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Conserved domains on  [gi|323510705|ref|NP_001191128|]
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signal recognition particle 19 kDa protein isoform 6 [Homo sapiens]

Protein Classification

signal recognition particle subunit SRP19/SEC65 family protein( domain architecture ID 10487531)

signal recognition particle subunit SRP19/SEC65 family protein may be a component of the signal recognition particle (SRP), which is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences

CATH:  3.30.56.30
Gene Ontology:  GO:0006614|GO:0008312|GO:0048500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-101 3.34e-37

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


:

Pssm-ID: 460383  Cd Length: 94  Bit Score: 120.66  E-value: 3.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705   17 CIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 96
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELAVENPTAKEIADACKKLGLPVVVEPDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75


                  ....*
gi 323510705   97 QFPSR 101
Cdd:pfam01922  76 EIKNK 80
 
Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-101 3.34e-37

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


Pssm-ID: 460383  Cd Length: 94  Bit Score: 120.66  E-value: 3.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705   17 CIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 96
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELAVENPTAKEIADACKKLGLPVVVEPDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75


                  ....*
gi 323510705   97 QFPSR 101
Cdd:pfam01922  76 EIKNK 80
SEC65 COG1400
Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular ...
 16-85 8.96e-20

Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441010  Cd Length: 96  Bit Score: 76.40  E-value: 8.96e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705  16 ICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRVQ 85
Cdd:COG1400    7 IVIWPAYFDASLSRSEGRRVPRELAVEKPTLEEIAKAAKKLGLNPEVERDKKYPRRWWEK---SGRVVVE 73
Sig_rec_Srp19_Halo NF041311
signal recognition particle subunit SRP19;
18-97 5.09e-15

signal recognition particle subunit SRP19;


Pssm-ID: 469208  Cd Length: 93  Bit Score: 64.38  E-value: 5.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705  18 IYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRVQLKQEDGSLCLVQ 97
Cdd:NF041311   6 IWPAYFDAELSRSEGRRVPEDLAVEEPTVDEIAKAVQQVGYDAVIERDVAYPREHWEE---RGRVLVKDADDAGKNDLVQ 82
PRK00754 PRK00754
signal recognition particle protein Srp19; Provisional
 16-84 1.43e-13

signal recognition particle protein Srp19; Provisional


Pssm-ID: 179110  Cd Length: 95  Bit Score: 60.49  E-value: 1.43e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 323510705  16 ICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRV 84
Cdd:PRK00754   7 IVIWPAYIDSTRSRSEGRIISRKLAVKEPRLEEIIEAAEKLGLNPEVEPDKAYPRSWWEV---SGRVLV 72
 
Name Accession Description Interval E-value
SRP19 pfam01922
SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins ...
 17-101 3.34e-37

SRP19 protein; The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein (Sec65 in yeast).


Pssm-ID: 460383  Cd Length: 94  Bit Score: 120.66  E-value: 3.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705   17 CIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWnrdvQYRGRVRVQLKQEDGsLCLV 96
Cdd:pfam01922   1 VIYPAYFDSKRTRAEGRRVPKELAVENPTAKEIADACKKLGLPVVVEPDKTHPRDW----ANPGRVRVQLKNDDG-PVNP 75


                  ....*
gi 323510705   97 QFPSR 101
Cdd:pfam01922  76 EIKNK 80
SEC65 COG1400
Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular ...
 16-85 8.96e-20

Signal recognition particle subunit SEC65 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441010  Cd Length: 96  Bit Score: 76.40  E-value: 8.96e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705  16 ICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRVQ 85
Cdd:COG1400    7 IVIWPAYFDASLSRSEGRRVPRELAVEKPTLEEIAKAAKKLGLNPEVERDKKYPRRWWEK---SGRVVVE 73
Sig_rec_Srp19_Halo NF041311
signal recognition particle subunit SRP19;
18-97 5.09e-15

signal recognition particle subunit SRP19;


Pssm-ID: 469208  Cd Length: 93  Bit Score: 64.38  E-value: 5.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323510705  18 IYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRVQLKQEDGSLCLVQ 97
Cdd:NF041311   6 IWPAYFDAELSRSEGRRVPEDLAVEEPTVDEIAKAVQQVGYDAVIERDVAYPREHWEE---RGRVLVKDADDAGKNDLVQ 82
PRK00754 PRK00754
signal recognition particle protein Srp19; Provisional
 16-84 1.43e-13

signal recognition particle protein Srp19; Provisional


Pssm-ID: 179110  Cd Length: 95  Bit Score: 60.49  E-value: 1.43e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 323510705  16 ICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDvqyRGRVRV 84
Cdd:PRK00754   7 IVIWPAYIDSTRSRSEGRIISRKLAVKEPRLEEIIEAAEKLGLNPEVEPDKAYPRSWWEV---SGRVLV 72
PRK03745 PRK03745
signal recognition particle protein Srp19; Provisional
 14-85 5.57e-05

signal recognition particle protein Srp19; Provisional


Pssm-ID: 235155  Cd Length: 100  Bit Score: 38.58  E-value: 5.57e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 323510705  14 RFIcIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVF-LEKNKMYSREWNRDVQYR--GRVRVQ 85
Cdd:PRK03745   3 RFV-VWPSELDSRLSRKYGRIVPKNLAVERPTLEEIVDAAEALGFKVIeVDREKLNPRLSGIDEELRtrGRIVIE 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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