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Conserved domains on  [gi|331028739|ref|NP_001193541|]
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chromatin target of PRMT1 protein isoform 2 [Homo sapiens]

Protein Classification

chromatin target of PRMT1 protein( domain architecture ID 10620570)

chromatin target of PRMT1 protein (CHTOP) plays an important role in the ligand-dependent activation of estrogen receptor target genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FoP_duplication pfam13865
C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are ...
 210-244 8.86e-08

C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localized to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it co-localizes with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation.


:

Pssm-ID: 464005  Cd Length: 81  Bit Score: 48.51  E-value: 8.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 331028739  210 PVLTKEQLDNQLDAYMSKT--KGHLDAELDAYMAQTD 244
Cdd:pfam13865  45 KPKTKEELDAELDEYMSPKtkKSKLDAELDEYMKKKG 81
 
Name Accession Description Interval E-value
FoP_duplication pfam13865
C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are ...
 210-244 8.86e-08

C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localized to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it co-localizes with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation.


Pssm-ID: 464005  Cd Length: 81  Bit Score: 48.51  E-value: 8.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 331028739  210 PVLTKEQLDNQLDAYMSKT--KGHLDAELDAYMAQTD 244
Cdd:pfam13865  45 KPKTKEELDAELDEYMSPKtkKSKLDAELDEYMKKKG 81
 
Name Accession Description Interval E-value
FoP_duplication pfam13865
C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are ...
 210-244 8.86e-08

C-terminal duplication domain of Friend of PRMT1; Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localized to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it co-localizes with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation.


Pssm-ID: 464005  Cd Length: 81  Bit Score: 48.51  E-value: 8.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 331028739  210 PVLTKEQLDNQLDAYMSKT--KGHLDAELDAYMAQTD 244
Cdd:pfam13865  45 KPKTKEELDAELDEYMSPKtkKSKLDAELDEYMKKKG 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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