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Conserved domains on  [gi|323714253|ref|NP_001191184|]
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lysosome membrane protein 2 isoform 2 [Homo sapiens]

Protein Classification

CD36 family protein( domain architecture ID 10471559)

CD36 family protein belongs to a class of scavenger receptors that may play roles in various signal transduction mechanisms; CD36 is a multifunctional membrane protein that acts as the cellular receptor for thrombospondin-1 (TSP-1) and is required for the anti-angiogenic activity of TSP-1, and generally promotes thrombosis in conditions of oxidative stress

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-314 3.42e-118

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


:

Pssm-ID: 460076  Cd Length: 454  Bit Score: 348.42  E-value: 3.42e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYR------------- 92
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYReyrekvnvtfndd 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253      --------------------------------------------------------------------------------
Cdd:pfam01130  96 ngtvsyqqrrtyifdpelsvgseddtittpnipllgaaskarnssfllrllnlllnslgeklfvtrtvgellfgyedpll 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   93 -----------------------------------------------------SLDWWiTDKCNMINGTDGDSFHPLITK 119
Cdd:pfam01130 176 dlakkllpslpipfdkfglfygrngtddgvftvytgkddisklgridswngktHLDWW-EGECNMINGTDGTLFPPFLTK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  120 DEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIMS 195
Cdd:pfam01130 255 DDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFLS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  196 FPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHID 275
Cdd:pfam01130 335 LPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAELD 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 323714253  276 KETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 314
Cdd:pfam01130 415 DELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-314 3.42e-118

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 348.42  E-value: 3.42e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYR------------- 92
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYReyrekvnvtfndd 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253      --------------------------------------------------------------------------------
Cdd:pfam01130  96 ngtvsyqqrrtyifdpelsvgseddtittpnipllgaaskarnssfllrllnlllnslgeklfvtrtvgellfgyedpll 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   93 -----------------------------------------------------SLDWWiTDKCNMINGTDGDSFHPLITK 119
Cdd:pfam01130 176 dlakkllpslpipfdkfglfygrngtddgvftvytgkddisklgridswngktHLDWW-EGECNMINGTDGTLFPPFLTK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  120 DEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIMS 195
Cdd:pfam01130 255 DDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFLS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  196 FPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHID 275
Cdd:pfam01130 335 LPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAELD 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 323714253  276 KETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 314
Cdd:pfam01130 415 DELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Name Accession Description Interval E-value
CD36 pfam01130
CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is ...
 28-314 3.42e-118

CD36 family; The CD36 family is thought to be a novel class of scavenger receptors. There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.


Pssm-ID: 460076  Cd Length: 454  Bit Score: 348.42  E-value: 3.42e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   28 VFQKAVDQSIEKK-IVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEIL-RGETPRVEEVGPYTYR------------- 92
Cdd:pfam01130  16 VFPPIIFNQIIKKeLVLKPGSESYELWKKPPVPVYLKFYLFNVTNPEEFLgGGAKPKVEEVGPYVYReyrekvnvtfndd 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253      --------------------------------------------------------------------------------
Cdd:pfam01130  96 ngtvsyqqrrtyifdpelsvgseddtittpnipllgaaskarnssfllrllnlllnslgeklfvtrtvgellfgyedpll 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253   93 -----------------------------------------------------SLDWWiTDKCNMINGTDGDSFHPLITK 119
Cdd:pfam01130 176 dlakkllpslpipfdkfglfygrngtddgvftvytgkddisklgridswngktHLDWW-EGECNMINGTDGTLFPPFLTK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  120 DEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTS---DNAGFCIPEGN-CLGSGVLNVSICKNGAPIIMS 195
Cdd:pfam01130 255 DDTLYIFSPDLCRSLPLVYEKDVTVKGIPGYRYVLPPNVFDNGTvnpDNKCFCPNKGNeCLPSGLLDVSPCKYGAPIFLS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323714253  196 FPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHID 275
Cdd:pfam01130 335 LPHFYLADPSYLEAVEGLNPNKEKHETYLDIEPTTGIPLEAAKRLQINLLVEPVPGISLLKNLPNVILPLFWFEESAELD 414

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 323714253  276 KETASRLKSMINTT-LIITNIPYIIMALGVFFGLVFTWLA 314
Cdd:pfam01130 415 DELANLLKKLLLVLpNIGLYLQYGLLALGLILLLVALILL 454
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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