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Conserved domains on  [gi|357430784|ref|NP_001239441|]
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sterol O-acyltransferase 1 isoform 3 [Homo sapiens]

Protein Classification

membrane-bound O-acyltransferase family protein( domain architecture ID 10503555)

membrane-bound O-acyltransferase (MBOAT) family protein catalyzes the transfer of an acyl group from acyl-CoA to an alcohol substrate to form the corresponding alcohol ester; such as sterol O-acyltransferase

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
106-455 1.52e-52

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


:

Pssm-ID: 427117  Cd Length: 334  Bit Score: 180.71  E-value: 1.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  106 FSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIgvlgfgptyvvlaytlpp 185
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRPV------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  186 asrfiiifeqirfvmkahsfvrENVPRVLNSAKEKSSTVPIPTVNQYLYF----LFAPTLIYRD--SYPRNPTVRWGY-- 257
Cdd:pfam03062  63 ----------------------SLSFRKLASAAALSQDPSLLEYLGYVFFypglLVGPIFSYSDymSFPRDPLFRWLYyv 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  258 ---VAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPF--SARVLVLCVFNSILPGVLILFLTFFAFLHcWLNAFAEMLR 332
Cdd:pfam03062 121 krnLAPALGALFLGLTYLILIQYLLSHLPDKDFSKFKFlsYAFLLRFSVIMRILLGLLWLFLLIFDFLG-WLFAEGEDIL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  333 FG----------DRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLwFFSKRFKSAAMLAVFAVSAVVHEYALAVC 402
Cdd:pfam03062 200 FGlgfngwdrvaPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG-KKGKLNKFLATLATFLFSAVWHGYYLGYL 278
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357430784  403 LSFFYPVLFVLF---MFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQ 455
Cdd:pfam03062 279 LWFVLRVLLLLAeklIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
106-455 1.52e-52

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 180.71  E-value: 1.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  106 FSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIgvlgfgptyvvlaytlpp 185
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRPV------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  186 asrfiiifeqirfvmkahsfvrENVPRVLNSAKEKSSTVPIPTVNQYLYF----LFAPTLIYRD--SYPRNPTVRWGY-- 257
Cdd:pfam03062  63 ----------------------SLSFRKLASAAALSQDPSLLEYLGYVFFypglLVGPIFSYSDymSFPRDPLFRWLYyv 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  258 ---VAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPF--SARVLVLCVFNSILPGVLILFLTFFAFLHcWLNAFAEMLR 332
Cdd:pfam03062 121 krnLAPALGALFLGLTYLILIQYLLSHLPDKDFSKFKFlsYAFLLRFSVIMRILLGLLWLFLLIFDFLG-WLFAEGEDIL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  333 FG----------DRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLwFFSKRFKSAAMLAVFAVSAVVHEYALAVC 402
Cdd:pfam03062 200 FGlgfngwdrvaPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG-KKGKLNKFLATLATFLFSAVWHGYYLGYL 278
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357430784  403 LSFFYPVLFVLF---MFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQ 455
Cdd:pfam03062 279 LWFVLRVLLLLAeklIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
PLN03242 PLN03242
diacylglycerol o-acyltransferase; Provisional
121-441 8.33e-34

diacylglycerol o-acyltransferase; Provisional


Pssm-ID: 178780  Cd Length: 410  Bit Score: 131.84  E-value: 8.33e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 121 WTWWIMFLSTFSVPYFLFQHWATGYSKSSHpLIRSLFHGFLFMIFQIGVLGFgPTYVVLAYTLPPASRFIIIFEQIRFVM 200
Cdd:PLN03242  67 LKDWPLVMCGLSLLAFPLAAYVIEKMLARR-YFPATFVMPLHLINLAAALLY-PIYVIWMLISDPLSGAVLMLIATITWL 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 201 KAHSFVRENVPrvLNSAKEKSSTVPIPTVNQYL------------YFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGC 268
Cdd:PLN03242 145 KLVSYAHTNAD--YRASKKDGGKIELPSDAPNIdypqnvtlkniaYFMAAPTLCYQISYPRSPRIRTGWVLRQLGKLIVF 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 269 FFYVYYIFERLCAPLFRNIkQEPFSARVL--VLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNST 346
Cdd:PLN03242 223 NGFMGFIIAQYVNPILRNS-VHPLKGNYLyaIERVLKLSIPNLYVWLLMFYCFFHLWLNIVAELLCFGDREFYKDWWNAS 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 347 SYSNYYRTWNVVVHDWLYYYAYkdFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMF---FGMAFNF 423
Cdd:PLN03242 302 EVSEYWRLWNMPVHYWLVRHVY--FPCLRLGMPKQLAILVVFFISAVFHEVCIAVPCHMIRGWAFLGIMFqvpLVLVTKV 379
                        330
                 ....*....|....*...
gi 357430784 424 IVNDSRKKPIWNVLMWTS 441
Cdd:PLN03242 380 LQRKFPSSMVGNMIFWFF 397
ARE1 COG5056
Acyl-CoA cholesterol acyltransferase [Lipid metabolism];
228-453 3.81e-28

Acyl-CoA cholesterol acyltransferase [Lipid metabolism];


Pssm-ID: 227389  Cd Length: 512  Bit Score: 117.22  E-value: 3.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 228 TVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFS--------ARVLVL 299
Cdd:COG5056  275 SVRNFLDFLLVPTLCYQLEYPRTARIRWRYVLEKACATFGTIFLMVIVADQYMVPVAMRAIDFENVtdasgtyiAIENWI 354
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 300 CVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFsKRF 379
Cdd:COG5056  355 NLLFDMIPFIVLYLLFFYLIFDCILNAVAEITRFADRYFYGDWWNCVSWDEFSRIWNKPVHKFLLRHVYHSSISGF-KLS 433
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357430784 380 KSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFvLFMFFGMAFNFIVNDS--RKKPIW-NVLMWTSLFLGNGVLLCFY 453
Cdd:COG5056  434 KSQATLFTFFISSVVHELVMSIITKKARGYLL-FFQLLQIPLIALTNTKfkRRRPILgNVFFWFGICVGPSVMCTLY 509
 
Name Accession Description Interval E-value
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
106-455 1.52e-52

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 180.71  E-value: 1.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  106 FSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIgvlgfgptyvvlaytlpp 185
Cdd:pfam03062   1 ILLYSYTSTGLLTLLWTLALSFLTLQLIALVLSYYDGLGKGSELTWDQKELLKLLLFSYRPV------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  186 asrfiiifeqirfvmkahsfvrENVPRVLNSAKEKSSTVPIPTVNQYLYF----LFAPTLIYRD--SYPRNPTVRWGY-- 257
Cdd:pfam03062  63 ----------------------SLSFRKLASAAALSQDPSLLEYLGYVFFypglLVGPIFSYSDymSFPRDPLFRWLYyv 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  258 ---VAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPF--SARVLVLCVFNSILPGVLILFLTFFAFLHcWLNAFAEMLR 332
Cdd:pfam03062 121 krnLAPALGALFLGLTYLILIQYLLSHLPDKDFSKFKFlsYAFLLRFSVIMRILLGLLWLFLLIFDFLG-WLFAEGEDIL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784  333 FG----------DRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLwFFSKRFKSAAMLAVFAVSAVVHEYALAVC 402
Cdd:pfam03062 200 FGlgfngwdrvaPENIYRCWENAVSFSEFWRAWNIPVHKWLKRYVYKPLG-KKGKLNKFLATLATFLFSAVWHGYYLGYL 278
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 357430784  403 LSFFYPVLFVLF---MFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQ 455
Cdd:pfam03062 279 LWFVLRVLLLLAeklIRRLVRLSFLKTDRRRPNLSNVIFWLGAFLGPSLALLLSLS 334
PLN03242 PLN03242
diacylglycerol o-acyltransferase; Provisional
121-441 8.33e-34

diacylglycerol o-acyltransferase; Provisional


Pssm-ID: 178780  Cd Length: 410  Bit Score: 131.84  E-value: 8.33e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 121 WTWWIMFLSTFSVPYFLFQHWATGYSKSSHpLIRSLFHGFLFMIFQIGVLGFgPTYVVLAYTLPPASRFIIIFEQIRFVM 200
Cdd:PLN03242  67 LKDWPLVMCGLSLLAFPLAAYVIEKMLARR-YFPATFVMPLHLINLAAALLY-PIYVIWMLISDPLSGAVLMLIATITWL 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 201 KAHSFVRENVPrvLNSAKEKSSTVPIPTVNQYL------------YFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGC 268
Cdd:PLN03242 145 KLVSYAHTNAD--YRASKKDGGKIELPSDAPNIdypqnvtlkniaYFMAAPTLCYQISYPRSPRIRTGWVLRQLGKLIVF 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 269 FFYVYYIFERLCAPLFRNIkQEPFSARVL--VLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNST 346
Cdd:PLN03242 223 NGFMGFIIAQYVNPILRNS-VHPLKGNYLyaIERVLKLSIPNLYVWLLMFYCFFHLWLNIVAELLCFGDREFYKDWWNAS 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 347 SYSNYYRTWNVVVHDWLYYYAYkdFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMF---FGMAFNF 423
Cdd:PLN03242 302 EVSEYWRLWNMPVHYWLVRHVY--FPCLRLGMPKQLAILVVFFISAVFHEVCIAVPCHMIRGWAFLGIMFqvpLVLVTKV 379
                        330
                 ....*....|....*...
gi 357430784 424 IVNDSRKKPIWNVLMWTS 441
Cdd:PLN03242 380 LQRKFPSSMVGNMIFWFF 397
PLN02401 PLN02401
diacylglycerol o-acyltransferase
174-439 6.80e-32

diacylglycerol o-acyltransferase


Pssm-ID: 215225  Cd Length: 446  Bit Score: 127.19  E-value: 6.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 174 PTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVP-RVLNSAKEKSSTVPI---------PTVNQYLYFLFAPTLIY 243
Cdd:PLN02401 143 PVLVILRCDSAVLSGVTLMLLACIVWLKLVSYAHTNYDmRALAKSIDKGEAPSTsanpevsydVTFKSLAYFMVAPTLCY 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 244 RDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNiKQEPFSARVL--VLCVFNSILPGVLILFLTFFAFLH 321
Cdd:PLN02401 223 QPSYPRSACIRKGWVVRQFVKLVIFTGFMGFIIEQYINPIVQN-SQHPLKGNLLyaIERVLKLSVPNLYVWLCMFYCFFH 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 322 CWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYkdFLWFFSKRFKSAAMLAVFAVSAVVHEYALAV 401
Cdd:PLN02401 302 LWLNILAELLRFGDREFYKDWWNAKTVEEYWRMWNMPVHKWMVRHIY--FPCLRNGISKGVAILIAFFVSAVFHELCIAV 379
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 357430784 402 CLSffypvLFVLFMFFGMAF--------NFIVNDSRKKPIWNVLMW 439
Cdd:PLN02401 380 PCH-----MFKLWAFLGIMFqvplvfitNYLQNKFKSSMVGNMIFW 420
ARE1 COG5056
Acyl-CoA cholesterol acyltransferase [Lipid metabolism];
228-453 3.81e-28

Acyl-CoA cholesterol acyltransferase [Lipid metabolism];


Pssm-ID: 227389  Cd Length: 512  Bit Score: 117.22  E-value: 3.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 228 TVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFS--------ARVLVL 299
Cdd:COG5056  275 SVRNFLDFLLVPTLCYQLEYPRTARIRWRYVLEKACATFGTIFLMVIVADQYMVPVAMRAIDFENVtdasgtyiAIENWI 354
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357430784 300 CVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFsKRF 379
Cdd:COG5056  355 NLLFDMIPFIVLYLLFFYLIFDCILNAVAEITRFADRYFYGDWWNCVSWDEFSRIWNKPVHKFLLRHVYHSSISGF-KLS 433
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 357430784 380 KSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFvLFMFFGMAFNFIVNDS--RKKPIW-NVLMWTSLFLGNGVLLCFY 453
Cdd:COG5056  434 KSQATLFTFFISSVVHELVMSIITKKARGYLL-FFQLLQIPLIALTNTKfkRRRPILgNVFFWFGICVGPSVMCTLY 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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