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Conserved domains on  [gi|342837688|ref|NP_001230173|]
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zinc finger and SCAN domain-containing protein 31 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-238 1.80e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688  79 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 145
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688 146 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 221
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                        170
                 ....*....|....*..
gi 342837688 222 CSQCSKLFSKRTLLKKH 238
Cdd:COG5048  448 LCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-238 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688  79 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 145
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688 146 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 221
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                        170
                 ....*....|....*..
gi 342837688 222 CSQCSKLFSKRTLLKKH 238
Cdd:COG5048  448 LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-173 3.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|...
gi 342837688  151 LTRHRRIHTGEKPYECKVCGKAF 173
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-238 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688  79 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 145
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688 146 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 221
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                        170
                 ....*....|....*..
gi 342837688 222 CSQCSKLFSKRTLLKKH 238
Cdd:COG5048  448 LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
61-247 2.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688  61 CKRDSKAEKQQAHSTGERRHRCNECGKSFTKSSVLIEHQRIHTGE-------KPYECEECGKAFSRRSSLNEHRRS--HT 131
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688 132 GE--KPYQCKE--CGKAFSASNGLTRHRRIHTGEKPYECK--VCGKAF--LLSSCLVQHQRIHTGEKRYQCRE-----CG 198
Cdd:COG5048  316 GEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKKSEtlsnsCI 395

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 342837688 199 KAFIQNAGLFQHLRVHTGEKPYQC--SQCSKLFSKRTLLKKHQKIHTGERP 247
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-166 8.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 8.72e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342837688 106 KPYECEECGKAFSRRSSLNEHRRSHTGEKPYQCKECGKAFSASNG--LTRHRRIHTGEKPYEC 166
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-135 1.24e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342837688  48 QRDVSLDSKYRETCKRDSKAEKQQahstgERRHRCNECGKSFTKSSVLIEHQRIHTGEKPYEC--EECGKAFSRRSSLNE 125
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNA-----PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSR 81

                         90
                 ....*....|
gi 342837688 126 HRRSHTGEKP 135
Cdd:COG5048   82 HLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 104-155 1.55e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342837688 104 GEKPYECE--ECGKAFSRRSSLNEHRR---------------SHTG----EKPYQCKECGKAFSASNGLTRHR 155
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
151-173 3.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|...
gi 342837688  151 LTRHRRIHTGEKPYECKVCGKAF 173
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
95-119 3.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 3.31e-04
                          10        20
                  ....*....|....*....|....*
gi 342837688   95 LIEHQRIHTGEKPYECEECGKAFSR 119
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
122-146 3.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 3.44e-04
                          10        20
                  ....*....|....*....|....*
gi 342837688  122 SLNEHRRSHTGEKPYQCKECGKAFS 146
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
134-187 8.31e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 8.31e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 342837688 134 KPYQCKECGKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHT 187
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-203 9.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 9.58e-04
                          10        20
                  ....*....|....*....|....*
gi 342837688  179 LVQHQRIHTGEKRYQCRECGKAFIQ 203
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 108-130 3.51e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 3.51e-03
                          10        20
                  ....*....|....*....|...
gi 342837688  108 YECEECGKAFSRRSSLNEHRRSH 130
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 4.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 4.90e-03
                          10        20
                  ....*....|....*....|....*
gi 342837688  207 LFQHLRVHTGEKPYQCSQCSKLFSK 231
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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