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Conserved domains on  [gi|338968888|ref|NP_001229805|]
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elongator complex protein 2 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-411 1.46e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 133 AAADSAVRLWSKKGPEVTWKTGQVErgrawkppaslalcsrscdSMVSCyasilckalwkeklhtfwhhnrISFLPSafr 212
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRTLTGHT-------------------SYVSS----------------------VAFSPD--- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 213 pIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNI 292
Cdd:cd00200  105 -GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASSSQDGTIKLW------------DLRTG 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 293 RLKEnTFTIENESVK-IAF----------------------AVTLETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSA 349
Cdd:cd00200  168 KCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKCLGTLRGHENGVNSVAFSP----DGYL-----LASG 237

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 338968888 350 SMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 411
Cdd:cd00200  238 SEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
195-691 2.51e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 2.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 195 LHTFWHHNRISFLPSAFRPIPILACGNDDcrIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRI 274
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGD--LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 275 WklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKT 354
Cdd:COG2319  105 W-------DLATG-------------------------LLLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGT 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 355 MILWapDEESGVWLEqrewtpeiVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGY 434
Cdd:COG2319  144 VRLW--DLATGKLLR--------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRTLTGHTG 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 435 DLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFqgDI 509
Cdd:COG2319  206 AVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGSVR--SV 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 510 ASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACkaa 584
Cdd:COG2319  253 AFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS--- 307

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 585 kkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnkitsvHS 664
Cdd:COG2319  308 --DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG--------HT 372

                        490       500
                 ....*....|....*....|....*..
gi 338968888 665 RIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
590-817 1.01e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 590 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 669
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 670 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 748
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968888 749 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 817
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-411 1.46e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 133 AAADSAVRLWSKKGPEVTWKTGQVErgrawkppaslalcsrscdSMVSCyasilckalwkeklhtfwhhnrISFLPSafr 212
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRTLTGHT-------------------SYVSS----------------------VAFSPD--- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 213 pIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNI 292
Cdd:cd00200  105 -GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASSSQDGTIKLW------------DLRTG 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 293 RLKEnTFTIENESVK-IAF----------------------AVTLETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSA 349
Cdd:cd00200  168 KCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKCLGTLRGHENGVNSVAFSP----DGYL-----LASG 237

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 338968888 350 SMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 411
Cdd:cd00200  238 SEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-409 2.63e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWS-KKGPEVTWKTGQVERGR--AWKPPASLaLCSRSCD 176
Cdd:COG2319  157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRsvAFSPDGKL-LASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 177 SMVscyasilckALW----KEKLHTFWHH----NRISFLPSAfrpiPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDW 248
Cdd:COG2319  226 GTV---------RLWdlatGKLLRTLTGHsgsvRSVAFSPDG----RLLASGSADGTVRLWDLATGELLRTLT--GHSGG 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 249 IRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAV 328
Cdd:COG2319  291 VNSVAFSPDGK--LLASGSDDGTVRLW-------DLATG-------------------------KLLRTLTGHTGAVRSV 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 329 HWQPvfykDGvlqqpVRLLSASMDKTMILWAPDeesgvwleqrEWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTR 408
Cdd:COG2319  337 AFSP----DG-----KTLASGSDDGTVRLWDLA----------TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                 .
gi 338968888 409 L 409
Cdd:COG2319  398 L 398
WD40 COG2319
WD40 repeat [General function prediction only];
195-691 2.51e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 2.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 195 LHTFWHHNRISFLPSAFRPIPILACGNDDcrIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRI 274
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGD--LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 275 WklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKT 354
Cdd:COG2319  105 W-------DLATG-------------------------LLLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGT 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 355 MILWapDEESGVWLEqrewtpeiVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGY 434
Cdd:COG2319  144 VRLW--DLATGKLLR--------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRTLTGHTG 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 435 DLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFqgDI 509
Cdd:COG2319  206 AVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGSVR--SV 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 510 ASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACkaa 584
Cdd:COG2319  253 AFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS--- 307

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 585 kkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnkitsvHS 664
Cdd:COG2319  308 --DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG--------HT 372

                        490       500
                 ....*....|....*....|....*..
gi 338968888 665 RIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-691 7.36e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 7.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 314 LETVLAGHENWVNAVHWQPvfykdgvlqQPVRLLSASMDKTMILWapDEESGvwleqrewTPEIVISGHFDGVQDLVWDP 393
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG--------ELLRTLKGHTGPVRDVAASA 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 394 EGEFIITVGTDQTTRLFapWKRKDQSQVTWHEiarpqiHGYDLKCLAMINRFQFVSGA-DEKVLRVFsaprNFVENFCAI 472
Cdd:cd00200   62 DGTYLASGSSDKTIRLW--DLETGECVRTLTG------HTSYVSSVAFSPDGRILSSSsRDKTIKVW----DVETGKCLT 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 473 TGQ----SLNHVLCNQDSDLpeGATvpalGLSNKAVFQGDIASqpsdeeelltstgfeyqqvafqpsiltepptedhllq 548
Cdd:cd00200  130 TLRghtdWVNSVAFSPDGTF--VAS----SSQDGTIKLWDLRT------------------------------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 549 ntlWPEVQKLYGHGYEIFCVTCNSSKTLLASAckAAKKEhaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVS 628
Cdd:cd00200  167 ---GKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT---IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 338968888 629 RDRT---WSLWKKqdtispefEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:cd00200  239 EDGTirvWDLRTG--------ECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
590-817 1.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 590 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 669
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 670 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 748
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968888 749 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 817
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 663-691 1.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.55e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968888   663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
663-691 2.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.22e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968888  663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-276 4.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968888   235 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-275 5.85e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968888  236 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 275
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 663-818 9.54e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 9.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 741
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 338968888 742 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 818
Cdd:cd00200   73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-411 1.46e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  54 LNGHTARVNCIQWickqdgSPSTE-LVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVHAVYQRrtsdpalcTLIVS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADG--------TYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 133 AAADSAVRLWSKKGPEVTWKTGQVErgrawkppaslalcsrscdSMVSCyasilckalwkeklhtfwhhnrISFLPSafr 212
Cdd:cd00200   69 GSSDKTIRLWDLETGECVRTLTGHT-------------------SYVSS----------------------VAFSPD--- 104

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 213 pIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstsletqDDDNI 292
Cdd:cd00200  105 -GRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGT--FVASSSQDGTIKLW------------DLRTG 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 293 RLKEnTFTIENESVK-IAF----------------------AVTLETVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSA 349
Cdd:cd00200  168 KCVA-TLTGHTGEVNsVAFspdgekllssssdgtiklwdlsTGKCLGTLRGHENGVNSVAFSP----DGYL-----LASG 237

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 338968888 350 SMDKTMILWapDEESGVwleqrewtPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFA 411
Cdd:cd00200  238 SEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-409 2.63e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPdGKTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 100 AvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWS-KKGPEVTWKTGQVERGR--AWKPPASLaLCSRSCD 176
Cdd:COG2319  157 T--LTGHSGAVTSV-AF----SPDG---KLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRsvAFSPDGKL-LASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 177 SMVscyasilckALW----KEKLHTFWHH----NRISFLPSAfrpiPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDW 248
Cdd:COG2319  226 GTV---------RLWdlatGKLLRTLTGHsgsvRSVAFSPDG----RLLASGSADGTVRLWDLATGELLRTLT--GHSGG 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 249 IRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAV 328
Cdd:COG2319  291 VNSVAFSPDGK--LLASGSDDGTVRLW-------DLATG-------------------------KLLRTLTGHTGAVRSV 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 329 HWQPvfykDGvlqqpVRLLSASMDKTMILWAPDeesgvwleqrEWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTR 408
Cdd:COG2319  337 AFSP----DG-----KTLASGSDDGTVRLWDLA----------TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                 .
gi 338968888 409 L 409
Cdd:COG2319  398 L 398
WD40 COG2319
WD40 repeat [General function prediction only];
195-691 2.51e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 2.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 195 LHTFWHHNRISFLPSAFRPIPILACGNDDcrIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRI 274
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGD--LTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 275 WklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLSASMDKT 354
Cdd:COG2319  105 W-------DLATG-------------------------LLLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGT 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 355 MILWapDEESGVWLEqrewtpeiVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIARPQIHGY 434
Cdd:COG2319  144 VRLW--DLATGKLLR--------TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLA-----TGKLLRTLTGHTG 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 435 DLKCLAminrF-----QFVSGADEKVLRVFsaprnfvenfcaitgqslnhvlcnqdsDLPEGATVPALGLSNKAVFqgDI 509
Cdd:COG2319  206 AVRSVA----FspdgkLLASGSADGTVRLW---------------------------DLATGKLLRTLTGHSGSVR--SV 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 510 ASQPSDEeeLLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACkaa 584
Cdd:COG2319  253 AFSPDGR--LLASGS------------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS--- 307

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 585 kkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTispefEPVFSLFAftnkitsvHS 664
Cdd:COG2319  308 --DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-----ELLRTLTG--------HT 372

                        490       500
                 ....*....|....*....|....*..
gi 338968888 665 RIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:COG2319  373 GAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
15-358 3.44e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  120 TGAVRSV-AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPdGKLLASGSDDGTVRLWDLA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  94 DNQLLKAvhLQGHEGPVYAVhAVyqrrTSDPalcTLIVSAAADSAVRLWSKKGPEVTwKTGQVERGRAWkppaSLA---- 169
Cdd:COG2319  193 TGKLLRT--LTGHTGAVRSV-AF----SPDG---KLLASGSADGTVRLWDLATGKLL-RTLTGHSGSVR----SVAfspd 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 170 ---LCSRSCDSMVScyasilckaLW----KEKLHTF-WHHNRISFLpsAFRPI-PILACGNDDCRIHIFAQQNDQFQKVL 240
Cdd:COG2319  258 grlLASGSADGTVR---------LWdlatGELLRTLtGHSGGVNSV--AFSPDgKLLASGSDDGTVRLWDLATGKLLRTL 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 241 SlcGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAG 320
Cdd:COG2319  327 T--GHTGAVRSVAFSPDGK--TLASGSDDGTVRLW-------DLATG-------------------------ELLRTLTG 370

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 338968888 321 HENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMILW 358
Cdd:COG2319  371 HTGAVTSVAFSP----DG-----RTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
21-461 2.43e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  21 VLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWIckqdgSPSTELVSGGSDNQVIHWEIEDNQLLka 100
Cdd:COG2319   41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 101 VHLQGHEGPVYAVhAVyqrrTSDpalCTLIVSAAADSAVRLWSkkgpevtWKTGQVergrawkppaslalcsrscdsmvs 180
Cdd:COG2319  114 RTLTGHTGAVRSV-AF----SPD---GKTLASGSADGTVRLWD-------LATGKL------------------------ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 181 cyasilckalwkekLHTFWHH----NRISFLPSAfrpiPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAA 256
Cdd:COG2319  155 --------------LRTLTGHsgavTSVAFSPDG----KLLASGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSP 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 257 FGRdlFLASCSQDCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfyk 336
Cdd:COG2319  215 DGK--LLASGSADGTVRLW-------DLATG-------------------------KLLRTLTGHSGSVRSVAFSP---- 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 337 DGVlqqpvRLLSASMDKTMILWAPDEESGVWLeqrewtpeivISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRK 416
Cdd:COG2319  257 DGR-----LLASGSADGTVRLWDLATGELLRT----------LTGHSGGVNSVAFSPDGKLLASGSDDGTVRL---WDLA 318

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 338968888 417 dqsqvTWHEIARPQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSA 461
Cdd:COG2319  319 -----TGKLLRTLTGHTGAVRSVA----FspdgkTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
189-636 4.38e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 4.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 189 ALWKEKLHTFWHHNRISFLPSAFRPIPILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQ 268
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPDGK--TLASGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 269 DCLIRIWklyikstSLETQdddnirlkentftienesvkiafavTLETVLAGHENWVNAVHWQPvfykDGVlqqpvRLLS 348
Cdd:COG2319  141 DGTVRLW-------DLATG-------------------------KLLRTLTGHSGAVTSVAFSP----DGK-----LLAS 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 349 ASMDKTMILWapDEESGVWLEqrewtpeiVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapWKRKdqsqvTWHEIAR 428
Cdd:COG2319  180 GSDDGTVRLW--DLATGKLLR--------TLTGHTGAVRSVAFSPDGKLLASGSADGTVRL---WDLA-----TGKLLRT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 429 PQIHGYDLKCLAminrF-----QFVSGADEKVLRVFSAPrnfvenfcaiTGQSLNhvlcnqdsdLPEGATVPALGLsnka 503
Cdd:COG2319  242 LTGHSGSVRSVA----FspdgrLLASGSADGTVRLWDLA----------TGELLR---------TLTGHSGGVNSV---- 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 504 VFqgdiasqpSDEEELLTSTGfeyqqvafqpsiltepptEDHLLQntLW-----PEVQKLYGHGYEIFCVTCNSSKTLLA 578
Cdd:COG2319  295 AF--------SPDGKLLASGS------------------DDGTVR--LWdlatgKLLRTLTGHTGAVRSVAFSPDGKTLA 346

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 338968888 579 SACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 636
Cdd:COG2319  347 SGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-691 7.36e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 7.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 314 LETVLAGHENWVNAVHWQPvfykdgvlqQPVRLLSASMDKTMILWapDEESGvwleqrewTPEIVISGHFDGVQDLVWDP 393
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG--------ELLRTLKGHTGPVRDVAASA 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 394 EGEFIITVGTDQTTRLFapWKRKDQSQVTWHEiarpqiHGYDLKCLAMINRFQFVSGA-DEKVLRVFsaprNFVENFCAI 472
Cdd:cd00200   62 DGTYLASGSSDKTIRLW--DLETGECVRTLTG------HTSYVSSVAFSPDGRILSSSsRDKTIKVW----DVETGKCLT 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 473 TGQ----SLNHVLCNQDSDLpeGATvpalGLSNKAVFQGDIASqpsdeeelltstgfeyqqvafqpsiltepptedhllq 548
Cdd:cd00200  130 TLRghtdWVNSVAFSPDGTF--VAS----SSQDGTIKLWDLRT------------------------------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 549 ntlWPEVQKLYGHGYEIFCVTCNSSKTLLASAckAAKKEhaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVS 628
Cdd:cd00200  167 ---GKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT---IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 338968888 629 RDRT---WSLWKKqdtispefEPVFSLFAftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:cd00200  239 EDGTirvWDLRTG--------ECVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-359 2.37e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  42 LYDPLKRVVVTNLNGHTARVNCIQWickqdgSPSTELVSGGS-DNQVIHWEIEDNQLLKAvhLQGHEGPVYAVhavyqrR 120
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAF------SPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGHTDWVNSV------A 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 121 TSDPAlcTLIVSAAADSAVRLWSkkgpevtwktgqverGRAWKPpaslalcsrscdsmvscyasilckalwkekLHTFWH 200
Cdd:cd00200  143 FSPDG--TFVASSSQDGTIKLWD---------------LRTGKC------------------------------VATLTG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 201 H----NRISFLPSAFRpipILACGNDDCrIHIFAQQNDQFQKVLSlcGHEDWIRGVEWaaFGRDLFLASCSQDCLIRIWK 276
Cdd:cd00200  176 HtgevNSVAFSPDGEK---LLSSSSDGT-IKLWDLSTGKCLGTLR--GHENGVNSVAF--SPDGYLLASGSEDGTIRVWD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 277 LYIKSTSletqdddnirlkentftienesvkiafavtleTVLAGHENWVNAVHWQPvfykDGvlqqpVRLLSASMDKTMI 356
Cdd:cd00200  248 LRTGECV--------------------------------QTLSGHTNSVTSLAWSP----DG-----KRLASGSADGTIR 286


                 ...
gi 338968888 357 LWA 359
Cdd:cd00200  287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-277 5.17e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  39 SVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIEDNQLLKAvhLQGHEGPVYAVhAVy 117
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAF------SPdGKLLASGSADGTVRLWDLATGKLLRT--LTGHSGSVRSV-AF- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 118 qrrTSDpalCTLIVSAAADSAVRLWS-KKGPEVTWKTGQVERGR--AWKPPASLaLCSRSCDSMVScyasilckaLW--- 191
Cdd:COG2319  255 ---SPD---GRLLASGSADGTVRLWDlATGELLRTLTGHSGGVNsvAFSPDGKL-LASGSDDGTVR---------LWdla 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 192 -KEKLHTFW-HHNRISFLpsAFRPI-PILACGNDDCRIHIFAQQNDQFQKVLSlcGHEDWIRGVEWAAFGRdlFLASCSQ 268
Cdd:COG2319  319 tGKLLRTLTgHTGAVRSV--AFSPDgKTLASGSDDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSA 392


                 ....*....
gi 338968888 269 DCLIRIWKL 277
Cdd:COG2319  393 DGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
551-813 1.79e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 551 LW-----PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 625
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 626 AVSRDRTWSLWkkqDTISPEfePVFSLfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 705
Cdd:COG2319  221 SGSADGTVRLW---DLATGK--LLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLAT------- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 706 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWKN 784
Cdd:COG2319  278 GELLRTLTGhSGGVNSVAF----SPDGKLLASGSDD-GTVRLWDLATGKLLRTLTG------------HTGAVRSVAFSP 340

                        250       260
                 ....*....|....*....|....*....
gi 338968888 785 cSGKTeqkeaegaewlhFASCGEDHTVKI 813
Cdd:COG2319  341 -DGKT------------LASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-813 5.01e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 5.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 554 EVQKLYGHGYEIFCVTCNSSKTLLASAckaakKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 633
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 634 SLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVLD 713
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLW----------DLSTGKCLGTLR 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 714 V-GGAVTAVSVCPvlhpsQRYVVAVGLECGKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqk 792
Cdd:cd00200  217 GhENGVNSVAFSP-----DGYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAWSP-DGKR--- 275

                        250       260
                 ....*....|....*....|.
gi 338968888 793 eaegaewlhFASCGEDHTVKI 813
Cdd:cd00200  276 ---------LASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 200-637 2.50e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 200 HHNRISFLpsAFRPI-PILACGNDDCRIHIFAQQNDQFQKvlSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWKLy 278
Cdd:cd00200    8 HTGGVTCV--AFSPDgKLLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--YLASGSSDKTIRLWDL- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 279 ikstsletQDDDNIRlkentftienesvkiafavtletVLAGHENWVNAVHWQPvfykDGVLqqpvrLLSASMDKTMILW 358
Cdd:cd00200   81 --------ETGECVR-----------------------TLTGHTSYVSSVAFSP----DGRI-----LSSSSRDKTIKVW 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 359 apDEESGvwleqrewTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLfapwkrkdqsqvtwheiarpqihgYDLKC 438
Cdd:cd00200  121 --DVETG--------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL------------------------WDLRT 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 439 LaminrfqfvsgadeKVLRVFSAPRNFVeNFCAITGQSLNHVLCNQDSDlpegatvpalglsnkaVFQGDIasqpsdeee 518
Cdd:cd00200  167 G--------------KCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT----------------IKLWDL--------- 206

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 519 lltSTGFEYQQvafqpsiltepptedhllqntlwpevqkLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTS 598
Cdd:cd00200  207 ---STGKCLGT----------------------------LRGHENGVNSVAFSPDGYLLASGSEDGT-----IRVWDLRT 250

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 338968888 599 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 637
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-813 8.62e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 8.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 554 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKkehaaIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTW 633
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-----IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 634 SLWKKQDTispefEPVFSLFAFTNKitsvhsriIWSCDWSPDSKYFFTGSRDKKVVVWgecdstddciEHNIGPCSSVL- 712
Cdd:cd00200   76 RLWDLETG-----ECVRTLTGHTSY--------VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLr 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 713 DVGGAVTAVSVcpvlHPSQRYVVAVGLECgkiCLYTWkktdqvpEINDWtHCVETsqSQSHTLAIRKLCWkncSGKTEqk 792
Cdd:cd00200  133 GHTDWVNSVAF----SPDGTFVASSSQDG---TIKLW-------DLRTG-KCVAT--LTGHTGEVNSVAF---SPDGE-- 190

                        250       260
                 ....*....|....*....|.
gi 338968888 793 eaegaewlHFASCGEDHTVKI 813
Cdd:cd00200  191 --------KLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
546-817 4.54e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 4.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 546 LLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACkaakkEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL 625
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 626 AVSRDRTWSLWkkqDTISPEFEPVFslfaftnkitSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehni 705
Cdd:COG2319  137 SGSADGTVRLW---DLATGKLLRTL----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLAT------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 706 GPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYTWKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkn 784
Cdd:COG2319  194 GKLLRTLTGhTGAVRSVAF----SPDGKLLASGSAD-GTVRLWDLATGKLLRTLTG------------HSGSVRSVAF-- 254

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 338968888 785 cS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 817
Cdd:COG2319  255 -SpdGRL------------LASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-276 1.10e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888   8 TSHVFCCpnrvrgvlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSPSTELVSGGSDNQV 87
Cdd:cd00200   93 TSYVSSV--------AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  88 IH-WEIEDNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWSKKGpevtwktgqvergrawkppa 166
Cdd:cd00200  159 IKlWDLRTGKCVAT--LTGHTGEVNSVAFSPDGEK--------LLSSSSDGTIKLWDLST-------------------- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 167 slalcsrscdsmvscyasilckalwKEKLHTFWHHNR----ISFLPSAFrpipILACGNDDCRIHIFaqQNDQFQKVLSL 242
Cdd:cd00200  209 -------------------------GKCLGTLRGHENgvnsVAFSPDGY----LLASGSEDGTIRVW--DLRTGECVQTL 257

                        250       260       270
                 ....*....|....*....|....*....|....
gi 338968888 243 CGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 276
Cdd:cd00200  258 SGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-143 6.78e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 6.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888  15 PNRVRGVlNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWickqdgSP-STELVSGGSDNQVIHWEIE 93
Cdd:COG2319  288 SGGVNSV-AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPdGKTLASGSDDGTVRLWDLA 360

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 338968888  94 DNQLLKAvhLQGHEGPVYAVHAVYQRRTsdpalctlIVSAAADSAVRLWS 143
Cdd:COG2319  361 TGELLRT--LTGHTGAVTSVAFSPDGRT--------LASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
590-817 1.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 590 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWkkqDTISPEFEPVFSLfaftnkitsvHSRIIWS 669
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG----------HTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 670 CDWSPDSKYFFTGSRDKKVVVWgecDSTDdciehniGPCSSVLDV-GGAVTAVSVcpvlHPSQRYVVAVGLEcGKICLYT 748
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW---DLAT-------GKLLRTLTGhSGAVTSVAF----SPDGKLLASGSDD-GTVRLWD 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 338968888 749 WKKTDQVPEINDwthcvetsqsqsHTLAIRKLCWkncS--GKTeqkeaegaewlhFASCGEDHTVKIHRVN 817
Cdd:COG2319  191 LATGKLLRTLTG------------HTGAVRSVAF---SpdGKL------------LASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 663-691 1.55e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.55e-05
                           10        20
                   ....*....|....*....|....*....
gi 338968888   663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
663-691 2.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.22e-05
                          10        20
                  ....*....|....*....|....*....
gi 338968888  663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 691
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 598-637 1.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 338968888   598 SWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWK 637
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 235-276 4.79e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 338968888   235 QFQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIWK 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-275 5.85e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 338968888  236 FQKVLSLCGHEDWIRGVEWAAFGRdlFLASCSQDCLIRIW 275
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 663-818 9.54e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 9.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968888 663 HSRIIWSCDWSPDSKYFFTGSRDKKVVVWgecD-STDDCIEHNIGPCSSVLDVggavtavsvcpVLHPSQRYVVAVGLEc 741
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW---DlETGELLRTLKGHTGPVRDV-----------AASADGTYLASGSSD- 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 338968888 742 GKICLYTWKKTDQVPEIndwthcvetsqsQSHTLAIRKLCWKNcSGKTeqkeaegaewlhFASCGEDHTVKIHRVNK 818
Cdd:cd00200   73 KTIRLWDLETGECVRTL------------TGHTSYVSSVAFSP-DGRI------------LSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
599-636 1.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 338968888  599 WKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 636
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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