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Conserved domains on  [gi|312222716|ref|NP_001185946|]
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leucine-rich repeat-containing protein 49 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-318 5.48e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 122 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 201
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 202 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 273
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222716 274 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 318
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-318 5.48e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 122 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 201
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 202 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 273
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222716 274 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 318
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-299 4.27e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 4.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  99 RLSLERQKLTVCPI-INGEDHLRLLNFQHNFITRIQN-ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKK 175
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 176 ISN-LENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH 253
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222716 254 LFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQN 299
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR_9 pfam14580
Leucine-rich repeat;
188-319 1.12e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  188 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 264
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 312222716  265 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 319
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-318 5.48e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 122 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 201
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 202 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 273
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222716 274 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 318
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-299 4.27e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 4.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  99 RLSLERQKLTVCPI-INGEDHLRLLNFQHNFITRIQN-ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKK 175
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 176 ISN-LENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH 253
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 312222716 254 LFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQN 299
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-286 1.61e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  56 LLQHDLERNYSSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNI 135
Cdd:COG4886   30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 136 SNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKI-SNLENLKSLDVLDLHGNQITKI-ENINHLCELRVLNL 212
Cdd:COG4886  110 SNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDL 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222716 213 ARNFLSHV-DNLNGLDSLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVSCLadsSSLSDITFDGNPI 286
Cdd:COG4886  190 SNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-307 1.17e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  70 GDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDN 149
Cdd:COG4886    5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 150 QIEEISGLSTLRCLRVLLLGKNriKKISNLENLKSldvLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLD 227
Cdd:COG4886   85 LLLGLTDLGDLTNLTELDLSGN--EELSNLTNLES---LDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 228 SLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVscLADSSSLSDITFDGNPIAQESwykhTVLQNMMQLRQL 306
Cdd:COG4886  160 NLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLP----EPLANLTNLETL 233


                 .
gi 312222716 307 D 307
Cdd:COG4886  234 D 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-266 1.61e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 119 LRLLNFQHNFITRI-QNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 197
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312222716 198 IeNINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDS 266
Cdd:COG4886  287 L-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR_9 pfam14580
Leucine-rich repeat;
188-319 1.12e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  188 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 264
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 312222716  265 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 319
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_8 pfam13855
Leucine rich repeat;
206-261 8.11e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 8.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  206 ELRVLNLARNFLSHVD--NLNGLDSLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNI 261
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-299 1.02e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 118 HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIK--KISNLENLKSLDVLDLHGNQI 195
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 196 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSS 275
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170       180
                 ....*....|....*....|....
gi 312222716 276 LSDITFDGNPIAQESWYKHTVLQN 299
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
121-308 2.34e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 121 LLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIEN 200
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 201 INHLCELRVLNLARNflshvDNLNGLDSLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNISSFDSVscLADSSSLSDI 279
Cdd:COG4886   92 LGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSL 164

                        170       180
                 ....*....|....*....|....*....
gi 312222716 280 TFDGNPIAQESwykhTVLQNMMQLRQLDM 308
Cdd:COG4886  165 DLSNNQLTDLP----EELGNLTNLKELDL 189
LRR_8 pfam13855
Leucine rich repeat;
184-239 9.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 9.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  184 SLDVLDLHGNQITKI--ENINHLCELRVLNLARNFLSHVDN--LNGLDSLTELNLRHNQI 239
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 163-203 1.77e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 312222716  163 LRVLLLGKNRIKKISNLENLKSLDVLDLHGN-QITKIENINH 203
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-279 3.95e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  99 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEIS--GLSTLRCLRVLLLGKNRIKKI 176
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlkELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 177 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFL 256
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        170       180
                 ....*....|....*....|...
gi 312222716 257 SFNNISSFDSVSCLADSSSLSDI 279
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 119-198 1.37e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 119 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLrclrvlllgknrikkisnLENLKSLDVLDLHGNQITKI 198
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDL------------------LSSWPSLRELDLTGNPVCKK 183
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 143-240 1.70e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 143 SLDLYDNQIEE------ISGLSTLRCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IENINHL 204
Cdd:COG5238  268 TLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqgaialAKALQEN 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 312222716 205 CELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQIT 240
Cdd:COG5238  348 TTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIG 389
LRR_8 pfam13855
Leucine rich repeat;
228-286 1.98e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312222716  228 SLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNISSFDSVScLADSSSLSDITFDGNPI 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 139-181 2.10e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 312222716  139 QKLISLDLYDNQIEEISGLSTLRCLRVL-LLGKNRIKKISNLEN 181
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 183-228 2.10e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 312222716  183 KSLDVLDLHGNQITKIENINHLCELRVLNLARNFLshVDNLNGLDS 228
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 140-262 8.38e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 8.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 140 KLISLDLYDNQI-----EEISG-LSTLRCLRVLLLGKN--------RIKKIsnLENLKSLDVLDLHGNQITKI------E 199
Cdd:cd00116  138 ALEKLVLGRNRLegascEALAKaLRANRDLKELNLANNgigdagirALAEG--LKANCNLEVLDLNNNGLTDEgasalaE 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222716 200 NINHLCELRVLNLARNFLSHVD-------NLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNIS 262
Cdd:cd00116  216 TLASLKSLEVLNLGDNNLTDAGaaalasaLLSPNISLLTLSLSCNDITddgakdLAEVLAEKESLLELDLRGNKFG 291
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 228-260 1.37e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.37e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 312222716  228 SLTELNLRHNQITFVRDVDNLPCLQHLFLSFNN 260
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 118-158 2.17e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 312222716  118 HLRLLNFQHNFITRIQNISNLQKLISLDLYDN-QIEEISGLS 158
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 132-289 2.55e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 132 IQNISNLQKLISLDLYDNQI--EEISGLSTL----RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK-- 197
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIgdEGVIALAEAlknnTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDeg 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 198 ----IENINHLCELRVLNLARNFLSHV------DNLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNI 261
Cdd:COG5238  309 aialAEGLQGNKTLHTLNLAYNGIGAQgaialaKALQENTTLHSLDLSDNQIGdegaiaLAKYLEGNTTLRELNLGKNNI 388

                        170       180       190
                 ....*....|....*....|....*....|.
gi 312222716 262 SSfDSVSCLADSS---SLSDITFDGNPIAQE 289
Cdd:COG5238  389 GK-QGAEALIDALqtnRLHTLILDGNLIGAE 418
LRR_8 pfam13855
Leucine rich repeat;
118-173 3.38e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716  118 HLRLLNFQHNFITRI--QNISNLQKLISLDLYDNQIEEISG--LSTLRCLRVLLLGKNRI 173
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 139-262 8.13e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 8.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222716 139 QKLISLDLYDNQIEEiSGLSTL-------RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IE 199
Cdd:COG5238  180 NSVETVYLGCNQIGD-EGIEELaealtqnTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGDegvialAE 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312222716 200 NINHLCELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH------LFLSFNNIS 262
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIG 333
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 207-249 8.55e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 312222716  207 LRVLNLARNFLSHVDNLNGLDSLTELNLRHNqiTFVRDVDNLP 249
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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