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Conserved domains on  [gi|338827650|ref|NP_001229759|]
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very long chain fatty acid elongase 5 isoform 3 [Homo sapiens]

Protein Classification

elongation of very long chain fatty acids protein( domain architecture ID 10471715)

elongation of very long chain fatty acids protein catalyzes the first and rate-limiting reaction of the four steps that constitute the long-chain fatty acids elongation cycle

EC:  2.3.1.199
Gene Ontology:  GO:0009922|GO:0042761

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
 27-170 2.62e-46

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


:

Pssm-ID: 460083  Cd Length: 242  Bit Score: 154.70  E-value: 2.62e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338827650   27 FLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTR-TAGES 105
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQpSESPF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 338827650  106 DMKIIRV-LWWYYFSKLIEFMDTFFFILRKNnhQITVLHVYHHASMLNIWWFVMNWVPCGHSSVCA 170
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFI 144
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
 27-170 2.62e-46

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 154.70  E-value: 2.62e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338827650   27 FLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTR-TAGES 105
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQpSESPF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 338827650  106 DMKIIRV-LWWYYFSKLIEFMDTFFFILRKNnhQITVLHVYHHASMLNIWWFVMNWVPCGHSSVCA 170
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFI 144
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
 27-170 2.62e-46

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 154.70  E-value: 2.62e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338827650   27 FLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFSCRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTR-TAGES 105
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQpSESPF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 338827650  106 DMKIIRV-LWWYYFSKLIEFMDTFFFILRKNnhQITVLHVYHHASMLNIWWFVMNWVPCGHSSVCA 170
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFI 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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