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Conserved domains on  [gi|312176368|ref|NP_001185886|]
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DDB1- and CUL4-associated factor 6 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-261 2.67e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTiRSGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEQDAETNRqcqFTCHYGTTYEIMTVPNDPYtFL 127
Cdd:cd00200   37 DLETGELLRT-LKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVAFSPDGRI-LS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 128 SCGEDGTVRWFDTRIKTSCTKEDCKDDilincrrAATSVAICPPiPYYLAVGCSDSSVRIYDrrmlgtratgnyagrGTT 207
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTD-------WVNSVAFSPD-GTFVASSSQDGTIKLWD---------------LRT 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 208 GMVARFIPSHlnnkSCRVTSLCYSEDGQEILVSySSDY-IYLFDPkdDTARELKT 261
Cdd:cd00200  167 GKCVATLTGH----TGEVNSVAFSPDGEKLLSS-SSDGtIKLWDL--STGKCLGT 214
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 790-849 1.53e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 790 GANFVMSGSDcGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200  189 GEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
363-712 1.35e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14949:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 944  Bit Score: 45.87  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 363 VSETAMEVDTPAEQFLQPSTSSTM-----------SAQAHSTSSPTESPHSTPLLSSPDSEQR-QSVEASGHHTHHQSEF 430
Cdd:PRK14949 367 QVDDPAEISLPEGQTPSALAAAVQaphanepqfvnAAPAEKKTALTEQTTAQQQVQAANAEAVaEADASAEPADTVEQAL 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 431 lrGPEIALLrKRL---QQLRLKKAEQQ----------RQQELAAHTQQQPSTS------------DQSSHEGSSQDPHAS 485
Cdd:PRK14949 447 --DDESELL-AALnaeQAVILSQAQSQgfeasssldaDNSAVPEQIDSTAEQSvvnpsvtdtqvdDTSASNNSAADNTVD 523

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 486 DSPS---SVVNKQLGSM-------SLDEQQDNNNEKLSPKPGTGEPvLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGI 555
Cdd:PRK14949 524 DNYSaedTLESNGLDEGdyaqdsaPLDAYQDDYVAFSSESYNALSD-DEQHSANVQSAQSAAEAQPSSQSLSPISAVTTA 602

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 556 -------------------------------GSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAEN 604
Cdd:PRK14949 603 aasladddildavlaardsllsdldalspkeGDGKKSSADRKPKTPPSRAPPASLSKPASSPDASQTSASFDLDPDFELA 682

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 605 PVENHINI-TQSDKFTAKPLDSNsgerndlNLDRSCGV--PE-ESASSEKAKEPETSDQTSTESATNENNTN----PEPQ 676
Cdd:PRK14949 683 THQSVPEAaLASGSAPAPPPVPD-------PYDRPPWEeaPEvASANDGPNNAAEGNLSESVEDASNSELQAveqqATHQ 755

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 312176368 677 FQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPG 712
Cdd:PRK14949 756 PQVQAEAQSPASTTALTQTSSEVQDTELNLVLLSSG 791
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-261 2.67e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTiRSGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEQDAETNRqcqFTCHYGTTYEIMTVPNDPYtFL 127
Cdd:cd00200   37 DLETGELLRT-LKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVAFSPDGRI-LS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 128 SCGEDGTVRWFDTRIKTSCTKEDCKDDilincrrAATSVAICPPiPYYLAVGCSDSSVRIYDrrmlgtratgnyagrGTT 207
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTD-------WVNSVAFSPD-GTFVASSSQDGTIKLWD---------------LRT 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 208 GMVARFIPSHlnnkSCRVTSLCYSEDGQEILVSySSDY-IYLFDPkdDTARELKT 261
Cdd:cd00200  167 GKCVATLTGH----TGEVNSVAFSPDGEKLLSS-SSDGtIKLWDL--STGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
48-261 5.22e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTIRsGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEqdaetNRQCQFTCHyGTTYEIMTV---PnDPY 124
Cdd:COG2319  190 DLATGKLLRTLT-GHTGAVRSVAFSP--DGKLLASGSADGTVRLWDLA-----TGKLLRTLT-GHSGSVRSVafsP-DGR 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 125 TFLSCGEDGTVRWFDTRiktscTKEDCKddILINCRRAATSVAICPPiPYYLAVGCSDSSVRIYDRRmlgtratgnyagr 204
Cdd:COG2319  260 LLASGSADGTVRLWDLA-----TGELLR--TLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLA------------- 318

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312176368 205 gtTGMVARFIPSHLNnkscRVTSLCYSEDGQeILVSYSSD-YIYLFDPkdDTARELKT 261
Cdd:COG2319  319 --TGKLLRTLTGHTG----AVRSVAFSPDGK-TLASGSDDgTVRLWDL--ATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 790-849 1.53e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 790 GANFVMSGSDcGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200  189 GEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 363-712 1.35e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 45.87  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 363 VSETAMEVDTPAEQFLQPSTSSTM-----------SAQAHSTSSPTESPHSTPLLSSPDSEQR-QSVEASGHHTHHQSEF 430
Cdd:PRK14949 367 QVDDPAEISLPEGQTPSALAAAVQaphanepqfvnAAPAEKKTALTEQTTAQQQVQAANAEAVaEADASAEPADTVEQAL 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 431 lrGPEIALLrKRL---QQLRLKKAEQQ----------RQQELAAHTQQQPSTS------------DQSSHEGSSQDPHAS 485
Cdd:PRK14949 447 --DDESELL-AALnaeQAVILSQAQSQgfeasssldaDNSAVPEQIDSTAEQSvvnpsvtdtqvdDTSASNNSAADNTVD 523

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 486 DSPS---SVVNKQLGSM-------SLDEQQDNNNEKLSPKPGTGEPvLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGI 555
Cdd:PRK14949 524 DNYSaedTLESNGLDEGdyaqdsaPLDAYQDDYVAFSSESYNALSD-DEQHSANVQSAQSAAEAQPSSQSLSPISAVTTA 602

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 556 -------------------------------GSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAEN 604
Cdd:PRK14949 603 aasladddildavlaardsllsdldalspkeGDGKKSSADRKPKTPPSRAPPASLSKPASSPDASQTSASFDLDPDFELA 682

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 605 PVENHINI-TQSDKFTAKPLDSNsgerndlNLDRSCGV--PE-ESASSEKAKEPETSDQTSTESATNENNTN----PEPQ 676
Cdd:PRK14949 683 THQSVPEAaLASGSAPAPPPVPD-------PYDRPPWEeaPEvASANDGPNNAAEGNLSESVEDASNSELQAveqqATHQ 755

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 312176368 677 FQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPG 712
Cdd:PRK14949 756 PQVQAEAQSPASTTALTQTSSEVQDTELNLVLLSSG 791
WD40 COG2319
WD40 repeat [General function prediction only];
796-850 8.79e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 8.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 796 SGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSP 850
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 810-849 3.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312176368   810 TAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-261 2.67e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTiRSGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEQDAETNRqcqFTCHYGTTYEIMTVPNDPYtFL 127
Cdd:cd00200   37 DLETGELLRT-LKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVAFSPDGRI-LS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 128 SCGEDGTVRWFDTRIKTSCTKEDCKDDilincrrAATSVAICPPiPYYLAVGCSDSSVRIYDrrmlgtratgnyagrGTT 207
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTD-------WVNSVAFSPD-GTFVASSSQDGTIKLWD---------------LRT 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 208 GMVARFIPSHlnnkSCRVTSLCYSEDGQEILVSySSDY-IYLFDPkdDTARELKT 261
Cdd:cd00200  167 GKCVATLTGH----TGEVNSVAFSPDGEKLLSS-SSDGtIKLWDL--STGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-244 1.15e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTIRsGHRANIFSAKFLPctNDKQIVSCSGDG-VIFYtnveqDAETNRQCQ-FTCHYGttyEIMTVPNDP-- 123
Cdd:cd00200  121 DVETGKCLTTLR-GHTDWVNSVAFSP--DGTFVASSSQDGtIKLW-----DLRTGKCVAtLTGHTG---EVNSVAFSPdg 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 124 YTFLSCGEDGTVRWFDTRiKTSCTKEdckddiLINCRRAATSVAICPPiPYYLAVGCSDSSVRIYDRRMLGTRATgnyag 203
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLS-TGKCLGT------LRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRTGECVQT----- 256

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 312176368 204 rgttgmvarfIPSHLNnkscRVTSLCYSEDGQeILVSYSSD 244
Cdd:cd00200  257 ----------LSGHTN----SVTSLAWSPDGK-RLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
48-261 5.22e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTIRsGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEqdaetNRQCQFTCHyGTTYEIMTV---PnDPY 124
Cdd:COG2319  190 DLATGKLLRTLT-GHTGAVRSVAFSP--DGKLLASGSADGTVRLWDLA-----TGKLLRTLT-GHSGSVRSVafsP-DGR 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 125 TFLSCGEDGTVRWFDTRiktscTKEDCKddILINCRRAATSVAICPPiPYYLAVGCSDSSVRIYDRRmlgtratgnyagr 204
Cdd:COG2319  260 LLASGSADGTVRLWDLA-----TGELLR--TLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLA------------- 318

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312176368 205 gtTGMVARFIPSHLNnkscRVTSLCYSEDGQeILVSYSSD-YIYLFDPkdDTARELKT 261
Cdd:COG2319  319 --TGKLLRTLTGHTG----AVRSVAFSPDGK-TLASGSDDgTVRLWDL--ATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
48-268 2.69e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTIRsGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEQDAETNRqcqFTCHygtTYEIMTV---PNDPy 124
Cdd:COG2319  148 DLATGKLLRTLT-GHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLATGKLLRT---LTGH---TGAVRSVafsPDGK- 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 125 TFLSCGEDGTVRWFDTR----IKTsctkedckddiLINCRRAATSVAICPPiPYYLAVGCSDSSVRIYDRrmlgtratgn 200
Cdd:COG2319  218 LLASGSADGTVRLWDLAtgklLRT-----------LTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDL---------- 275

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312176368 201 yagrgTTGMVARFIPSHlnnkSCRVTSLCYSEDGQeILVSYSSDY-IYLFDPkdDTARELKTPSAEERR 268
Cdd:COG2319  276 -----ATGELLRTLTGH----SGGVNSVAFSPDGK-LLASGSDDGtVRLWDL--ATGKLLRTLTGHTGA 332
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-189 7.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 7.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  60 SGHRANIFSAKFLPctNDKQIVSCSGDGVIFYTNVEQDAETnrqCQFTCHygtTYEIMTV--PNDPYTFLSCGEDGTVRW 137
Cdd:cd00200  174 TGHTGEVNSVAFSP--DGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGH---ENGVNSVafSPDGYLLASGSEDGTIRV 245

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 312176368 138 FDTRiKTSCTKEdckddiLINCRRAATSVAICPPIPyYLAVGCSDSSVRIYD 189
Cdd:cd00200  246 WDLR-TGECVQT------LSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-253 4.59e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 4.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368  48 NVHDGCVLTTIRsGHRANIFSAKFLPctNDKQIVSCSGDGVI-FYtnveqDAETNRQCQ-FTCHYGTTYEIMTVPnDPYT 125
Cdd:COG2319  232 DLATGKLLRTLT-GHSGSVRSVAFSP--DGRLLASGSADGTVrLW-----DLATGELLRtLTGHSGGVNSVAFSP-DGKL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 126 FLSCGEDGTVRWFDTRIKTSCTkedckddILINCRRAATSVAIcPPIPYYLAVGCSDSSVRIYDRRmlgtratgnyagrg 205
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLA-------------- 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 312176368 206 tTGMVARFIPSHLNnkscRVTSLCYSEDGQeILVSYSSDY-IYLFDPKD 253
Cdd:COG2319  361 -TGELLRTLTGHTG----AVTSVAFSPDGR-TLASGSADGtVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 790-849 1.53e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 790 GANFVMSGSDcGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200  189 GEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 772-849 1.28e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312176368 772 VYKGHRNSRTMIKEANfwGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200    4 TLKGHTGGVTCVAFSP--DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 363-712 1.35e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 45.87  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 363 VSETAMEVDTPAEQFLQPSTSSTM-----------SAQAHSTSSPTESPHSTPLLSSPDSEQR-QSVEASGHHTHHQSEF 430
Cdd:PRK14949 367 QVDDPAEISLPEGQTPSALAAAVQaphanepqfvnAAPAEKKTALTEQTTAQQQVQAANAEAVaEADASAEPADTVEQAL 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 431 lrGPEIALLrKRL---QQLRLKKAEQQ----------RQQELAAHTQQQPSTS------------DQSSHEGSSQDPHAS 485
Cdd:PRK14949 447 --DDESELL-AALnaeQAVILSQAQSQgfeasssldaDNSAVPEQIDSTAEQSvvnpsvtdtqvdDTSASNNSAADNTVD 523

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 486 DSPS---SVVNKQLGSM-------SLDEQQDNNNEKLSPKPGTGEPvLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGI 555
Cdd:PRK14949 524 DNYSaedTLESNGLDEGdyaqdsaPLDAYQDDYVAFSSESYNALSD-DEQHSANVQSAQSAAEAQPSSQSLSPISAVTTA 602

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 556 -------------------------------GSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAEN 604
Cdd:PRK14949 603 aasladddildavlaardsllsdldalspkeGDGKKSSADRKPKTPPSRAPPASLSKPASSPDASQTSASFDLDPDFELA 682

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 605 PVENHINI-TQSDKFTAKPLDSNsgerndlNLDRSCGV--PE-ESASSEKAKEPETSDQTSTESATNENNTN----PEPQ 676
Cdd:PRK14949 683 THQSVPEAaLASGSAPAPPPVPD-------PYDRPPWEeaPEvASANDGPNNAAEGNLSESVEDASNSELQAveqqATHQ 755

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 312176368 677 FQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPG 712
Cdd:PRK14949 756 PQVQAEAQSPASTTALTQTSSEVQDTELNLVLLSSG 791
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 763-850 3.42e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312176368 763 NIRRPLVKMVYKGHRNSrtmIKEANF-WGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGI 841
Cdd:cd00200  121 DVETGKCLTTLRGHTDW---VNSVAFsPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197


                 ....*....
gi 312176368 842 DYDIKIWSP 850
Cdd:cd00200  198 DGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 792-849 7.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 7.53e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312176368 792 NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
796-850 8.79e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 8.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 796 SGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSP 850
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 796-850 1.28e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 312176368 796 SGSDcGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSP 850
Cdd:cd00200  111 SSRD-KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
792-850 1.74e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.74e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312176368 792 NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSP 850
Cdd:COG2319  343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 792-849 2.86e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.86e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312176368 792 NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 810-849 3.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 3.84e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312176368   810 TAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWS 849
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
792-850 4.88e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 4.88e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312176368 792 NFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSP 850
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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