:cd13147 173 LDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdTYVSLSLKnfkFDKKIVKD---ILKVGIPASL-------E 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 273 YEIGSFLMGLLSVVdLSAQAVIYEVATVTymrHSHRLAYAAhvtRIPL-GLSIGVCVRVGMALGAADTVQAKRSAVSGVL 351
Cdd:cd13147 243 QLIMSVLMIILNLI-LVIVAGTDGVAVYT---AGWRIVSFA---IIPLiGIATAVTSVTGAAYGARNYEKLKTAYNYSIK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 352 SIVGISLVLGTLISILKNQLGHIFT---NDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYI 428
Cdd:cd13147 316 LGLIIELIIAILIFIFAPQIAYLFTyseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELI 395
|
410 420 430
....*....|....*....|....*....|....*....
gi 375331925 429 IGLPLGILLTFVVRMRIMGLWLGMLACVflATAAFVAYT 467
Cdd:cd13147 396 FQVLFAYLFAIVLGLGLFGVWWGIVLGN--AIGSIVGYL 432
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
252-469 |
8.09e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 57.85 E-value: 8.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 252 WGPFFSLAVPSMlmicvewwayeIGSFLMGLLSVVD-----------LSAQAVIYEVATVTYMrhshrlayaahvtrIPL 320
Cdd:COG0534 7 LKLLLRLALPII-----------LGNLLQSLYGLVDtifvgrlgtaaLAAVGLAFPIFFLLIA--------------LGI 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 321 GLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEA 400
Cdd:COG0534 62 GLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLL 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 375331925 401 ICCVYGGVLRGTGK-------QAFGAAVNAItyyiiglpLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTAR 469
Cdd:COG0534 142 LFNVLNGILRGLGDtktpmiiMLIGNVLNIV--------LDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFR 209
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-454 |
2.46e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 56.53 E-value: 2.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVgLSSACDTLMSQSFGSPNKKHvgvILQ 113
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGS-ISIGFTILGSQSVGAKDIKR---IND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 114 RGALVLLLCCLPCWALFL----NTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVV 189
Cdd:cd13135 79 YAISSIVYNSIIGVILFLlwlfGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 190 GNCVNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLLYIV-LKKLHLETWAGWSSQclQDWGPFF---SLAVP 261
Cdd:cd13135 159 KNLLNVILDYVLIfgnfGFPRLGIIGAAIATTIANVLNLIILVYLCRkIKKLTFKLSNTKVLK--ANIRPYKftiKLGLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 262 SMLMicvewwayeigSFLMGLLSVVDLSAQAVIYEVATVTYmrhSHRLAYAAHVTRIPLGLSIGVCVRVGMALGAADTVQ 341
Cdd:cd13135 237 LGGE-----------EFLWNIGNLAVIRILNRIGELALGIY---TLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKE 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 342 AKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGK------- 414
Cdd:cd13135 303 ALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDtkwmlyt 382
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 375331925 415 QAFGAavnaityyIIGLPLGILLTFVVRMRIMGLWLGMLA 454
Cdd:cd13135 383 QIIGT--------IIVVSVALLLIFVFKLGLAGVYITLFI 414
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
31-230 |
3.10e-08 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 55.92 E-value: 3.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 31 MWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGV 110
Cdd:COG0534 228 LKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDRARR 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 111 ILQRGALV-LLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVV 189
Cdd:COG0534 307 AARLALLLaLGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLL 386
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 375331925 190 GNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLY 230
Cdd:COG0534 387 RLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-473 |
4.66e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 55.70 E-value: 4.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCgVSVGVGLSSACDTLMSQSFGSPNKKHVGV-IL 112
Cdd:cd13139 16 IFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFaAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 113 QRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNC 192
Cdd:cd13139 95 QAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 193 VNGVAN----YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWagwSSQCLQDWGPFFSL---AVPSMLM 265
Cdd:cd13139 175 LNIILDplfiFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIR---RRHLKLDWAIIKKIikiAVGGILQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 266 icvewwaYEIGS----FLMGLLSVVDLSAQAViYEVATVTYMrhshrlayaahVTRIPL-GLSIGVCVRVGMALGAADTV 340
Cdd:cd13139 252 -------FLIASsswiFLVRIIAEFGSTALAG-YTIAIRIIM-----------FALLPAwGLSNAAATLVGQNLGAGQPD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 341 QAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAiccvYGGVLrgtgKQAFGAA 420
Cdd:cd13139 313 RAEKSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYG----YGMVL----SQAFNGA 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 375331925 421 --------VNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWK 473
Cdd:cd13139 385 gdtktptlINLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWK 445
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-462 |
1.87e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 50.38 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 33 TLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGvSVGVGLSSACDTLMSQSFGSPNKKHVGVIL 112
Cdd:cd13149 10 HLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAKRLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 113 QRGALVLLLCCLPCWALFLNTQHILL-LFRQDPDVSRLTQDYVMIFIPGLPVIFL---YNLLAKYLQNQKItwPQVLSGV 188
Cdd:cd13149 89 TDSLILSLLLSVIVSLLGLFTIPPLFsLLGASGEILPLIVEYMAIWYLGLVFLVLpmvGNAIIRATGDTKR--PSLVMLG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 189 VGnCVNGVANYALV----SVLNLGVRGSAYANIISQFAQTVFLLlYIVLKKLHLETWAGWS-SQCLQDWGPFFSLAVPSm 263
Cdd:cd13149 167 AA-LVNVILDPILIfgfgPIPGMGIAGAAIATVISRALGLGAAL-YFLHYHHRLIDFSEPSlKALFRSWKDILSIGIPA- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 264 lmicvewwayeIGSFLMGLLSVVDLSAQAVIYEVATVTYMRHSHRLAYAAHVtrIPLGLSIGVCVRVGMALGAADTVQAK 343
Cdd:cd13149 244 -----------ALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFI--IVMALSSALGPFVGQNWGAGQYERVQ 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 344 RSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNA 423
Cdd:cd13149 311 EGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNL 390
|
410 420 430
....*....|....*....|....*....|....*....
gi 375331925 424 ITYYIIGLPLGILltfvvrmrimGLWLGMLACVFLATAA 462
Cdd:cd13149 391 IRVFLLYIPLAYV----------GSHLLGFAGVFIGALA 419
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
143-320 |
8.14e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 45.53 E-value: 8.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 143 DPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSVLnlGVRGSAYANIISQFA 222
Cdd:COG0728 338 TAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALV 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 223 QtVFLLLYIVLKKLHLETWAGWssqclqdWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTY 302
Cdd:COG0728 416 N-ALLLLVLLRRRLGGLPLRGI-------LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVY 487
|
170
....*....|....*...
gi 375331925 303 mrhshrlAYAAHVTRIPL 320
Cdd:COG0728 488 -------FALLLLLGVRL 498
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
30-231 |
9.34e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 45.01 E-value: 9.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 30 EMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHL-GKVELASVTLAVAFVNVcGVSVGVGLSSACDTLMSQSFGSPNKKHV 108
Cdd:cd12082 217 LLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASL-AFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 109 GVILQRGALVLLLCCLPCWA-LFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSG 187
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLlILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 375331925 188 VVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYI 231
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
34-231 |
2.98e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 43.46 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 34 LFALSGPL---FLFQVLTFmiyIVSTVFCGHLGKVELASVTLA--VAFVNVCGVSVgvgLSSACDTLMSQSFGSPNKKHV 108
Cdd:cd13141 13 IISMALPIaigMIIQTLYF---LVDLYFVGQLGDAALAGVSLAgnVMFFVMALTQV---LNVGTAALVSHAVGRKDQGEA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 109 GVIL-QRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKITWP----Q 183
Cdd:cd13141 87 NAVFnQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPfmviQ 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 375331925 184 VLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYI 231
Cdd:cd13141 167 ILAVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYF 214
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
31-156 |
1.70e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 40.69 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 31 MWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVsVGVGLSSACDTLMSQSFGSPNKKHVGV 110
Cdd:TIGR00797 215 LKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFM-PAFGFGIAVSILVGQALGAGDPKRAKE 293
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 375331925 111 ILQRGALV-LLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMI 156
Cdd:TIGR00797 294 VARVALKLsLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIF 340
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
53-282 |
4.55e-03 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 39.59 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 53 IVSTVFCGH-LGKVELASVTLA---VAFVNVCGVSVGVGLSSacdtLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWA 128
Cdd:PRK09575 33 IVDGIFIGHyVGAEGLAGINMAwpvIGIILGIGLMVGMGTGS----LLSIKRGEGDLEKAKRILTTGLLLLLLLGPIVSV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 129 L-FLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKItwPQVLSG--VVGNCVNGVANYALVSVL 205
Cdd:PRK09575 109 IlFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGALINIVLDYLFIGWL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 206 NLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLEtwagWSSQCLQ-DW---GPFFSLAVPSMLMicvewwaYEIGSFLMG 281
Cdd:PRK09575 187 DWGLTGAAIATALAQLVVTVLGLGYFFSSRANIR----LTLKELRfNWslaPKIVLLGSSSFFM-------YLYGSFVVA 255
|
.
gi 375331925 282 L 282
Cdd:PRK09575 256 L 256
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
153-234 |
8.26e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 38.68 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331925 153 YVMIFIPGLPVIFLYNLLAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSvlNLGVRGSAYANIISQFaqTVFLLLYIV 232
Cdd:cd13128 325 VLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIP--KYGIIGAAIATLISEF--IIFILLLYL 400
|
..
gi 375331925 233 LK 234
Cdd:cd13128 401 LK 402
|
|
| |
