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Conserved domains on  [gi|333440434|ref|NP_001193953|]
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cation-dependent mannose-6-phosphate receptor isoform 2 precursor [Homo sapiens]

Protein Classification

cation-dependent mannose-6-phosphate receptor( domain architecture ID 1563581)

cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component of the lysosomal enzyme targeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and transports them to endosomal compartments

Gene Ontology:  GO:0015031
PubMed:  3156583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG27 super family cl39051
Autophagy-related protein 27;
24-191 9.88e-103

Autophagy-related protein 27;


The actual alignment was detected with superfamily member pfam02157:

Pssm-ID: 476860  Cd Length: 254  Bit Score: 295.92  E-value: 9.88e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434   24 SWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVV 103
Cdd:pfam02157   1 SATTEEKKCDLVGEESSESQKERALLKRLEPLANKSFEVTVGSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  104 GRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTL--------------------------------- 150
Cdd:pfam02157  81 GRINETQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMISCNRKVLadnftivieerekeqdcfylfeldsslacpped 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  151 -----------------------------------------------------ADGCDFVCRSKPRNVPAAYRGVGDDQL 177
Cdd:pfam02157 161 shlsvgsillivffslvavyiiggflyqrlvvgakgmeqfpnyafwqdlgnlvADGCDFVCRSKPRNAPAAYRGVGDDQL 240

                         250
                  ....*....|....
gi 333440434  178 GEESEERDDHLLPM 191
Cdd:pfam02157 241 GEESEERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 24-191 9.88e-103

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 295.92  E-value: 9.88e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434   24 SWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVV 103
Cdd:pfam02157   1 SATTEEKKCDLVGEESSESQKERALLKRLEPLANKSFEVTVGSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  104 GRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTL--------------------------------- 150
Cdd:pfam02157  81 GRINETQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMISCNRKVLadnftivieerekeqdcfylfeldsslacpped 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  151 -----------------------------------------------------ADGCDFVCRSKPRNVPAAYRGVGDDQL 177
Cdd:pfam02157 161 shlsvgsillivffslvavyiiggflyqrlvvgakgmeqfpnyafwqdlgnlvADGCDFVCRSKPRNAPAAYRGVGDDQL 240

                         250
                  ....*....|....
gi 333440434  178 GEESEERDDHLLPM 191
Cdd:pfam02157 241 GEESEERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 24-191 9.88e-103

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 295.92  E-value: 9.88e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434   24 SWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVV 103
Cdd:pfam02157   1 SATTEEKKCDLVGEESSESQKERALLKRLEPLANKSFEVTVGSGPETYTYNFRVCREVGKTASDAGLVQIDKKNGKETVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  104 GRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTL--------------------------------- 150
Cdd:pfam02157  81 GRINETQVFNGSDWIMLIYKGGDEYGSHCGKEKRKAIIMISCNRKVLadnftivieerekeqdcfylfeldsslacpped 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440434  151 -----------------------------------------------------ADGCDFVCRSKPRNVPAAYRGVGDDQL 177
Cdd:pfam02157 161 shlsvgsillivffslvavyiiggflyqrlvvgakgmeqfpnyafwqdlgnlvADGCDFVCRSKPRNAPAAYRGVGDDQL 240

                         250
                  ....*....|....
gi 333440434  178 GEESEERDDHLLPM 191
Cdd:pfam02157 241 GEESEERDDHLLPM 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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