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Conserved domains on  [gi|318068039|ref|NP_001186976|]
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nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 2 [Homo sapiens]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 7-144 1.25e-72

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member cd09286:

Pssm-ID: 469580 [Multi-domain]  Cd Length: 225  Bit Score: 217.56  E-value: 1.25e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   7 VVLLACGSFNPITNMHLRMFEVARDHLHQT-------------------------------------------------- 36
Cdd:cd09286    1 VVLLACGSFNPITNMHLRMFELARDHLHETgryevvggiispvndaygkkglasakhrvamcrlavqssdwirvddwesl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  37 -------------------------------------AVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRV 79
Cdd:cd09286   81 qpewmrtakvlrhhreeinnkyggiegaakrvldgsrREVKIMLLCGADLLESFGIPGLWKDADLEEILGEFGLVVVERT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 318068039  80 GHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:cd09286  161 GSDPENFIASSDILRKYQDNIHLVKDWIPNDISSTKVRRALRRGMSVKYLLPDPVIEYIEQHQLY 225
 
Name Accession Description Interval E-value
NMNAT_Eukarya cd09286
Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide ...
 7-144 1.25e-72

Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis. This subfamily consists strictly of eukaryotic members and includes secondary structural elements not found in all NMNATs.


Pssm-ID: 185681 [Multi-domain]  Cd Length: 225  Bit Score: 217.56  E-value: 1.25e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   7 VVLLACGSFNPITNMHLRMFEVARDHLHQT-------------------------------------------------- 36
Cdd:cd09286    1 VVLLACGSFNPITNMHLRMFELARDHLHETgryevvggiispvndaygkkglasakhrvamcrlavqssdwirvddwesl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  37 -------------------------------------AVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRV 79
Cdd:cd09286   81 qpewmrtakvlrhhreeinnkyggiegaakrvldgsrREVKIMLLCGADLLESFGIPGLWKDADLEEILGEFGLVVVERT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 318068039  80 GHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:cd09286  161 GSDPENFIASSDILRKYQDNIHLVKDWIPNDISSTKVRRALRRGMSVKYLLPDPVIEYIEQHQLY 225
TIGR00482 TIGR00482
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the ...
 10-144 7.24e-49

nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273101 [Multi-domain]  Cd Length: 193  Bit Score: 155.94  E-value: 7.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   10 LACGSFNPITNMHLRMFEVARDHLHQTAV--------------------------------------------------- 38
Cdd:TIGR00482   1 LFGGSFDPIHYGHLLLAEEALDHLDLDKVifvptanpphkktyeaasshhrlamlklaiednpkfevddfeikrggpsyt 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   39 -------------PELKLLCGADVLKTFQtpnLWKdaHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKE 105
Cdd:TIGR00482  81 idtlkhlkkkypdVELYFIIGADALRSFP---LWK--DWQELLELVHLVIVPRPGYTLDKALLEKAILRMHHGNLTLLHN 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 318068039  106 PVqNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:TIGR00482 156 PR-VPISSTEIRQRIRQGKSIEYLLPDPVIKYIKQHGLY 193
PLN02945 PLN02945
nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase
 1-145 1.46e-44

nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase


Pssm-ID: 178531 [Multi-domain]  Cd Length: 236  Bit Score: 146.37  E-value: 1.46e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   1 MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQ--------------------------------------------- 35
Cdd:PLN02945  17 TGPRTRVVLVATGSFNPPTYMHLRMFELARDALMSegyhvlggymspvndaykkkglasaehriqmcqlacedsdfimvd 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  36 --------------------------TAVPELK----LLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKG 85
Cdd:PLN02945  97 pwearqstyqrtltvlarvetslnnnGLASEESvrvmLLCGSDLLESFSTPGVWIPDQVRTICRDYGVVCIRREGQDVEK 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  86 YIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYT 145
Cdd:PLN02945 177 LVSQDEILNENRGNILVVDDLVPNSISSTRVRECISRGLSVKYLTPDGVIDYIKEHGLYM 236
NadD COG1057
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; ...
 40-144 5.00e-24

Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; Nicotinate-nucleotide adenylyltransferase NadD is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 440677 [Multi-domain]  Cd Length: 197  Bit Score: 92.49  E-value: 5.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  40 ELKLLCGADVLKTFQTpnlWKDahIQEIVEKFGLVCVGRVGHDPKGYIAESPILrmHQHNIHLAKEPVQnEISATYIRRA 119
Cdd:COG1057  100 ELYFIIGADALLQLPK---WKR--WEELLELAHLVVVPRPGYELDELEELEALK--PGGRIILLDVPLL-DISSTEIRER 171

                         90       100
                 ....*....|....*....|....*
gi 318068039 120 LGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:COG1057  172 LAEGKSIRYLVPDAVEDYIREHGLY 196
CTP_transf_like pfam01467
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ...
 10-119 2.90e-06

Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.


Pssm-ID: 396172 [Multi-domain]  Cd Length: 134  Bit Score: 44.23  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   10 LACGSFNPITNMHLRMFEVARDHLHQT---AVP-------------------------------------ELK------- 42
Cdd:pfam01467   1 LFGGTFDPIHLGHLRLLEQAKELFDEDlivGVPsdepphklkrplfsaeerlemlelakwvdevivvapwELTrellkel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   43 ----LLCGADVLKTFqtpnlWKDahIQEIVEKFGLVCVGRvghdpkgyiaespilrmhqhNIHLAKEPVQNEISATYIRR 118
Cdd:pfam01467  81 npdvLVIGADSLLDF-----WYE--LDEILGNVKLVVVVR--------------------PVFFIPLKPTNGISSTDIRE 133


                  .
gi 318068039  119 A 119
Cdd:pfam01467 134 R 134
 
Name Accession Description Interval E-value
NMNAT_Eukarya cd09286
Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide ...
 7-144 1.25e-72

Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis. This subfamily consists strictly of eukaryotic members and includes secondary structural elements not found in all NMNATs.


Pssm-ID: 185681 [Multi-domain]  Cd Length: 225  Bit Score: 217.56  E-value: 1.25e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   7 VVLLACGSFNPITNMHLRMFEVARDHLHQT-------------------------------------------------- 36
Cdd:cd09286    1 VVLLACGSFNPITNMHLRMFELARDHLHETgryevvggiispvndaygkkglasakhrvamcrlavqssdwirvddwesl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  37 -------------------------------------AVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRV 79
Cdd:cd09286   81 qpewmrtakvlrhhreeinnkyggiegaakrvldgsrREVKIMLLCGADLLESFGIPGLWKDADLEEILGEFGLVVVERT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 318068039  80 GHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:cd09286  161 GSDPENFIASSDILRKYQDNIHLVKDWIPNDISSTKVRRALRRGMSVKYLLPDPVIEYIEQHQLY 225
TIGR00482 TIGR00482
nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the ...
 10-144 7.24e-49

nicotinate (nicotinamide) nucleotide adenylyltransferase; This model represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1), synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273101 [Multi-domain]  Cd Length: 193  Bit Score: 155.94  E-value: 7.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   10 LACGSFNPITNMHLRMFEVARDHLHQTAV--------------------------------------------------- 38
Cdd:TIGR00482   1 LFGGSFDPIHYGHLLLAEEALDHLDLDKVifvptanpphkktyeaasshhrlamlklaiednpkfevddfeikrggpsyt 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   39 -------------PELKLLCGADVLKTFQtpnLWKdaHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKE 105
Cdd:TIGR00482  81 idtlkhlkkkypdVELYFIIGADALRSFP---LWK--DWQELLELVHLVIVPRPGYTLDKALLEKAILRMHHGNLTLLHN 155

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 318068039  106 PVqNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:TIGR00482 156 PR-VPISSTEIRQRIRQGKSIEYLLPDPVIKYIKQHGLY 193
PLN02945 PLN02945
nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase
 1-145 1.46e-44

nicotinamide-nucleotide adenylyltransferase/nicotinate-nucleotide adenylyltransferase


Pssm-ID: 178531 [Multi-domain]  Cd Length: 236  Bit Score: 146.37  E-value: 1.46e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   1 MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQ--------------------------------------------- 35
Cdd:PLN02945  17 TGPRTRVVLVATGSFNPPTYMHLRMFELARDALMSegyhvlggymspvndaykkkglasaehriqmcqlacedsdfimvd 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  36 --------------------------TAVPELK----LLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKG 85
Cdd:PLN02945  97 pwearqstyqrtltvlarvetslnnnGLASEESvrvmLLCGSDLLESFSTPGVWIPDQVRTICRDYGVVCIRREGQDVEK 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  86 YIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYT 145
Cdd:PLN02945 177 LVSQDEILNENRGNILVVDDLVPNSISSTRVRECISRGLSVKYLTPDGVIDYIKEHGLYM 236
NadD COG1057
Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; ...
 40-144 5.00e-24

Nicotinate-nucleotide adenylyltransferase NadD [Coenzyme transport and metabolism]; Nicotinate-nucleotide adenylyltransferase NadD is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 440677 [Multi-domain]  Cd Length: 197  Bit Score: 92.49  E-value: 5.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  40 ELKLLCGADVLKTFQTpnlWKDahIQEIVEKFGLVCVGRVGHDPKGYIAESPILrmHQHNIHLAKEPVQnEISATYIRRA 119
Cdd:COG1057  100 ELYFIIGADALLQLPK---WKR--WEELLELAHLVVVPRPGYELDELEELEALK--PGGRIILLDVPLL-DISSTEIRER 171

                         90       100
                 ....*....|....*....|....*
gi 318068039 120 LGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:COG1057  172 LAEGKSIRYLVPDAVEDYIREHGLY 196
NMNAT cd02165
Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate ...
 40-144 1.25e-16

Nicotinamide/nicotinate mononucleotide adenylyltransferase; Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT). NMNAT represents the primary bacterial and eukaryotic adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide. It is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). Nicotinamide-nucleotide adenylyltransferase synthesizes NAD via the salvage pathway, while nicotinate-nucleotide adenylyltransferase synthesizes the immediate precursor of NAD via the de novo pathway. Human NMNAT displays unique dual substrate specificity toward both NMN and NaMN, and can participate in both de novo and salvage pathways of NAD synthesis.


Pssm-ID: 185680 [Multi-domain]  Cd Length: 192  Bit Score: 73.05  E-value: 1.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  40 ELKLLCGADVLKTFQTpnlWKDahIQEIVEKFGLVCVGRVGHDPKGYIAESPILrmHQHNIHLAKEPVQNeISATYIRRA 119
Cdd:cd02165   96 ELYFIIGSDNLIRLPK---WYD--WEELLSLVHLVVAPRPGYPIEDASLEKLLL--PGGRIILLDNPLLN-ISSTEIRER 167

                         90       100
                 ....*....|....*....|....*
gi 318068039 120 LGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:cd02165  168 LKNGKSIRYLLPPAVADYIKEHGLY 192
nadD PRK00071
nicotinate-nucleotide adenylyltransferase;
46-144 6.00e-16

nicotinate-nucleotide adenylyltransferase;


Pssm-ID: 234611 [Multi-domain]  Cd Length: 203  Bit Score: 71.40  E-value: 6.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  46 GADVLKTFQTpnlWKDahIQEIVEKFGLVCVGRvghdpKGYIAESPILRMHQH------NIHLAKEPvQNEISATYIRRA 119
Cdd:PRK00071 108 GADALAQLPR---WKR--WEEILDLVHFVVVPR-----PGYPLEALALPALQQlleaagAITLLDVP-LLAISSTAIRER 176

                         90       100
                 ....*....|....*....|....*
gi 318068039 120 LGQGQSVKYLIPDAVITYIKDHGLY 144
Cdd:PRK00071 177 IKEGRPIRYLLPEAVLDYIEKHGLY 201
CTP_transf_like pfam01467
Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; ...
 10-119 2.90e-06

Cytidylyltransferase-like; This family includes: Cholinephosphate cytidylyltransferase; glycerol-3-phosphate cytidylyltransferase. It also includes putative adenylyltransferases, and FAD synthases.


Pssm-ID: 396172 [Multi-domain]  Cd Length: 134  Bit Score: 44.23  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   10 LACGSFNPITNMHLRMFEVARDHLHQT---AVP-------------------------------------ELK------- 42
Cdd:pfam01467   1 LFGGTFDPIHLGHLRLLEQAKELFDEDlivGVPsdepphklkrplfsaeerlemlelakwvdevivvapwELTrellkel 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   43 ----LLCGADVLKTFqtpnlWKDahIQEIVEKFGLVCVGRvghdpkgyiaespilrmhqhNIHLAKEPVQNEISATYIRR 118
Cdd:pfam01467  81 npdvLVIGADSLLDF-----WYE--LDEILGNVKLVVVVR--------------------PVFFIPLKPTNGISSTDIRE 133


                  .
gi 318068039  119 A 119
Cdd:pfam01467 134 R 134
cytidylyltransferase_like cd02039
Cytidylyltransferase-like domain; Cytidylyltransferase-like domain. Many of these proteins are ...
 8-119 1.11e-03

Cytidylyltransferase-like domain; Cytidylyltransferase-like domain. Many of these proteins are known to use CTP or ATP and release pyrophosphate. Protein families that contain at least one copy of this domain include citrate lyase ligase, pantoate-beta-alanine ligase, glycerol-3-phosphate cytidyltransferase, ADP-heptose synthase, phosphocholine cytidylyltransferase, lipopolysaccharide core biosynthesis protein KdtB, the bifunctional protein NadR, and a number whose function is unknown.


Pssm-ID: 185678 [Multi-domain]  Cd Length: 143  Bit Score: 37.42  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039   8 VLLACGSFNPITNMHLRMFEVARDHL------------------------------------------------------ 33
Cdd:cd02039    1 VGIIIGRFEPFHLGHLKLIKEALEEAldeviiiivsnppkkkrnkdpfslhervemlkeilkdrlkvvpvdfpevkilla 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318068039  34 ------HQTAVPELKLLCGADvlkTFQTPNLWKDAHIQEIVEKFGLVCVGRVGhdpkgyiaespilrmhqhnihlakepV 107
Cdd:cd02039   81 vvfilkILLKVGPDKVVVGED---FAFGKNASYNKDLKELFLDIEIVEVPRVR--------------------------D 131

                        170
                 ....*....|..
gi 318068039 108 QNEISATYIRRA 119
Cdd:cd02039  132 GKKISSTLIREL 143
NadR COG1056
Nicotinamide mononucleotide adenylyltransferase [Coenzyme transport and metabolism]; ...
 108-140 7.75e-03

Nicotinamide mononucleotide adenylyltransferase [Coenzyme transport and metabolism]; Nicotinamide mononucleotide adenylyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 440676 [Multi-domain]  Cd Length: 162  Bit Score: 35.17  E-value: 7.75e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 318068039 108 QNEISATYIRRALGQGQSVKYLIPDAVITYIKD 140
Cdd:COG1056  124 REEYSGTEIRRLMLEGEDWESLVPPAVAEVIEE 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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