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Conserved domains on  [gi|358679303|ref|NP_001240622|]
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mucolipin-3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 70-221 1.59e-103

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


:

Pssm-ID: 410968  Cd Length: 169  Bit Score: 306.63  E-value: 1.59e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  70 IAMVTIQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLN 149
Cdd:cd21072   18 IDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNIYPLQPFHNGTAAENKLN 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358679303 150 LTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGS 221
Cdd:cd21072   98 FTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRECKDWHVSGS 169
PKD_channel super family cl37568
Polycystin cation channel; This family contains the cation channel region from group II of ...
 319-452 1.31e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


The actual alignment was detected with superfamily member pfam08016:

Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.36  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  319 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 398
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 358679303  399 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 452
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
 
Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 70-221 1.59e-103

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


Pssm-ID: 410968  Cd Length: 169  Bit Score: 306.63  E-value: 1.59e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  70 IAMVTIQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLN 149
Cdd:cd21072   18 IDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNIYPLQPFHNGTAAENKLN 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358679303 150 LTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGS 221
Cdd:cd21072   98 FTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRECKDWHVSGS 169
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 319-452 1.31e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.36  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  319 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 398
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 358679303  399 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 452
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 320-458 1.95e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 47.63  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  320 LLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLI 399
Cdd:PLN03223 1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 358679303  400 NGD-DMFatFAKMQQKSYLVWLFSRIYLYSFiSLFIYMILSLF-IALITDTYETIKQYQQD 458
Cdd:PLN03223 1374 LGDiTYF--NEDLKNLTGLQFVVGMIYFYSY-NIFVFMILFNFlLAIICDAFGEVKANAAE 1431
 
Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 70-221 1.59e-103

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


Pssm-ID: 410968  Cd Length: 169  Bit Score: 306.63  E-value: 1.59e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  70 IAMVTIQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLN 149
Cdd:cd21072   18 IDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNIYPLQPFHNGTAAENKLN 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358679303 150 LTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGS 221
Cdd:cd21072   98 FTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRECKDWHVSGS 169
ELD_TRPML1 cd21070
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 1 ...
 76-220 7.78e-61

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 1 (TRPML1); TRPML1, also called mucolipin-1 (ML1), or MG-2, or Mucolipidin, may play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML1. It forms a tight tetramer that is crucial for full-length TRPML1 assembly and localization.


Pssm-ID: 410966  Cd Length: 171  Bit Score: 196.95  E-value: 7.78e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  76 QYLQLYNVSVGNHAY-ENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFH-IGTPAENKLNLTLD 153
Cdd:cd21070   24 QYLALPNVTLGRYAYvRGGWTNGSALALCQQYYHKGHIDPANDTFNIDPLVVTDCIGVDPPERPPpPLESSRSYKNFTLK 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358679303 154 FHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSG 220
Cdd:cd21070  104 FHKLINVTIQFQLKAINLQTIINNEIPDCYTFSITITFDNKAHSGRIKISLENQAHIKECKDPSVFG 170
ELD_TRPML2 cd21071
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 2 ...
 73-216 8.00e-49

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 2 (TRPML2); TRPML2, also called mucolipin-2 (ML2), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It may activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML2. It forms a tight tetramer that is crucial for full-length TRPML2 assembly and localization.


Pssm-ID: 410967  Cd Length: 167  Bit Score: 165.26  E-value: 8.00e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  73 VTIQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTL 152
Cdd:cd21071   24 AIDQYAQLKNLSVGPLSYAEDEDELLPLKICKQLYKKGSVKPSEEVYDIDAQLETVCLTIDPKTLNDKKWKMSNSSFFEL 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 358679303 153 DFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDW 216
Cdd:cd21071  104 DFYRLVQIEITFRLKGINLQTIRSRELPDCYTFFVTITFDNQCHSGKIKIYFDSDAVSSACKDW 167
ELD_TRPML cd21050
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins ...
 73-214 1.81e-47

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs); TRPML family proteins contain a linker between the first two transmembrane helices (S1 and S2), which is called TRPML I-II linker. It forms a tight tetramer that is crucial for full-length TRPMLs assembly and localization. In lysosomes and endosomes, this linker faces the lumen (it is therefore also referred to as the 'luminal linker'); on the plasma membrane, it faces the extracellular solution. TRPML I-II linker has been named as extracytosolic/lumenal domain (ELD).


Pssm-ID: 410965  Cd Length: 167  Bit Score: 162.03  E-value: 1.81e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  73 VTIQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENK----- 147
Cdd:cd21050   21 AVNQYYNLENIAIGSYGYDSNNGTPPPITLCVTQYKNGEVDPFNNTYVFDPTVITDCLSIPPTYPENDNLWDSIKdflks 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358679303 148 LNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECK 214
Cdd:cd21050  101 KNFTLNFDRLIKIELKFSLKTIHLKSLKPLDSPECYKFNVTILFDNSAHDGQMPVSLDTNISELECN 167
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 319-452 1.31e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.36  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  319 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 398
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 358679303  399 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 452
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 329-457 1.23e-05

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 46.49  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  329 WLGVIRYLGFFAKYNLLILTLQAALPNVIRFC----------CCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 398
Cdd:pfam00520 102 LLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLlllllflfifAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQT 181

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 358679303  399 INGDDMFATFAKMQQKSYLVWlfSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQ 457
Cdd:pfam00520 182 MTTEGWGDIMYDTIDGKGEFW--AYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 320-458 1.95e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 47.63  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358679303  320 LLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLI 399
Cdd:PLN03223 1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 358679303  400 NGD-DMFatFAKMQQKSYLVWLFSRIYLYSFiSLFIYMILSLF-IALITDTYETIKQYQQD 458
Cdd:PLN03223 1374 LGDiTYF--NEDLKNLTGLQFVVGMIYFYSY-NIFVFMILFNFlLAIICDAFGEVKANAAE 1431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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