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Conserved domains on  [gi|908212412|ref|NP_001233807|]
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homeotic protein knotted-1 [Solanum lycopersicum]

Protein Classification

homeobox protein( domain architecture ID 11145407)

homeobox protein similar to tobacco homeobox proteins, NTH1, NTH9, NTH20, NTH22 (Nicotiana tabacum homeobox), each NTH protein specifies the function of the SAM (shoot apical meristem) zone with which it is associated

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KNOX2 pfam03791
KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 146-192 4.14e-24

KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


:

Pssm-ID: 427506  Cd Length: 48  Bit Score: 93.05  E-value: 4.14e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 908212412  146 DVSKDPELDQFMEAYYDMLVKYREELTRPLQEAMEFMQKIEAQLNML 192
Cdd:pfam03791   1 SVGADPELDQFMEAYCDVLVKYKEELTRPFEEATEFLREIESQLNSL 47
KNOX1 pfam03790
KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 93-132 2.06e-18

KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


:

Pssm-ID: 461051  Cd Length: 40  Bit Score: 77.72  E-value: 2.06e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 908212412   93 ALKAKIIAHPQCSNLLDAYMDCQKVGAPPEVAARLSAVRQ 132
Cdd:pfam03790   1 AIKAKIASHPLYPSLLSAYVDCQKVGAPPEVAARLDEIAQ 40
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 277-315 4.93e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 76.40  E-value: 4.93e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 908212412  277 WELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKR 315
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
ELK pfam03789
ELK domain; This domain is required for the nuclear localization of these proteins. All of ...
 236-257 2.73e-07

ELK domain; This domain is required for the nuclear localization of these proteins. All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox pfam00046.


:

Pssm-ID: 427504  Cd Length: 22  Bit Score: 46.27  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|..
gi 908212412  236 ELKNHLLRKYSGYLSSLKQELS 257
Cdd:pfam03789   1 ELKEQLLRKYSGYLSSLRREFS 22
 
Name Accession Description Interval E-value
KNOX2 pfam03791
KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 146-192 4.14e-24

KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


Pssm-ID: 427506  Cd Length: 48  Bit Score: 93.05  E-value: 4.14e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 908212412  146 DVSKDPELDQFMEAYYDMLVKYREELTRPLQEAMEFMQKIEAQLNML 192
Cdd:pfam03791   1 SVGADPELDQFMEAYCDVLVKYKEELTRPFEEATEFLREIESQLNSL 47
KNOX1 pfam03790
KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 93-132 2.06e-18

KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


Pssm-ID: 461051  Cd Length: 40  Bit Score: 77.72  E-value: 2.06e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 908212412   93 ALKAKIIAHPQCSNLLDAYMDCQKVGAPPEVAARLSAVRQ 132
Cdd:pfam03790   1 AIKAKIASHPLYPSLLSAYVDCQKVGAPPEVAARLDEIAQ 40
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 277-315 4.93e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 76.40  E-value: 4.93e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 908212412  277 WELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKR 315
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 268-320 7.53e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 59.95  E-value: 7.53e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 908212412 268 DARQKLITWWElhyKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPS 320
Cdd:cd00086   10 EQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 284-317 1.48e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.10  E-value: 1.48e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 908212412   284 PYPSESEKVALAESTGLDQKQINNWFINQRKRHW 317
Cdd:smart00389  24 PYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
ELK pfam03789
ELK domain; This domain is required for the nuclear localization of these proteins. All of ...
 236-257 2.73e-07

ELK domain; This domain is required for the nuclear localization of these proteins. All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox pfam00046.


Pssm-ID: 427504  Cd Length: 22  Bit Score: 46.27  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|..
gi 908212412  236 ELKNHLLRKYSGYLSSLKQELS 257
Cdd:pfam03789   1 ELKEQLLRKYSGYLSSLRREFS 22
 
Name Accession Description Interval E-value
KNOX2 pfam03791
KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 146-192 4.14e-24

KNOX2 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


Pssm-ID: 427506  Cd Length: 48  Bit Score: 93.05  E-value: 4.14e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 908212412  146 DVSKDPELDQFMEAYYDMLVKYREELTRPLQEAMEFMQKIEAQLNML 192
Cdd:pfam03791   1 SVGADPELDQFMEAYCDVLVKYKEELTRPFEEATEFLREIESQLNSL 47
KNOX1 pfam03790
KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a ...
 93-132 2.06e-18

KNOX1 domain; The MEINOX region is comprised of two domains, KNOX1 and KNOX2. KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerization.


Pssm-ID: 461051  Cd Length: 40  Bit Score: 77.72  E-value: 2.06e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 908212412   93 ALKAKIIAHPQCSNLLDAYMDCQKVGAPPEVAARLSAVRQ 132
Cdd:pfam03790   1 AIKAKIASHPLYPSLLSAYVDCQKVGAPPEVAARLDEIAQ 40
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 277-315 4.93e-18

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 76.40  E-value: 4.93e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 908212412  277 WELHYKWPYPSESEKVALAESTGLDQKQINNWFINQRKR 315
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 268-320 7.53e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 59.95  E-value: 7.53e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 908212412 268 DARQKLITWWElhyKWPYPSESEKVALAESTGLDQKQINNWFINQRKRHWKPS 320
Cdd:cd00086   10 EQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 284-317 1.48e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.10  E-value: 1.48e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 908212412   284 PYPSESEKVALAESTGLDQKQINNWFINQRKRHW 317
Cdd:smart00389  24 PYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
ELK pfam03789
ELK domain; This domain is required for the nuclear localization of these proteins. All of ...
 236-257 2.73e-07

ELK domain; This domain is required for the nuclear localization of these proteins. All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox pfam00046.


Pssm-ID: 427504  Cd Length: 22  Bit Score: 46.27  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|..
gi 908212412  236 ELKNHLLRKYSGYLSSLKQELS 257
Cdd:pfam03789   1 ELKEQLLRKYSGYLSSLRREFS 22
Homeodomain pfam00046
Homeodomain;
284-318 1.31e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.10  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 908212412  284 PYPSESEKVALAESTGLDQKQINNWFINQRKRhWK 318
Cdd:pfam00046  23 PYPSAEEREELAAQLGLTERQVKVWFQNRRAK-WK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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