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Conserved domains on  [gi|313482852|ref|NP_001186252|]
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biogenesis of lysosome-related organelles complex 1 subunit 5 isoform 3 [Homo sapiens]

Protein Classification

Muted superfamily-containing protein( domain architecture ID 140914)

Muted superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Muted super family cl20826
Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to ...
 36-85 1.38e-20

Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.


The actual alignment was detected with superfamily member pfam14942:

Pssm-ID: 464390 [Multi-domain]  Cd Length: 146  Bit Score: 79.62  E-value: 1.38e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 313482852   36 IKDLGEIHSRLLDHRPVIQGETRYFVKEFECKqlmtqsvdsnRGNRNEKR 85
Cdd:pfam14942   1 IKDIGEIYSRLLDHRPFIQGEIKYFLKEFEEK----------RGDREVRR 40
 
Name Accession Description Interval E-value
Muted pfam14942
Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to ...
 36-85 1.38e-20

Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.


Pssm-ID: 464390 [Multi-domain]  Cd Length: 146  Bit Score: 79.62  E-value: 1.38e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 313482852   36 IKDLGEIHSRLLDHRPVIQGETRYFVKEFECKqlmtqsvdsnRGNRNEKR 85
Cdd:pfam14942   1 IKDIGEIYSRLLDHRPFIQGEIKYFLKEFEEK----------RGDREVRR 40
 
Name Accession Description Interval E-value
Muted pfam14942
Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to ...
 36-85 1.38e-20

Organelle biogenesis, Muted-like protein; The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.


Pssm-ID: 464390 [Multi-domain]  Cd Length: 146  Bit Score: 79.62  E-value: 1.38e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 313482852   36 IKDLGEIHSRLLDHRPVIQGETRYFVKEFECKqlmtqsvdsnRGNRNEKR 85
Cdd:pfam14942   1 IKDIGEIYSRLLDHRPFIQGEIKYFLKEFEEK----------RGDREVRR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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