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Conserved domains on  [gi|321400126|ref|NP_001189479|]
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WD repeat-containing protein 27 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
418-726 1.54e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 1.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 570
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 571 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 649
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321400126 650 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 726
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-139 2.28e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDpSHQLLILRGHHQPITAMAFGNkvNPLLICSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFIDAES 123
Cdd:cd00200  198 DGT-IKLWDLST-GKCLGTLRGHENGVNSVAFSP--DGYLLASGSEDGTIrVWDLRTGECvQTLSGHtnSVTSLAWSPDG 273

                         90
                 ....*....|....*.
gi 321400126 124 RQLVTGCADGQLWIFS 139
Cdd:cd00200  274 KRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
418-726 1.54e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 1.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 570
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 571 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 649
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321400126 650 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 726
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-727 5.06e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 5.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 576
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 577 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 655
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 321400126 656 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 452-486 1.79e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.79e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 321400126   452 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 486
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
452-486 1.91e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.91e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 321400126  452 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 486
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-139 2.28e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDpSHQLLILRGHHQPITAMAFGNkvNPLLICSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFIDAES 123
Cdd:cd00200  198 DGT-IKLWDLST-GKCLGTLRGHENGVNSVAFSP--DGYLLASGSEDGTIrVWDLRTGECvQTLSGHtnSVTSLAWSPDG 273

                         90
                 ....*....|....*.
gi 321400126 124 RQLVTGCADGQLWIFS 139
Cdd:cd00200  274 KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-140 3.25e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDPsHQLLILRGHHQPITAMAFGNKVNPLLicSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFIDAES 123
Cdd:COG2319  309 DGT-VRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLA--SGSDDGTVrLWDLATGELlRTLTGHtgAVTSVAFSPDG 384

                         90
                 ....*....|....*..
gi 321400126 124 RQLVTGCADGQLWIFSL 140
Cdd:COG2319  385 RTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
418-726 1.54e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 1.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 570
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 571 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 649
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 321400126 650 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 726
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-727 5.06e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 5.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 576
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 577 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 655
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 321400126 656 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
418-727 4.89e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 4.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 496
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 497 GKdmfSKPIQSAQFyyidafillssgpefqllryhidtckdeikrykqksksklicrlSTTGavdmtslsavndfysHIV 576
Cdd:COG2319  160 GH---SGAVTSVAF--------------------------------------------SPDG---------------KLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 577 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCERHFEGH 655
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS---PD--GKLLASGSADGTvRLWDLATGKLLRTLTGH 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 321400126 656 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:COG2319  246 --SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
424-727 8.34e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 8.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 424 YSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKdmFSK 503
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG--HTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 504 PIQSAQFyyidafillssgpefqllryhidtckdeikrykqksksklicrlSTTGavdmtslsavndfysHIVLAAGRNR 583
Cdd:COG2319  122 AVRSVAF--------------------------------------------SPDG---------------KTLASGSADG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 584 TVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTTQqpqayNLFLTTAIGDG-MRLWDLRTLRCERHFEGHPTRGYpc 662
Cdd:COG2319  143 TVRLWDLATGKLLRTL-TGHSGAVTSV------AFSPD-----GKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVR-- 208

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321400126 663 GIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
418-689 9.94e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 9.94e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG 497
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 498 KDmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVNDf 571
Cdd:COG2319  244 GH--SGSVRSV------AFspdgrLLASGSADGTVRLWDLAT-------------GELLRTLTGhSGGV--NSVAFSPD- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126 572 ySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqpqAYNLFLTTAIGDGM-RLWDLRTLRCER 650
Cdd:COG2319  300 -GKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS-----PDGKTLASGSDDGTvRLWDLATGELLR 366

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 321400126 651 HFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGS 689
Cdd:COG2319  367 TLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-486 1.24e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 1.24e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 321400126 418 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 486
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 452-486 1.79e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.79e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 321400126   452 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 486
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
452-486 1.91e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.91e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 321400126  452 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 486
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-139 2.28e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDpSHQLLILRGHHQPITAMAFGNkvNPLLICSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFIDAES 123
Cdd:cd00200  198 DGT-IKLWDLST-GKCLGTLRGHENGVNSVAFSP--DGYLLASGSEDGTIrVWDLRTGECvQTLSGHtnSVTSLAWSPDG 273

                         90
                 ....*....|....*.
gi 321400126 124 RQLVTGCADGQLWIFS 139
Cdd:cd00200  274 KRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 689-727 5.40e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 321400126   689 SSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
48-140 3.25e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDPsHQLLILRGHHQPITAMAFGNKVNPLLicSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFIDAES 123
Cdd:COG2319  309 DGT-VRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLA--SGSDDGTVrLWDLATGELlRTLTGHtgAVTSVAFSPDG 384

                         90
                 ....*....|....*..
gi 321400126 124 RQLVTGCADGQLWIFSL 140
Cdd:COG2319  385 RTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
694-727 5.91e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 321400126  694 HRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 727
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-144 8.13e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECREK---VLQAYPLLSLFIDAESRQLVTGCADGQLWIFSLMD 142
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGELLrtlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82


                 ..
gi 321400126 143 GH 144
Cdd:cd00200   83 GE 84
WD40 COG2319
WD40 repeat [General function prediction only];
48-140 1.24e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTkDPSHQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFID 120
Cdd:COG2319  267 DGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFspdGK-----LLASGSDDGTVrLWDLATGKLlRTLTGHtgAVRSVAFS 339

                         90       100
                 ....*....|....*....|
gi 321400126 121 AESRQLVTGCADGQLWIFSL 140
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
48-143 1.56e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQAY--PLLSLFID 120
Cdd:COG2319  141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHtgAVRSVAFS 213

                         90       100
                 ....*....|....*....|...
gi 321400126 121 AESRQLVTGCADGQLWIFSLMDG 143
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
48-143 1.68e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321400126  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVIM-WNLDECREKVL---QAYPLLSLFID 120
Cdd:COG2319  225 DGT-VRLWDLATGK-LLRTLTGHSGSVRSVAFspdGR-----LLASGSADGTVRlWDLATGELLRTltgHSGGVNSVAFS 297

                         90       100
                 ....*....|....*....|...
gi 321400126 121 AESRQLVTGCADGQLWIFSLMDG 143
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATG 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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