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Conserved domains on  [gi|357933641|ref|NP_001239553|]
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sodium/calcium exchanger 1 isoform E precursor [Homo sapiens]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-965 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1745.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641    4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   84 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 163
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  164 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 243
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  244 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 323
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  324 REMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 403
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  404 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  484 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 563
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFtit 643
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAL--- 630

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  644 gkylfgqpvfrkvharehpILSTVITiadeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIK 723
Cdd:TIGR00845 631 -------------------LLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIK 686

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  724 KTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 803
Cdd:TIGR00845 687 KTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMI 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  804 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 883
Cdd:TIGR00845 767 GVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 846

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  884 YHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIK 963
Cdd:TIGR00845 847 YHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIK 926


                  ..
gi 357933641  964 GF 965
Cdd:TIGR00845 927 GF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-965 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1745.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641    4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   84 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 163
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  164 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 243
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  244 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 323
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  324 REMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 403
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  404 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  484 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 563
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFtit 643
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAL--- 630

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  644 gkylfgqpvfrkvharehpILSTVITiadeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIK 723
Cdd:TIGR00845 631 -------------------LLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIK 686

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  724 KTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 803
Cdd:TIGR00845 687 KTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMI 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  804 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 883
Cdd:TIGR00845 767 GVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 846

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  884 YHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIK 963
Cdd:TIGR00845 847 YHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIK 926


                  ..
gi 357933641  964 GF 965
Cdd:TIGR00845 927 GF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 254-390 7.51e-82

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 260.70  E-value: 7.51e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  254 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 332
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357933641  333 LKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 390
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 406-496 3.79e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 125.83  E-value: 3.79e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   406 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIF 485
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 357933641   486 EEDENFLVHLS 496
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
785-953 3.13e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 785 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 864
Cdd:COG0530  146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 865 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 941
Cdd:COG0530  225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                        170
                 ....*....|..
gi 357933641 942 LFVLLWLLYIFF 953
Cdd:COG0530  281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 813-952 2.51e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 813 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 887
Cdd:PRK10734 200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357933641 888 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 952
Cdd:PRK10734 272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-965 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1745.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641    4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   84 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 163
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  164 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 243
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  244 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 323
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  324 REMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 403
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  404 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  484 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 563
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFtit 643
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAL--- 630

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  644 gkylfgqpvfrkvharehpILSTVITiadeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIK 723
Cdd:TIGR00845 631 -------------------LLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIK 686

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  724 KTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 803
Cdd:TIGR00845 687 KTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMI 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  804 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 883
Cdd:TIGR00845 767 GVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAI 846

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  884 YHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIK 963
Cdd:TIGR00845 847 YHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIK 926


                  ..
gi 357933641  964 GF 965
Cdd:TIGR00845 927 GF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 254-390 7.51e-82

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 260.70  E-value: 7.51e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  254 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 332
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 357933641  333 LKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 390
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
406-496 5.54e-42

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 148.17  E-value: 5.54e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIF 485
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 357933641  486 EEDENFLVHLS 496
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 406-496 3.79e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 125.83  E-value: 3.79e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   406 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIF 485
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 357933641   486 EEDENFLVHLS 496
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 537-627 6.47e-26

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 102.33  E-value: 6.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   537 AGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARgGGEDFEDTCGELEFQNDEIVKIITIRIFDREEY 616
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 357933641   617 EKECSFSLVLE 627
Cdd:smart00237  80 EKDETFYVRLS 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 792-956 1.24e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  792 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVF 871
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  872 LGIGVAWSIAAIYHAANGEqfkvspgTLAFSVTLFTIFAFINVGVLLYRRRpeiggelggPRTAKLLTSCLFVLLWLLYI 951
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLL-------KLDLGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 357933641  952 FFSSL 956
Cdd:pfam01699 145 VFQIV 149
Calx-beta pfam03160
Calx-beta domain;
537-626 1.09e-24

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 98.86  E-value: 1.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  537 AGIFTFEEPVTHVSESIGIMEVKVLRTSGA-RGNVIVPYKTIEGTARGGgEDFEDTCGELEFQNDEIVKIITIRIFDREE 615
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|.
gi 357933641  616 YEKECSFSLVL 626
Cdd:pfam03160  80 YEGDENFFVLL 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 80-251 2.38e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.73  E-value: 2.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   80 VYFVAMVYMFLGVSIIADRFMSSIEVITsqekeitikkpngettktTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGH 159
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  160 NftaGDLGPSTIVGSAAFNMFIIIALCVYV--VPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILsvisPGVVEVWEGLL 237
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 357933641  238 TFFFFPICVVFAWV 251
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
785-953 3.13e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 785 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 864
Cdd:COG0530  146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 865 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 941
Cdd:COG0530  225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                        170
                 ....*....|..
gi 357933641 942 LFVLLWLLYIFF 953
Cdd:COG0530  281 LLLALYLAYLAL 292
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
805-954 3.03e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 59.38  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 805 LLTAFIGDLASHFGctigLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGIGVAWSIAAIy 884
Cdd:COG0530    3 LLVRGADALARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIRPL- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 885 haangeqfKVSPGTLAFSVTLFTIFAFINVGVLLyrrrpeiggelggPRTAKLLTSCLFVLLWLLYIFFS 954
Cdd:COG0530   77 --------AVDRRVLRRDLPFLLLASLLLLALLL-------------DGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
137-255 2.39e-07

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.60  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 137 LTLMALGSSAPEILLSVIEVCGHNFtagDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI--KHLRVFFVTAAwsifa 214
Cdd:COG0530   24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPLAVDRRVlrRDLPFLLLASL----- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 357933641 215 ytwlyIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRR 255
Cdd:COG0530   96 -----LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 85-186 3.80e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 54.23  E-value: 3.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641    85 MVYMFLGVSIIADR-FMSSIEVITSQekeitikkpngettkttVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFTA 163
Cdd:TIGR00927  464 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVF---ISH 522

                           90       100
                   ....*....|....*....|...
gi 357933641   164 GDLGPSTIVGSAAFNMFIIIALC 186
Cdd:TIGR00927  523 SNVGIGTIVGSAVFNILFVIGTC 545
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 800-915 4.99e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.63  E-value: 4.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  800 ILMIGLLTAFIG----------DLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVN 869
Cdd:TIGR00367   1 LLLIGYLILGLIlliygadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 357933641  870 VFLGIGVAWSIAAIYHAANGEQFKVsPGTLAFSVTLFTIFAFINVG 915
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDI-LFYLLVSILLLFFGLDGQIS 124
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 83-286 1.40e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.09  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   83 VAMVYMFLGVSII-ADRFMSSIEVITSqekeiTIKKPNgettkttvriwneTVSNLTLMALGSSAPEILLSVIEVCGHNf 161
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  162 taGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkikhlrvfFVTAAWSIFAYTWLYIILSVIspgvvevwegLLTFFF 241
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRRDILFYLLVSIL----------LLFFGL 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 357933641  242 F----PICVVFAWVAdrRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSK 286
Cdd:TIGR00367 120 DgqisRIDGVVLLIL--YIVYLLFLVKNERWVKYDTYTEENLDENNRRP 166
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 796-930 1.57e-04

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 45.01  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  796 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 875
Cdd:TIGR00367 175 LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE-LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLG 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 357933641  876 VAWSIAAIyhaangeQFKVSPGTLAFSVTLFTIFAFinvgVLLYRRRPEIGGELG 930
Cdd:TIGR00367 254 VPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG 297
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 796-910 1.69e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.76  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641   796 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDqYADASIGNVTGSNAVNVFLGIG 875
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LGDMAVSSSVGSNIFDITVGLP 1016

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 357933641   876 VAWsiaAIYHAANGEQ-FKVSPG------TLAFSVTLFTIFA 910
Cdd:TIGR00927 1017 VPW---LLFSLINGLQpVPVSSNglfcaiVLLFLMLLFVISS 1055
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 813-952 2.51e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 813 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 887
Cdd:PRK10734 200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 357933641 888 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 952
Cdd:PRK10734 272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 800-877 1.20e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 42.33  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 800 ILMIGLLTAFIGD-----LASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGI 874
Cdd:PRK10734   7 LLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLIL 85


                 ...
gi 357933641 875 GVA 877
Cdd:PRK10734  86 GLA 88
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 80-261 2.40e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 41.67  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641  80 VYFVAMVYMfLGvSIIADRFMSSIEVITSqekeiTIKKPngettkttvriwnETVSNLTLMALGSSAPEILLSVIEVCGH 159
Cdd:PLN03151 145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 160 NftAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKhlRVFFVTAAWSIFAYTWLYIILSVispGVVEVWEGLLtf 239
Cdd:PLN03151 205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVGGAIA-- 275

                        170       180
                 ....*....|....*....|..
gi 357933641 240 fFFPICVVFAWVADRRLLFYKY 261
Cdd:PLN03151 276 -FVSIYVVYAFLVAANEILRKH 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
130-248 4.45e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933641 130 WNETVSNLTLMALGSSAPEILLSVIEVC-GHnftaGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkIKHLRVFFVTA 208
Cdd:COG0530  184 VSELVIGLTIVAIGTSLPELATSIVAARkGE----DDLAVGNIIGSNIFNILLVLGIGALITP------IPVDPAVLSFD 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 357933641 209 AWSIFAYTWLYIILsVISPGVVEVWEGLLTFFFFPICVVF 248
Cdd:COG0530  254 LPVMLAATLLLLGL-LRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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