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Conserved domains on  [gi|362999411|ref|NP_001241669|]
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sodium/potassium/calcium exchanger 1 isoform 2 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 14-426 1.16e-176

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 522.63  E-value: 1.16e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    14 LAKEKEEESLNQGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG-------- 85
Cdd:TIGR00927  621 VAKVMALGDLSKGDVAEAEHTGERTGEEGERP-----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqeg 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    86 -------EEGETAGEGETEEKSGGETQPEG---EGETETQGKGEECE--------DENEAEGKGDN-------------- 133
Cdd:TIGR00927  696 egeieakEADHKGETEAEEVEHEGETEAEGtedEGEIETGEEGEEVEdegegeaeGKHEVETEGDRketehegeteaegk 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   134 EGEDEGEIHA-EDGEMKGNEG----------------------------------ETESQELSAENHGEAKNDEKGVEDG 178
Cdd:TIGR00927  776 EDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGG 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   179 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 258
Cdd:TIGR00927  856 GGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 928

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   259 ESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 338
Cdd:TIGR00927  929 EARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 1008

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   339 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 418
Cdd:TIGR00927 1009 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 1088


                   ....*...
gi 362999411   419 IISCPVSV 426
Cdd:TIGR00927 1089 IISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 14-426 1.16e-176

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 522.63  E-value: 1.16e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    14 LAKEKEEESLNQGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG-------- 85
Cdd:TIGR00927  621 VAKVMALGDLSKGDVAEAEHTGERTGEEGERP-----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqeg 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    86 -------EEGETAGEGETEEKSGGETQPEG---EGETETQGKGEECE--------DENEAEGKGDN-------------- 133
Cdd:TIGR00927  696 egeieakEADHKGETEAEEVEHEGETEAEGtedEGEIETGEEGEEVEdegegeaeGKHEVETEGDRketehegeteaegk 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   134 EGEDEGEIHA-EDGEMKGNEG----------------------------------ETESQELSAENHGEAKNDEKGVEDG 178
Cdd:TIGR00927  776 EDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGG 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   179 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 258
Cdd:TIGR00927  856 GGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 928

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   259 ESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 338
Cdd:TIGR00927  929 EARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 1008

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   339 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 418
Cdd:TIGR00927 1009 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 1088


                   ....*...
gi 362999411   419 IISCPVSV 426
Cdd:TIGR00927 1089 IISCPVSV 1096
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 263-414 2.84e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 116.93  E-value: 2.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411  263 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 342
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 362999411  343 VGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIascKWRMNKILGFTMFLLYFVFLIISVM 414
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL---FGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
252-411 4.46e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 100.98  E-value: 4.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 252 VPDVRRQESRKFFVFTFLGSIMwIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 331
Cdd:COG0530  142 LEEKPKMSLWKALLLLVLGLAL-LVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 332 SSVGSNIFDITVGLPVPWLlfslingLQPVPVSSN------------GLFCAIvllflmllfvissIASCKWRMNKILGF 399
Cdd:COG0530  221 NIIGSNIFNILLVLGIGAL-------ITPIPVDPAvlsfdlpvmlaaTLLLLG-------------LLRTGGRIGRWEGL 280

                        170
                 ....*....|..
gi 362999411 400 TMFLLYFVFLII 411
Cdd:COG0530  281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 294-351 1.77e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 73.91  E-value: 1.77e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 362999411 294 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 351
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 14-426 1.16e-176

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 522.63  E-value: 1.16e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    14 LAKEKEEESLNQGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPG-------- 85
Cdd:TIGR00927  621 VAKVMALGDLSKGDVAEAEHTGERTGEEGERP-----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAerkgeqeg 695

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411    86 -------EEGETAGEGETEEKSGGETQPEG---EGETETQGKGEECE--------DENEAEGKGDN-------------- 133
Cdd:TIGR00927  696 egeieakEADHKGETEAEEVEHEGETEAEGtedEGEIETGEEGEEVEdegegeaeGKHEVETEGDRketehegeteaegk 775

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   134 EGEDEGEIHA-EDGEMKGNEG----------------------------------ETESQELSAENHGEAKNDEKGVEDG 178
Cdd:TIGR00927  776 EDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqaddtevkdETGEQELNAENQGEAKQDEKGVDGG 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   179 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 258
Cdd:TIGR00927  856 GGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQ 928

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   259 ESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 338
Cdd:TIGR00927  929 EARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNI 1008

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411   339 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 418
Cdd:TIGR00927 1009 FDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 1088


                   ....*...
gi 362999411   419 IISCPVSV 426
Cdd:TIGR00927 1089 IISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 259-408 2.90e-40

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 145.54  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411  259 ESRKFFVFTFL---GSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVG 335
Cdd:TIGR00367 163 NRRPQIFFSLVlliIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIG 242

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 362999411  336 SNIFDITVGLPVPWLLFSLIngLQPVPVSSNGLFCAIVLLFLMLLFVIsSIASCKWrmnkiLGFTMFLLYFVF 408
Cdd:TIGR00367 243 SNIFNILVGLGVPSLFMPIP--VEPLAYNLDAPVMVIVTLLLMLFFKT-SMKLGRW-----EGILLLALYIAY 307
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 263-414 2.84e-31

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 116.93  E-value: 2.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411  263 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 342
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 362999411  343 VGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIascKWRMNKILGFTMFLLYFVFLIISVM 414
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL---FGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
252-411 4.46e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 100.98  E-value: 4.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 252 VPDVRRQESRKFFVFTFLGSIMwIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 331
Cdd:COG0530  142 LEEKPKMSLWKALLLLVLGLAL-LVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 332 SSVGSNIFDITVGLPVPWLlfslingLQPVPVSSN------------GLFCAIvllflmllfvissIASCKWRMNKILGF 399
Cdd:COG0530  221 NIIGSNIFNILLVLGIGAL-------ITPIPVDPAvlsfdlpvmlaaTLLLLG-------------LLRTGGRIGRWEGL 280

                        170
                 ....*....|..
gi 362999411 400 TMFLLYFVFLII 411
Cdd:COG0530  281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 294-351 1.77e-14

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 73.91  E-value: 1.77e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 362999411 294 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 351
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
286-368 1.93e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 70.55  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 286 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFslinglqPVPVSS 365
Cdd:COG0530    8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-------PLAVDR 80


                 ...
gi 362999411 366 NGL 368
Cdd:COG0530   81 RVL 83
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 289-416 6.25e-11

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 63.11  E-value: 6.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411  289 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLlfslingLQPVPVSSNGL 368
Cdd:TIGR00367  28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAI-------FSPIIVDKDWL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 362999411  369 FcaIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 416
Cdd:TIGR00367 101 R--RDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNE 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 251-413 6.31e-08

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 54.77  E-value: 6.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 251 TVPDvrrQESRKFFVFTFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlG 326
Cdd:PLN03151 471 TEPD---RPPRRFLIPWVLGgfimSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-G 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 327 D---MAVSSSVGSNIFDITVGLPVPWLL--FSLINGLQPVPvSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTM 401
Cdd:PLN03151 547 DgvqIAMSGCYAGPMFNTLVGLGMSMLLgaWSKSPESYMLP-EDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGL 625

                        170
                 ....*....|..
gi 362999411 402 FLLYFVFLIISV 413
Cdd:PLN03151 626 IALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 282-341 8.24e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 53.50  E-value: 8.24e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411 282 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 341
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNI 81
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 267-349 1.44e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 44.40  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 362999411  267 TFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGL 345
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837


                  ....
gi 362999411  346 PVPW 349
Cdd:TIGR00845 838 GVAW 841
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 28-84 4.83e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 38.83  E-value: 4.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 362999411  28 RAQPQAKAESKPEEEEPAklpAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMP 84
Cdd:PHA03264 252 GVVPPYFEESKGYEPPPA---PSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEG 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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