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Conserved domains on  [gi|371121601|ref|NP_001243048|]
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N-alpha-acetyltransferase 10 isoform 2 [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-113 1.01e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96


                  ....*.
gi 371121601  108 SLHVRK 113
Cdd:pfam00583  97 FLEVAA 102
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-113 1.01e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96


                  ....*.
gi 371121601  108 SLHVRK 113
Cdd:pfam00583  97 FLEVAA 102
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-136 4.52e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 58.56  E-value: 4.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   3 IRNARPEDLMNMQHCNLLCLPENYQMKY-YFYHGLSWPQLSYIAEDeNGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSH 81
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELvDRLREDPAAGLSLVAED-DGEIVGHVALSPVDIDGEGPALLLGPLAVDPEY 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 371121601  82 RRLGLAQKLMDQASRAMIENfNAKYVSLHVRKRI---------SEVEPKYYADGEDAYAMKRDL 136
Cdd:COG3153   80 RGQGIGRALMRAALEAARER-GARAVVLLGDPSLlpfyerfgfRPAGELGLTLGPDEVFLAKEL 142
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-110 8.33e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 8.33e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371121601  42 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 110
Cdd:cd04301    1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 39-113 2.57e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 36.83  E-value: 2.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371121601  39 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRK 113
Cdd:PRK03624  44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVRE 111
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 28-113 1.01e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   28 MKYYFYHGLSWPQLSYIAEDENGKIVGYVLAKMeeDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIEnFNAKYV 107
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSI--IDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERI 96


                  ....*.
gi 371121601  108 SLHVRK 113
Cdd:pfam00583  97 FLEVAA 102
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-136 4.52e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 58.56  E-value: 4.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   3 IRNARPEDLMNMQHCNLLCLPENYQMKY-YFYHGLSWPQLSYIAEDeNGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSH 81
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELvDRLREDPAAGLSLVAED-DGEIVGHVALSPVDIDGEGPALLLGPLAVDPEY 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 371121601  82 RRLGLAQKLMDQASRAMIENfNAKYVSLHVRKRI---------SEVEPKYYADGEDAYAMKRDL 136
Cdd:COG3153   80 RGQGIGRALMRAALEAARER-GARAVVLLGDPSLlpfyerfgfRPAGELGLTLGPDEVFLAKEL 142
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-110 8.33e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.05  E-value: 8.33e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371121601  42 SYIAEDEnGKIVGYVLAKMEEDPDDvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLH 110
Cdd:cd04301    1 FLVAEDD-GEIVGFASLSPDGSGGD--TAYIGDLAVLPEYRGKGIGSALLEAAEEEARER-GAKRLRLE 65
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-137 2.47e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 52.74  E-value: 2.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601  54 GYVLAKMEEDPDdvpHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRK--------------RISEVE 119
Cdd:COG0456    1 GFALLGLVDGGD---EAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREdneaaialyeklgfEEVGER 76

                         90
                 ....*....|....*...
gi 371121601 120 PKYYADgeDAYAMKRDLT 137
Cdd:COG0456   77 PNYYGD--DALVMEKELA 92
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 1-94 2.02e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 48.45  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   1 MNIRNARPEDLMNMQHcnlLCLPENYQMKYYFYhglswpqlsYIAEdENGKIVGYV-LAKMEEDpddvpHGHITSLAVKR 79
Cdd:COG1246    1 MTIRPATPDDVPAILE---LIRPYALEEEIGEF---------WVAE-EDGEIVGCAaLHPLDED-----LAELRSLAVHP 62

                         90
                 ....*....|....*
gi 371121601  80 SHRRLGLAQKLMDQA 94
Cdd:COG1246   63 DYRGRGIGRRLLEAL 77
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-114 2.25e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 47.06  E-value: 2.25e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 371121601   43 YIAEDeNGKIVGYVLAKMEEDPDDVPHGHItslAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHVRKR 114
Cdd:pfam13508   6 FVAED-DGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRALLEAAEAAAKEG-GIKLLELETTNR 72
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
48-137 2.61e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 42.48  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601  48 ENGKIVGY--VLakmeedPDDVPHGHITSLAVKRSHRRLGLAQKLMdQASRAMIENFNAKYVSLHVR------------K 113
Cdd:COG2153   41 DDGELVATarLL------PPGDGEAKIGRVAVLPEYRGQGLGRALM-EAAIEEARERGARRIVLSAQahavgfyeklgfV 113

                         90       100
                 ....*....|....*....|....
gi 371121601 114 RISEVepkYYADGEDAYAMKRDLT 137
Cdd:COG2153  114 PVGEE---FLEAGIPHIDMRKPLS 134
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-136 6.23e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 41.90  E-value: 6.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601   1 MNIRNARPEDLMNMQHCNLLCLPENY-----------QMKYYFYHGLSWPQLSYIAEdENGKIVGYVLAKMEEDPDDVPH 69
Cdd:COG1247    2 MTIRPATPEDAPAIAAIYNEAIAEGTatfeteppseeEREAWFAAILAPGRPVLVAE-EDGEVVGFASLGPFRPRPAYRG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371121601  70 GHITSLAVKRSHRRLGLAQKLMD---QASRAM--------IENFNAKYVSLHVR---KRISEVEPKYYADGE--DAYAMK 133
Cdd:COG1247   81 TAEESIYVDPDARGRGIGRALLEaliERARARgyrrlvavVLADNEASIALYEKlgfEEVGTLPEVGFKFGRwlDLVLMQ 160


                 ...
gi 371121601 134 RDL 136
Cdd:COG1247  161 KRL 163
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 47-110 3.48e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 39.18  E-value: 3.48e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371121601   47 DENGKIVGYVLAKMeedpddvpHGHITSLAVKRSHRRLGLAQKLMDQA-SRAMIENFNAKYVSLH 110
Cdd:pfam13673  37 FEGGQIVGVIALRD--------RGHISLLFVDPDYQGQGIGKALLEAVeDYAEKDGIKLSELTVN 93
PRK03624 PRK03624
putative acetyltransferase; Provisional
 39-113 2.57e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 36.83  E-value: 2.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371121601  39 PQLSYIAEDeNGKIVGYVLAKMeedpdDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFNAKyVSLHVRK 113
Cdd:PRK03624  44 PSLFLVAEV-GGEVVGTVMGGY-----DGHRGWAYYLAVHPDFRGRGIGRALVARLEKKLIARGCPK-INLQVRE 111
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
56-111 5.11e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 34.88  E-value: 5.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 371121601  56 VLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENfNAKYVSLHV 111
Cdd:COG3393    2 LVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALAR-GARTPFLYV 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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