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Conserved domains on  [gi|314122220|ref|NP_001186621|]
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anion exchange protein 2 isoform 1 [Homo sapiens]

Protein Classification

anion exchange protein( domain architecture ID 11489727)

TC 2.A.31 family anion exchange protein preferentially catalyzes anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
324-1240 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


:

Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1476.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   324 FVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVE 403
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   404 QMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHhhgqGAESDPHVTEPlmggvpETRLEVER 482
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGgLSRARSQSSIGKTLSH----DASEMPNPDNG------APLLPHQP 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   483 ERELPPPAPPAGITrSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP 562
Cdd:TIGR00834  151 LTEMQLLSVPGDIG-SREKSKLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGP 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   563 SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--- 639
Cdd:TIGR00834  230 SGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKRYEpst 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   640 -QGRLLPTGAGLEPksaqdkallQMVEAAGAAEDD-PLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717
Cdd:TIGR00834  310 vRPENPTMGGDTEP---------EDGGSEGPHGDDdPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYF 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   718 AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIG 797
Cdd:TIGR00834  381 AALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIG 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   798 FWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVD--GGENMTWAgar 875
Cdd:TIGR00834  461 LWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQVFYNTLFCVPPkpQGPSVSAL--- 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   876 ptLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIE 955
Cdd:TIGR00834  538 --LEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFIG 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   956 DTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLD 1035
Cdd:TIGR00834  616 DTYTQKLSVPSGLKVTNPSARGWFIPPLGENRPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLD 695
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1036 LLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPL 1115
Cdd:TIGR00834  696 LLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRIPL 775
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1116 AVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILIL 1195
Cdd:TIGR00834  776 AVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVLIL 855
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 314122220  1196 TVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMP 1240
Cdd:TIGR00834  856 TVPLRRLLLPRLFTERELKCLDKEDAKVTFDEEDGEDEYNEVPMP 900
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
324-1240 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1476.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   324 FVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVE 403
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   404 QMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHhhgqGAESDPHVTEPlmggvpETRLEVER 482
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGgLSRARSQSSIGKTLSH----DASEMPNPDNG------APLLPHQP 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   483 ERELPPPAPPAGITrSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP 562
Cdd:TIGR00834  151 LTEMQLLSVPGDIG-SREKSKLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGP 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   563 SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--- 639
Cdd:TIGR00834  230 SGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKRYEpst 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   640 -QGRLLPTGAGLEPksaqdkallQMVEAAGAAEDD-PLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717
Cdd:TIGR00834  310 vRPENPTMGGDTEP---------EDGGSEGPHGDDdPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYF 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   718 AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIG 797
Cdd:TIGR00834  381 AALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIG 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   798 FWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVD--GGENMTWAgar 875
Cdd:TIGR00834  461 LWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQVFYNTLFCVPPkpQGPSVSAL--- 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   876 ptLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIE 955
Cdd:TIGR00834  538 --LEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFIG 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   956 DTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLD 1035
Cdd:TIGR00834  616 DTYTQKLSVPSGLKVTNPSARGWFIPPLGENRPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLD 695
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1036 LLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPL 1115
Cdd:TIGR00834  696 LLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRIPL 775
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1116 AVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILIL 1195
Cdd:TIGR00834  776 AVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVLIL 855
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 314122220  1196 TVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMP 1240
Cdd:TIGR00834  856 TVPLRRLLLPRLFTERELKCLDKEDAKVTFDEEDGEDEYNEVPMP 900
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
680-1167 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 781.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGA 759
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   760 QPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYET 839
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   840 FYKLVKIFQEHPLH-----GCSASNSSEVDGGENMTWAGARPTLGPG--NRSLAGQSGQGKPRG-----QPNTALLSLVL 907
Cdd:pfam00955  161 FKKLIKIFKKYPLYlnydcTCVPPSSNNTTNSTLSLSTESSSINWSSllTNSECTESYGGTLVGsgcgyVPDTALLSLIL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   908 MAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEdTYTQKLSVPSGFSVTAPeKRGWVINPLGeks 987
Cdd:pfam00955  241 FLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLG-VYTPKLQVPSGFKPTRP-DRGWIINPFG--- 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   988 PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANA 1067
Cdd:pfam00955  316 KNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNS 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1068 LTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPK 1147
Cdd:pfam00955  396 LKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFFDRILLLFMPQK 475
                          490       500
                   ....*....|....*....|
gi 314122220  1148 HHPDVTYVKKVRTLRMHLFT 1167
Cdd:pfam00955  476 HQPDTHYLRHVPLRKVHLFT 495
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
524-606 1.78e-07

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 51.78  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  524 VEFLSRPTMAFVRLREAVELDAVLEVPVpvRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAIN 603
Cdd:COG1762    70 PEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLK 147

                  ...
gi 314122220  604 AFL 606
Cdd:COG1762   148 EAE 150
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
324-1240 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1476.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   324 FVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVE 403
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   404 QMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS-FPRNISAGSLGSLLGHhhgqGAESDPHVTEPlmggvpETRLEVER 482
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGgLSRARSQSSIGKTLSH----DASEMPNPDNG------APLLPHQP 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   483 ERELPPPAPPAGITrSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGP 562
Cdd:TIGR00834  151 LTEMQLLSVPGDIG-SREKSKLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGP 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   563 SSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREE--- 639
Cdd:TIGR00834  230 SGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKRYEpst 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   640 -QGRLLPTGAGLEPksaqdkallQMVEAAGAAEDD-PLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYF 717
Cdd:TIGR00834  310 vRPENPTMGGDTEP---------EDGGSEGPHGDDdPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYF 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   718 AALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIG 797
Cdd:TIGR00834  381 AALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIG 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   798 FWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVD--GGENMTWAgar 875
Cdd:TIGR00834  461 LWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQVFYNTLFCVPPkpQGPSVSAL--- 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   876 ptLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIE 955
Cdd:TIGR00834  538 --LEKDCSKLGGTLGGNNCRFQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFIG 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   956 DTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLD 1035
Cdd:TIGR00834  616 DTYTQKLSVPSGLKVTNPSARGWFIPPLGENRPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLD 695
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1036 LLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPL 1115
Cdd:TIGR00834  696 LLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILKRIPL 775
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1116 AVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILIL 1195
Cdd:TIGR00834  776 AVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVLIL 855
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 314122220  1196 TVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMP 1240
Cdd:TIGR00834  856 TVPLRRLLLPRLFTERELKCLDKEDAKVTFDEEDGEDEYNEVPMP 900
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
680-1167 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 781.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   680 RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGA 759
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   760 QPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYET 839
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   840 FYKLVKIFQEHPLH-----GCSASNSSEVDGGENMTWAGARPTLGPG--NRSLAGQSGQGKPRG-----QPNTALLSLVL 907
Cdd:pfam00955  161 FKKLIKIFKKYPLYlnydcTCVPPSSNNTTNSTLSLSTESSSINWSSllTNSECTESYGGTLVGsgcgyVPDTALLSLIL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   908 MAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEdTYTQKLSVPSGFSVTAPeKRGWVINPLGeks 987
Cdd:pfam00955  241 FLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLG-VYTPKLQVPSGFKPTRP-DRGWIINPFG--- 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   988 PFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANA 1067
Cdd:pfam00955  316 KNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNS 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  1068 LTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPK 1147
Cdd:pfam00955  396 LKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFFDRILLLFMPQK 475
                          490       500
                   ....*....|....*....|
gi 314122220  1148 HHPDVTYVKKVRTLRMHLFT 1167
Cdd:pfam00955  476 HQPDTHYLRHVPLRKVHLFT 495
Band_3_cyto pfam07565
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
359-613 6.18e-126

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


Pssm-ID: 429542  Cd Length: 255  Bit Score: 387.85  E-value: 6.18e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   359 RWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFS- 437
Cdd:pfam07565    8 RWGKPHVATLSFHSLLELRRCLAKGTVLLDLEATSLPGVAHLVLDQMIYSGQIRPEDREEVLRALLLKHSHQNELKELGg 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   438 -FPRNISAGSLGSLLGHHHGqGAESDPHVTEPLMGGVPETRLEVERERElpppappaGITRSKSKHELKLLEKIPENAEA 516
Cdd:pfam07565   88 vKPAVRSLSSIGSSLSHGHD-DSKPLLPQQSSLEGGLLCEQGEGPNSDE--------QLTVSESKSPLHFLKKIPEDAEA 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   517 TVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERE 596
Cdd:pfam07565  159 TNVLVGEVDFLERPVLAFVRLKEAVPLEGVTEVPVPVRFLFILLGPSGPGLDYHEIGRAIATLMSDEVFHDVAYKADDRE 238
                          250
                   ....*....|....*..
gi 314122220   597 DLLTAINAFLDCSVVLP 613
Cdd:pfam07565  239 DLLAGIDEFLDCSIVLP 255
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
524-606 1.78e-07

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 51.78  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220  524 VEFLSRPTMAFVRLREAVELDAVLEVPVpvRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAIN 603
Cdd:COG1762    70 PEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLK 147

                  ...
gi 314122220  604 AFL 606
Cdd:COG1762   148 EAE 150
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
524-603 6.73e-03

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 38.34  E-value: 6.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 314122220   524 VEFLSRPTMAFVRLREAVELDAvlEVPVPVRFLFLLLGPSSANMDYHEIGRsISTLMSDKQFHEAAYLADEREDLLTAIN 603
Cdd:pfam00359   63 SEAVKKPGIAVLTLKEPVDFGS--EDGKPVKLIFLLAAPDNEASHLKILSQ-LARLLQDEEFVEKLLKAKDPEEILEILK 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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