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Conserved domains on  [gi|338968892|ref|NP_001229807|]
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elongator complex protein 2 isoform 5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-346 5.34e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 5.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 133 AAADSAVRLWSKKGPEV--------------------PILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAF 192
Cdd:cd00200   69 GSSDKTIRLWDLETGECvrtltghtsyvssvafspdgRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 193 GRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKEnTFTIENESVK-IAF----------------------AVTL 249
Cdd:cd00200  147 GT--FVASSSQDGTIKLW------------DLRTGKCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 250 ETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPE 329
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPD 272

                        330
                 ....*....|....*..
gi 338968892 330 GEFIITVGTDQTTRLFA 346
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
486-748 1.43e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 486 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 560
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 561 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 640
Cdd:COG2319  221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 641 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 719
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                        250       260
                 ....*....|....*....|....*....
gi 338968892 720 cSGKTeqkeaegaewlhFASCGEDHTVKI 748
Cdd:COG2319  341 -DGKT------------LASGSDDGTVRL 356
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-346 5.34e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 5.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 133 AAADSAVRLWSKKGPEV--------------------PILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAF 192
Cdd:cd00200   69 GSSDKTIRLWDLETGECvrtltghtsyvssvafspdgRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 193 GRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKEnTFTIENESVK-IAF----------------------AVTL 249
Cdd:cd00200  147 GT--FVASSSQDGTIKLW------------DLRTGKCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 250 ETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPE 329
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPD 272

                        330
                 ....*....|....*..
gi 338968892 330 GEFIITVGTDQTTRLFA 346
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-344 5.96e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 5.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  120 TGAVRSV-AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  94 DNQLLKAvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEVP--------------------ILA 153
Cdd:COG2319  193 TGKLLRT--LTGHTGAVRSV-AF----SPDG---KLLASGSADGTVRLWDLATGKLLrtltghsgsvrsvafspdgrLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 154 CGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkent 233
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGK--LLASGSDDGTVRLW-------DLATG----------- 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 234 ftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDeesgvwleqrEWTPEIV 313
Cdd:COG2319  321 --------------KLLRTLTGHTGAVRSVAFSP----DG-----KTLASGSDDGTVRLWDLA----------TGELLRT 367

                        330       340       350
                 ....*....|....*....|....*....|.
gi 338968892 314 ISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 344
Cdd:COG2319  368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
486-748 1.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 486 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 560
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 561 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 640
Cdd:COG2319  221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 641 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 719
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                        250       260
                 ....*....|....*....|....*....
gi 338968892 720 cSGKTeqkeaegaewlhFASCGEDHTVKI 748
Cdd:COG2319  341 -DGKT------------LASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 489-748 3.15e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 489 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 568
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 569 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 648
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 649 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 727
Cdd:cd00200  217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                        250       260
                 ....*....|....*....|.
gi 338968892 728 eaegaewlhFASCGEDHTVKI 748
Cdd:cd00200  276 ---------LASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 598-626 1.24e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.24e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968892   598 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
598-626 1.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.69e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968892  598 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-211 3.92e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968892   170 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 211
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
171-210 4.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968892  171 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 210
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-346 5.34e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 5.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 133 AAADSAVRLWSKKGPEV--------------------PILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAF 192
Cdd:cd00200   69 GSSDKTIRLWDLETGECvrtltghtsyvssvafspdgRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 193 GRdlFLASCSQDCLIRIWklyikstsletqDDDNIRLKEnTFTIENESVK-IAF----------------------AVTL 249
Cdd:cd00200  147 GT--FVASSSQDGTIKLW------------DLRTGKCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKC 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 250 ETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPE 329
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPD 272

                        330
                 ....*....|....*..
gi 338968892 330 GEFIITVGTDQTTRLFA 346
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-344 5.96e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 5.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  120 TGAVRSV-AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  94 DNQLLKAvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEVP--------------------ILA 153
Cdd:COG2319  193 TGKLLRT--LTGHTGAVRSV-AF----SPDG---KLLASGSADGTVRLWDLATGKLLrtltghsgsvrsvafspdgrLLA 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 154 CGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkent 233
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGK--LLASGSDDGTVRLW-------DLATG----------- 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 234 ftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDeesgvwleqrEWTPEIV 313
Cdd:COG2319  321 --------------KLLRTLTGHTGAVRSVAFSP----DG-----KTLASGSDDGTVRLWDLA----------TGELLRT 367

                        330       340       350
                 ....*....|....*....|....*....|.
gi 338968892 314 ISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 344
Cdd:COG2319  368 LTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
21-396 6.24e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 6.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEVpilacgnddcrihifaqqndqfqkVLSLCG 179
Cdd:COG2319  157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDLATGKL------------------------LRTLTG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 180 HEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENW 259
Cdd:COG2319  203 HTGAVRSVAFSPDGK--LLASGSADGTVRLW-------DLATG-------------------------KLLRTLTGHSGS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 260 VNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWAPDEESGVWLeqrewtpeivISGHFDGVQDLVWDPEGEFIITVGTD 339
Cdd:COG2319  249 VRSVAFSP----DG-----RLLASGSADGTVRLWDLATGELLRT----------LTGHSGGVNSVAFSPDGKLLASGSDD 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 338968892 340 QTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSA 396
Cdd:COG2319  310 GTVRL---WDLA-----TGKLLRTLTGHTGAVRSVA----FspdgkTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
73-626 2.24e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 2.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  73 SPSTELVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSKKGPEVPil 152
Cdd:COG2319   46 PDGARLAAGAGDLTLLLLDAAAGALLAT--LLGHTAAVLSVAFSPDGRL--------LASASADGTVRLWDLATGLLL-- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 153 acgnddcrihifaqqndqfqkvLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlken 232
Cdd:COG2319  114 ----------------------RTLTGHTGAVRSVAFSPDGK--TLASGSADGTVRLW-------DLATG---------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 233 tftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEqrewtpei 312
Cdd:COG2319  153 ---------------KLLRTLTGHSGAVTSVAFSP----DGK-----LLASGSDDGTVRLW--DLATGKLLR-------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 313 VISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGAD 387
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRL---WDLA-----TGKLLRTLTGHSGSVRSVA----FspdgrLLASGSA 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 388 EKVLRVFSAPrnfvenfcaiTGQslnhvlcnqdsdlpegatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvaf 467
Cdd:COG2319  267 DGTVRLWDLA----------TGE--------------------------------------------------------- 279

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 468 qpsiltepptedhllqntlwpEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTV 547
Cdd:COG2319  280 ---------------------LLRTLTGHSGGVNSVAFSPDGKLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAV 333

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 338968892 548 TQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-626 2.15e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 102 HLQGHEGPVYAVHAVYQRRtsdpalctLIVSAAADSAVRLWSKKGPEVpilacgnddcrihifaqqndqfqkVLSLCGHE 181
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGK--------LLATGSGDGTIKVWDLETGEL------------------------LRTLKGHT 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 182 DWIRGVEWAAFGRdlFLASCSQDCLIRIWKLyikstsletQDDDNIRlkentftienesvkiafavtletVLAGHENWVN 261
Cdd:cd00200   52 GPVRDVAASADGT--YLASGSSDKTIRLWDL---------ETGECVR-----------------------TLTGHTSYVS 97

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 262 AVHWQPvfykDGVLqqpvrLLSASMDKTMILWapDEESGvwleqrewTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQT 341
Cdd:cd00200   98 SVAFSP----DGRI-----LSSSSRDKTIKVW--DVETG--------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 342 TRLfapwkrkdqsqvtwheiarpqihgYDLKCLaminrfqfvsgadeKVLRVFSAPRNFVeNFCAITGQSLNHVLCNQDS 421
Cdd:cd00200  159 IKL------------------------WDLRTG--------------KCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDG 199

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 422 Dlpegatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvafqpsiltepptedhllqntlwpevqklyghgyeif 501
Cdd:cd00200  200 T------------------------------------------------------------------------------- 200

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 502 cvtcnssktllasackaakkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT---WSLWKKqdtis 578
Cdd:cd00200  201 ------------------------IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTG----- 251

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 338968892 579 pefEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:cd00200  252 ---ECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-294 1.57e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892   8 TSHVFCCpnrvrgvlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSPSTELVSGGSDNQV 87
Cdd:cd00200   93 TSYVSSV--------AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  88 IH-WEIEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSkkgpevpilacgnddcrihifaq 166
Cdd:cd00200  159 IKlWDLRTGKCVAT--LTGHTGEVNSVAFSPDGEK--------LLSSSSDGTIKLWD----------------------- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 167 qNDQFQKVLSLCGHEDWIRGVEWaaFGRDLFLASCSQDCLIRIWKLYIKSTSletqdddnirlkentftienesvkiafa 246
Cdd:cd00200  206 -LSTGKCLGTLRGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRTGECV---------------------------- 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 338968892 247 vtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILWA 294
Cdd:cd00200  255 ----QTLSGHTNSVTSLAWSP----DG-----KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
486-748 1.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 486 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 560
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 561 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 640
Cdd:COG2319  221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 641 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 719
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                        250       260
                 ....*....|....*....|....*....
gi 338968892 720 cSGKTeqkeaegaewlhFASCGEDHTVKI 748
Cdd:COG2319  341 -DGKT------------LASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
15-212 2.11e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  15 PNRVRGVlNWSsgPRG-LLAFGTS-CSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWE 91
Cdd:COG2319  204 TGAVRSV-AFS--PDGkLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPdGRLLASGSADGTVRLWD 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892  92 IEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSKKGPEVP--------------------I 151
Cdd:COG2319  275 LATGELLRT--LTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLrtltghtgavrsvafspdgkT 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968892 152 LACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKL 212
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-646 2.49e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 2.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 249 LETVLAGHENWVNAVHWQPvfykdgvlqQPVRLLSASMDKTMILWapDEESGvwleqrewTPEIVISGHFDGVQDLVWDP 328
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG--------ELLRTLKGHTGPVRDVAASA 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 329 EGEFIITVGTDQTTRLFapWKRKDQSQVTWHEiarpqiHGYDLKCLAMINRFQFVSGA-DEKVLRVFsaprnfvenfcai 407
Cdd:cd00200   62 DGTYLASGSSDKTIRLW--DLETGECVRTLTG------HTSYVSSVAFSPDGRILSSSsRDKTIKVW------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 408 tgqslnhvlcnqdsDLPEGatvpalglsnkavfqgdiasqpsdeeelltstgfeyqqvafqpsiltepptedhllqntlw 487
Cdd:cd00200  121 --------------DVETG------------------------------------------------------------- 125

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 488 PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT 567
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-----IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 568 WSLWKKQdtispEFEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW----GECDSTddCIEHNiGPC 643
Cdd:cd00200  201 IKLWDLS-----TGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSEDGTIRVWdlrtGECVQT--LSGHT-NSV 264


                 ...
gi 338968892 644 SSV 646
Cdd:cd00200  265 TSL 267
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 489-748 3.15e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 489 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 568
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 569 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 648
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 649 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 727
Cdd:cd00200  217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                        250       260
                 ....*....|....*....|.
gi 338968892 728 eaegaewlhFASCGEDHTVKI 748
Cdd:cd00200  276 ---------LASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 489-748 5.43e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 5.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 489 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 568
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 569 SLWKKQDTispefEPVFSLFAFTNKitsvhsriIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVL- 647
Cdd:cd00200   76 RLWDLETG-----ECVRTLTGHTSY--------VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLr 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 648 DVGGAVTAVSVcpvlHPSQRYVVAVGLECgkiCLYTWkktdqvpEINDWtHCVETsqSQSHTLAIRKLCWkncSGKTEqk 727
Cdd:cd00200  133 GHTDWVNSVAF----SPDGTFVASSSQDG---TIKLW-------DLRTG-KCVAT--LTGHTGEVNSVAF---SPDGE-- 190

                        250       260
                 ....*....|....*....|.
gi 338968892 728 eaegaewlHFASCGEDHTVKI 748
Cdd:cd00200  191 --------KLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
481-752 3.45e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 481 LLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 560
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 561 AVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 640
Cdd:COG2319  137 SGSADGTVRLW---DLATGKLLRTL----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLAT------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 641 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkn 719
Cdd:COG2319  194 GKLLRTLTGhTGAVRSVAF----SPDGKLLASGSAD-GTVRLWDLATGKLLRTLTG------------HSGSVRSVAF-- 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 338968892 720 cS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 752
Cdd:COG2319  255 -SpdGRL------------LASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
525-752 8.01e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 8.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 525 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 604
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 605 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 683
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968892 684 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 752
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 598-626 1.24e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.24e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968892   598 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
598-626 1.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.69e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968892  598 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 626
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-572 1.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 338968892   533 SWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 170-211 3.92e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968892   170 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 211
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
171-210 4.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968892  171 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 210
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 598-753 7.05e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968892 598 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 676
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 338968892 677 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 753
Cdd:cd00200   73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
534-571 9.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 9.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 338968892  534 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 571
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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