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Conserved domains on  [gi|350539005|ref|NP_001232863|]
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optic atrophy 3 protein homolog isoform 2 [Bos taurus]

Protein Classification

OPA3 family protein( domain architecture ID 10537153)

OPA3 family protein similar to human optic atrophy 3 protein (OPA3) that may play some role in mitochondrial processes

Gene Ontology:  GO:0005739

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 9-129 2.00e-38

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


:

Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 128.01  E-value: 2.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539005    9 AKLLYLGIRQVSKPLANRIKEAARRSEFFKtYICLPPAQLYHWVEMRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGE 86
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFR-RVCIPLAQLYHRLEMRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 350539005   87 ATIFIVGGGCLVLEYWRHQAQQRRKEEEQRAAWDAMRDEVGHL 129
Cdd:pfam07047  80 AFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 9-129 2.00e-38

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 128.01  E-value: 2.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539005    9 AKLLYLGIRQVSKPLANRIKEAARRSEFFKtYICLPPAQLYHWVEMRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGE 86
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFR-RVCIPLAQLYHRLEMRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 350539005   87 ATIFIVGGGCLVLEYWRHQAQQRRKEEEQRAAWDAMRDEVGHL 129
Cdd:pfam07047  80 AFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
 
Name Accession Description Interval E-value
OPA3 pfam07047
Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) ...
 9-129 2.00e-38

Optic atrophy 3 protein (OPA3); This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity.


Pssm-ID: 462072 [Multi-domain]  Cd Length: 122  Bit Score: 128.01  E-value: 2.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539005    9 AKLLYLGIRQVSKPLANRIKEAARRSEFFKtYICLPPAQLYHWVEMRTKMRIMGF--RGTVIKPLNEEAAAELGAELLGE 86
Cdd:pfam07047   1 FKLGSLAIRTLSKPIANRIKRQAKEHPRFR-RVCIPLAQLYHRLEMRLRMRLLGLakPTRKIRPLNEEKAVELGADLLGE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 350539005   87 ATIFIVGGGCLVLEYWRHQAQQRRKEEEQRAAWDAMRDEVGHL 129
Cdd:pfam07047  80 AFIFSVAGGLILYEYWRSARKEAKKEEKLKEELEELEERIEEL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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