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Conserved domains on  [gi|313482820|ref|NP_001186232|]
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CCR4-NOT transcription complex subunit 2 isoform a [Homo sapiens]

Protein Classification

NOT2/NOT3/NOT5 family protein( domain architecture ID 10514428)

NOT2/NOT3/NOT5 family protein similar to Homo sapiens CCR4-NOT transcription complex subunit 2 (CNOT2), which is a component of the CCR4-NOT complex that is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
396-519 1.54e-50

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


:

Pssm-ID: 461199  Cd Length: 121  Bit Score: 169.32  E-value: 1.54e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820  396 YPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKlAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEE 475
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYPQEPLPRLE-SPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 313482820  476 RVWITRAPgmEPTMKTNTYERGTYYFFDcLNWRKVAK-EFHLEYD 519
Cdd:pfam04153  80 RTWFTRDE--EPKVITNEYERGTYIYFD-YTWEQRRKkDFTLDYE 121
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
396-519 1.54e-50

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 169.32  E-value: 1.54e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820  396 YPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKlAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEE 475
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYPQEPLPRLE-SPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 313482820  476 RVWITRAPgmEPTMKTNTYERGTYYFFDcLNWRKVAK-EFHLEYD 519
Cdd:pfam04153  80 RTWFTRDE--EPKVITNEYERGTYIYFD-YTWEQRRKkDFTLDYE 121
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
370-522 3.35e-30

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 116.23  E-value: 3.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820 370 DPGMVHLALGSDLTTLGLNLNSP----ENLYPKFASPWASSPCRPQDIDFHVPSEYlTNIH----IRDKLAAIKLGRYGE 441
Cdd:COG5601   13 DEEQSIHDLGKDLLSEILSLVRPkkyqDRPSTTLYSPWAESTKKPVQPMFMLPNCY-PNAPnppiFKVNIEDMKMDNFHD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820 442 DLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKL 521
Cdd:COG5601   92 ETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPGMSPATADHVKERGSYVFFDPFSWSKVSLDFLLDYKAV 171

                 .
gi 313482820 522 E 522
Cdd:COG5601  172 R 172
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
396-519 1.54e-50

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 169.32  E-value: 1.54e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820  396 YPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKlAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEE 475
Cdd:pfam04153   1 YSTFNSPWPLDAERPYEPDFRNPACYPQEPLPRLE-SPEKFSKFDDETLFYIFYSMPGDYAQYLAAKELKKRSWRYHKKL 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 313482820  476 RVWITRAPgmEPTMKTNTYERGTYYFFDcLNWRKVAK-EFHLEYD 519
Cdd:pfam04153  80 RTWFTRDE--EPKVITNEYERGTYIYFD-YTWEQRRKkDFTLDYE 121
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
370-522 3.35e-30

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 116.23  E-value: 3.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820 370 DPGMVHLALGSDLTTLGLNLNSP----ENLYPKFASPWASSPCRPQDIDFHVPSEYlTNIH----IRDKLAAIKLGRYGE 441
Cdd:COG5601   13 DEEQSIHDLGKDLLSEILSLVRPkkyqDRPSTTLYSPWAESTKKPVQPMFMLPNCY-PNAPnppiFKVNIEDMKMDNFHD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482820 442 DLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKL 521
Cdd:COG5601   92 ETLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPGMSPATADHVKERGSYVFFDPFSWSKVSLDFLLDYKAV 171

                 .
gi 313482820 522 E 522
Cdd:COG5601  172 R 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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